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The map label for this gene is rnz

Identifier: 108759389

GI number: 108759389

Start: 762526

End: 763449

Strand: Reverse

Name: rnz

Synonym: MXAN_0663

Alternate gene names: 108759389

Gene position: 763449-762526 (Counterclockwise)

Preceding gene: 108761266

Following gene: 108757886

Centisome position: 8.35

GC content: 70.24

Gene sequence:

>924_bases
ATGTCCCTCCTCAGGCTCACGTTCCTTGGTACATCCGCCGCGCAGCCCACGCTGCACCGGAACCTGTCCGGACTCGCGGT
GAAGGCGCACTCAGACCTGCTGCTCTTCGACTGTGGCGAGGGCAGCCAGCGGCAGATGGTGCGCTACGGCACCGGCTTCA
CCGTGGACGCGGTGTTCTTCACGCATTTCCACGCGGACCACTACCTGGGCATCATCGGCTTCCTGCGCACGCTGGGCATG
ACGGGGCGCTCCGAGCCCATCCACCTGTACGGCCCGCCCTCCGCGAAGCGCCTGCTCCACCAGGCCGTCCACCTGGGCGT
GGAGTCCATGTCCTTCCCAGTGGAGATTCACGAACTGAAGGACGGTGACGTGGTGCCACGCAAGGGCTACGCGGTCCACG
CGGTGGGCGTGGACCACCGCATCAACGCCCTGGGCTACGCGCTGGTGGAGGACGACCGGCCCGGACGCTTCAACCTGGAC
GTGGCGCGCTCACTGGGCGTGCCGGAGGGCCCCAGCTTCGGAAAGCTCCAGCGGGGCGAGCCGGTGACGCTGGAGGACGG
GCGGACGGTGAAGCCGGAGGACGTGCTCGGCGCGCCACGCCCGGGGCGCCGGCTGGTCATCTCCGGGGACACGCGCCCGT
GCCCGGCGCTGGTGAAGGCCGCGAAGGACGCGGACCTGCTGGTCCACGAGTCCACCTTCTCCGACGACGAACAGGAGCGG
GCCGTGGAGACCCGGCACTCCACCGCGCGGGAAGCGGCGCGCGTGGCGCGAGAGGCGGGAGCACGGCGGCTGGTGCTCAC
CCACCTCTCCAGCCGGCACGACACCGACCCCTCGAAACTGCTCACGCAGGCGCGCGAGGAGTACCAGGGGCCGGTGGAGG
TGGCCTTCGACGGGTTCACCGTCGAATTACCCCTCCGGGACTGA

Upstream 100 bases:

>100_bases
GGCGGCCACATAGCATGGGTGCCTCCAACCCTGGTAAATGGCCCCCTCGCGTCGGCGGTTGCCTGGCGCGGGAGGTCCTC
AACGCGTGGGAAGTGCCGGC

Downstream 100 bases:

>100_bases
GGCTACTGAATCTTCTCGGACTCGGCGCGCAGGGCCGACGCGGACTCGGCGTCCACGCGCTGGACCAGCTCCCACTCCAG
CGCCTCGTCCCGGGTGATGT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSLLRLTFLGTSAAQPTLHRNLSGLAVKAHSDLLLFDCGEGSQRQMVRYGTGFTVDAVFFTHFHADHYLGIIGFLRTLGM
TGRSEPIHLYGPPSAKRLLHQAVHLGVESMSFPVEIHELKDGDVVPRKGYAVHAVGVDHRINALGYALVEDDRPGRFNLD
VARSLGVPEGPSFGKLQRGEPVTLEDGRTVKPEDVLGAPRPGRRLVISGDTRPCPALVKAAKDADLLVHESTFSDDEQER
AVETRHSTAREAARVAREAGARRLVLTHLSSRHDTDPSKLLTQAREEYQGPVEVAFDGFTVELPLRD

Sequences:

>Translated_307_residues
MSLLRLTFLGTSAAQPTLHRNLSGLAVKAHSDLLLFDCGEGSQRQMVRYGTGFTVDAVFFTHFHADHYLGIIGFLRTLGM
TGRSEPIHLYGPPSAKRLLHQAVHLGVESMSFPVEIHELKDGDVVPRKGYAVHAVGVDHRINALGYALVEDDRPGRFNLD
VARSLGVPEGPSFGKLQRGEPVTLEDGRTVKPEDVLGAPRPGRRLVISGDTRPCPALVKAAKDADLLVHESTFSDDEQER
AVETRHSTAREAARVAREAGARRLVLTHLSSRHDTDPSKLLTQAREEYQGPVEVAFDGFTVELPLRD
>Mature_306_residues
SLLRLTFLGTSAAQPTLHRNLSGLAVKAHSDLLLFDCGEGSQRQMVRYGTGFTVDAVFFTHFHADHYLGIIGFLRTLGMT
GRSEPIHLYGPPSAKRLLHQAVHLGVESMSFPVEIHELKDGDVVPRKGYAVHAVGVDHRINALGYALVEDDRPGRFNLDV
ARSLGVPEGPSFGKLQRGEPVTLEDGRTVKPEDVLGAPRPGRRLVISGDTRPCPALVKAAKDADLLVHESTFSDDEQERA
VETRHSTAREAARVAREAGARRLVLTHLSSRHDTDPSKLLTQAREEYQGPVEVAFDGFTVELPLRD

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=319, Percent_Identity=33.5423197492163, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI260166619, Length=307, Percent_Identity=29.9674267100977, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI145553959, Length=311, Percent_Identity=29.903536977492, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI260166622, Length=311, Percent_Identity=29.903536977492, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI87082078, Length=306, Percent_Identity=38.2352941176471, Blast_Score=210, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71985814, Length=76, Percent_Identity=48.6842105263158, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71985808, Length=76, Percent_Identity=48.6842105263158, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_MYXXD (Q1DEJ2)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_628931.1
- ProteinModelPortal:   Q1DEJ2
- SMR:   Q1DEJ2
- STRING:   Q1DEJ2
- GeneID:   4101051
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_0663
- TIGR:   MXAN_0663
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- PhylomeDB:   Q1DEJ2
- ProtClustDB:   CLSK945015
- BioCyc:   MXAN246197:MXAN_0663-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 33674; Mature: 33542

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLRLTFLGTSAAQPTLHRNLSGLAVKAHSDLLLFDCGEGSQRQMVRYGTGFTVDAVFF
CCEEEEEEECCCCCCCHHHCCCCCEEEEECCCEEEEECCCCCHHHHEEECCCCEEEEEEE
THFHADHYLGIIGFLRTLGMTGRSEPIHLYGPPSAKRLLHQAVHLGVESMSFPVEIHELK
EHHCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHCCHHHCCCCEEEEECC
DGDVVPRKGYAVHAVGVDHRINALGYALVEDDRPGRFNLDVARSLGVPEGPSFGKLQRGE
CCCCCCCCCCEEEEECCCCHHHHEEEEEEECCCCCEEEHHHHHHCCCCCCCCCCCCCCCC
PVTLEDGRTVKPEDVLGAPRPGRRLVISGDTRPCPALVKAAKDADLLVHESTFSDDEQER
CEEECCCCEECHHHHCCCCCCCCEEEEECCCCCCHHHHHHCCCCCEEEEECCCCCCHHHH
AVETRHSTAREAARVAREAGARRLVLTHLSSRHDTDPSKLLTQAREEYQGPVEVAFDGFT
HHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCEE
VELPLRD
EEEECCC
>Mature Secondary Structure 
SLLRLTFLGTSAAQPTLHRNLSGLAVKAHSDLLLFDCGEGSQRQMVRYGTGFTVDAVFF
CEEEEEEECCCCCCCHHHCCCCCEEEEECCCEEEEECCCCCHHHHEEECCCCEEEEEEE
THFHADHYLGIIGFLRTLGMTGRSEPIHLYGPPSAKRLLHQAVHLGVESMSFPVEIHELK
EHHCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHCCHHHCCCCEEEEECC
DGDVVPRKGYAVHAVGVDHRINALGYALVEDDRPGRFNLDVARSLGVPEGPSFGKLQRGE
CCCCCCCCCCEEEEECCCCHHHHEEEEEEECCCCCEEEHHHHHHCCCCCCCCCCCCCCCC
PVTLEDGRTVKPEDVLGAPRPGRRLVISGDTRPCPALVKAAKDADLLVHESTFSDDEQER
CEEECCCCEECHHHHCCCCCCCCEEEEECCCCCCHHHHHHCCCCCEEEEECCCCCCHHHH
AVETRHSTAREAARVAREAGARRLVLTHLSSRHDTDPSKLLTQAREEYQGPVEVAFDGFT
HHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCEE
VELPLRD
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA