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The map label for this gene is coaBC [H]

Identifier: 108759385

GI number: 108759385

Start: 5398560

End: 5399780

Strand: Reverse

Name: coaBC [H]

Synonym: MXAN_4395

Alternate gene names: 108759385

Gene position: 5399780-5398560 (Counterclockwise)

Preceding gene: 108759448

Following gene: 108760490

Centisome position: 59.08

GC content: 71.66

Gene sequence:

>1221_bases
ATGGACGTGACGACTCTGAAAGGCCGCCGGGTGGTCGTTGGCGTGGGTGGCGGCATCGCGGCGTACAAGGCCTGCGAGCT
GGTGCGGGAACTGTCGCGTGCAGGCGCCGAGGTGCGGGTGGCCATGACGGAGTCCGCGCGCCAGTTCGTCACCCCGCTCA
CCTTCCAGGCGCTCAGCGGGCACCCTGTGCTCACGGACTATTTCGACCCTGCCCAGGAGGGGAACTTCGGCCACCTGGAC
CTTGCGCGCTGGGCCGAGGTGTTCGTCGTGGCGCCGGCCACCGCGGACCTGCTGGCGCGCATCCGCGCGGGCATGGGGAA
CGACGCCGTGACGACGTCGCTGCTTGCCTTCCGGGGGCCGGTGGTGCTGGCGCCGGCGATGAACGTGGCCATGTGGGACA
ACCCCCTGACGCAGGAGAACCTGGCGGCCCTGCTGGCCTATCCGCGCTTCTCGCGCGTGGGCCCAGGCGCGGGGATGCTG
GCCTGTGGTGACGTGGGGGAGGGGCGACTGGCGGACGTTCCAGCCATCGTCCAGGCGGTCGCGGCGCGTTTCGGCGCTGG
CCCACTGGCGGGGAAGCGGGTGCTGCTGACGGCGGGCCCCACGCGCGAGTTCCTGGACCCGGTGCGGTTCATCTCCAATC
CCTCCACGGGGAAGATGGGCATGGCGCTCGCGCACGCGGCCCGGACCCTGGGCGCCGAGGTGACAGTGGTGCTTGGTCCC
GTGGGCACCGTGGAGCGCGGCGGCTTGGACATCGTGGACGTGGTGAGCGCGGACGACATGGCGCGCGAGGTGCTCTCACG
GGTGGGCACGGTGGATGTGTTCATCGCCACTGCGGCGGTCAGCGACTGGCGCCCGGAGACGCGCGCGCCGCAGAAGGTGA
AGAAGGGCGCTTCGACGTCGCCCGAGGCGCTGACGCTCGTGCGCACGCCGGACGTGCTCGCGGAGGCCTCCCGCCAGGTG
GCGGGACAGCCGAAGCGGCCGGTGCTGGTGGGCTTCGCGGCGGAAACGGAGCGCGTGGTGGCGCACGCGCGCGACAAGCT
GGAGCGCAAGGGGCTGGACGCGATTGTCGCCAACGACGTGACGGCCCCTGGCGCGGGCTTTGGAACGGACACCAACCGGG
TGACGGTGCTCACGCGTTCGGGCGCGCAGCATGAACTCCAGGGCAGCAAGCGCGAGGTGGCGCAGGCCCTCATCGAGCTG
CTGCTCGTGTCTCCGTCCTAG

Upstream 100 bases:

>100_bases
CGTCGTGGATGTGCCTTCGAGCAGTGACGTCGTGATGATGGCCCACTGAGGCCCTGCCGGGACGGTTGCGAGCCCGCCTC
CCCGCGCATTAGGAAGCCGC

Downstream 100 bases:

>100_bases
CGGGGCTCCATCACTGCGAGGGTGACGGTGGTCTTCGACACGAGCCGGGGCGTGCCGCCGGAGACGGCGTGGACCTCGGA
CTCCGTGACGATGAGCCGGC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MDVTTLKGRRVVVGVGGGIAAYKACELVRELSRAGAEVRVAMTESARQFVTPLTFQALSGHPVLTDYFDPAQEGNFGHLD
LARWAEVFVVAPATADLLARIRAGMGNDAVTTSLLAFRGPVVLAPAMNVAMWDNPLTQENLAALLAYPRFSRVGPGAGML
ACGDVGEGRLADVPAIVQAVAARFGAGPLAGKRVLLTAGPTREFLDPVRFISNPSTGKMGMALAHAARTLGAEVTVVLGP
VGTVERGGLDIVDVVSADDMAREVLSRVGTVDVFIATAAVSDWRPETRAPQKVKKGASTSPEALTLVRTPDVLAEASRQV
AGQPKRPVLVGFAAETERVVAHARDKLERKGLDAIVANDVTAPGAGFGTDTNRVTVLTRSGAQHELQGSKREVAQALIEL
LLVSPS

Sequences:

>Translated_406_residues
MDVTTLKGRRVVVGVGGGIAAYKACELVRELSRAGAEVRVAMTESARQFVTPLTFQALSGHPVLTDYFDPAQEGNFGHLD
LARWAEVFVVAPATADLLARIRAGMGNDAVTTSLLAFRGPVVLAPAMNVAMWDNPLTQENLAALLAYPRFSRVGPGAGML
ACGDVGEGRLADVPAIVQAVAARFGAGPLAGKRVLLTAGPTREFLDPVRFISNPSTGKMGMALAHAARTLGAEVTVVLGP
VGTVERGGLDIVDVVSADDMAREVLSRVGTVDVFIATAAVSDWRPETRAPQKVKKGASTSPEALTLVRTPDVLAEASRQV
AGQPKRPVLVGFAAETERVVAHARDKLERKGLDAIVANDVTAPGAGFGTDTNRVTVLTRSGAQHELQGSKREVAQALIEL
LLVSPS
>Mature_406_residues
MDVTTLKGRRVVVGVGGGIAAYKACELVRELSRAGAEVRVAMTESARQFVTPLTFQALSGHPVLTDYFDPAQEGNFGHLD
LARWAEVFVVAPATADLLARIRAGMGNDAVTTSLLAFRGPVVLAPAMNVAMWDNPLTQENLAALLAYPRFSRVGPGAGML
ACGDVGEGRLADVPAIVQAVAARFGAGPLAGKRVLLTAGPTREFLDPVRFISNPSTGKMGMALAHAARTLGAEVTVVLGP
VGTVERGGLDIVDVVSADDMAREVLSRVGTVDVFIATAAVSDWRPETRAPQKVKKGASTSPEALTLVRTPDVLAEASRQV
AGQPKRPVLVGFAAETERVVAHARDKLERKGLDAIVANDVTAPGAGFGTDTNRVTVLTRSGAQHELQGSKREVAQALIEL
LLVSPS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=182, Percent_Identity=35.7142857142857, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI87082301, Length=379, Percent_Identity=47.4934036939314, Blast_Score=308, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17560194, Length=178, Percent_Identity=33.7078651685393, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322762, Length=198, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=30.6451612903226, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42504; Mature: 42504

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVTTLKGRRVVVGVGGGIAAYKACELVRELSRAGAEVRVAMTESARQFVTPLTFQALSG
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCHHHHHCCC
HPVLTDYFDPAQEGNFGHLDLARWAEVFVVAPATADLLARIRAGMGNDAVTTSLLAFRGP
CCCEECCCCCCCCCCCCCEEHHHHCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCC
VVLAPAMNVAMWDNPLTQENLAALLAYPRFSRVGPGAGMLACGDVGEGRLADVPAIVQAV
EEEECCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHH
AARFGAGPLAGKRVLLTAGPTREFLDPVRFISNPSTGKMGMALAHAARTLGAEVTVVLGP
HHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECC
VGTVERGGLDIVDVVSADDMAREVLSRVGTVDVFIATAAVSDWRPETRAPQKVKKGASTS
CCCCCCCCCCEEEECCHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCCHHHHHCCCCCC
PEALTLVRTPDVLAEASRQVAGQPKRPVLVGFAAETERVVAHARDKLERKGLDAIVANDV
CCEEEEEECCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCC
TAPGAGFGTDTNRVTVLTRSGAQHELQGSKREVAQALIELLLVSPS
CCCCCCCCCCCCEEEEEECCCCCHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDVTTLKGRRVVVGVGGGIAAYKACELVRELSRAGAEVRVAMTESARQFVTPLTFQALSG
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCHHHHHCCC
HPVLTDYFDPAQEGNFGHLDLARWAEVFVVAPATADLLARIRAGMGNDAVTTSLLAFRGP
CCCEECCCCCCCCCCCCCEEHHHHCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCC
VVLAPAMNVAMWDNPLTQENLAALLAYPRFSRVGPGAGMLACGDVGEGRLADVPAIVQAV
EEEECCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHH
AARFGAGPLAGKRVLLTAGPTREFLDPVRFISNPSTGKMGMALAHAARTLGAEVTVVLGP
HHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECC
VGTVERGGLDIVDVVSADDMAREVLSRVGTVDVFIATAAVSDWRPETRAPQKVKKGASTS
CCCCCCCCCCEEEECCHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCCHHHHHCCCCCC
PEALTLVRTPDVLAEASRQVAGQPKRPVLVGFAAETERVVAHARDKLERKGLDAIVANDV
CCEEEEEECCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCC
TAPGAGFGTDTNRVTVLTRSGAQHELQGSKREVAQALIELLLVSPS
CCCCCCCCCCCCEEEEEECCCCCHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]