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The map label for this gene is cobB [H]

Identifier: 108759295

GI number: 108759295

Start: 3879991

End: 3880728

Strand: Direct

Name: cobB [H]

Synonym: MXAN_3337

Alternate gene names: 108759295

Gene position: 3879991-3880728 (Clockwise)

Preceding gene: 108763576

Following gene: 108757726

Centisome position: 42.45

GC content: 68.97

Gene sequence:

>738_bases
ATGGATTCGCTCATCCTCGATTCGAATACCTGGCTGCTCGTTCTCACGGGCGCGGGAGTCTCCGCTGAAAGCGGAGTTCC
CACCTTCCGCGGGATGAGCGGACTCTGGGAGGACCAACCCGTGGAGGCCGTGGCGTCGCCCGAGGGCTTCCGGAAGGACC
CGGCGCTGGTGTGGCGCTTCTATTCGGAGCGCCGCAAGGCCGCCGCCGCCGTCCACCCCAACCCGGGCCACGAGGCGCTC
GTCGCCTGGGAACGCCACCTGGGGGACCGCTTCCTGCTCGCCACCCAGAACGTCGATGGCCTGCACACGCGCGCTGGAAG
TCAGCGGGTGGTGGAGATGCACGGCAACCTCTTCAAGACGCGCTGCAGCCGCTGCGGGCGGCCCCCGTTCGAGGACGCCA
CCGTGTACCCCGCAGGGGCGGTGCCCGAGTGCGACGCGTGTGGAAAGCTGCTGCGGCCCCACATCGTCTGGTTCGGCGAA
TACCTGGACCCGGCGGACATCCAGCGCATCGAGGACTTCTCGCTGCGGGCCGCCACTTCGGGTGGACGCTTCGTCTTTCT
GGCGGCGGGGACCTCTGGCGCCGTGTACCCGGCCGCTGGAATCGTGGACCAGGTGCGCAAGGCGGGCGGGAAGACGTGGC
TCGTCAACCTGGACCCGGCGGAGAACTCCAACCGCTTCGAGCACCGCATCGTGGACAAGAGCGGGGAAGTCCTCCCGACC
CTCGCGAAGCTCGCCTGA

Upstream 100 bases:

>100_bases
TGATGGGACCTCGCAAGGCGACCTCCCGCGAGCATCAGGCCCCGGTAGGGTCAGCGTCCCATCCATAGCTTGATTCGCTT
TCCGCCGCACAGGAGCCGAC

Downstream 100 bases:

>100_bases
CGCGGGGGGCGGAAGGACAGGGGGCACCGCGGTGCTTCCGCGTGCCCCCGTAGCGACTATTCGAAGACGGAGATGTCAGG
CCCGGACGGGCTCGCCGGCT

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MDSLILDSNTWLLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRFYSERRKAAAAVHPNPGHEAL
VAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRCGRPPFEDATVYPAGAVPECDACGKLLRPHIVWFGE
YLDPADIQRIEDFSLRAATSGGRFVFLAAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPT
LAKLA

Sequences:

>Translated_245_residues
MDSLILDSNTWLLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRFYSERRKAAAAVHPNPGHEAL
VAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRCGRPPFEDATVYPAGAVPECDACGKLLRPHIVWFGE
YLDPADIQRIEDFSLRAATSGGRFVFLAAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPT
LAKLA
>Mature_245_residues
MDSLILDSNTWLLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRFYSERRKAAAAVHPNPGHEAL
VAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRCGRPPFEDATVYPAGAVPECDACGKLLRPHIVWFGE
YLDPADIQRIEDFSLRAATSGGRFVFLAAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPT
LAKLA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912664, Length=253, Percent_Identity=38.7351778656126, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI13787215, Length=242, Percent_Identity=39.6694214876033, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI300795542, Length=234, Percent_Identity=40.5982905982906, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI6912662, Length=263, Percent_Identity=28.5171102661597, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI300797577, Length=241, Percent_Identity=31.1203319502075, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI63054862, Length=217, Percent_Identity=32.7188940092166, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI6912660, Length=219, Percent_Identity=31.9634703196347, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7657575, Length=213, Percent_Identity=29.1079812206573, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI308199517, Length=236, Percent_Identity=44.4915254237288, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17567771, Length=268, Percent_Identity=28.7313432835821, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71990482, Length=269, Percent_Identity=27.8810408921933, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71990487, Length=271, Percent_Identity=27.3062730627306, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17541892, Length=169, Percent_Identity=31.9526627218935, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325242, Length=235, Percent_Identity=29.7872340425532, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571445, Length=274, Percent_Identity=29.9270072992701, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24645650, Length=242, Percent_Identity=25.6198347107438, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571443, Length=202, Percent_Identity=29.2079207920792, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28571441, Length=202, Percent_Identity=29.2079207920792, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137536, Length=185, Percent_Identity=29.1891891891892, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26678; Mature: 26678

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00369 PTS_HPR_HIS ; PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSLILDSNTWLLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRF
CCCEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHH
YSERRKAAAAVHPNPGHEALVAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKT
HHHHHHHEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCHHHHHHCHHHHH
RCSRCGRPPFEDATVYPAGAVPECDACGKLLRPHIVWFGEYLDPADIQRIEDFSLRAATS
HHHHCCCCCCCCCEECCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHCEEEEECC
GGRFVFLAAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPT
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHEECCCCCCCHHH
LAKLA
HHHCC
>Mature Secondary Structure
MDSLILDSNTWLLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRF
CCCEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHH
YSERRKAAAAVHPNPGHEALVAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKT
HHHHHHHEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCHHHHHHCHHHHH
RCSRCGRPPFEDATVYPAGAVPECDACGKLLRPHIVWFGEYLDPADIQRIEDFSLRAATS
HHHHCCCCCCCCCEECCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHCEEEEECC
GGRFVFLAAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPT
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHEECCCCCCCHHH
LAKLA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]