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The map label for this gene is srrB [H]

Identifier: 108759268

GI number: 108759268

Start: 396925

End: 398613

Strand: Reverse

Name: srrB [H]

Synonym: MXAN_0340

Alternate gene names: 108759268

Gene position: 398613-396925 (Counterclockwise)

Preceding gene: 108757903

Following gene: 108760734

Centisome position: 4.36

GC content: 72.23

Gene sequence:

>1689_bases
GTGCGTCCGGAACGAACACTCCCAGGCCAGGGATGTTCGACATTCGCGACGGCATGGCCGCCCTGCCCGGAGGGACGCTC
CTCGCCCCGTTACAGCCATGCTCCCATGCAACACGATGGGTGGGGGGACTCGATGACGATGTTGGCGGCACTTGGTCAGG
CAGAAGCCCGGCGGTCCGGAGCACGAGGTCCAGCGATGCTGGAAGCCATCCTCCAGGTCTCCCCCCTGGCCATCCACCTG
ATGGACGTGGATGGCACGGTGCGGCTGTGGAACCCCGCCGCCGAGCGGCTCTTCGGCTGGAGCCGGGAGGACGTGCTTGG
CCACCGCGCCCCCTGGGCCACCGACGCCCGCTGGGAGAAGTTCCGCCGCCATCAGGAGCAGGCCACGCAGGGCATGGAGC
CGCCCTGTCTGGAGCTGGAGCTCCACCGGCGAGATGGCACGCCCCTCCATGTGGAGCTGTGGGCGGCGCCCATGCCACCG
GCCACCACCGGTCCCGCCCAGTGCCTGGGCATGCTGGTGGACGTCACCGAGCGGCGCCGGGGCGAGGCCCACCGACGGCT
CCTGTCAGAGGCCAGTGAAGTCCTCGGCTCCAGCCTGGAGCAGGACGCGACGCTGGAGCACCTGGTGCGGCTCGCCGTGC
CTGCCTGCGCGGATTCCTGCCGCGTGTTCCTCGAAGATGCCCCGGGCGAGGTGCGATGCGTGGCGTCCGCGGGCCTGGAT
GCACGGGAGCCCCTGAATGCGGGTACGCCTCTCGTCCCGGACGAAGCGGCGGTGTCGCGAATCATCGCGTCCGGAGAGCC
GGCGCTGCACGACGCGGAGCCGCCGTCCTGGCTGGGCGTGCCGCTGGCGTGGCCGGGGCGGAAGGGCGCCGCGCTTGTCT
TCTCGCGCACCGGACGGACCTTCGACGCGCGGGACGTGGCACTGGCGCGGGAGTTGGCGCGCCGGGCGTCACTCGCCCTG
GACCACGTGCGCCAGTACCACGAGGCGTGCCAGGCCATCCGCGCGCGCGAGGAGCTCTTGGCCATCGCCAGCCATGAGCT
GAAGTCCCCCCTCAGCGCGCTCCAGCTCCAGGTGCAGAACCTGCGCACCGCGCTGGAGCGCTCACCGGACGCCGTCCCCC
GGGAGCGGCTGCACCGGGGGCTGGACCTGATGGGCCGGCAGGCGAAGCGTCAGGCGAAGCTCATCGACGCGCTGCTGGAC
GTGTCGCGCATCCACGCCGGACGGCTGGAGCTGAACCCGGAGCCGGTGGACCTGGGCGCCCTGGTCCGCGAAGTGGCGGA
GCGCCTCGAGCCGGAGCTGGCGGGCGCGGGCACGCGCCTGACGTTGACACTGCCGTTGGAGGCCCACGGCTACTGGGACC
GGCTGCGACTGGACCAGGTGCTCACCAACCTGGTGTCCAACGCCATGAAGTACGGGCGGGGCAACCCCGTCCAGGTGACG
CTGTCCAGCACCCAGGCCCACGTGCGCCTGGACGTGCGCGACGCGGGCATCGGCATCGCGCCGGAGCACCTGCACCGCCT
CTTCCACCGCTTCGAGCGCGCCGTGTCCGGCCGGGACTACAGCGGCGTCGGCCTGGGGCTGTGGATTGTCCGCGAGGTGG
TGGAGGCCATGGGCGGCCACGTCACCGTGAGCAGCGAGCTGGGCGTGGGCTCCACCTTCACCGTCGTGCTGCCGCGGGCG
CGCGGGTGA

Upstream 100 bases:

>100_bases
AACCCGGGCCTGGAGCAACCGCCACCGTATCGCGCACAGAGTATTCCCTTGTGCGCCTGACGCCTCCCCGCCTCGGCGTC
ACAGGGCCCTAGGGCGGGGA

Downstream 100 bases:

>100_bases
GGACGCCGGGGCTCACCCGCGCGGGCGCGCCCCTCACAGCGCGAGGAACAGGATGGCGGCCTTCTCCTCGGGGCTCGCCG
CGAGGAACTCGTCCGGCAGC

Product: sensory box histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MRPERTLPGQGCSTFATAWPPCPEGRSSPRYSHAPMQHDGWGDSMTMLAALGQAEARRSGARGPAMLEAILQVSPLAIHL
MDVDGTVRLWNPAAERLFGWSREDVLGHRAPWATDARWEKFRRHQEQATQGMEPPCLELELHRRDGTPLHVELWAAPMPP
ATTGPAQCLGMLVDVTERRRGEAHRRLLSEASEVLGSSLEQDATLEHLVRLAVPACADSCRVFLEDAPGEVRCVASAGLD
AREPLNAGTPLVPDEAAVSRIIASGEPALHDAEPPSWLGVPLAWPGRKGAALVFSRTGRTFDARDVALARELARRASLAL
DHVRQYHEACQAIRAREELLAIASHELKSPLSALQLQVQNLRTALERSPDAVPRERLHRGLDLMGRQAKRQAKLIDALLD
VSRIHAGRLELNPEPVDLGALVREVAERLEPELAGAGTRLTLTLPLEAHGYWDRLRLDQVLTNLVSNAMKYGRGNPVQVT
LSSTQAHVRLDVRDAGIGIAPEHLHRLFHRFERAVSGRDYSGVGLGLWIVREVVEAMGGHVTVSSELGVGSTFTVVLPRA
RG

Sequences:

>Translated_562_residues
MRPERTLPGQGCSTFATAWPPCPEGRSSPRYSHAPMQHDGWGDSMTMLAALGQAEARRSGARGPAMLEAILQVSPLAIHL
MDVDGTVRLWNPAAERLFGWSREDVLGHRAPWATDARWEKFRRHQEQATQGMEPPCLELELHRRDGTPLHVELWAAPMPP
ATTGPAQCLGMLVDVTERRRGEAHRRLLSEASEVLGSSLEQDATLEHLVRLAVPACADSCRVFLEDAPGEVRCVASAGLD
AREPLNAGTPLVPDEAAVSRIIASGEPALHDAEPPSWLGVPLAWPGRKGAALVFSRTGRTFDARDVALARELARRASLAL
DHVRQYHEACQAIRAREELLAIASHELKSPLSALQLQVQNLRTALERSPDAVPRERLHRGLDLMGRQAKRQAKLIDALLD
VSRIHAGRLELNPEPVDLGALVREVAERLEPELAGAGTRLTLTLPLEAHGYWDRLRLDQVLTNLVSNAMKYGRGNPVQVT
LSSTQAHVRLDVRDAGIGIAPEHLHRLFHRFERAVSGRDYSGVGLGLWIVREVVEAMGGHVTVSSELGVGSTFTVVLPRA
RG
>Mature_562_residues
MRPERTLPGQGCSTFATAWPPCPEGRSSPRYSHAPMQHDGWGDSMTMLAALGQAEARRSGARGPAMLEAILQVSPLAIHL
MDVDGTVRLWNPAAERLFGWSREDVLGHRAPWATDARWEKFRRHQEQATQGMEPPCLELELHRRDGTPLHVELWAAPMPP
ATTGPAQCLGMLVDVTERRRGEAHRRLLSEASEVLGSSLEQDATLEHLVRLAVPACADSCRVFLEDAPGEVRCVASAGLD
AREPLNAGTPLVPDEAAVSRIIASGEPALHDAEPPSWLGVPLAWPGRKGAALVFSRTGRTFDARDVALARELARRASLAL
DHVRQYHEACQAIRAREELLAIASHELKSPLSALQLQVQNLRTALERSPDAVPRERLHRGLDLMGRQAKRQAKLIDALLD
VSRIHAGRLELNPEPVDLGALVREVAERLEPELAGAGTRLTLTLPLEAHGYWDRLRLDQVLTNLVSNAMKYGRGNPVQVT
LSSTQAHVRLDVRDAGIGIAPEHLHRLFHRFERAVSGRDYSGVGLGLWIVREVVEAMGGHVTVSSELGVGSTFTVVLPRA
RG

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=29.2887029288703, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=34.0425531914894, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=29.5833333333333, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI48994928, Length=316, Percent_Identity=25.6329113924051, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=29.3103448275862, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=330, Percent_Identity=28.7878787878788, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=29.8319327731092, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790861, Length=231, Percent_Identity=32.034632034632, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=29.8804780876494, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=219, Percent_Identity=30.1369863013699, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=28.8793103448276, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=29.646017699115, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=229, Percent_Identity=30.5676855895196, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61524; Mature: 61524

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPERTLPGQGCSTFATAWPPCPEGRSSPRYSHAPMQHDGWGDSMTMLAALGQAEARRSG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
ARGPAMLEAILQVSPLAIHLMDVDGTVRLWNPAAERLFGWSREDVLGHRAPWATDARWEK
CCCHHHHHHHHHCCCEEEEEEECCCEEEECCHHHHHHHCCCHHHHHCCCCCCCCCHHHHH
FRRHQEQATQGMEPPCLELELHRRDGTPLHVELWAAPMPPATTGPAQCLGMLVDVTERRR
HHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHC
GEAHRRLLSEASEVLGSSLEQDATLEHLVRLAVPACADSCRVFLEDAPGEVRCVASAGLD
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCC
AREPLNAGTPLVPDEAAVSRIIASGEPALHDAEPPSWLGVPLAWPGRKGAALVFSRTGRT
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
FDARDVALARELARRASLALDHVRQYHEACQAIRAREELLAIASHELKSPLSALQLQVQN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
LRTALERSPDAVPRERLHRGLDLMGRQAKRQAKLIDALLDVSRIHAGRLELNPEPVDLGA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHH
LVREVAERLEPELAGAGTRLTLTLPLEAHGYWDRLRLDQVLTNLVSNAMKYGRGNPVQVT
HHHHHHHHHCHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
LSSTQAHVRLDVRDAGIGIAPEHLHRLFHRFERAVSGRDYSGVGLGLWIVREVVEAMGGH
EECCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCC
VTVSSELGVGSTFTVVLPRARG
EEEECCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MRPERTLPGQGCSTFATAWPPCPEGRSSPRYSHAPMQHDGWGDSMTMLAALGQAEARRSG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
ARGPAMLEAILQVSPLAIHLMDVDGTVRLWNPAAERLFGWSREDVLGHRAPWATDARWEK
CCCHHHHHHHHHCCCEEEEEEECCCEEEECCHHHHHHHCCCHHHHHCCCCCCCCCHHHHH
FRRHQEQATQGMEPPCLELELHRRDGTPLHVELWAAPMPPATTGPAQCLGMLVDVTERRR
HHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHC
GEAHRRLLSEASEVLGSSLEQDATLEHLVRLAVPACADSCRVFLEDAPGEVRCVASAGLD
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCC
AREPLNAGTPLVPDEAAVSRIIASGEPALHDAEPPSWLGVPLAWPGRKGAALVFSRTGRT
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
FDARDVALARELARRASLALDHVRQYHEACQAIRAREELLAIASHELKSPLSALQLQVQN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
LRTALERSPDAVPRERLHRGLDLMGRQAKRQAKLIDALLDVSRIHAGRLELNPEPVDLGA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHH
LVREVAERLEPELAGAGTRLTLTLPLEAHGYWDRLRLDQVLTNLVSNAMKYGRGNPVQVT
HHHHHHHHHCHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
LSSTQAHVRLDVRDAGIGIAPEHLHRLFHRFERAVSGRDYSGVGLGLWIVREVVEAMGGH
EECCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCC
VTVSSELGVGSTFTVVLPRARG
EEEECCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA