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The map label for this gene is atoC [H]

Identifier: 108759138

GI number: 108759138

Start: 5983631

End: 5984974

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_4785

Alternate gene names: 108759138

Gene position: 5984974-5983631 (Counterclockwise)

Preceding gene: 108757476

Following gene: 108760693

Centisome position: 65.48

GC content: 72.1

Gene sequence:

>1344_bases
ATGAGCACCTATCTGTTGCTGGTCGATGACGACCGGACCTTCGCCTCGCTGGCGGCCTCCGTGCTGCGACACGAGGGCTT
CCGCGTCACGCTGGCGCATTCACTCCACGACGCACGTGGGGCCATGTCCCGCGAGGCGCCGGACCTGGTGGTGTTGGACC
GGCGCCTGCCGGACGGGGACGGCATCGACTTCCTGCCGGAGCTGCGCGCCCAGCTTCCGAACACGCCCGTGTTGATGGTG
ACGGCGCACGGCGACATCGCCAGCGCGGTGGAGGCCATCCAGGCGGGCGCGCGCGACTACCTGTCCAAGCCGGTGGAGCT
GGATGACCTGGTGCTGCGCGCCCGTCGCGCCGTCGCGGACCTGCAGCTCCAGGAGCGGCTGCGTCTGGCGGAGAGCGAGC
TGGGCGGACGGCGGCGCCTGTCGCGTCCGCACTCGCCGAAGATGCTCGCCGCGCTGCAGATGCTGGAGCGCATCGCCAAG
GCGCCGCGCAGCCCGGTGCTGCTGCTGGGCGAGACGGGCGTGGGCAAGGAGGTGATTGCGCGCCACCTGCACGCGCTGCA
AGGTGGGCAGGGCTCCTTCGTCCACGTCAACTGCGCCGCGCTGCCCGCCACGATGGTGGAAAGCGAACTCTTCGGCCACG
AGCGCGGCGCCTTCACCGACGCGCGAACCGCCCGCCGCGGCCTGGTGGAAGTGGCCGCGGGCGGCGTGCTCTTCCTGGAC
GAGGTGGGCGAGTTGCCGCTGCAGCTCCAGGCGAAGCTGCTCACCTTCCTGGACAAGGGCGCCTTCCGCCGCCTGGGTGG
CACCGCCGAGCTGAGCAGCAGCGCGCGCGTGGTGACGGCCACCAACCGCGACCTGACCAAGGAGGTGGCCGAGGGCCGCT
TCCGCGAGGACCTCTACTTCCGCCTGAGCGTCTTCCGGGTGGACATTCCGCCGCTGCGCGAGCGCCGCGAGGACTTGTTG
CCTCTTGCACAGTCCCTGGTGGCGGAGCTGGGCGCCGAGCTGGGGCGCCGGCCCGTGAGCTTCTCCAGCGCCGCGCGCGC
CCGGCTGGAGCGCTACCCGTTCCCCGGCAACGTCCGTGAGCTGCGCAACGTGCTCGAACGGGCCCTGGTGCTGGAGGCCG
GACCCGAACTGGAGCTCGCCGCCCTGGAGCCGCAGGGCACCAGCGGCCCGCCCGATGTGGACCCCGACGCGTTCGTCGTC
TCTGGGGCTCCGCGCCCCTTGCAGGACGTGGAGCGGTTGTACGTCCGGCACGTCCTCGCCCGCTTGGATGGGCGCCGGAT
GGAGGCCGCCCGGGTGCTGGGGCTCTCCTATCCCACCTTCCTCCGCCGGCTTGAGGAGGAGTAG

Upstream 100 bases:

>100_bases
TGGCGCGTGCCTCCGTGGAGGCCCATGGTGGCAGTCTGAACTATGTCCGGAGTCCGCTGGGAAGCCGCTTCACGCTGCGC
CTTCCGTTGGAGGTGGCCCG

Downstream 100 bases:

>100_bases
GCGAGCGCGCTTCAAGATTCTTGAGGCTGGCGGCCTCAAGGATTTTTAAGTCTGGATTCGGGACTTAAAATCGTTTTCAT
ATTCCCGACCGCAATCACCT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSTYLLLVDDDRTFASLAASVLRHEGFRVTLAHSLHDARGAMSREAPDLVVLDRRLPDGDGIDFLPELRAQLPNTPVLMV
TAHGDIASAVEAIQAGARDYLSKPVELDDLVLRARRAVADLQLQERLRLAESELGGRRRLSRPHSPKMLAALQMLERIAK
APRSPVLLLGETGVGKEVIARHLHALQGGQGSFVHVNCAALPATMVESELFGHERGAFTDARTARRGLVEVAAGGVLFLD
EVGELPLQLQAKLLTFLDKGAFRRLGGTAELSSSARVVTATNRDLTKEVAEGRFREDLYFRLSVFRVDIPPLRERREDLL
PLAQSLVAELGAELGRRPVSFSSAARARLERYPFPGNVRELRNVLERALVLEAGPELELAALEPQGTSGPPDVDPDAFVV
SGAPRPLQDVERLYVRHVLARLDGRRMEAARVLGLSYPTFLRRLEEE

Sequences:

>Translated_447_residues
MSTYLLLVDDDRTFASLAASVLRHEGFRVTLAHSLHDARGAMSREAPDLVVLDRRLPDGDGIDFLPELRAQLPNTPVLMV
TAHGDIASAVEAIQAGARDYLSKPVELDDLVLRARRAVADLQLQERLRLAESELGGRRRLSRPHSPKMLAALQMLERIAK
APRSPVLLLGETGVGKEVIARHLHALQGGQGSFVHVNCAALPATMVESELFGHERGAFTDARTARRGLVEVAAGGVLFLD
EVGELPLQLQAKLLTFLDKGAFRRLGGTAELSSSARVVTATNRDLTKEVAEGRFREDLYFRLSVFRVDIPPLRERREDLL
PLAQSLVAELGAELGRRPVSFSSAARARLERYPFPGNVRELRNVLERALVLEAGPELELAALEPQGTSGPPDVDPDAFVV
SGAPRPLQDVERLYVRHVLARLDGRRMEAARVLGLSYPTFLRRLEEE
>Mature_446_residues
STYLLLVDDDRTFASLAASVLRHEGFRVTLAHSLHDARGAMSREAPDLVVLDRRLPDGDGIDFLPELRAQLPNTPVLMVT
AHGDIASAVEAIQAGARDYLSKPVELDDLVLRARRAVADLQLQERLRLAESELGGRRRLSRPHSPKMLAALQMLERIAKA
PRSPVLLLGETGVGKEVIARHLHALQGGQGSFVHVNCAALPATMVESELFGHERGAFTDARTARRGLVEVAAGGVLFLDE
VGELPLQLQAKLLTFLDKGAFRRLGGTAELSSSARVVTATNRDLTKEVAEGRFREDLYFRLSVFRVDIPPLRERREDLLP
LAQSLVAELGAELGRRPVSFSSAARARLERYPFPGNVRELRNVLERALVLEAGPELELAALEPQGTSGPPDVDPDAFVVS
GAPRPLQDVERLYVRHVLARLDGRRMEAARVLGLSYPTFLRRLEEE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=38.9380530973451, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI1790299, Length=463, Percent_Identity=36.0691144708423, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=37.3873873873874, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1788905, Length=446, Percent_Identity=37.8923766816144, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI1789087, Length=341, Percent_Identity=43.108504398827, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI87082117, Length=273, Percent_Identity=45.0549450549451, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI87082152, Length=297, Percent_Identity=42.4242424242424, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI1786524, Length=331, Percent_Identity=38.6706948640483, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1789233, Length=304, Percent_Identity=35.8552631578947, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081872, Length=304, Percent_Identity=39.1447368421053, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=36.2179487179487, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1789828, Length=294, Percent_Identity=36.734693877551, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI87081858, Length=290, Percent_Identity=28.6206896551724, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786911, Length=116, Percent_Identity=37.0689655172414, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786599, Length=134, Percent_Identity=29.8507462686567, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786838, Length=109, Percent_Identity=40.3669724770642, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789809, Length=111, Percent_Identity=34.2342342342342, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786784, Length=112, Percent_Identity=36.6071428571429, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI2367329, Length=111, Percent_Identity=40.5405405405405, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49161; Mature: 49030

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYLLLVDDDRTFASLAASVLRHEGFRVTLAHSLHDARGAMSREAPDLVVLDRRLPDGD
CCEEEEEEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCEEEEECCCCCCC
GIDFLPELRAQLPNTPVLMVTAHGDIASAVEAIQAGARDYLSKPVELDDLVLRARRAVAD
CCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHH
LQLQERLRLAESELGGRRRLSRPHSPKMLAALQMLERIAKAPRSPVLLLGETGVGKEVIA
HHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
RHLHALQGGQGSFVHVNCAALPATMVESELFGHERGAFTDARTARRGLVEVAAGGVLFLD
HHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
EVGELPLQLQAKLLTFLDKGAFRRLGGTAELSSSARVVTATNRDLTKEVAEGRFREDLYF
HHCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEEECCHHHHHHHHCCHHHHHHEE
RLSVFRVDIPPLRERREDLLPLAQSLVAELGAELGRRPVSFSSAARARLERYPFPGNVRE
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
LRNVLERALVLEAGPELELAALEPQGTSGPPDVDPDAFVVSGAPRPLQDVERLYVRHVLA
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHH
RLDGRRMEAARVLGLSYPTFLRRLEEE
HHCCCHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
STYLLLVDDDRTFASLAASVLRHEGFRVTLAHSLHDARGAMSREAPDLVVLDRRLPDGD
CEEEEEEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCEEEEECCCCCCC
GIDFLPELRAQLPNTPVLMVTAHGDIASAVEAIQAGARDYLSKPVELDDLVLRARRAVAD
CCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHH
LQLQERLRLAESELGGRRRLSRPHSPKMLAALQMLERIAKAPRSPVLLLGETGVGKEVIA
HHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
RHLHALQGGQGSFVHVNCAALPATMVESELFGHERGAFTDARTARRGLVEVAAGGVLFLD
HHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
EVGELPLQLQAKLLTFLDKGAFRRLGGTAELSSSARVVTATNRDLTKEVAEGRFREDLYF
HHCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEEECCHHHHHHHHCCHHHHHHEE
RLSVFRVDIPPLRERREDLLPLAQSLVAELGAELGRRPVSFSSAARARLERYPFPGNVRE
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
LRNVLERALVLEAGPELELAALEPQGTSGPPDVDPDAFVVSGAPRPLQDVERLYVRHVLA
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHH
RLDGRRMEAARVLGLSYPTFLRRLEEE
HHCCCHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]