Click here to switch to the map view.

The map label for this gene is capA [H]

Identifier: 108759107

GI number: 108759107

Start: 10660

End: 12276

Strand: Reverse

Name: capA [H]

Synonym: MXAN_0010

Alternate gene names: 108759107

Gene position: 12276-10660 (Counterclockwise)

Preceding gene: 108763632

Following gene: 108757369

Centisome position: 0.13

GC content: 71.24

Gene sequence:

>1617_bases
ATGCCCTCGTCCGTCTTCCTCTTGATGGCGCTCGCCACCACGCCGGGTGCTGCTTCGGCGCGTGAGTCCGCCCCCGCCCA
GCACGTCTCTCCATCGCAAGGCCCCAGCGCCGATTCGAGCTCGACCCGAGGCCCAGATTCCCAGGGCACTGCGCCCGCGC
CAGAGACTGTCATCACGGACCTCAACGCCTACCCTCGTGCCGGTGACTCCGGCGCGGTGCTGGACCTGGGCCGTGCCGCC
GCGGAGGCCGGCGCCGCCGCCCTGCGCGCCGCGGCCCTGGCCATGGGCAAGAGCGCCACCCCGCGTGGCCCGCTGGCCGA
CCCGGACACGAGCTACGCCCGAGGCATGGAGGCCCTCCAGGCGAAGGACGCACCCACGGCCATCACCCAACTGTCCGCCT
GCGTGGAGGCCGCGCCCTCGCGCGTGGATTGCCGCTGGGAGCTGGGCTGGGCGCACTCGCTGGAGAACCAGTGGGCGGAG
GCCTACACGCAGTGGTCCGAGGTACAGAAGCTCCAGCCGGACCACCCGGACCTCGAGGGCGCGCTGGCCCAGGCCCGTGG
GCAGGCCATGCTCCAGGCGAAGCTGTCGCAGGGGCCTCAGCTCATCAACCGCCCTCCCCCGCCGGCCAACGCGAAGGTGC
GCATCCGCGCGGTGGGTGACGTCATGCTGGGCACCACCGTGCCCGAAGGCCACCTGCCTCCCGATGGCGCCGGCAGCGTG
ATTGCCGGCGTACGCCCGTTGCTGGAGGACGCGGACCTCACCTTCATCAACCTGGAAGGGCCGCTGTGCGACACGGGCGA
GACGAAGAAGTGCCGCTCGTCGAAAAACTGCTACGCGTTCCGCTCGCCCACCGAATACGGCCAGTACCTGAAGGAGTCCG
GGGTGGACCTGGCGTCCACGGCCAACAACCACTCGGGTGACTTCGGCGAGGAGTGCCGCCGCGCGACGGAGTCCACGCTC
GACGCGCTGGGCATCGCGTGGAGCGGCGCGCCGGGCACGGTGGCCACGGTGGAGCGCAACGGCCTGCTCATCGGCATGGT
GGCGTTCCACACGTCGCCGTCCTGCAACCACCTCAACAACCTGACCACGGCGACGGGGCTGGTGCGCGTGGCCGCGGCCG
AGCACGACATCGTCATCGTGTCGTTCCACGGCGGCGCGGAGGGCAGCAAGGCGCTGCACGTGCCCAAGGGCCGGGAGAAG
TTCCACGGCGAGGACCGGGGTGATTTGCGGGCCTTCTCGCGCGCGGTGGTGGACGCGGGCGCGCACCTGGTCATCGGCCA
TGGCCCGCACGTGGTGCGCGGCATGGAGTTCTACAAGGGCCGGCTCATCGCCTACTCGCTGGGCAACTTCGCCACCTATG
GCCGGTTCAACCTGCGCGGTCCGCAGGGCCTGGGCATGGTGCTGGAGGTCGAGCTGAACCGCGACGGCGACTTCACGGCG
GGCCGCATCCTCCCCACGAAGCAGGTGGACAGGGGCATCGCCGTGCCGGACCCGAAGGGCGCCGTCATCAAGGCGGTCCG
CGACCTCACCGCGGATGACTTCCCGGAGACGGGCGCGCGCATCTCCGACGACGGCACCGTGAAGGTCCGCGGCAAGGGCC
CTGTCTCCATGCGCTGA

Upstream 100 bases:

>100_bases
CCCTGACCGATGAGGTGTGTGTCGCCTGTCTGGCTGCTGGGCAGGGTGAGGTCATCTCCCCTGTCACAGAATCCCAGGAG
GGCCTCTAGAATGGCGGGAC

Downstream 100 bases:

>100_bases
CACGGCGTCTCATGCGCACGGCGGCGTGTGGGTGCTTCACGGACCTGGAGCCCGGGCTGAAGCGCGGCTGCTGGATGTGT
CCCAGCTTCCGTCATAGCGG

Product: CapA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MPSSVFLLMALATTPGAASARESAPAQHVSPSQGPSADSSSTRGPDSQGTAPAPETVITDLNAYPRAGDSGAVLDLGRAA
AEAGAAALRAAALAMGKSATPRGPLADPDTSYARGMEALQAKDAPTAITQLSACVEAAPSRVDCRWELGWAHSLENQWAE
AYTQWSEVQKLQPDHPDLEGALAQARGQAMLQAKLSQGPQLINRPPPPANAKVRIRAVGDVMLGTTVPEGHLPPDGAGSV
IAGVRPLLEDADLTFINLEGPLCDTGETKKCRSSKNCYAFRSPTEYGQYLKESGVDLASTANNHSGDFGEECRRATESTL
DALGIAWSGAPGTVATVERNGLLIGMVAFHTSPSCNHLNNLTTATGLVRVAAAEHDIVIVSFHGGAEGSKALHVPKGREK
FHGEDRGDLRAFSRAVVDAGAHLVIGHGPHVVRGMEFYKGRLIAYSLGNFATYGRFNLRGPQGLGMVLEVELNRDGDFTA
GRILPTKQVDRGIAVPDPKGAVIKAVRDLTADDFPETGARISDDGTVKVRGKGPVSMR

Sequences:

>Translated_538_residues
MPSSVFLLMALATTPGAASARESAPAQHVSPSQGPSADSSSTRGPDSQGTAPAPETVITDLNAYPRAGDSGAVLDLGRAA
AEAGAAALRAAALAMGKSATPRGPLADPDTSYARGMEALQAKDAPTAITQLSACVEAAPSRVDCRWELGWAHSLENQWAE
AYTQWSEVQKLQPDHPDLEGALAQARGQAMLQAKLSQGPQLINRPPPPANAKVRIRAVGDVMLGTTVPEGHLPPDGAGSV
IAGVRPLLEDADLTFINLEGPLCDTGETKKCRSSKNCYAFRSPTEYGQYLKESGVDLASTANNHSGDFGEECRRATESTL
DALGIAWSGAPGTVATVERNGLLIGMVAFHTSPSCNHLNNLTTATGLVRVAAAEHDIVIVSFHGGAEGSKALHVPKGREK
FHGEDRGDLRAFSRAVVDAGAHLVIGHGPHVVRGMEFYKGRLIAYSLGNFATYGRFNLRGPQGLGMVLEVELNRDGDFTA
GRILPTKQVDRGIAVPDPKGAVIKAVRDLTADDFPETGARISDDGTVKVRGKGPVSMR
>Mature_537_residues
PSSVFLLMALATTPGAASARESAPAQHVSPSQGPSADSSSTRGPDSQGTAPAPETVITDLNAYPRAGDSGAVLDLGRAAA
EAGAAALRAAALAMGKSATPRGPLADPDTSYARGMEALQAKDAPTAITQLSACVEAAPSRVDCRWELGWAHSLENQWAEA
YTQWSEVQKLQPDHPDLEGALAQARGQAMLQAKLSQGPQLINRPPPPANAKVRIRAVGDVMLGTTVPEGHLPPDGAGSVI
AGVRPLLEDADLTFINLEGPLCDTGETKKCRSSKNCYAFRSPTEYGQYLKESGVDLASTANNHSGDFGEECRRATESTLD
ALGIAWSGAPGTVATVERNGLLIGMVAFHTSPSCNHLNNLTTATGLVRVAAAEHDIVIVSFHGGAEGSKALHVPKGREKF
HGEDRGDLRAFSRAVVDAGAHLVIGHGPHVVRGMEFYKGRLIAYSLGNFATYGRFNLRGPQGLGMVLEVELNRDGDFTAG
RILPTKQVDRGIAVPDPKGAVIKAVRDLTADDFPETGARISDDGTVKVRGKGPVSMR

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 56378; Mature: 56247

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSVFLLMALATTPGAASARESAPAQHVSPSQGPSADSSSTRGPDSQGTAPAPETVITD
CCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
LNAYPRAGDSGAVLDLGRAAAEAGAAALRAAALAMGKSATPRGPLADPDTSYARGMEALQ
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
AKDAPTAITQLSACVEAAPSRVDCRWELGWAHSLENQWAEAYTQWSEVQKLQPDHPDLEG
CCCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ALAQARGQAMLQAKLSQGPQLINRPPPPANAKVRIRAVGDVMLGTTVPEGHLPPDGAGSV
HHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCCCCH
IAGVRPLLEDADLTFINLEGPLCDTGETKKCRSSKNCYAFRSPTEYGQYLKESGVDLAST
HHHHHHHHCCCCEEEEECCCCCCCCCCCHHHCCCCCEEEECCCHHHHHHHHHCCCCEECC
ANNHSGDFGEECRRATESTLDALGIAWSGAPGTVATVERNGLLIGMVAFHTSPSCNHLNN
CCCCCCCHHHHHHHHHHHHHHHHCEEECCCCCCEEEEECCCEEEEEEEECCCCCHHHHHH
LTTATGLVRVAAAEHDIVIVSFHGGAEGSKALHVPKGREKFHGEDRGDLRAFSRAVVDAG
HHHHHHHEEEEECCCCEEEEEECCCCCCCCEEECCCCHHHCCCCCCHHHHHHHHHHHHCC
AHLVIGHGPHVVRGMEFYKGRLIAYSLGNFATYGRFNLRGPQGLGMVLEVELNRDGDFTA
CEEEECCCCHHHHHHHHHCCEEEEEECCCCEECCEEECCCCCCCCEEEEEEECCCCCCCC
GRILPTKQVDRGIAVPDPKGAVIKAVRDLTADDFPETGARISDDGTVKVRGKGPVSMR
CCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCEEEEECCCCCCCC
>Mature Secondary Structure 
PSSVFLLMALATTPGAASARESAPAQHVSPSQGPSADSSSTRGPDSQGTAPAPETVITD
CCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
LNAYPRAGDSGAVLDLGRAAAEAGAAALRAAALAMGKSATPRGPLADPDTSYARGMEALQ
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
AKDAPTAITQLSACVEAAPSRVDCRWELGWAHSLENQWAEAYTQWSEVQKLQPDHPDLEG
CCCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ALAQARGQAMLQAKLSQGPQLINRPPPPANAKVRIRAVGDVMLGTTVPEGHLPPDGAGSV
HHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCCCCH
IAGVRPLLEDADLTFINLEGPLCDTGETKKCRSSKNCYAFRSPTEYGQYLKESGVDLAST
HHHHHHHHCCCCEEEEECCCCCCCCCCCHHHCCCCCEEEECCCHHHHHHHHHCCCCEECC
ANNHSGDFGEECRRATESTLDALGIAWSGAPGTVATVERNGLLIGMVAFHTSPSCNHLNN
CCCCCCCHHHHHHHHHHHHHHHHCEEECCCCCCEEEEECCCEEEEEEEECCCCCHHHHHH
LTTATGLVRVAAAEHDIVIVSFHGGAEGSKALHVPKGREKFHGEDRGDLRAFSRAVVDAG
HHHHHHHEEEEECCCCEEEEEECCCCCCCCEEECCCCHHHCCCCCCHHHHHHHHHHHHCC
AHLVIGHGPHVVRGMEFYKGRLIAYSLGNFATYGRFNLRGPQGLGMVLEVELNRDGDFTA
CEEEECCCCHHHHHHHHHCCEEEEEECCCCEECCEEECCCCCCCCEEEEEEECCCCCCCC
GRILPTKQVDRGIAVPDPKGAVIKAVRDLTADDFPETGARISDDGTVKVRGKGPVSMR
CCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]