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The map label for this gene is prkC [H]

Identifier: 108759010

GI number: 108759010

Start: 6868627

End: 6869541

Strand: Direct

Name: prkC [H]

Synonym: MXAN_5517

Alternate gene names: 108759010

Gene position: 6868627-6869541 (Clockwise)

Preceding gene: 108758264

Following gene: 108759551

Centisome position: 75.15

GC content: 70.71

Gene sequence:

>915_bases
GTGAATCCGACCTGCCCCACATGTCATACGCCCCACCCTGGTGCCGAGGCAGGTCCGCGACGCACCTGCGCCGCCTGCGG
TGCGGACCTCACGCCCGGCGCGCAGGCGCGAAGCACACCGCCGGAGCCGGACCTCACGGGTGAATCCCTGGCGGGCTTCC
AGCTGAACTCCCGCCTGGGCACCGACGCCACGGGCTCACTGTACGCAGCGGAAGGCCATGTGGGTCCATGCGTGGTGAAG
GTGATGTCTTCCTCGGTGACAGCGGATGCGGAGGCGCGAGCACGCTTCCACCGGGAAGCGGAGACACTGCGAAGCCTCCG
CCACCCAGGTATTGTCCGCGTCCTCGCGGTGGGCGAGGAGCGCGGCCACTGCTGGTACGCCCTGGAGCCCGTGATTGCGC
CCGCCCTGGAGGCGAGACTGGACCGGGCGAACGCACTGCCCTTCCAAGAGGTGGAGCAACTGGCGCTGCGGCTGCTCGAT
GCGCTCGGCGCCGCGCACGACACAGGGCTTGTCCACGGGGACGTGCGGCCCCAGAACATCCTGCTCGCGAAGGACGGCGC
GATGCTGACGAACTTCGGCCTGTCGCTCGTGCCTCCCGGTGCCCATGGCTACCAGGCCCCCGAGCAACGACAATGGGGCC
GCGCCGTCCCGCAGTCGGACCTGCATGCGCTGGGGCGCGTCCTGCACGAGGCGCTCACGGGAGGCATGCCGGAGACGCAG
CCACTCCCCCAGGGCGTGCCCCGGCACCTGCGCCGGTTGCTGAAAAGCCTGCTCTCGGAAGCCATCCAGGACCGCCCCGA
CAGCGCCATCTCCGCGCGGCGACTGCTGACCCAGCGTGCGCCGCTGGGCCCTTTGGCCGTGGGCATCGCAGCGCTGCTGG
CGATGCTGATGTTCCTGCTGCTGCGTGCGGCGTGA

Upstream 100 bases:

>100_bases
ACGGCCTTGGGCGCCGTCCCCGCCACGCCACACGGGAGCATGGCTTGCGGACGACGAGGACGGCCCGGAAGATGGCGAAG
AATCGACCCGGCCCGGCCCC

Downstream 100 bases:

>100_bases
GCGCCTCCCGCTCAGAGGCCCTGGAGCTGGACACCGGACATGCGGTGCTTGGGCTTGCGGCGGATGAAGCGGTTCGCATC
GCCGCGCCGGTAGCAGGTGA

Product: putative serine/threonine protein kinase

Products: NA

Alternate protein names: Ser/Thr-protein kinase PrkC [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNPTCPTCHTPHPGAEAGPRRTCAACGADLTPGAQARSTPPEPDLTGESLAGFQLNSRLGTDATGSLYAAEGHVGPCVVK
VMSSSVTADAEARARFHREAETLRSLRHPGIVRVLAVGEERGHCWYALEPVIAPALEARLDRANALPFQEVEQLALRLLD
ALGAAHDTGLVHGDVRPQNILLAKDGAMLTNFGLSLVPPGAHGYQAPEQRQWGRAVPQSDLHALGRVLHEALTGGMPETQ
PLPQGVPRHLRRLLKSLLSEAIQDRPDSAISARRLLTQRAPLGPLAVGIAALLAMLMFLLLRAA

Sequences:

>Translated_304_residues
MNPTCPTCHTPHPGAEAGPRRTCAACGADLTPGAQARSTPPEPDLTGESLAGFQLNSRLGTDATGSLYAAEGHVGPCVVK
VMSSSVTADAEARARFHREAETLRSLRHPGIVRVLAVGEERGHCWYALEPVIAPALEARLDRANALPFQEVEQLALRLLD
ALGAAHDTGLVHGDVRPQNILLAKDGAMLTNFGLSLVPPGAHGYQAPEQRQWGRAVPQSDLHALGRVLHEALTGGMPETQ
PLPQGVPRHLRRLLKSLLSEAIQDRPDSAISARRLLTQRAPLGPLAVGIAALLAMLMFLLLRAA
>Mature_304_residues
MNPTCPTCHTPHPGAEAGPRRTCAACGADLTPGAQARSTPPEPDLTGESLAGFQLNSRLGTDATGSLYAAEGHVGPCVVK
VMSSSVTADAEARARFHREAETLRSLRHPGIVRVLAVGEERGHCWYALEPVIAPALEARLDRANALPFQEVEQLALRLLD
ALGAAHDTGLVHGDVRPQNILLAKDGAMLTNFGLSLVPPGAHGYQAPEQRQWGRAVPQSDLHALGRVLHEALTGGMPETQ
PLPQGVPRHLRRLLKSLLSEAIQDRPDSAISARRLLTQRAPLGPLAVGIAALLAMLMFLLLRAA

Specific function: Protein kinase that is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy. PrkC is thus a germination receptor that binds peptidoglycan fragments containing m-Dpm (meso-diaminopimelate), which act

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Spore core membrane; Single-pass type II membrane protein. Note=Is associated with the inner membrane of the spore [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI83627721, Length=256, Percent_Identity=26.953125, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI62865639, Length=222, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4502553, Length=245, Percent_Identity=25.3061224489796, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI209364619, Length=244, Percent_Identity=27.0491803278689, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI62865641, Length=214, Percent_Identity=25.7009345794392, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI209364621, Length=244, Percent_Identity=27.0491803278689, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI7657214, Length=265, Percent_Identity=25.2830188679245, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539480, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325047, Length=244, Percent_Identity=25, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR005543
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR002290 [H]

Pfam domain/function: PF03793 PASTA; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 32299; Mature: 32299

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00109 PROTEIN_KINASE_TYR ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTCPTCHTPHPGAEAGPRRTCAACGADLTPGAQARSTPPEPDLTGESLAGFQLNSRLG
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
TDATGSLYAAEGHVGPCVVKVMSSSVTADAEARARFHREAETLRSLRHPGIVRVLAVGEE
CCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
RGHCWYALEPVIAPALEARLDRANALPFQEVEQLALRLLDALGAAHDTGLVHGDVRPQNI
CCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHCCCEEECCCCCCEE
LLAKDGAMLTNFGLSLVPPGAHGYQAPEQRQWGRAVPQSDLHALGRVLHEALTGGMPETQ
EEECCCCCHHHCCCEECCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCC
PLPQGVPRHLRRLLKSLLSEAIQDRPDSAISARRLLTQRAPLGPLAVGIAALLAMLMFLL
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LRAA
HHCC
>Mature Secondary Structure
MNPTCPTCHTPHPGAEAGPRRTCAACGADLTPGAQARSTPPEPDLTGESLAGFQLNSRLG
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
TDATGSLYAAEGHVGPCVVKVMSSSVTADAEARARFHREAETLRSLRHPGIVRVLAVGEE
CCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
RGHCWYALEPVIAPALEARLDRANALPFQEVEQLALRLLDALGAAHDTGLVHGDVRPQNI
CCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHCCCEEECCCCCCEE
LLAKDGAMLTNFGLSLVPPGAHGYQAPEQRQWGRAVPQSDLHALGRVLHEALTGGMPETQ
EEECCCCCHHHCCCEECCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCC
PLPQGVPRHLRRLLKSLLSEAIQDRPDSAISARRLLTQRAPLGPLAVGIAALLAMLMFLL
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LRAA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]