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The map label for this gene is yogA [H]

Identifier: 108759002

GI number: 108759002

Start: 2649638

End: 2650648

Strand: Reverse

Name: yogA [H]

Synonym: MXAN_2282

Alternate gene names: 108759002

Gene position: 2650648-2649638 (Counterclockwise)

Preceding gene: 108757720

Following gene: 108763879

Centisome position: 29.0

GC content: 70.23

Gene sequence:

>1011_bases
ATGAAAGCCTACGAACTGAAGCAGACAGGGAGCGCCGACGCATGGGTGCAGGTGGAGCGGCCGGAGCCCACGCCGGGCCA
CGGCCAGGCGCTGGTCCGGATCCGCGCGGTGTCCCTCAACTACCGGGACCTCTACATCGCCCTGGGCCGCTATCCCGGAC
CGCGCCCTGCCTCCCTCATCCCCGTGTCGGACGGCGCGGGAGAAGTCGTGGCCGTGGGCCCCGGCGTCTCACGCGTGACG
CCGGGTGACCGCGTGGCCCCCACCTTCTTCCAGACCTGGACGGATGGCCCAGCCTCGCCGGAGAAGACGCGGAACGCCCT
GGGTGGCAGCGTGAATGGCGTGCTCGCGGAGTACGTCGTCGTGGACGCGGAGGGGCTCGTCCTCCTCCCTGACCACCTGT
CCTTCGAGGAAGGCGCCACCCTCCCGTGCGCCGCCGTCACCGCCTGGAACGCCCTGGTCGCCGAAGGCCGGCTCCAGCCG
GGCCAGACGGTGCTGGCGCAGGGCACCGGCGGCGTGTCCATCTTCGCGCTCCAGTTGGCCAAGGCGCTGGGGGCGCGCGT
CCTCATCACCTCCAGCCAGGACGCGAAGCTGAAGCACGCCCGGACGTTGGGTGCGGATGGCACCATCAACTACAAGACGC
ACCCGGACTGGGAGGAGCAGGTGCTGGCGCTCACCGGCGGCCAGGGCGTGGACCACGTCCTGGAGGTGGCCGGCGAGGAG
ACATTCCCCCACTCCGTCCGGGCCACGAAGCCCGGGGGCCACATCTCCCTCATCGGCATGCTCAGCGGCGGCTTCGCCAA
GCCGGACCCCGCCCTGGTGGAGCCCAAGAAGCTCGACGTCCAGCGGACTTACGTGGGCAGCCGCGCCATGTTCGAGGACA
TGAACCGGCTCCTCATCCAGCACCGCCTCGAGCCCGTCATCGACCGGAGCTTCCCCTTTGAGCAGGCGCGCGAGGCCCTG
CGTTACATGGAGTCCGGCGCCCACTTCGGGAAGATTGTCATCGCCGTCTGA

Upstream 100 bases:

>100_bases
CACGGCGAACCACTTCACTCCGGGCAAATCCACCCAGCCAGCGAGCCCTTCCCGCATGGTTGTCTGGCCGCCCTGACGGT
CCGTGGATAGTCATGCCCGC

Downstream 100 bases:

>100_bases
GCGGCCGGGGCGCGAGCAAGGTGGCCAGCCCTGGCTCCCACCCTCTGCCACCGGCGGGCGCGCCCTAGCGAGGGAGAAAG
CCACAGGCAAGCAGAAAGGA

Product: zinc-binding dehydrogenase family oxidoreductase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKAYELKQTGSADAWVQVERPEPTPGHGQALVRIRAVSLNYRDLYIALGRYPGPRPASLIPVSDGAGEVVAVGPGVSRVT
PGDRVAPTFFQTWTDGPASPEKTRNALGGSVNGVLAEYVVVDAEGLVLLPDHLSFEEGATLPCAAVTAWNALVAEGRLQP
GQTVLAQGTGGVSIFALQLAKALGARVLITSSQDAKLKHARTLGADGTINYKTHPDWEEQVLALTGGQGVDHVLEVAGEE
TFPHSVRATKPGGHISLIGMLSGGFAKPDPALVEPKKLDVQRTYVGSRAMFEDMNRLLIQHRLEPVIDRSFPFEQAREAL
RYMESGAHFGKIVIAV

Sequences:

>Translated_336_residues
MKAYELKQTGSADAWVQVERPEPTPGHGQALVRIRAVSLNYRDLYIALGRYPGPRPASLIPVSDGAGEVVAVGPGVSRVT
PGDRVAPTFFQTWTDGPASPEKTRNALGGSVNGVLAEYVVVDAEGLVLLPDHLSFEEGATLPCAAVTAWNALVAEGRLQP
GQTVLAQGTGGVSIFALQLAKALGARVLITSSQDAKLKHARTLGADGTINYKTHPDWEEQVLALTGGQGVDHVLEVAGEE
TFPHSVRATKPGGHISLIGMLSGGFAKPDPALVEPKKLDVQRTYVGSRAMFEDMNRLLIQHRLEPVIDRSFPFEQAREAL
RYMESGAHFGKIVIAV
>Mature_336_residues
MKAYELKQTGSADAWVQVERPEPTPGHGQALVRIRAVSLNYRDLYIALGRYPGPRPASLIPVSDGAGEVVAVGPGVSRVT
PGDRVAPTFFQTWTDGPASPEKTRNALGGSVNGVLAEYVVVDAEGLVLLPDHLSFEEGATLPCAAVTAWNALVAEGRLQP
GQTVLAQGTGGVSIFALQLAKALGARVLITSSQDAKLKHARTLGADGTINYKTHPDWEEQVLALTGGQGVDHVLEVAGEE
TFPHSVRATKPGGHISLIGMLSGGFAKPDPALVEPKKLDVQRTYVGSRAMFEDMNRLLIQHRLEPVIDRSFPFEQAREAL
RYMESGAHFGKIVIAV

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=352, Percent_Identity=29.5454545454545, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI22538444, Length=352, Percent_Identity=29.5454545454545, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI18379349, Length=331, Percent_Identity=27.4924471299094, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI28557745, Length=345, Percent_Identity=31.0144927536232, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI47519420, Length=297, Percent_Identity=31.6498316498317, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI194239674, Length=302, Percent_Identity=24.8344370860927, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI13236495, Length=302, Percent_Identity=24.8344370860927, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=24.4031830238727, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI41872631, Length=254, Percent_Identity=31.496062992126, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI194239676, Length=191, Percent_Identity=29.8429319371728, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=25.1515151515152, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=28.4810126582279, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790485, Length=341, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082125, Length=331, Percent_Identity=26.8882175226586, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790045, Length=329, Percent_Identity=27.355623100304, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=290, Percent_Identity=27.9310344827586, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788073, Length=264, Percent_Identity=28.030303030303, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=256, Percent_Identity=32.8125, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=233, Percent_Identity=31.7596566523605, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17507255, Length=262, Percent_Identity=29.7709923664122, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=274, Percent_Identity=24.8175182481752, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=204, Percent_Identity=26.9607843137255, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=344, Percent_Identity=26.453488372093, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=297, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=336, Percent_Identity=27.9761904761905, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=336, Percent_Identity=27.9761904761905, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=326, Percent_Identity=24.8466257668712, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=24.8466257668712, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=25.0764525993884, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=321, Percent_Identity=24.6105919003115, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221330659, Length=236, Percent_Identity=29.2372881355932, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19920632, Length=236, Percent_Identity=29.2372881355932, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24581345, Length=236, Percent_Identity=27.1186440677966, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 35865; Mature: 35865

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYELKQTGSADAWVQVERPEPTPGHGQALVRIRAVSLNYRDLYIALGRYPGPRPASLI
CCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCEEE
PVSDGAGEVVAVGPGVSRVTPGDRVAPTFFQTWTDGPASPEKTRNALGGSVNGVLAEYVV
EECCCCCCEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCHHHHEEEEEE
VDAEGLVLLPDHLSFEEGATLPCAAVTAWNALVAEGRLQPGQTVLAQGTGGVSIFALQLA
ECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHH
KALGARVLITSSQDAKLKHARTLGADGTINYKTHPDWEEQVLALTGGQGVDHVLEVAGEE
HHCCCEEEEECCCCCHHHHHHHCCCCCEEECCCCCCHHHEEEEEECCCCHHHHHHHHCCC
TFPHSVRATKPGGHISLIGMLSGGFAKPDPALVEPKKLDVQRTYVGSRAMFEDMNRLLIQ
CCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEHHHCCCHHHHHHHHHHHHH
HRLEPVIDRSFPFEQAREALRYMESGAHFGKIVIAV
HHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MKAYELKQTGSADAWVQVERPEPTPGHGQALVRIRAVSLNYRDLYIALGRYPGPRPASLI
CCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCEEE
PVSDGAGEVVAVGPGVSRVTPGDRVAPTFFQTWTDGPASPEKTRNALGGSVNGVLAEYVV
EECCCCCCEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCHHHHEEEEEE
VDAEGLVLLPDHLSFEEGATLPCAAVTAWNALVAEGRLQPGQTVLAQGTGGVSIFALQLA
ECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHH
KALGARVLITSSQDAKLKHARTLGADGTINYKTHPDWEEQVLALTGGQGVDHVLEVAGEE
HHCCCEEEEECCCCCHHHHHHHCCCCCEEECCCCCCHHHEEEEEECCCCHHHHHHHHCCC
TFPHSVRATKPGGHISLIGMLSGGFAKPDPALVEPKKLDVQRTYVGSRAMFEDMNRLLIQ
CCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEHHHCCCHHHHHHHHHHHHH
HRLEPVIDRSFPFEQAREALRYMESGAHFGKIVIAV
HHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+; NADH [C]

Metal ions: Co2+ Zn2+-depleted [C]

Kcat value (1/min): 150 [C]

Specific activity: 19

Km value (mM): 0.2 {tryptophol}} 0.0074 {NAD+}} 0.0069 {NAD+}} 13 {ethylene} 6 {methanol}} 27 {pentanol}} 0.44 {1-butanol}} 120 {ethanol}} 0.91 {acetaldehyde}} 0.1 {acetaldehyde}} 0.005 {1-octanol}} 0.004 {benzyl} 0.005 {cyclohe

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: 2, 2'-Bipyridyl; 4-Methyl pyrazole acetaldehyde; 8-Amino-6-methoxyquinoline; 8-Hydroxy quinoline-5-sulfonic acid; Acetaldehyde; Dipicolinic acid; EDTA; Ethanol; GSH; Heptafluorbutanol; Imidazole; Iodoacetamide; Iodoacetate; Isobutyramide EDTA; NAD+; NADH;

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]