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The map label for this gene is fur [H]

Identifier: 108758800

GI number: 108758800

Start: 4414907

End: 4415425

Strand: Direct

Name: fur [H]

Synonym: MXAN_3702

Alternate gene names: 108758800

Gene position: 4414907-4415425 (Clockwise)

Preceding gene: 108757840

Following gene: 108761387

Centisome position: 48.3

GC content: 65.51

Gene sequence:

>519_bases
ATGGCGCGGACCCGCGGCGACTTTGAAGGATTTCTCATGAGCAACAGTCACAGCCATCACCACGACGACCACGACAAGGA
CGAGGGGCTTGCCCGCTACATGGCCCAGCACGGCCTGAAGAGCACGCGGCAGCGCAGCCTCATCATCGACACGTTCTTCG
CGGTGGGAGGCCACCTGTCGGTGGAGGAGCTGTGGAACAAGGTGCGTGAACAGGACACCAAGGTGTCCGTCGCCACCGTT
TACCGGACCATGAAGCTGCTCAGCGAGTGTGGCCTGGCCCACGCGCGCAACTTCGGGGACGGGCAGACGCGCTACGAGGC
GGCCGCGGGGCGCGACCACCATGACCACCTGGTCTGTACGCGCTGCGGCACCATCATCGAGTTCGAGAACGAGCGCATCG
AGGCGCTTCAGGACGCCGTGGCCCGCAAGCACGGCTTCAAGGTGACGTCGCACAAGATGGAGCTGTACGGCCTGTGTCGT
GACTGTCAGCGGGCCGGGTCGGCCGCCTCGGAGGCCTGA

Upstream 100 bases:

>100_bases
CTTTGTTGGGAAATGGCCGGGTCGCGAGAGTTGGCCGAATTGGTTACAACAAGAGCGGAGGGCGAGGCAGCGCGGGCCTC
CACCCAAGTGCGCCCGAGGC

Downstream 100 bases:

>100_bases
TCTCCATGTCCCGCGTGCTGCTACGGGGTGCCGTCGTGGCGCTGGTGGCGCTGGCCGGCTGCCGGGGCACCCGGCCGGTG
GACGCGGGGTACGCCTTCCT

Product: FUR family transcriptional regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MARTRGDFEGFLMSNSHSHHHDDHDKDEGLARYMAQHGLKSTRQRSLIIDTFFAVGGHLSVEELWNKVREQDTKVSVATV
YRTMKLLSECGLAHARNFGDGQTRYEAAAGRDHHDHLVCTRCGTIIEFENERIEALQDAVARKHGFKVTSHKMELYGLCR
DCQRAGSAASEA

Sequences:

>Translated_172_residues
MARTRGDFEGFLMSNSHSHHHDDHDKDEGLARYMAQHGLKSTRQRSLIIDTFFAVGGHLSVEELWNKVREQDTKVSVATV
YRTMKLLSECGLAHARNFGDGQTRYEAAAGRDHHDHLVCTRCGTIIEFENERIEALQDAVARKHGFKVTSHKMELYGLCR
DCQRAGSAASEA
>Mature_171_residues
ARTRGDFEGFLMSNSHSHHHDDHDKDEGLARYMAQHGLKSTRQRSLIIDTFFAVGGHLSVEELWNKVREQDTKVSVATVY
RTMKLLSECGLAHARNFGDGQTRYEAAAGRDHHDHLVCTRCGTIIEFENERIEALQDAVARKHGFKVTSHKMELYGLCRD
CQRAGSAASEA

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=133, Percent_Identity=35.3383458646617, Blast_Score=91, Evalue=4e-20,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 19400; Mature: 19269

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTRGDFEGFLMSNSHSHHHDDHDKDEGLARYMAQHGLKSTRQRSLIIDTFFAVGGHLS
CCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VEELWNKVREQDTKVSVATVYRTMKLLSECGLAHARNFGDGQTRYEAAAGRDHHDHLVCT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHCCCCCCCCCHHH
RCGTIIEFENERIEALQDAVARKHGFKVTSHKMELYGLCRDCQRAGSAASEA
HCCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ARTRGDFEGFLMSNSHSHHHDDHDKDEGLARYMAQHGLKSTRQRSLIIDTFFAVGGHLS
CCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VEELWNKVREQDTKVSVATVYRTMKLLSECGLAHARNFGDGQTRYEAAAGRDHHDHLVCT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHCCCCCCCCCHHH
RCGTIIEFENERIEALQDAVARKHGFKVTSHKMELYGLCRDCQRAGSAASEA
HCCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083178 [H]