Click here to switch to the map view.

The map label for this gene is atpB

Identifier: 108758604

GI number: 108758604

Start: 463924

End: 464835

Strand: Direct

Name: atpB

Synonym: MXAN_0402

Alternate gene names: 108758604

Gene position: 463924-464835 (Clockwise)

Preceding gene: 108763521

Following gene: 108757866

Centisome position: 5.08

GC content: 65.02

Gene sequence:

>912_bases
GTGGACTCACCCTACCTGGAGATCGAGGTCCCGCTTAGCAGCCCCATCCACGCGTTTGACTTCCCGCAGTGGCACGTCCC
GCTGAAGGCCGGCGCGTGCGCGCCCCGGATGACGGAGCACGGTGAGGAGATTCCGGGCTTGATGGACGGCTGCCTGGACC
TGTCCATCACGAAGCACACCGTGATGATGTGGCTGGCCGCTCTGCTGCTGATGGCCACCCTGTTCATCTGGGGCAACCGC
GACAAGACGAAGCTGGTGCCGCGCGGCGCGGGCGCCAACATCCTCGAGATGCTGGTGCTGTTCGTTCGTGACGAGCTGGC
CATCAAGAACATCGGCAAGGAGGAGGGCCCCCGCTACGTGCCCTTCCTGCTCACCGTGTTCTTCTTCATCCTCTTCATGA
ACATGCTGGGCATGGTTCCCTGGATGGCGACCGCCACCGGCAACCTGGCCGTGACCATGGCGCTGGCGCTGTGCACCTTC
GTCATCACCCAGGTGGCGGGTATTCGCGCGGCGGGTCTGGGCGGCTACCTGAAGCACCTGACGGGTGGCGTGGCCCCCTG
GTTGTGGCCCATCATGGTTCCGGTGGAGGTGCTGGGTCTGTTCACCAAGCCCTTCGCCCTCACGATGCGTCTGTTCGCCA
ACATGCTGGCGGGCCACATCGTCTACTTCTTCCTCCTGGGCCTCATCTTCCTCCTCGGCCACCCTGCGGTGGCGGCGGTG
AGTGTGCCCTTCGCCTTCGCCATCTTCCTGCTCGAGCTGTTCGTTGCCTTCGTGCAGGCGTACGTCTTCGCGATGTTGTC
GGCGCTGTTCATCGGCATGAGCGTGGCCATGGGTCACCACCATGACGACCACGGCCACGACCACCCGGAAGCGGGCCCCA
GCCACGACCAGGGCAAGGCGCACCACGCCTAG

Upstream 100 bases:

>100_bases
GATGCGCAAGGCAATGGTGCTGTTCGCCAGTCTGTTTGCTGCCACGGCGTGGGCCGCGGGGTCTGAAGACGACGTGCCGG
GGTACATCCTCCACCACGTC

Downstream 100 bases:

>100_bases
GTCGTTCTGACGAGTTAGCGGGGCGCTGAAGTCCGGTGCCCCGGTCGAAGACCCGGCGGTTCGAAAGGCCGCCGGAGGTA
GTCCTCAAGGGACATCACGA

Product: ATP synthase F0 subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MDSPYLEIEVPLSSPIHAFDFPQWHVPLKAGACAPRMTEHGEEIPGLMDGCLDLSITKHTVMMWLAALLLMATLFIWGNR
DKTKLVPRGAGANILEMLVLFVRDELAIKNIGKEEGPRYVPFLLTVFFFILFMNMLGMVPWMATATGNLAVTMALALCTF
VITQVAGIRAAGLGGYLKHLTGGVAPWLWPIMVPVEVLGLFTKPFALTMRLFANMLAGHIVYFFLLGLIFLLGHPAVAAV
SVPFAFAIFLLELFVAFVQAYVFAMLSALFIGMSVAMGHHHDDHGHDHPEAGPSHDQGKAHHA

Sequences:

>Translated_303_residues
MDSPYLEIEVPLSSPIHAFDFPQWHVPLKAGACAPRMTEHGEEIPGLMDGCLDLSITKHTVMMWLAALLLMATLFIWGNR
DKTKLVPRGAGANILEMLVLFVRDELAIKNIGKEEGPRYVPFLLTVFFFILFMNMLGMVPWMATATGNLAVTMALALCTF
VITQVAGIRAAGLGGYLKHLTGGVAPWLWPIMVPVEVLGLFTKPFALTMRLFANMLAGHIVYFFLLGLIFLLGHPAVAAV
SVPFAFAIFLLELFVAFVQAYVFAMLSALFIGMSVAMGHHHDDHGHDHPEAGPSHDQGKAHHA
>Mature_303_residues
MDSPYLEIEVPLSSPIHAFDFPQWHVPLKAGACAPRMTEHGEEIPGLMDGCLDLSITKHTVMMWLAALLLMATLFIWGNR
DKTKLVPRGAGANILEMLVLFVRDELAIKNIGKEEGPRYVPFLLTVFFFILFMNMLGMVPWMATATGNLAVTMALALCTF
VITQVAGIRAAGLGGYLKHLTGGVAPWLWPIMVPVEVLGLFTKPFALTMRLFANMLAGHIVYFFLLGLIFLLGHPAVAAV
SVPFAFAIFLLELFVAFVQAYVFAMLSALFIGMSVAMGHHHDDHGHDHPEAGPSHDQGKAHHA

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=215, Percent_Identity=24.6511627906977, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6226527, Length=232, Percent_Identity=26.2931034482759, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_MYXXD (Q1DFA0)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_628673.1
- ProteinModelPortal:   Q1DFA0
- STRING:   Q1DFA0
- GeneID:   4104593
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_0402
- TIGR:   MXAN_0402
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   DISITKH
- PhylomeDB:   Q1DFA0
- BioCyc:   MXAN246197:MXAN_0402-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 33217; Mature: 33217

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x135d402c)-; HASH(0x124c3ee4)-; HASH(0x140adfac)-; HASH(0x134a7d34)-; HASH(0x138b715c)-; HASH(0x13970674)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSPYLEIEVPLSSPIHAFDFPQWHVPLKAGACAPRMTEHGEEIPGLMDGCLDLSITKHT
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHCCHHHHHHHHHHHHHHH
VMMWLAALLLMATLFIWGNRDKTKLVPRGAGANILEMLVLFVRDELAIKNIGKEEGPRYV
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCHH
PFLLTVFFFILFMNMLGMVPWMATATGNLAVTMALALCTFVITQVAGIRAAGLGGYLKHL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGGVAPWLWPIMVPVEVLGLFTKPFALTMRLFANMLAGHIVYFFLLGLIFLLGHPAVAAV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
SVPFAFAIFLLELFVAFVQAYVFAMLSALFIGMSVAMGHHHDDHGHDHPEAGPSHDQGKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
HHA
CCH
>Mature Secondary Structure
MDSPYLEIEVPLSSPIHAFDFPQWHVPLKAGACAPRMTEHGEEIPGLMDGCLDLSITKHT
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHCCHHHHHHHHHHHHHHH
VMMWLAALLLMATLFIWGNRDKTKLVPRGAGANILEMLVLFVRDELAIKNIGKEEGPRYV
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCHH
PFLLTVFFFILFMNMLGMVPWMATATGNLAVTMALALCTFVITQVAGIRAAGLGGYLKHL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGGVAPWLWPIMVPVEVLGLFTKPFALTMRLFANMLAGHIVYFFLLGLIFLLGHPAVAAV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
SVPFAFAIFLLELFVAFVQAYVFAMLSALFIGMSVAMGHHHDDHGHDHPEAGPSHDQGKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
HHA
CCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA