Click here to switch to the map view.

The map label for this gene is aphA [H]

Identifier: 108758524

GI number: 108758524

Start: 6549525

End: 6550556

Strand: Reverse

Name: aphA [H]

Synonym: MXAN_5253

Alternate gene names: 108758524

Gene position: 6550556-6549525 (Counterclockwise)

Preceding gene: 108761126

Following gene: 108762970

Centisome position: 71.67

GC content: 72.09

Gene sequence:

>1032_bases
ATGCGAGTCGTTCATTCCCCGCGGCACGCCCTTCACGACGGCGGCATGGAGTTGCACCGAGGTGAGCTGGTGCCCTGCTT
CGAGATGCCCGCGCGCGCGGACTTCATCCTGCAGGCGGTGAGGCAGGCCGGCCTGGAGGTGAGCGAGCCGCAGGCCTTCG
GACTGGAGTCGCTGTGGGGCGTGCACGACGCCGGCTTCGTGGAGTTCCTGCGCACCGCGCACGCGCAGTGGAGGGCCATC
GGCAAGCAGGGCTTCATGCTGCCGAGCGGCTTTCCGGCGCGGGGCATGCGCCGCGACCACCTGCCCTCCGGCATCAACGG
ACAGATGGGCTACTACGCCTTCGACGCCGGAACGCCCATCGTCCAGGGCACCTGGGACGCCGCCTTCGCCGCCGCGCAGT
GCGCGCTGACGGCCGCGGCCTGGGTGGCGGAGGGGGAGCGCAGCGCCTACGCGCTGTGCCGACCTCCGGGGCACCACGCG
GGTCACTCCACCTACGGCGGCTACTGCTTCCTCAACAACGCGGCGCTGGCGGCGCAGCACCTGCGCGAGCGCGGCTGCGC
GCGCGTGGCGGTGCTGGACGTGGACTACCACCACGGCAACGGCACCCAGGACATCTTCTGGGAGCGCGCCGACGTACTCG
TCGTCTCGCTGCACGGCACGCCGGAGACGGAGTACCCCTACTTCCTCGGCTACGCCGACGAACGCGGGGCCGGCGCCGGC
GAGGGCTTCACCCACAACTTCCCGCTGCCGCGCGGCACCACCTGGGCGCAGTACAGCGCCGCGCTCGACTCCGCGCTGGA
CGCCGTGGCCCGCTTCGGCCCGGATGCGCTGGTGGTGTCGCTGGGCGTGGACACCTACGTGGGAGACCCCATCAGCGCCT
TCGCGCTCGAGCGCGAGCACTTCCCTCTCATGGGCCGGCGCCTCGCGCAGTTGAGGCTGCCCACGGTGTTCGTGCAGGAG
GGCGGCTACGCGGTGGAGGACCTCGGCCTCAACGTGGCCGGCGTGCTCGAGGGCTTCGACGCCGGACGCTGA

Upstream 100 bases:

>100_bases
CCGGCGGGCGAGTACCCGGCTGAGCGCGTCACGCCATCGTTACGAAGGTCCTGTAACGTCTTGTGCTGGCACGGCGCACG
TGCAACCTGGAGCCATTCCG

Downstream 100 bases:

>100_bases
AGGTGGGGGCAGGCACGCTACTCCTGGACGGGCTCGGCGGGCTGCTCGCTGCGCCGGTGCCGCGCGTAGAGCGCGTCGCG
CCAGGCGACGATGTCCGGAT

Product: putative acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRVVHSPRHALHDGGMELHRGELVPCFEMPARADFILQAVRQAGLEVSEPQAFGLESLWGVHDAGFVEFLRTAHAQWRAI
GKQGFMLPSGFPARGMRRDHLPSGINGQMGYYAFDAGTPIVQGTWDAAFAAAQCALTAAAWVAEGERSAYALCRPPGHHA
GHSTYGGYCFLNNAALAAQHLRERGCARVAVLDVDYHHGNGTQDIFWERADVLVVSLHGTPETEYPYFLGYADERGAGAG
EGFTHNFPLPRGTTWAQYSAALDSALDAVARFGPDALVVSLGVDTYVGDPISAFALEREHFPLMGRRLAQLRLPTVFVQE
GGYAVEDLGLNVAGVLEGFDAGR

Sequences:

>Translated_343_residues
MRVVHSPRHALHDGGMELHRGELVPCFEMPARADFILQAVRQAGLEVSEPQAFGLESLWGVHDAGFVEFLRTAHAQWRAI
GKQGFMLPSGFPARGMRRDHLPSGINGQMGYYAFDAGTPIVQGTWDAAFAAAQCALTAAAWVAEGERSAYALCRPPGHHA
GHSTYGGYCFLNNAALAAQHLRERGCARVAVLDVDYHHGNGTQDIFWERADVLVVSLHGTPETEYPYFLGYADERGAGAG
EGFTHNFPLPRGTTWAQYSAALDSALDAVARFGPDALVVSLGVDTYVGDPISAFALEREHFPLMGRRLAQLRLPTVFVQE
GGYAVEDLGLNVAGVLEGFDAGR
>Mature_343_residues
MRVVHSPRHALHDGGMELHRGELVPCFEMPARADFILQAVRQAGLEVSEPQAFGLESLWGVHDAGFVEFLRTAHAQWRAI
GKQGFMLPSGFPARGMRRDHLPSGINGQMGYYAFDAGTPIVQGTWDAAFAAAQCALTAAAWVAEGERSAYALCRPPGHHA
GHSTYGGYCFLNNAALAAQHLRERGCARVAVLDVDYHHGNGTQDIFWERADVLVVSLHGTPETEYPYFLGYADERGAGAG
EGFTHNFPLPRGTTWAQYSAALDSALDAVARFGPDALVVSLGVDTYVGDPISAFALEREHFPLMGRRLAQLRLPTVFVQE
GGYAVEDLGLNVAGVLEGFDAGR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795204, Length=209, Percent_Identity=34.4497607655502, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI30795202, Length=209, Percent_Identity=34.4497607655502, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI17158039, Length=211, Percent_Identity=34.5971563981043, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI169234807, Length=178, Percent_Identity=38.7640449438202, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI148539870, Length=178, Percent_Identity=38.7640449438202, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI153085395, Length=171, Percent_Identity=38.0116959064327, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI8923769, Length=305, Percent_Identity=25.9016393442623, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI20070354, Length=327, Percent_Identity=30.8868501529052, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13128864, Length=227, Percent_Identity=35.2422907488987, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI13128860, Length=287, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073088, Length=180, Percent_Identity=32.2222222222222, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI62750347, Length=218, Percent_Identity=32.1100917431193, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI62750349, Length=218, Percent_Identity=32.1100917431193, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI293336691, Length=261, Percent_Identity=26.0536398467433, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI226529806, Length=322, Percent_Identity=29.1925465838509, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI262073092, Length=235, Percent_Identity=24.6808510638298, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540334, Length=329, Percent_Identity=30.6990881458967, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17540332, Length=329, Percent_Identity=30.6990881458967, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193206283, Length=329, Percent_Identity=30.6990881458967, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193209491, Length=305, Percent_Identity=30.8196721311475, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508561, Length=240, Percent_Identity=28.75, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17537347, Length=221, Percent_Identity=32.1266968325792, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561978, Length=285, Percent_Identity=25.9649122807018, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17534739, Length=317, Percent_Identity=24.9211356466877, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25154020, Length=227, Percent_Identity=27.3127753303965, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25154022, Length=178, Percent_Identity=28.0898876404494, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=216, Percent_Identity=36.1111111111111, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323999, Length=213, Percent_Identity=26.7605633802817, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321244, Length=222, Percent_Identity=26.5765765765766, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325141, Length=63, Percent_Identity=49.2063492063492, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281360899, Length=216, Percent_Identity=37.5, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281360799, Length=217, Percent_Identity=36.405529953917, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24641720, Length=217, Percent_Identity=36.405529953917, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24642146, Length=216, Percent_Identity=37.5, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24642144, Length=216, Percent_Identity=37.5, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI281360801, Length=217, Percent_Identity=36.405529953917, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24642142, Length=216, Percent_Identity=37.5, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24657891, Length=293, Percent_Identity=26.2798634812287, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644244, Length=175, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37107; Mature: 37107

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVHSPRHALHDGGMELHRGELVPCFEMPARADFILQAVRQAGLEVSEPQAFGLESLWG
CCCCCCCHHHHHCCCCEECCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHC
VHDAGFVEFLRTAHAQWRAIGKQGFMLPSGFPARGMRRDHLPSGINGQMGYYAFDAGTPI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCEEEECCCCCC
VQGTWDAAFAAAQCALTAAAWVAEGERSAYALCRPPGHHAGHSTYGGYCFLNNAALAAQH
EECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEECCHHHHHHH
LRERGCARVAVLDVDYHHGNGTQDIFWERADVLVVSLHGTPETEYPYFLGYADERGAGAG
HHHCCCEEEEEEEEEEECCCCCHHHHEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCC
EGFTHNFPLPRGTTWAQYSAALDSALDAVARFGPDALVVSLGVDTYVGDPISAFALEREH
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHCCCCHHHHHCCCCC
FPLMGRRLAQLRLPTVFVQEGGYAVEDLGLNVAGVLEGFDAGR
CCHHHHHHHHHCCCEEEEECCCEEEHHHCCCHHHHHCCCCCCC
>Mature Secondary Structure
MRVVHSPRHALHDGGMELHRGELVPCFEMPARADFILQAVRQAGLEVSEPQAFGLESLWG
CCCCCCCHHHHHCCCCEECCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHC
VHDAGFVEFLRTAHAQWRAIGKQGFMLPSGFPARGMRRDHLPSGINGQMGYYAFDAGTPI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCEEEECCCCCC
VQGTWDAAFAAAQCALTAAAWVAEGERSAYALCRPPGHHAGHSTYGGYCFLNNAALAAQH
EECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEECCHHHHHHH
LRERGCARVAVLDVDYHHGNGTQDIFWERADVLVVSLHGTPETEYPYFLGYADERGAGAG
HHHCCCEEEEEEEEEEECCCCCHHHHEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCC
EGFTHNFPLPRGTTWAQYSAALDSALDAVARFGPDALVVSLGVDTYVGDPISAFALEREH
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHCCCCHHHHHCCCCC
FPLMGRRLAQLRLPTVFVQEGGYAVEDLGLNVAGVLEGFDAGR
CCHHHHHHHHHCCCEEEEECCCEEEHHHCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]