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The map label for this gene is zraS [H]

Identifier: 108758491

GI number: 108758491

Start: 4838064

End: 4840166

Strand: Reverse

Name: zraS [H]

Synonym: MXAN_3974

Alternate gene names: 108758491

Gene position: 4840166-4838064 (Counterclockwise)

Preceding gene: 108762386

Following gene: 108760115

Centisome position: 52.96

GC content: 71.52

Gene sequence:

>2103_bases
GTGTTTGGGGCCACGGAGCAGAGCGACTGGATGAAGTTCCTGTGTCTCACCTCTGATGACCGGCATCCCGTGGCGGAGGA
GCTGCGGCGCCAGGGCCAGGCCGTGTTCATCACCGCCGACGTGGTGGAAGCCGGCGCGGCGCTGGGGCACGGGCCCGTGG
ACGTGCTGGTGGTGGACGCGGCGGACCTGGTGGAGGACGCGCGCTGGCTGGACGCGCTGCGGACGCGGGCCCGTCCCGAG
GAGCCGCTGGTGCTGGGGTTGGCGCGGGAAGGCACCGACGCGGCGCTCGAGCCGCTGCTGGCCGCGGGCGTGGACGAGTT
CCTGGTGGAGCCCTTCACCCCGGTGCAGGTGCGCTCACGGCGGTTGTTGCTGGAGCGGCGGGTGGCGGCGCGGCGCCAGC
GGCGGACGTCCGAGGCGGAGGCGCGGGGCGAGGTGGCGCGGCTGGCCTCCATCATCCAGATGCAGTCGGACGTGGCGATG
GCGGGCTACGGGCTCGACGAGCTGATGCGGTTGCTGTGCGAGCGCTCGCGGGTGTTGTGCGGCGCGGACGGCGCGGCGGT
GGCGCTGCTGGGGGCGGACACCGACGAGGAGGTGACCTACCTGGTGGCCAGCGGCAGCCTGATGCCCTTCATCGGCTTCC
GGCTGAAGGTGGAGGGCAGTCTCACGGGCGCCAGCCTGCTGCAGGGCGAGGTGATGCGCACGGATGACTCGGAGACGGAC
GTCCGGGTCAACGTGACGGCGCTGCGCCAGGTGGGCGCGCGGTCGATGATTTGCGTGCCGCTGTGGCGCGAGGGCCGCCC
GGTGGGCGTGCTCAACGTCACCAGCCGGCGGCCGAACACGTTCGAGGACCGGGACGTGCGCACGCTGGAGCTGATGGCGG
GTCTGCTCGGCGCGGCCATGGGCAACGCGGCCGAGGCCCAGGCGCGTCAGGAGTTGATGGTGCAGAACACGCTGGCGATG
GGCGCGCTGGAGGAGTCGCAGGAGCTGTTCGCGTCCTTCATGGACAACATCCCCGCGGTGGCCTTCATGAAGGACGAGCG
GGGCCGCCGCATCTGGGTGAACGCGCGCTACAGCCGGTTCTTCGGCTTCCCGGTGGGCGCGGACATGTCCAACGTGTCCG
ACGTGGATTTGATGCCCGCGGCCTCCGCCGAGCAGTCGCGCCGGGATGACGACGCGGTGCTGACCTCCGGCAAGCAGAGC
ATCACCGAGATGATGGTTCCCGCGCGCGACGGCACCGAGCGCCACTGGCTCACCTACCGCTTCATCGTGCGGGAGCGCTC
GGGGCGGCGGCTGCTGGCGGGCGTGGCGGTGGACATCACCGACCGCAAGGCCATGCAGGCGCAGCTCGTGGTGTCGGACC
GGCTGGCGGCGGTGGGGACGCTGGCGGCGGGCGTGGCACACGAAATCAACAACCCGCTGGCCTTCGTCCTCTCCAACCTG
TCGTTCCTCGCGGGCGAACTGCACGCCCTGGCGCCGGAGTTGCCGTCGGGCCGCATGGCGGAGCTGGAGGAGGTGCTGCG
CGAGGCCACCGACGGCGCGCACCGCGTGCGGCAGATCGTCCGGGACTTGAGGACCTTCTCCCGGGGCGACGACGAGGTGG
CCACCGCCGTCAACGTGCAGGCGGTGCTCGAGTCGGCCATCACCCTGGCGCGCAGCGAGCTGAAGCTGCGCGCGCAGTTG
GTCCGCGACTACTGCGAGGTGCCGCTGGTGGAGGGCAACGAGGGCCGCTTCGGACAGGTGTTCCTCAACCTGCTCATCAA
CGCCGCGCAGGCCATTCCGATGGGCCAGACGGAGCAGCACGAGGTCCGGCTGAGCCTGCGAAGCGCAGGGGACCGCGTCA
TCATCGAGGTGCGCGACACGGGCGTGGGCATGCCTCCGGAGGTGCGCGCCCGCATCTTCGACCCCTTCTTCACCACCAAG
CCGGTGGGCGAGGGCACGGGGCTGGGCCTGTCCATCTGCCACGGCATCGTCACCGGCTTCGGTGGAGACATCTCCGTGGA
GAGCGAGGAGGGACGGGGCAGCACCTTCCGCGTCTCCCTGCCGGTGGCACGGCGCGCGAAGGAGCCGGTGGATCCGCCGC
TGCGCATGCCCCTGGTGGGCTGA

Upstream 100 bases:

>100_bases
GTATGTTTCCACCGGGCATGGGGTGCGCCTGACCCCCGCCAGTCAGGACGCTCCTGGCTGGAAATGCCGTGCTACAGAAT
CATAGTATTTTTCACCCCGT

Downstream 100 bases:

>100_bases
GGTCAGCGGCGGAACATGGGCGGGAAGACGCGGGGGGCCTTCTTCTTGCGCAGGCAGCGCACGACCGCGTCCATGTAGCA
GGCGGAGAAGGCGCGGCGGC

Product: sensory box sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 700; Mature: 700

Protein sequence:

>700_residues
MFGATEQSDWMKFLCLTSDDRHPVAEELRRQGQAVFITADVVEAGAALGHGPVDVLVVDAADLVEDARWLDALRTRARPE
EPLVLGLAREGTDAALEPLLAAGVDEFLVEPFTPVQVRSRRLLLERRVAARRQRRTSEAEARGEVARLASIIQMQSDVAM
AGYGLDELMRLLCERSRVLCGADGAAVALLGADTDEEVTYLVASGSLMPFIGFRLKVEGSLTGASLLQGEVMRTDDSETD
VRVNVTALRQVGARSMICVPLWREGRPVGVLNVTSRRPNTFEDRDVRTLELMAGLLGAAMGNAAEAQARQELMVQNTLAM
GALEESQELFASFMDNIPAVAFMKDERGRRIWVNARYSRFFGFPVGADMSNVSDVDLMPAASAEQSRRDDDAVLTSGKQS
ITEMMVPARDGTERHWLTYRFIVRERSGRRLLAGVAVDITDRKAMQAQLVVSDRLAAVGTLAAGVAHEINNPLAFVLSNL
SFLAGELHALAPELPSGRMAELEEVLREATDGAHRVRQIVRDLRTFSRGDDEVATAVNVQAVLESAITLARSELKLRAQL
VRDYCEVPLVEGNEGRFGQVFLNLLINAAQAIPMGQTEQHEVRLSLRSAGDRVIIEVRDTGVGMPPEVRARIFDPFFTTK
PVGEGTGLGLSICHGIVTGFGGDISVESEEGRGSTFRVSLPVARRAKEPVDPPLRMPLVG

Sequences:

>Translated_700_residues
MFGATEQSDWMKFLCLTSDDRHPVAEELRRQGQAVFITADVVEAGAALGHGPVDVLVVDAADLVEDARWLDALRTRARPE
EPLVLGLAREGTDAALEPLLAAGVDEFLVEPFTPVQVRSRRLLLERRVAARRQRRTSEAEARGEVARLASIIQMQSDVAM
AGYGLDELMRLLCERSRVLCGADGAAVALLGADTDEEVTYLVASGSLMPFIGFRLKVEGSLTGASLLQGEVMRTDDSETD
VRVNVTALRQVGARSMICVPLWREGRPVGVLNVTSRRPNTFEDRDVRTLELMAGLLGAAMGNAAEAQARQELMVQNTLAM
GALEESQELFASFMDNIPAVAFMKDERGRRIWVNARYSRFFGFPVGADMSNVSDVDLMPAASAEQSRRDDDAVLTSGKQS
ITEMMVPARDGTERHWLTYRFIVRERSGRRLLAGVAVDITDRKAMQAQLVVSDRLAAVGTLAAGVAHEINNPLAFVLSNL
SFLAGELHALAPELPSGRMAELEEVLREATDGAHRVRQIVRDLRTFSRGDDEVATAVNVQAVLESAITLARSELKLRAQL
VRDYCEVPLVEGNEGRFGQVFLNLLINAAQAIPMGQTEQHEVRLSLRSAGDRVIIEVRDTGVGMPPEVRARIFDPFFTTK
PVGEGTGLGLSICHGIVTGFGGDISVESEEGRGSTFRVSLPVARRAKEPVDPPLRMPLVG
>Mature_700_residues
MFGATEQSDWMKFLCLTSDDRHPVAEELRRQGQAVFITADVVEAGAALGHGPVDVLVVDAADLVEDARWLDALRTRARPE
EPLVLGLAREGTDAALEPLLAAGVDEFLVEPFTPVQVRSRRLLLERRVAARRQRRTSEAEARGEVARLASIIQMQSDVAM
AGYGLDELMRLLCERSRVLCGADGAAVALLGADTDEEVTYLVASGSLMPFIGFRLKVEGSLTGASLLQGEVMRTDDSETD
VRVNVTALRQVGARSMICVPLWREGRPVGVLNVTSRRPNTFEDRDVRTLELMAGLLGAAMGNAAEAQARQELMVQNTLAM
GALEESQELFASFMDNIPAVAFMKDERGRRIWVNARYSRFFGFPVGADMSNVSDVDLMPAASAEQSRRDDDAVLTSGKQS
ITEMMVPARDGTERHWLTYRFIVRERSGRRLLAGVAVDITDRKAMQAQLVVSDRLAAVGTLAAGVAHEINNPLAFVLSNL
SFLAGELHALAPELPSGRMAELEEVLREATDGAHRVRQIVRDLRTFSRGDDEVATAVNVQAVLESAITLARSELKLRAQL
VRDYCEVPLVEGNEGRFGQVFLNLLINAAQAIPMGQTEQHEVRLSLRSAGDRVIIEVRDTGVGMPPEVRARIFDPFFTTK
PVGEGTGLGLSICHGIVTGFGGDISVESEEGRGSTFRVSLPVARRAKEPVDPPLRMPLVG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=35.4581673306773, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1788549, Length=256, Percent_Identity=30.859375, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI145693157, Length=266, Percent_Identity=32.3308270676692, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI48994928, Length=398, Percent_Identity=24.6231155778894, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790300, Length=256, Percent_Identity=31.25, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=275, Percent_Identity=29.8181818181818, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1786783, Length=244, Percent_Identity=26.2295081967213, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=26.6917293233083, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=337, Percent_Identity=24.3323442136499, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=284, Percent_Identity=26.4084507042254, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76316; Mature: 76316

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGATEQSDWMKFLCLTSDDRHPVAEELRRQGQAVFITADVVEAGAALGHGPVDVLVVDA
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHCHHCCCCCEEEEEECH
ADLVEDARWLDALRTRARPEEPLVLGLAREGTDAALEPLLAAGVDEFLVEPFTPVQVRSR
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHCCCCCHHHHHH
RLLLERRVAARRQRRTSEAEARGEVARLASIIQMQSDVAMAGYGLDELMRLLCERSRVLC
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCEEE
GADGAAVALLGADTDEEVTYLVASGSLMPFIGFRLKVEGSLTGASLLQGEVMRTDDSETD
CCCCCEEEEEECCCCCCEEEEEECCCCCEEECEEEEEECCCCCHHHHCCCCEECCCCCCC
VRVNVTALRQVGARSMICVPLWREGRPVGVLNVTSRRPNTFEDRDVRTLELMAGLLGAAM
EEEEHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
GNAAEAQARQELMVQNTLAMGALEESQELFASFMDNIPAVAFMKDERGRRIWVNARYSRF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEHHE
FGFPVGADMSNVSDVDLMPAASAEQSRRDDDAVLTSGKQSITEMMVPARDGTERHWLTYR
ECCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHCCHHHHHHHHCCCCCCCCCCEEEEE
FIVRERSGRRLLAGVAVDITDRKAMQAQLVVSDRLAAVGTLAAGVAHEINNPLAFVLSNL
EEEECCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SFLAGELHALAPELPSGRMAELEEVLREATDGAHRVRQIVRDLRTFSRGDDEVATAVNVQ
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AVLESAITLARSELKLRAQLVRDYCEVPLVEGNEGRFGQVFLNLLINAAQAIPMGQTEQH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHH
EVRLSLRSAGDRVIIEVRDTGVGMPPEVRARIFDPFFTTKPVGEGTGLGLSICHGIVTGF
HHEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCC
GGDISVESEEGRGSTFRVSLPVARRAKEPVDPPLRMPLVG
CCCEEEECCCCCCCEEEEECCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFGATEQSDWMKFLCLTSDDRHPVAEELRRQGQAVFITADVVEAGAALGHGPVDVLVVDA
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHCHHCCCCCEEEEEECH
ADLVEDARWLDALRTRARPEEPLVLGLAREGTDAALEPLLAAGVDEFLVEPFTPVQVRSR
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHCCCCCHHHHHH
RLLLERRVAARRQRRTSEAEARGEVARLASIIQMQSDVAMAGYGLDELMRLLCERSRVLC
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCEEE
GADGAAVALLGADTDEEVTYLVASGSLMPFIGFRLKVEGSLTGASLLQGEVMRTDDSETD
CCCCCEEEEEECCCCCCEEEEEECCCCCEEECEEEEEECCCCCHHHHCCCCEECCCCCCC
VRVNVTALRQVGARSMICVPLWREGRPVGVLNVTSRRPNTFEDRDVRTLELMAGLLGAAM
EEEEHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
GNAAEAQARQELMVQNTLAMGALEESQELFASFMDNIPAVAFMKDERGRRIWVNARYSRF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEHHE
FGFPVGADMSNVSDVDLMPAASAEQSRRDDDAVLTSGKQSITEMMVPARDGTERHWLTYR
ECCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHCCHHHHHHHHCCCCCCCCCCEEEEE
FIVRERSGRRLLAGVAVDITDRKAMQAQLVVSDRLAAVGTLAAGVAHEINNPLAFVLSNL
EEEECCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SFLAGELHALAPELPSGRMAELEEVLREATDGAHRVRQIVRDLRTFSRGDDEVATAVNVQ
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AVLESAITLARSELKLRAQLVRDYCEVPLVEGNEGRFGQVFLNLLINAAQAIPMGQTEQH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHH
EVRLSLRSAGDRVIIEVRDTGVGMPPEVRARIFDPFFTTKPVGEGTGLGLSICHGIVTGF
HHEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCC
GGDISVESEEGRGSTFRVSLPVARRAKEPVDPPLRMPLVG
CCCEEEECCCCCCCEEEEECCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]