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The map label for this gene is crdA [H]

Identifier: 108758352

GI number: 108758352

Start: 6436937

End: 6438433

Strand: Direct

Name: crdA [H]

Synonym: MXAN_5153

Alternate gene names: 108758352

Gene position: 6436937-6438433 (Clockwise)

Preceding gene: 108763833

Following gene: 108762239

Centisome position: 70.43

GC content: 67.67

Gene sequence:

>1497_bases
ATGCCCGCCTCTGTCCTCATCGTCGATGACGAGAAGAACATCCTCCTCACCCTGAGCCAGTCGCTCCAACTGGCGGGGTA
TCAGACGCACCTGGCAAACAGCGGGCAGGTGGCCCTGGATGTCGTCAGCGCCCGTCCCGTGGACGCGGTGCTGATGGACG
TGAAGATGCCGGACATGGACGGCCTCACGGCCCTGGCGAAGCTGACCGAGCTGAAGCCGGAGCTGCCCGTCATCATGATG
TCCGGGCACGGCACCATCGACACCGCGGTGAAGGCTACCCAGTTGGGGGCCAGGGATTTCCTGGAAAAGCCAATCGCCCG
GGAGCGGCTGCTGGTGGCGCTGCGCAACGTGCTCAAGCACCAGGCGGCCATGGCGGAGCTCCAGGAGCTGCGGGCGCAGT
TGGGCCGCTACGACATGGTCGGCAGTGGACCGGCCATGCAGCGCATCTTCTCGCTCATCCAGCGAACGGCGCCGTCCGAG
GGCCGCGTGCTGATTACGGGTGAGAACGGCACGGGCAAGGAGCTCATCGCGCGGGCGCTGCACCAGCACTCGAAGCGCAA
GGGGCAGCCCTTCGTGAAGCTCAACTGCGCCGCGGTGCCGCACGAGCTCATCGAGAGCGAGCTGTTCGGCCACGAGAAGG
GCGCCTTCACCGGCGCGGTGAGCGTGCGGCGAGGCAAGTTCGAGCTGGCCCACGAGGGCACGCTCTTCCTGGACGAGATT
GGCGACATGCCGCAGGCGATGCAGGCCAAGCTGCTGCGCGTGTTGCAGGAAGGCGAGTTGGAGCGCGTGGGCGGCGCGGA
GACGCACAAGGTGGACGTGCGCGTCGTCGCGGCGACGAACAAGAACCTGGAGGCGGAGATTGCCGCCGGGCGCTTCCGCG
AGGACCTCTACTACCGCATCAACGTGGTGCAGATTCATTCGCCTCCGCTGCGTGAGCGGCGCGAAGATTTGCCGGACCTC
ATCAAGACGTTCCTCGACGAGGCCTGCGCCAAGAATGGACGCCGGCCGTTGACGCTGTCCCCCGACGCGCTGGCGGTGAT
GAGCGCCTACGACTATCCCGGCAACGTGCGCGAGCTGCGCAACCTCGTGGAGCGGCTGGCCATCCTGTGTGAAGGCCCCA
TCGTCACCCGGACGGATGCGCTGGAGCTGTTGCCCCGGGGCCGGAACGTGCCGCCGCCCGCACCGGTGGAGACACCCGCG
AGCCCCCTACCCCCTCCTTCTCCCGAGGCGGCCGTGGTCCTGGCGTCCAGTACGCCCGCGCCCGCCATCGCCGCCCCGGT
GGCGACCGAGCCTCCCGCGCCCGTGGGCTTCCGGCCTCGCGCGGACCGGACGTTCCGCGAGCAGGTGGAAGACGCCGAGC
GGGAAATCATCCAGCACGTGCTTTCCCATACACACGACAACGTGACGGAAGCCGCGCGATTGCTCGACCTGGAACGCGGT
CACTTCTACAAAAAAATGAAGGCCCTGGGCTTGCGCCGCGGCAGCTCCGAGTCGTAA

Upstream 100 bases:

>100_bases
CCATCGCCGAAACCCTTGAATCTCCAAATATTTTCCGTGAGATTGTCACGATTGACCCGCGTGTGGCGCGCCCCGTGGCA
CGCCTCGGGGAAAGCCCGCC

Downstream 100 bases:

>100_bases
CGCTGCGGATTCATTGTCCCTCCATGGTGGCTGCGCGTGTGTGGCGAGTACTACCGAGTCCCGTGTGCTCGCCGCGTGCT
CAACTGAGAGAACCGAAACG

Product: sigma-54 dependent DNA-binding reponse regulator CrdA

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MPASVLIVDDEKNILLTLSQSLQLAGYQTHLANSGQVALDVVSARPVDAVLMDVKMPDMDGLTALAKLTELKPELPVIMM
SGHGTIDTAVKATQLGARDFLEKPIARERLLVALRNVLKHQAAMAELQELRAQLGRYDMVGSGPAMQRIFSLIQRTAPSE
GRVLITGENGTGKELIARALHQHSKRKGQPFVKLNCAAVPHELIESELFGHEKGAFTGAVSVRRGKFELAHEGTLFLDEI
GDMPQAMQAKLLRVLQEGELERVGGAETHKVDVRVVAATNKNLEAEIAAGRFREDLYYRINVVQIHSPPLRERREDLPDL
IKTFLDEACAKNGRRPLTLSPDALAVMSAYDYPGNVRELRNLVERLAILCEGPIVTRTDALELLPRGRNVPPPAPVETPA
SPLPPPSPEAAVVLASSTPAPAIAAPVATEPPAPVGFRPRADRTFREQVEDAEREIIQHVLSHTHDNVTEAARLLDLERG
HFYKKMKALGLRRGSSES

Sequences:

>Translated_498_residues
MPASVLIVDDEKNILLTLSQSLQLAGYQTHLANSGQVALDVVSARPVDAVLMDVKMPDMDGLTALAKLTELKPELPVIMM
SGHGTIDTAVKATQLGARDFLEKPIARERLLVALRNVLKHQAAMAELQELRAQLGRYDMVGSGPAMQRIFSLIQRTAPSE
GRVLITGENGTGKELIARALHQHSKRKGQPFVKLNCAAVPHELIESELFGHEKGAFTGAVSVRRGKFELAHEGTLFLDEI
GDMPQAMQAKLLRVLQEGELERVGGAETHKVDVRVVAATNKNLEAEIAAGRFREDLYYRINVVQIHSPPLRERREDLPDL
IKTFLDEACAKNGRRPLTLSPDALAVMSAYDYPGNVRELRNLVERLAILCEGPIVTRTDALELLPRGRNVPPPAPVETPA
SPLPPPSPEAAVVLASSTPAPAIAAPVATEPPAPVGFRPRADRTFREQVEDAEREIIQHVLSHTHDNVTEAARLLDLERG
HFYKKMKALGLRRGSSES
>Mature_497_residues
PASVLIVDDEKNILLTLSQSLQLAGYQTHLANSGQVALDVVSARPVDAVLMDVKMPDMDGLTALAKLTELKPELPVIMMS
GHGTIDTAVKATQLGARDFLEKPIARERLLVALRNVLKHQAAMAELQELRAQLGRYDMVGSGPAMQRIFSLIQRTAPSEG
RVLITGENGTGKELIARALHQHSKRKGQPFVKLNCAAVPHELIESELFGHEKGAFTGAVSVRRGKFELAHEGTLFLDEIG
DMPQAMQAKLLRVLQEGELERVGGAETHKVDVRVVAATNKNLEAEIAAGRFREDLYYRINVVQIHSPPLRERREDLPDLI
KTFLDEACAKNGRRPLTLSPDALAVMSAYDYPGNVRELRNLVERLAILCEGPIVTRTDALELLPRGRNVPPPAPVETPAS
PLPPPSPEAAVVLASSTPAPAIAAPVATEPPAPVGFRPRADRTFREQVEDAEREIIQHVLSHTHDNVTEAARLLDLERGH
FYKKMKALGLRRGSSES

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=494, Percent_Identity=40.8906882591093, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1790299, Length=487, Percent_Identity=40.2464065708419, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI1790437, Length=373, Percent_Identity=47.4530831099196, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1788905, Length=397, Percent_Identity=41.5617128463476, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI87082117, Length=245, Percent_Identity=50.6122448979592, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87082152, Length=354, Percent_Identity=40.6779661016949, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1789087, Length=303, Percent_Identity=44.5544554455446, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1789233, Length=249, Percent_Identity=46.5863453815261, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1786524, Length=271, Percent_Identity=46.1254612546125, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI87081872, Length=352, Percent_Identity=36.9318181818182, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI1787583, Length=248, Percent_Identity=41.9354838709677, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI87081858, Length=251, Percent_Identity=32.6693227091633, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789828, Length=276, Percent_Identity=31.8840579710145, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=27.0742358078603, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790552, Length=122, Percent_Identity=30.327868852459, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54482; Mature: 54350

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASVLIVDDEKNILLTLSQSLQLAGYQTHLANSGQVALDVVSARPVDAVLMDVKMPDMD
CCCEEEEEECCCCEEEEEECHHHHCCHHHHCCCCCCEEEEEECCCCCCCEEEECCCCCCC
GLTALAKLTELKPELPVIMMSGHGTIDTAVKATQLGARDFLEKPIARERLLVALRNVLKH
HHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHH
QAAMAELQELRAQLGRYDMVGSGPAMQRIFSLIQRTAPSEGRVLITGENGTGKELIARAL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHH
HQHSKRKGQPFVKLNCAAVPHELIESELFGHEKGAFTGAVSVRRGKFELAHEGTLFLDEI
HHHHHHCCCCEEEEECHHCCHHHHHHHHHCCCCCCEEEEEEEECCCEEECCCCCEEHHHH
GDMPQAMQAKLLRVLQEGELERVGGAETHKVDVRVVAATNKNLEAEIAAGRFREDLYYRI
CCCHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEEEECCCCCEEHHHHHHHHHCEEEEE
NVVQIHSPPLRERREDLPDLIKTFLDEACAKNGRRPLTLSPDALAVMSAYDYPGNVRELR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCHHHHH
NLVERLAILCEGPIVTRTDALELLPRGRNVPPPAPVETPASPLPPPSPEAAVVLASSTPA
HHHHHHHHHHCCCCEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
PAIAAPVATEPPAPVGFRPRADRTFREQVEDAEREIIQHVLSHTHDNVTEAARLLDLERG
CCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HFYKKMKALGLRRGSSES
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PASVLIVDDEKNILLTLSQSLQLAGYQTHLANSGQVALDVVSARPVDAVLMDVKMPDMD
CCEEEEEECCCCEEEEEECHHHHCCHHHHCCCCCCEEEEEECCCCCCCEEEECCCCCCC
GLTALAKLTELKPELPVIMMSGHGTIDTAVKATQLGARDFLEKPIARERLLVALRNVLKH
HHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHH
QAAMAELQELRAQLGRYDMVGSGPAMQRIFSLIQRTAPSEGRVLITGENGTGKELIARAL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHH
HQHSKRKGQPFVKLNCAAVPHELIESELFGHEKGAFTGAVSVRRGKFELAHEGTLFLDEI
HHHHHHCCCCEEEEECHHCCHHHHHHHHHCCCCCCEEEEEEEECCCEEECCCCCEEHHHH
GDMPQAMQAKLLRVLQEGELERVGGAETHKVDVRVVAATNKNLEAEIAAGRFREDLYYRI
CCCHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEEEECCCCCEEHHHHHHHHHCEEEEE
NVVQIHSPPLRERREDLPDLIKTFLDEACAKNGRRPLTLSPDALAVMSAYDYPGNVRELR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCHHHHH
NLVERLAILCEGPIVTRTDALELLPRGRNVPPPAPVETPASPLPPPSPEAAVVLASSTPA
HHHHHHHHHHCCCCEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
PAIAAPVATEPPAPVGFRPRADRTFREQVEDAEREIIQHVLSHTHDNVTEAARLLDLERG
CCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HFYKKMKALGLRRGSSES
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]