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The map label for this gene is macA [H]

Identifier: 108758331

GI number: 108758331

Start: 765073

End: 766182

Strand: Direct

Name: macA [H]

Synonym: MXAN_0666

Alternate gene names: 108758331

Gene position: 765073-766182 (Clockwise)

Preceding gene: 108760474

Following gene: 108756809

Centisome position: 8.37

GC content: 73.78

Gene sequence:

>1110_bases
GTGAAACCCAACCTGAAGCCGTCCGCTGTCCGCGTGTTCGCCGCGGCGGGCATGGCCACCGCCGTGCTGTCGCTGACCGC
ATGCCAGAAGGCGGATGCCTCGTCGTCGCCGCCCGCCAAGGGGTCGGCGCAGGAGGTGGTGCCCACGGTGAAGGTCGTCT
CCGCGCGGACGGTGCGGGCCGCGCCGAGCGAGTCGGTGACGGGGACGCTGTTCCCCGCGCAGGGATTGATGGTGGGCTTC
GAGGTGGGAGGCCGCCTGTCGGTCGTCCGGGTGAAGAAGGGGCAGGGGGTGAAGAAGGGTGACGTGCTGGCGCAACTGGA
CCCGGAGATCGCCGACGCGCAGGTGGCCCAGGCCGAGGCCGCGGTGGCCGCCGCGGAGGCCGCCTCCACCATGGCCGCCG
ACGTGGCCGCCCGCAACGAGAAGCTCCAGCAGCAGGGTGGGGTGAGCGAGGTGGCCCACCGCACCGCCAGCGCCAATGCG
GCGCAGGCGCAGGCGCAGTGGATGGCCGCCAAGGCGCAGCTGGCTCAGGCGCGCGCGTCCCGCCGCCGGCACGACCTGCG
GGCGCCCTTCGACGGCACCCTCATCGACGCACCGGAGCAGACGGGCGCGACGGTGGCGCCGGGCACGCCGCTGTTCAACC
TGGAGCGCCTGGACACGCTACTCTTGAAGACGACGGTGTCGGAGGCCCTGCGCTCGCAGTTGGAGCCCGGCGCCAAGGTG
CGCGTGGAGTCGGTGGGCGCGCGCGTGTCCTCGGACGAGGCGGTGGTGCGCACCATCCTCCCCTCCGCGGACCCCGCCAC
GCGCCGCATCCCGGTGGAGCTGGCCGTCCCCAACGCGGATGGCCGCTTCGTGGCGCACACGCTGGCGCGGGCGGTCCTCT
CGCTGGGGCAGGTGCAGGACGCCCAGGTGCTGCCGGGCACCGCGTTGTCGGCCCTCAACGGGGACCATGTCTGGGTGGTG
GCGTCCGGTCAGGTGCGTCGCGTGGACGTGCGGGTGTTGGAGCGGCGCGAGCAGGGCGAGGTGGTGGTGCTGGCGTCCTC
GCCGCTCGACTCCGTCGTTGACCACCCCACTCCGGGCCTGTCGCAGGGCGCCCGCGTCTCCGTGAAGTAG

Upstream 100 bases:

>100_bases
AGGAGGGCACCCGTCCGGCGTCGCCCGCCCCGTCCAAGCGTGTTGCGCGCCGGCCCCGGGCCGCCGCCGAGAAACCCCGA
AAGACCCCGAGGAAACGCTC

Downstream 100 bases:

>100_bases
GGAGCCCTCCCCATGCTGCTCAGCGACGTCTCCATCCGCAGGCCCGTCTTCACCGCGATGTTGTCGCTGTGCCTCGTCGT
GCTCGGCCTCATGGGCCTGG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKPNLKPSAVRVFAAAGMATAVLSLTACQKADASSSPPAKGSAQEVVPTVKVVSARTVRAAPSESVTGTLFPAQGLMVGF
EVGGRLSVVRVKKGQGVKKGDVLAQLDPEIADAQVAQAEAAVAAAEAASTMAADVAARNEKLQQQGGVSEVAHRTASANA
AQAQAQWMAAKAQLAQARASRRRHDLRAPFDGTLIDAPEQTGATVAPGTPLFNLERLDTLLLKTTVSEALRSQLEPGAKV
RVESVGARVSSDEAVVRTILPSADPATRRIPVELAVPNADGRFVAHTLARAVLSLGQVQDAQVLPGTALSALNGDHVWVV
ASGQVRRVDVRVLERREQGEVVVLASSPLDSVVDHPTPGLSQGARVSVK

Sequences:

>Translated_369_residues
MKPNLKPSAVRVFAAAGMATAVLSLTACQKADASSSPPAKGSAQEVVPTVKVVSARTVRAAPSESVTGTLFPAQGLMVGF
EVGGRLSVVRVKKGQGVKKGDVLAQLDPEIADAQVAQAEAAVAAAEAASTMAADVAARNEKLQQQGGVSEVAHRTASANA
AQAQAQWMAAKAQLAQARASRRRHDLRAPFDGTLIDAPEQTGATVAPGTPLFNLERLDTLLLKTTVSEALRSQLEPGAKV
RVESVGARVSSDEAVVRTILPSADPATRRIPVELAVPNADGRFVAHTLARAVLSLGQVQDAQVLPGTALSALNGDHVWVV
ASGQVRRVDVRVLERREQGEVVVLASSPLDSVVDHPTPGLSQGARVSVK
>Mature_369_residues
MKPNLKPSAVRVFAAAGMATAVLSLTACQKADASSSPPAKGSAQEVVPTVKVVSARTVRAAPSESVTGTLFPAQGLMVGF
EVGGRLSVVRVKKGQGVKKGDVLAQLDPEIADAQVAQAEAAVAAAEAASTMAADVAARNEKLQQQGGVSEVAHRTASANA
AQAQAQWMAAKAQLAQARASRRRHDLRAPFDGTLIDAPEQTGATVAPGTPLFNLERLDTLLLKTTVSEALRSQLEPGAKV
RVESVGARVSSDEAVVRTILPSADPATRRIPVELAVPNADGRFVAHTLARAVLSLGQVQDAQVLPGTALSALNGDHVWVV
ASGQVRRVDVRVLERREQGEVVVLASSPLDSVVDHPTPGLSQGARVSVK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=335, Percent_Identity=27.1641791044776, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38219; Mature: 38219

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPNLKPSAVRVFAAAGMATAVLSLTACQKADASSSPPAKGSAQEVVPTVKVVSARTVRA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEC
APSESVTGTLFPAQGLMVGFEVGGRLSVVRVKKGQGVKKGDVLAQLDPEIADAQVAQAEA
CCCCCCEEEEECCCCEEEEEECCCEEEEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHH
AVAAAEAASTMAADVAARNEKLQQQGGVSEVAHRTASANAAQAQAQWMAAKAQLAQARAS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RRRHDLRAPFDGTLIDAPEQTGATVAPGTPLFNLERLDTLLLKTTVSEALRSQLEPGAKV
HHHHCCCCCCCCCEECCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
RVESVGARVSSDEAVVRTILPSADPATRRIPVELAVPNADGRFVAHTLARAVLSLGQVQD
EEHHHCCCCCCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
AQVLPGTALSALNGDHVWVVASGQVRRVDVRVLERREQGEVVVLASSPLDSVVDHPTPGL
CCCCCCHHHHHCCCCEEEEEECCCEEEEHHHHHHCCCCCCEEEEECCCHHHHHCCCCCCC
SQGARVSVK
CCCCEEECC
>Mature Secondary Structure
MKPNLKPSAVRVFAAAGMATAVLSLTACQKADASSSPPAKGSAQEVVPTVKVVSARTVRA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEC
APSESVTGTLFPAQGLMVGFEVGGRLSVVRVKKGQGVKKGDVLAQLDPEIADAQVAQAEA
CCCCCCEEEEECCCCEEEEEECCCEEEEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHH
AVAAAEAASTMAADVAARNEKLQQQGGVSEVAHRTASANAAQAQAQWMAAKAQLAQARAS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RRRHDLRAPFDGTLIDAPEQTGATVAPGTPLFNLERLDTLLLKTTVSEALRSQLEPGAKV
HHHHCCCCCCCCCEECCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
RVESVGARVSSDEAVVRTILPSADPATRRIPVELAVPNADGRFVAHTLARAVLSLGQVQD
EEHHHCCCCCCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
AQVLPGTALSALNGDHVWVVASGQVRRVDVRVLERREQGEVVVLASSPLDSVVDHPTPGL
CCCCCCHHHHHCCCCEEEEEECCCEEEEHHHHHHCCCCCCEEEEECCCHHHHHCCCCCCC
SQGARVSVK
CCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]