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The map label for this gene is tmk [H]

Identifier: 108758316

GI number: 108758316

Start: 3964987

End: 3965652

Strand: Direct

Name: tmk [H]

Synonym: MXAN_3412

Alternate gene names: 108758316

Gene position: 3964987-3965652 (Clockwise)

Preceding gene: 108757280

Following gene: 108757988

Centisome position: 43.38

GC content: 72.97

Gene sequence:

>666_bases
GTGAGCGCCGCCCGGAAGAAGGCCGCCGCGCGCCGTCCAGGGCGTTTCATCGTCCTGGAGGGACTGGATGGGGCGGGTAC
CACGACGCAGGTGGAGCGGCTTGCCGCGGCCCTGCGCGCGGAGGGGCACTCGGTGCTGACCACGCGGGAGCCGTCTGACG
GCCCCGTGGGGACGATGATTCGCCAGGCGCTCACGGGCCGGTTGGGACTGCCCGGTGGGGCGGGCCCGCTGGCGCCGGAG
ACGCTGGCGTTGCTGTTCGCCGCGGACCGGACGGACCACCTCACGGCCCGGGTGCTCCCGGCGCTGGCGGCGGGCCAGAT
TGTCCTGTGTGACCGCTACGTCCTGTCGTCCCTCGCCTACCAGGGGGCGTCGCTGCCCATGGAATGGGTGGAGGCGGTGA
ATGCGTGCGCGGTGTCGCCGGACCTGACGCTGTTCGTCGGCGTGGCGCCAGAGGTGGCGGCACGGCGCCGCAAGGCACGC
GGCGGGGCGGCGGAGCTGTTCGAGGCGGACGAGGCACAGCGGCGGATTGCGAAGCAGTACGTGGCCGCCATCCGCCGCCG
GGAGAAGCACGAGCGCATCGTCCACATCGACGGCGAACAGGGCATCGAGGCCGTGACGGCCGCGTCGTTGGTGGAGATTC
GCAAGCTGCTGGCCCGCAAGCGCTGA

Upstream 100 bases:

>100_bases
TGGGCCGGAAGGTCCTGGTGGATGAGCTGAAGCAATACGAGTCGATGCTGGCCCTGCGCAGCGAGCTGCGGCTGGACGAC
CCCTCGGCGCTGCTTCCCCG

Downstream 100 bases:

>100_bases
ACTGTCTGGGGCGGTTTTCCCCGCCCGGCGGCGCCTTGCCTTGGATGCCGTCTTCGCCAGCGACGGAAGCGCTCAGTGTC
CCGAGTGCTCGTGACGCTTC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSAARKKAAARRPGRFIVLEGLDGAGTTTQVERLAAALRAEGHSVLTTREPSDGPVGTMIRQALTGRLGLPGGAGPLAPE
TLALLFAADRTDHLTARVLPALAAGQIVLCDRYVLSSLAYQGASLPMEWVEAVNACAVSPDLTLFVGVAPEVAARRRKAR
GGAAELFEADEAQRRIAKQYVAAIRRREKHERIVHIDGEQGIEAVTAASLVEIRKLLARKR

Sequences:

>Translated_221_residues
MSAARKKAAARRPGRFIVLEGLDGAGTTTQVERLAAALRAEGHSVLTTREPSDGPVGTMIRQALTGRLGLPGGAGPLAPE
TLALLFAADRTDHLTARVLPALAAGQIVLCDRYVLSSLAYQGASLPMEWVEAVNACAVSPDLTLFVGVAPEVAARRRKAR
GGAAELFEADEAQRRIAKQYVAAIRRREKHERIVHIDGEQGIEAVTAASLVEIRKLLARKR
>Mature_220_residues
SAARKKAAARRPGRFIVLEGLDGAGTTTQVERLAAALRAEGHSVLTTREPSDGPVGTMIRQALTGRLGLPGGAGPLAPET
LALLFAADRTDHLTARVLPALAAGQIVLCDRYVLSSLAYQGASLPMEWVEAVNACAVSPDLTLFVGVAPEVAARRRKARG
GAAELFEADEAQRRIAKQYVAAIRRREKHERIVHIDGEQGIEAVTAASLVEIRKLLARKR

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=201, Percent_Identity=29.8507462686567, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17535647, Length=203, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573735, Length=208, Percent_Identity=27.4038461538462, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23572; Mature: 23440

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAARKKAAARRPGRFIVLEGLDGAGTTTQVERLAAALRAEGHSVLTTREPSDGPVGTMI
CCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
RQALTGRLGLPGGAGPLAPETLALLFAADRTDHLTARVLPALAAGQIVLCDRYVLSSLAY
HHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
QGASLPMEWVEAVNACAVSPDLTLFVGVAPEVAARRRKARGGAAELFEADEAQRRIAKQY
CCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VAAIRRREKHERIVHIDGEQGIEAVTAASLVEIRKLLARKR
HHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAARKKAAARRPGRFIVLEGLDGAGTTTQVERLAAALRAEGHSVLTTREPSDGPVGTMI
CHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
RQALTGRLGLPGGAGPLAPETLALLFAADRTDHLTARVLPALAAGQIVLCDRYVLSSLAY
HHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
QGASLPMEWVEAVNACAVSPDLTLFVGVAPEVAARRRKARGGAAELFEADEAQRRIAKQY
CCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VAAIRRREKHERIVHIDGEQGIEAVTAASLVEIRKLLARKR
HHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]