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The map label for this gene is dut [H]

Identifier: 108758286

GI number: 108758286

Start: 2408994

End: 2409449

Strand: Direct

Name: dut [H]

Synonym: MXAN_2076

Alternate gene names: 108758286

Gene position: 2408994-2409449 (Clockwise)

Preceding gene: 108759514

Following gene: 108763163

Centisome position: 26.36

GC content: 71.93

Gene sequence:

>456_bases
ATGTCTTCCCCCCTCACGGTGAAGGTGCGCCGCGTGCGCACCCATGCGGAGCCTCTGCCACTTCCCCGCTACGAAACGGC
ACAGGCCGCGGGCCTGGACCTGCGCGCGGACATCGACGGGGAACGGGTGCTGGGGCCCCTGGACCGGCTGGCGGTGCCCA
CCGGGCTCGCGCTCGCGCTACCCGCTGGGTACGAAGGGCAGGTGCGCCCGCGCTCGGGCCTGGCGCTCCGGCATGGCGTC
ACGCTCCTCAACTCGCCGGGGACGGTGGACGCGGACTACCGGGGGGAGGTGCAGGTCATCCTCATCAACCTCTCCCATGA
GCCCTTCACCCTGCGCCGGGGCGACCGCGTGGCCCAACTGGTGGTGGCCGCCGTGCCGCCGGTCTCCCTCCTGGAGGTGG
AGTTTCTGGAGGAAACCTCCCGGGGTGGAAATGGCTTCGGGTCCACGGGGCGCTAG

Upstream 100 bases:

>100_bases
TGCGGCCCGTGGCGAAGGACCCTGCGCCCTGAGGGGCCGACGCGCGAGGTTGTCACGCGGCCGTGGCACGAAGCGGGGGA
AGCTGTGTTAGTCCCAGCGC

Downstream 100 bases:

>100_bases
TTGCTGACTTCCTCGCTCGGCGTTCCTTGATGACAGGGGAGCGTGCAGAATAAGAGGCTGGGCCTTCCCCCGAGGTGGCC
CCCCGACTGCCTCCTGGAGT

Product: dUTP diphosphatase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MSSPLTVKVRRVRTHAEPLPLPRYETAQAAGLDLRADIDGERVLGPLDRLAVPTGLALALPAGYEGQVRPRSGLALRHGV
TLLNSPGTVDADYRGEVQVILINLSHEPFTLRRGDRVAQLVVAAVPPVSLLEVEFLEETSRGGNGFGSTGR

Sequences:

>Translated_151_residues
MSSPLTVKVRRVRTHAEPLPLPRYETAQAAGLDLRADIDGERVLGPLDRLAVPTGLALALPAGYEGQVRPRSGLALRHGV
TLLNSPGTVDADYRGEVQVILINLSHEPFTLRRGDRVAQLVVAAVPPVSLLEVEFLEETSRGGNGFGSTGR
>Mature_150_residues
SSPLTVKVRRVRTHAEPLPLPRYETAQAAGLDLRADIDGERVLGPLDRLAVPTGLALALPAGYEGQVRPRSGLALRHGVT
LLNSPGTVDADYRGEVQVILINLSHEPFTLRRGDRVAQLVVAAVPPVSLLEVEFLEETSRGGNGFGSTGR

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=147, Percent_Identity=38.7755102040816, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4503423, Length=147, Percent_Identity=38.7755102040816, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI70906441, Length=147, Percent_Identity=38.7755102040816, Blast_Score=104, Evalue=3e-23,
Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=38.5135135135135, Blast_Score=100, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71988561, Length=151, Percent_Identity=41.7218543046358, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319729, Length=145, Percent_Identity=37.9310344827586, Blast_Score=99, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19921126, Length=125, Percent_Identity=41.6, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583610, Length=125, Percent_Identity=41.6, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16166; Mature: 16035

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPLTVKVRRVRTHAEPLPLPRYETAQAAGLDLRADIDGERVLGPLDRLAVPTGLALAL
CCCCEEEEEEEEECCCCCCCCCCCCCCHHCCCEEEECCCCCHHCCCHHHHCCCCCEEEEE
PAGYEGQVRPRSGLALRHGVTLLNSPGTVDADYRGEVQVILINLSHEPFTLRRGDRVAQL
CCCCCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCEEEEEEEECCCCEEEECCCHHHHH
VVAAVPPVSLLEVEFLEETSRGGNGFGSTGR
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SSPLTVKVRRVRTHAEPLPLPRYETAQAAGLDLRADIDGERVLGPLDRLAVPTGLALAL
CCCEEEEEEEEECCCCCCCCCCCCCCHHCCCEEEECCCCCHHCCCHHHHCCCCCEEEEE
PAGYEGQVRPRSGLALRHGVTLLNSPGTVDADYRGEVQVILINLSHEPFTLRRGDRVAQL
CCCCCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCEEEEEEEECCCCEEEECCCHHHHH
VVAAVPPVSLLEVEFLEETSRGGNGFGSTGR
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA