| Definition | Myxococcus xanthus DK 1622 chromosome, complete genome. |
|---|---|
| Accession | NC_008095 |
| Length | 9,139,763 |
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The map label for this gene is gyrB [H]
Identifier: 108758234
GI number: 108758234
Start: 312232
End: 314679
Strand: Direct
Name: gyrB [H]
Synonym: MXAN_0264
Alternate gene names: 108758234
Gene position: 312232-314679 (Clockwise)
Preceding gene: 108759326
Following gene: 108761917
Centisome position: 3.42
GC content: 66.38
Gene sequence:
>2448_bases ATGGAAAAGACCCCCGCTACCGGCTCGGCGGTTGCTCCGCCGCCCGTGGAGTATGGGACGGACAGCATTACCAAGCTCGA GGGCCGCGAGGCGGTCCGGAAGCGCCCCGGCATGTACATCGGCGACACGATGGCCTACGGGCTCCACAAGCTCGTGTACG AGGTCGTCGACAACGCGGTGGACGAGTCGCTGGCCGGGCACTGCACCGACATCGAGGTCGTCATCCACGTGGATGGCTCC CTGAGCGTGCAGGACAACGGGCGCGGCATCCCCGTGGGCCCGCACCCCAAGTTCCCCGGCAAGGACACCCTGGAGGTCGT CCTCACGGAGCTGCACGCCGGCAGCAAGTTCGGCAACGGCGCGTACAAGGTCTCCGGCGGCCTCCACGGCGTGGGCGTCA CCTGCGTCAACTTCCTCTCGGAGTGGTTCAAGGTCCGCGTCCATCGCAACGGCATTGTCTACGAGCAGGCCTACGCGCAG GGCGTCCCGGACACCCCGCCGCGCGAGGTGGGCACCACCGACAAGCGCGGCACGCACATCGCCTTCAAACCAGACGCCAC GGTGATGGAGTTGGTGGAGTTCAACTTCGAGACGCTCAGCCAGCGTCTGCGTGAGCTGGCCTTCCTCAACGCGGGCCTGC ATATCGTCGTCCGCGACGAGCGCACGAACAAGGAGCACGACTTCAAGTTCGACGGCGGCATCTCCTCGTTCGTGGAGTAC CTCAACAAGTCGAAGCAGACGCTCCACGACAAGCCCATCTCCTTCAGCACGGAGCGCGAGGGCGTCATGCTCGACATCGC GATGCAGTGGAATGACGGCTACGACGAGCGCATCTACACCTTCGCGAACAACATCAACACCCACGAGGGTGGCAGCCACC TGTCCGGCTTCAAGGCGGCGCTGACGCGCACGCTCAACAGCTACGCGGAGAAGGGCAGCCTCTGGAAGGACCTCAAGGAG ACGCCCACCGGCGAGGACGCGCGTGAAGGCCTGTCCGCCGTCATCTCCGTCAAGCTGACCAACCCCCAGTTCGAGGGGCA GACGAAGACGAAGCTGGGCAACAGCGAGGTGAAGGGCCTGGTCGAGCAGATGGTGAACGACCAGCTCGGCTCCTTCCTGG AAGAGACGCCCATGGTCGCCAAGAAGGTCGTGGCGAAGATTGGCGACGCCTGCCGGGCGCGTCTGGCCGCGCGCAAGGCG CGTGAGACGGTGCGCCGCAAGGGCGTGCTGGACGGCGGCGGGCTCCCCGGAAAGCTGGCGGACTGTCAGAGCCGCGACCC GAACGAGAGCGAGCTCTACATCGTGGAGGGCGACTCCGCAGGTGGCTCCGCGAAGCAGGGCAGAGACAGGCGCAACCAGG CCATCCTTCCGCTGCGCGGCAAGATTCTCAACGTGGAGAAGGCCCGCTTCGAGAAGATGCTCACCAGCGCCGAAATCGTG ACGCTGATTACGGCATTGGGCACGGGCATCGGCGCGGAGGACTACGACCCGGAGAAGGCGCGCTACCACCGCATCATCCT GATGACGGACGCCGACGTGGACGGCAGCCACATCCGTACGCTGCTGCTCACCTTCTTCTTCCGGCAGATGCCGGAGCTCT TGCAGAAGGGCTATCTCTACATCGCGCAGCCGCCGCTCTACAAAGTCACGCGCAACAAGAAGGACCAGTACGTCAAGGAC GAGCACGCGCTGAACGAGTACCTGCTCAAGATTGCCTCCGAGCACGCGCGGGTGCTGACGCCCGGGGGCGAGCTGGGCGG CGCGGAGCTGAAGGCGCTGCTGGAGAAGGTGATTACGTACGAGGAGCGCCTGGAGAAGCAGGCCAAGCGCCGGGACGCGC GCGTGGTGGACGCGCTGGTGCAGGGCGCGCGCCTGTCCGCGGAGACGCTGACGGACGAGGCTGCCCTGGAGGCGGCGGTG AAGGCCGCCTATGACACCTTCGAGCGCCGCATGCCGGACGTGCTGGGCCGCGTGCGCCACGAGCTGGTGCAGGACCCCGA GCACCACACCAAGAAGCTGGTGTTCCACACCGACGTGAATGGCGCCATGCGGGAGACGGTGCTCGACCACGCCTTCCTGT CGTCGCCGGAGTACCTGGAGCTGTCGTCGCTGCGCGACGCCTTCGTGGCGCTGGGCAAGGCGCCGTACAAGGTCCGCGTG GACGCGGGGGAAATCACCGTCTTCTCCGTGCAAGAGGTGCTCGCCGCCGTCCGCAAGGACGCGCAGCGTGGCCTGGGCCT GCAGCGCTACAAGGGTCTGGGTGAGATGAACCCGGAGCAGCTCTGGGACACGACGATGAACCCGGCCACGCGCACGCTGC TCCAGGTGCGGGTGGAGGACGCGGTGGAGAGCGACGAAATCTTCTCGCTGCTGATGGGCGAGGCGGTGGAGCCGCGGCGC GAGTTCATCGAGCGCAACGCTCTGGACGTGCAGAACCTGGACATCTGA
Upstream 100 bases:
>100_bases TTTACGCAGCCTTGCGAGTCCTCGTTAACCTTGTTCGACGTGCCTTGAAGTGGTACGCACGGACCTGTTGCAAGGCTCCT TTTCCCAAGGACAGCTTCAC
Downstream 100 bases:
>100_bases GTCCGTCCCACGGAAAGACGCGTGGGCCCGGTGCCCCTCGGCCCCGCGCCCACGTGCCTTTCCCGTCCTTGTCGAGCCGG GCCTTCGCGCTGCCGGGCCC
Product: DNA gyrase subunit B
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 815; Mature: 815
Protein sequence:
>815_residues MEKTPATGSAVAPPPVEYGTDSITKLEGREAVRKRPGMYIGDTMAYGLHKLVYEVVDNAVDESLAGHCTDIEVVIHVDGS LSVQDNGRGIPVGPHPKFPGKDTLEVVLTELHAGSKFGNGAYKVSGGLHGVGVTCVNFLSEWFKVRVHRNGIVYEQAYAQ GVPDTPPREVGTTDKRGTHIAFKPDATVMELVEFNFETLSQRLRELAFLNAGLHIVVRDERTNKEHDFKFDGGISSFVEY LNKSKQTLHDKPISFSTEREGVMLDIAMQWNDGYDERIYTFANNINTHEGGSHLSGFKAALTRTLNSYAEKGSLWKDLKE TPTGEDAREGLSAVISVKLTNPQFEGQTKTKLGNSEVKGLVEQMVNDQLGSFLEETPMVAKKVVAKIGDACRARLAARKA RETVRRKGVLDGGGLPGKLADCQSRDPNESELYIVEGDSAGGSAKQGRDRRNQAILPLRGKILNVEKARFEKMLTSAEIV TLITALGTGIGAEDYDPEKARYHRIILMTDADVDGSHIRTLLLTFFFRQMPELLQKGYLYIAQPPLYKVTRNKKDQYVKD EHALNEYLLKIASEHARVLTPGGELGGAELKALLEKVITYEERLEKQAKRRDARVVDALVQGARLSAETLTDEAALEAAV KAAYDTFERRMPDVLGRVRHELVQDPEHHTKKLVFHTDVNGAMRETVLDHAFLSSPEYLELSSLRDAFVALGKAPYKVRV DAGEITVFSVQEVLAAVRKDAQRGLGLQRYKGLGEMNPEQLWDTTMNPATRTLLQVRVEDAVESDEIFSLLMGEAVEPRR EFIERNALDVQNLDI
Sequences:
>Translated_815_residues MEKTPATGSAVAPPPVEYGTDSITKLEGREAVRKRPGMYIGDTMAYGLHKLVYEVVDNAVDESLAGHCTDIEVVIHVDGS LSVQDNGRGIPVGPHPKFPGKDTLEVVLTELHAGSKFGNGAYKVSGGLHGVGVTCVNFLSEWFKVRVHRNGIVYEQAYAQ GVPDTPPREVGTTDKRGTHIAFKPDATVMELVEFNFETLSQRLRELAFLNAGLHIVVRDERTNKEHDFKFDGGISSFVEY LNKSKQTLHDKPISFSTEREGVMLDIAMQWNDGYDERIYTFANNINTHEGGSHLSGFKAALTRTLNSYAEKGSLWKDLKE TPTGEDAREGLSAVISVKLTNPQFEGQTKTKLGNSEVKGLVEQMVNDQLGSFLEETPMVAKKVVAKIGDACRARLAARKA RETVRRKGVLDGGGLPGKLADCQSRDPNESELYIVEGDSAGGSAKQGRDRRNQAILPLRGKILNVEKARFEKMLTSAEIV TLITALGTGIGAEDYDPEKARYHRIILMTDADVDGSHIRTLLLTFFFRQMPELLQKGYLYIAQPPLYKVTRNKKDQYVKD EHALNEYLLKIASEHARVLTPGGELGGAELKALLEKVITYEERLEKQAKRRDARVVDALVQGARLSAETLTDEAALEAAV KAAYDTFERRMPDVLGRVRHELVQDPEHHTKKLVFHTDVNGAMRETVLDHAFLSSPEYLELSSLRDAFVALGKAPYKVRV DAGEITVFSVQEVLAAVRKDAQRGLGLQRYKGLGEMNPEQLWDTTMNPATRTLLQVRVEDAVESDEIFSLLMGEAVEPRR EFIERNALDVQNLDI >Mature_815_residues MEKTPATGSAVAPPPVEYGTDSITKLEGREAVRKRPGMYIGDTMAYGLHKLVYEVVDNAVDESLAGHCTDIEVVIHVDGS LSVQDNGRGIPVGPHPKFPGKDTLEVVLTELHAGSKFGNGAYKVSGGLHGVGVTCVNFLSEWFKVRVHRNGIVYEQAYAQ GVPDTPPREVGTTDKRGTHIAFKPDATVMELVEFNFETLSQRLRELAFLNAGLHIVVRDERTNKEHDFKFDGGISSFVEY LNKSKQTLHDKPISFSTEREGVMLDIAMQWNDGYDERIYTFANNINTHEGGSHLSGFKAALTRTLNSYAEKGSLWKDLKE TPTGEDAREGLSAVISVKLTNPQFEGQTKTKLGNSEVKGLVEQMVNDQLGSFLEETPMVAKKVVAKIGDACRARLAARKA RETVRRKGVLDGGGLPGKLADCQSRDPNESELYIVEGDSAGGSAKQGRDRRNQAILPLRGKILNVEKARFEKMLTSAEIV TLITALGTGIGAEDYDPEKARYHRIILMTDADVDGSHIRTLLLTFFFRQMPELLQKGYLYIAQPPLYKVTRNKKDQYVKD EHALNEYLLKIASEHARVLTPGGELGGAELKALLEKVITYEERLEKQAKRRDARVVDALVQGARLSAETLTDEAALEAAV KAAYDTFERRMPDVLGRVRHELVQDPEHHTKKLVFHTDVNGAMRETVLDHAFLSSPEYLELSSLRDAFVALGKAPYKVRV DAGEITVFSVQEVLAAVRKDAQRGLGLQRYKGLGEMNPEQLWDTTMNPATRTLLQVRVEDAVESDEIFSLLMGEAVEPRR EFIERNALDVQNLDI
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0187
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the type II topoisomerase family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=536, Percent_Identity=26.4925373134328, Blast_Score=124, Evalue=5e-28, Organism=Homo sapiens, GI19913408, Length=559, Percent_Identity=24.865831842576, Blast_Score=122, Evalue=2e-27, Organism=Escherichia coli, GI48994957, Length=802, Percent_Identity=51.1221945137157, Blast_Score=785, Evalue=0.0, Organism=Escherichia coli, GI1789408, Length=550, Percent_Identity=38.3636363636364, Blast_Score=355, Evalue=4e-99, Organism=Caenorhabditis elegans, GI17535065, Length=552, Percent_Identity=24.4565217391304, Blast_Score=129, Evalue=8e-30, Organism=Caenorhabditis elegans, GI212645845, Length=534, Percent_Identity=26.5917602996255, Blast_Score=117, Evalue=3e-26, Organism=Saccharomyces cerevisiae, GI6324241, Length=596, Percent_Identity=25, Blast_Score=116, Evalue=1e-26, Organism=Drosophila melanogaster, GI17136538, Length=537, Percent_Identity=25.6983240223464, Blast_Score=125, Evalue=1e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR011557 - InterPro: IPR020568 - InterPro: IPR014721 - InterPro: IPR001241 - InterPro: IPR013759 - InterPro: IPR002288 - InterPro: IPR013506 - InterPro: IPR013760 - InterPro: IPR018522 [H]
Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 90412; Mature: 90412
Theoretical pI: Translated: 6.23; Mature: 6.23
Prosite motif: PS00177 TOPOISOMERASE_II
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEKTPATGSAVAPPPVEYGTDSITKLEGREAVRKRPGMYIGDTMAYGLHKLVYEVVDNAV CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHH DESLAGHCTDIEVVIHVDGSLSVQDNGRGIPVGPHPKFPGKDTLEVVLTELHAGSKFGNG HHHHCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC AYKVSGGLHGVGVTCVNFLSEWFKVRVHRNGIVYEQAYAQGVPDTPPREVGTTDKRGTHI CEEECCCCCCHHHHHHHHHHHHHHEEHHCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCEE AFKPDATVMELVEFNFETLSQRLRELAFLNAGLHIVVRDERTNKEHDFKFDGGISSFVEY EECCCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEECCCHHHHHHH LNKSKQTLHDKPISFSTEREGVMLDIAMQWNDGYDERIYTFANNINTHEGGSHLSGFKAA HHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHH LTRTLNSYAEKGSLWKDLKETPTGEDAREGLSAVISVKLTNPQFEGQTKTKLGNSEVKGL HHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHEEEEEEECCCCCCCCHHHCCCCHHHHHH VEQMVNDQLGSFLEETPMVAKKVVAKIGDACRARLAARKARETVRRKGVLDGGGLPGKLA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC DCQSRDPNESELYIVEGDSAGGSAKQGRDRRNQAILPLRGKILNVEKARFEKMLTSAEIV CCCCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHH TLITALGTGIGAEDYDPEKARYHRIILMTDADVDGSHIRTLLLTFFFRQMPELLQKGYLY HHHHHHHCCCCCCCCCCCHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE IAQPPLYKVTRNKKDQYVKDEHALNEYLLKIASEHARVLTPGGELGGAELKALLEKVITY EECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHH EERLEKQAKRRDARVVDALVQGARLSAETLTDEAALEAAVKAAYDTFERRMPDVLGRVRH HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ELVQDPEHHTKKLVFHTDVNGAMRETVLDHAFLSSPEYLELSSLRDAFVALGKAPYKVRV HHHCCCCHHHHEEEEEECCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCEEEEE DAGEITVFSVQEVLAAVRKDAQRGLGLQRYKGLGEMNPEQLWDTTMNPATRTLLQVRVED CCCCEEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHH AVESDEIFSLLMGEAVEPRREFIERNALDVQNLDI HCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCC >Mature Secondary Structure MEKTPATGSAVAPPPVEYGTDSITKLEGREAVRKRPGMYIGDTMAYGLHKLVYEVVDNAV CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHH DESLAGHCTDIEVVIHVDGSLSVQDNGRGIPVGPHPKFPGKDTLEVVLTELHAGSKFGNG HHHHCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC AYKVSGGLHGVGVTCVNFLSEWFKVRVHRNGIVYEQAYAQGVPDTPPREVGTTDKRGTHI CEEECCCCCCHHHHHHHHHHHHHHEEHHCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCEE AFKPDATVMELVEFNFETLSQRLRELAFLNAGLHIVVRDERTNKEHDFKFDGGISSFVEY EECCCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEECCCHHHHHHH LNKSKQTLHDKPISFSTEREGVMLDIAMQWNDGYDERIYTFANNINTHEGGSHLSGFKAA HHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHH LTRTLNSYAEKGSLWKDLKETPTGEDAREGLSAVISVKLTNPQFEGQTKTKLGNSEVKGL HHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHEEEEEEECCCCCCCCHHHCCCCHHHHHH VEQMVNDQLGSFLEETPMVAKKVVAKIGDACRARLAARKARETVRRKGVLDGGGLPGKLA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC DCQSRDPNESELYIVEGDSAGGSAKQGRDRRNQAILPLRGKILNVEKARFEKMLTSAEIV CCCCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHH TLITALGTGIGAEDYDPEKARYHRIILMTDADVDGSHIRTLLLTFFFRQMPELLQKGYLY HHHHHHHCCCCCCCCCCCHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE IAQPPLYKVTRNKKDQYVKDEHALNEYLLKIASEHARVLTPGGELGGAELKALLEKVITY EECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHH EERLEKQAKRRDARVVDALVQGARLSAETLTDEAALEAAVKAAYDTFERRMPDVLGRVRH HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ELVQDPEHHTKKLVFHTDVNGAMRETVLDHAFLSSPEYLELSSLRDAFVALGKAPYKVRV HHHCCCCHHHHEEEEEECCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCEEEEE DAGEITVFSVQEVLAAVRKDAQRGLGLQRYKGLGEMNPEQLWDTTMNPATRTLLQVRVED CCCCEEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHH AVESDEIFSLLMGEAVEPRREFIERNALDVQNLDI HCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9639935 [H]