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The map label for this gene is atoC [H]

Identifier: 108757675

GI number: 108757675

Start: 3930163

End: 3931755

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_3381

Alternate gene names: 108757675

Gene position: 3931755-3930163 (Counterclockwise)

Preceding gene: 108761877

Following gene: 108760920

Centisome position: 43.02

GC content: 67.11

Gene sequence:

>1593_bases
GTGGGGATGGACTACGGGAAGCATCTGAACCTGCACACCATCATCATGCTCAGGGATGTCATCCGCAAGTGGTGGCAGGT
CGAGCTGGCGTTCGCGGACCGCCACGGCATGGTGCATGAGTGGCAGCGCGGGGAAATCAGCCCGCCGCCGAACGCCTTCT
GCCGTGCCTCCCTGACCTCAAAAGAGGGCTTGCGGCGCTGCGGCCAGTCCGTCCGTGTACTGAACGAGAAGTTCAAGGCC
AACAAGAAGGTGCGCCGCTCGCTCATCCACGACTGCCACCTCAACTTCAGCATCGTGGGCGCGCCCCTCTACATCGCCAA
CGAATACGAGGGGTTCCTCTTCGTCGAGGGCTTCGCCCGCCAGCCTCTTGACGCGCGCGAAGCGGACGTCCTCAAGTCGA
AGGTGCGCCAGTTCGCCCCGCAGCACGCGACCCTGGACGGGAGGAGCGAGCAGGTTCCCGTCCTGGACGGCGCCGAGCTG
AGCAAGCTGTCCGACCTGCTCGAGTGCGCGGCGAACGAAATCGCCAACCACGAAGCGGCGGAGGCCTCCCGGCAGGAGGA
CGGCGCGCCCGGGTCGTCCCGTGAGCTGAGCGACCGCTACCGCTTCGAGAAGATCATCGGGCGCTCCGGGCCCATGATGG
AGGTGTTCCGGTTGATGGAGAAGGTGGCCAACTCCGACTCCACCGTCCTCATCAATGGCGAGTCCGGCACCGGCAAGGAG
CTGGTGGCCCGCGCCATCCACCTCAGCGGCCCGCGCGCGCAGCAGCCCTTCGTGGTGCAGAACTGCTCCGCCTTCAACGA
CAACCTGCTGGAGAGCGCCCTCTTCGGCCACACCCGCGGCGCCTTCACCGGCGCGCTGCGCGACAAGAAGGGACTCTTCG
AGGTCGCCGACAGCGGCACGTTCTTCCTGGATGAAGTGGGCGACATGTCCGCCGCGCTGCAGGTGAAGCTCCTGCGCGTG
CTCCAAGAGGGAACCTTCCTGCCCGTGGGCGGCACGCAGCTCAAGGAGGTCAACGTCCGCGTCATCGCCGCCACCCACAA
GGACCTGAGCGAGCTGGTGAAGCGGGGCGAGTTCCGCGAGGACCTCTACTACCGCATCAACGTCATCCGCGTGCAGCTGC
CGCCCCTGCGGGAGCGGCGCGACGACATGCCCGTCCTCATCGACCACTTCCTGCGCAAACACCACCGCGAGGGCCAGCGC
GCGCGGGGGCTGGACGCGGAGGCCCTGGCCATCCTGGGCGCGTACGCGTGGCCGGGGAACATCCGCGAGTTGGAGAACGA
AATCGAACGCCTGCTCGTGCTGGGGGGCGACTTGGAGTCCATCCCCGCCGAGCTCATCTCCAGCCGCATCCGCGACGCCG
TGTTGCCCGGAGGAGGCCCCTTCATCTCTCCGCGCGCCCACGGCAAGCTGCACGAGGCCGTGGAGGCCCTGGAGCGGGAG
ATGATTCAGCAGGGACTGATGCGCACGCGCTACAACAAGAGCCGGCTGGCGCGAGAGCTGGGCATCAGCCGCTCCAACCT
CATCTTGAAGATCTCGCGCTACGGCCTGGACAAGGGCCTGCCCGAGGACGAGTCGGAGATGGGCGACGCATGA

Upstream 100 bases:

>100_bases
GGTGCGGCTAATGCCCAGTCATGAGGTATGAGAGGCCGGGAATCTGGCTGCCGCCAGGCCCGGCATCCCCTGCTCCGGAG
CGTGGGGAGACGCGACGGAG

Downstream 100 bases:

>100_bases
GCCCTGGTCCGCGGTACTTCCACCAGGATCGCCTGCGCGTCCCGGATGGCGCGCAGTTGTATTACCAGGTCCAGGGAGAT
GGCCTTCCGGGCATGGTCTT

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MGMDYGKHLNLHTIIMLRDVIRKWWQVELAFADRHGMVHEWQRGEISPPPNAFCRASLTSKEGLRRCGQSVRVLNEKFKA
NKKVRRSLIHDCHLNFSIVGAPLYIANEYEGFLFVEGFARQPLDAREADVLKSKVRQFAPQHATLDGRSEQVPVLDGAEL
SKLSDLLECAANEIANHEAAEASRQEDGAPGSSRELSDRYRFEKIIGRSGPMMEVFRLMEKVANSDSTVLINGESGTGKE
LVARAIHLSGPRAQQPFVVQNCSAFNDNLLESALFGHTRGAFTGALRDKKGLFEVADSGTFFLDEVGDMSAALQVKLLRV
LQEGTFLPVGGTQLKEVNVRVIAATHKDLSELVKRGEFREDLYYRINVIRVQLPPLRERRDDMPVLIDHFLRKHHREGQR
ARGLDAEALAILGAYAWPGNIRELENEIERLLVLGGDLESIPAELISSRIRDAVLPGGGPFISPRAHGKLHEAVEALERE
MIQQGLMRTRYNKSRLARELGISRSNLILKISRYGLDKGLPEDESEMGDA

Sequences:

>Translated_530_residues
MGMDYGKHLNLHTIIMLRDVIRKWWQVELAFADRHGMVHEWQRGEISPPPNAFCRASLTSKEGLRRCGQSVRVLNEKFKA
NKKVRRSLIHDCHLNFSIVGAPLYIANEYEGFLFVEGFARQPLDAREADVLKSKVRQFAPQHATLDGRSEQVPVLDGAEL
SKLSDLLECAANEIANHEAAEASRQEDGAPGSSRELSDRYRFEKIIGRSGPMMEVFRLMEKVANSDSTVLINGESGTGKE
LVARAIHLSGPRAQQPFVVQNCSAFNDNLLESALFGHTRGAFTGALRDKKGLFEVADSGTFFLDEVGDMSAALQVKLLRV
LQEGTFLPVGGTQLKEVNVRVIAATHKDLSELVKRGEFREDLYYRINVIRVQLPPLRERRDDMPVLIDHFLRKHHREGQR
ARGLDAEALAILGAYAWPGNIRELENEIERLLVLGGDLESIPAELISSRIRDAVLPGGGPFISPRAHGKLHEAVEALERE
MIQQGLMRTRYNKSRLARELGISRSNLILKISRYGLDKGLPEDESEMGDA
>Mature_529_residues
GMDYGKHLNLHTIIMLRDVIRKWWQVELAFADRHGMVHEWQRGEISPPPNAFCRASLTSKEGLRRCGQSVRVLNEKFKAN
KKVRRSLIHDCHLNFSIVGAPLYIANEYEGFLFVEGFARQPLDAREADVLKSKVRQFAPQHATLDGRSEQVPVLDGAELS
KLSDLLECAANEIANHEAAEASRQEDGAPGSSRELSDRYRFEKIIGRSGPMMEVFRLMEKVANSDSTVLINGESGTGKEL
VARAIHLSGPRAQQPFVVQNCSAFNDNLLESALFGHTRGAFTGALRDKKGLFEVADSGTFFLDEVGDMSAALQVKLLRVL
QEGTFLPVGGTQLKEVNVRVIAATHKDLSELVKRGEFREDLYYRINVIRVQLPPLRERRDDMPVLIDHFLRKHHREGQRA
RGLDAEALAILGAYAWPGNIRELENEIERLLVLGGDLESIPAELISSRIRDAVLPGGGPFISPRAHGKLHEAVEALEREM
IQQGLMRTRYNKSRLARELGISRSNLILKISRYGLDKGLPEDESEMGDA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=323, Percent_Identity=46.749226006192, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1790437, Length=313, Percent_Identity=46.3258785942492, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1790299, Length=330, Percent_Identity=45.1515151515152, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1788905, Length=333, Percent_Identity=42.6426426426426, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1789087, Length=329, Percent_Identity=46.8085106382979, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=40.7975460122699, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI87082117, Length=231, Percent_Identity=53.2467532467532, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082152, Length=319, Percent_Identity=44.5141065830721, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=38.8198757763975, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87081872, Length=307, Percent_Identity=39.7394136807818, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786524, Length=327, Percent_Identity=40.0611620795107, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1789828, Length=227, Percent_Identity=37.8854625550661, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081858, Length=304, Percent_Identity=31.5789473684211, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 59351; Mature: 59219

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMDYGKHLNLHTIIMLRDVIRKWWQVELAFADRHGMVHEWQRGEISPPPNAFCRASLTS
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCHHCCCCCCCCCCCHHHCCCCHH
KEGLRRCGQSVRVLNEKFKANKKVRRSLIHDCHLNFSIVGAPLYIANEYEGFLFVEGFAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECCCC
QPLDAREADVLKSKVRQFAPQHATLDGRSEQVPVLDGAELSKLSDLLECAANEIANHEAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
EASRQEDGAPGSSRELSDRYRFEKIIGRSGPMMEVFRLMEKVANSDSTVLINGESGTGKE
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHH
LVARAIHLSGPRAQQPFVVQNCSAFNDNLLESALFGHTRGAFTGALRDKKGLFEVADSGT
HHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCEECCCCC
FFLDEVGDMSAALQVKLLRVLQEGTFLPVGGTQLKEVNVRVIAATHKDLSELVKRGEFRE
EEEHHHCCHHHHHHHHHHHHHHCCCEECCCCCCEEEEEEEEEEECHHHHHHHHHCCCHHH
DLYYRINVIRVQLPPLRERRDDMPVLIDHFLRKHHREGQRARGLDAEALAILGAYAWPGN
HHEEEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHCCCCC
IRELENEIERLLVLGGDLESIPAELISSRIRDAVLPGGGPFISPRAHGKLHEAVEALERE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
MIQQGLMRTRYNKSRLARELGISRSNLILKISRYGLDKGLPEDESEMGDA
HHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCCHHHCCCC
>Mature Secondary Structure 
GMDYGKHLNLHTIIMLRDVIRKWWQVELAFADRHGMVHEWQRGEISPPPNAFCRASLTS
CCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCHHCCCCCCCCCCCHHHCCCCHH
KEGLRRCGQSVRVLNEKFKANKKVRRSLIHDCHLNFSIVGAPLYIANEYEGFLFVEGFAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECCCC
QPLDAREADVLKSKVRQFAPQHATLDGRSEQVPVLDGAELSKLSDLLECAANEIANHEAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
EASRQEDGAPGSSRELSDRYRFEKIIGRSGPMMEVFRLMEKVANSDSTVLINGESGTGKE
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHH
LVARAIHLSGPRAQQPFVVQNCSAFNDNLLESALFGHTRGAFTGALRDKKGLFEVADSGT
HHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCEECCCCC
FFLDEVGDMSAALQVKLLRVLQEGTFLPVGGTQLKEVNVRVIAATHKDLSELVKRGEFRE
EEEHHHCCHHHHHHHHHHHHHHCCCEECCCCCCEEEEEEEEEEECHHHHHHHHHCCCHHH
DLYYRINVIRVQLPPLRERRDDMPVLIDHFLRKHHREGQRARGLDAEALAILGAYAWPGN
HHEEEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHCCCCC
IRELENEIERLLVLGGDLESIPAELISSRIRDAVLPGGGPFISPRAHGKLHEAVEALERE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
MIQQGLMRTRYNKSRLARELGISRSNLILKISRYGLDKGLPEDESEMGDA
HHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]