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The map label for this gene is cyaA [H]

Identifier: 108757453

GI number: 108757453

Start: 4818221

End: 4819954

Strand: Reverse

Name: cyaA [H]

Synonym: MXAN_3956

Alternate gene names: 108757453

Gene position: 4819954-4818221 (Counterclockwise)

Preceding gene: 108761964

Following gene: 108760330

Centisome position: 52.74

GC content: 68.45

Gene sequence:

>1734_bases
GTGGTGATTTCCGAGCGTTCCCCGGTGCCGATGGCCTCTGGTAGTGTCCGGGCCGGTGAGGATTTCCGCGTGAGCCAGTC
CCCCGTCCCGTTCGCTCCCAAACCCGGGCAGATTCGCGGCCCCCGACTGACAGGGCGCTTCGCGGATGGCACGCTCGGAG
AGTTTCCCCTGGGGCCGGCGACGTCCCTGGGCCGGCATCCGTCCAACACGTTGCGGCTGGTGGACCGGGAGGTTTCCAAG
GAACACGCGGTCATCGAGCGCGTGGGCAAGGACTTCATCCTCAAGGACCTGGGCTCGTCCAACGGCACCTTCGTGAATGG
CCGCCGGGTGAAGGAGCTCAAGCTGCGCGACGGGGACGAAATCTCCCTGGGCGCCTCGCGGCTCATCTTCCACAGCGGCG
AGCCGGTGGCGCCGGCCAACGCGCCCACCGCGCCGGGCGTGACGGTGGTGGCGCAGTCCATCTCCATGCCGGCCTTCCTG
GCGCAGATGGACCAGGTGCCGCAGAACTTCCGGCCCGCCGAACAGGTGTCGGACGTGGAGGCGCTGCGCCGCGACTACGA
GAAGCTGCGCATCGCCCATGAGTTCCACCGCCAGGTGAGCCTGCAGGGCAGCCAGACGGGGCTCTTCGAGCAGATCCTCA
AAGTGGCCTTCCAACTGCTGGCCGCGGACCACGGCGTCATCCTGAAGGTGGCCGCGGACGGCGAGTTCATCCCGTCGGCG
GTGCACCACCGCTCCGACAAGGCCGTCAACGTCATGCTGTCCGACACCGTGCTCAAGCGCGTGGTGGAGACGGGCAAGGC
GGTGCTGACGGCGGACGCCATCATCGACGAGCGCTTCTCCGCGGCGGAGAGCATCGTCGCACAGGGCATCCGGTCCGCCA
TGGCGGTGCCGCTGAAGGTGAACGGGAAGATTCAGGCGGTGCTCTTCCTGGACAGCCGGCAGCAGATCAACGCCTTCTCG
GAGAAGGACCTGACCATCCTCTCCGGCATCGCCTCGCAGGCGAGCATCGCGCTGGAGAACGCGGCGCTGGCCGAGCAGAT
TCGCGCCGAGGCCGTGACGCGCGCGGAGCTCAGCCGCTTCCTGTCCAAGGCCGTCGCCGACGCGGTGATCGCCGGTGAGA
CGGAAGACCTGGCGCAGAGCCGGCTGGCGGAGGTGAGCTGCCTCTTCGCGGACATCCGCGGGTTCACCACCATCTCGGAG
AACGATTCTCCGCAAGAGGTGGTAGACATGCTCAACGCATTCTTCACCGCCATGGCCGGGGTGGTGTTCCGCCACGAGGG
GAACCTGGACAAGTTCATTGGGGACTGTGTCATGGCCGTCTGGGGGCCGCCGCTGTCGCACCCGGACGATGCCGCCCGCG
CGCTTCGGGCTGCCTTGGAGATGCAGGACGCCGTGCATGAGCTGAACCGCCGCCGCGTGGCCGCGGGCAAGCAGCCCATC
GAGGTCGGCATCGGGGTGAACACCGGGCAGGCCGTTGTCGGCTACATGGGCAGCGCCGAGCGCCACGAGTTCACCGCCAT
TGGCGACACGGTGAACACGGCCTCGCGCCTGTGTGGCATGGCGAAGAGCGGTGAGGTCCTGGCCTCCGAGTCTACGGTGC
GCAGGGCGGGCGCCGGCTTCGACGTGGAGGGGCTGCCGGCCCTCCAGGTGAAGGGCAAGGAGAAGGCCGTGCCGACCTAC
CGCGTCCACGGGCTGGAGTACACCACCGCCGCTTCCTCCTCACGCCGCGCATGA

Upstream 100 bases:

>100_bases
CTTCAGTGGGCCTGGCCATCCGGGCGGGCGGTTCGGACAGGAAGCCGACGGCCGGTCGCTGAGGAGCCGTCCCGCCAGGC
GGACGCTGCTCGGAAGTGCA

Downstream 100 bases:

>100_bases
GTCCGACGACGCAGGCCTGCCCCAACTGCGGCCATCTACACGACATCCGCGTCTACGTGAGCGGCCAGCGTGTCCAGTGC
CGCTGCGGCATCCGGTTCGA

Product: putative adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MVISERSPVPMASGSVRAGEDFRVSQSPVPFAPKPGQIRGPRLTGRFADGTLGEFPLGPATSLGRHPSNTLRLVDREVSK
EHAVIERVGKDFILKDLGSSNGTFVNGRRVKELKLRDGDEISLGASRLIFHSGEPVAPANAPTAPGVTVVAQSISMPAFL
AQMDQVPQNFRPAEQVSDVEALRRDYEKLRIAHEFHRQVSLQGSQTGLFEQILKVAFQLLAADHGVILKVAADGEFIPSA
VHHRSDKAVNVMLSDTVLKRVVETGKAVLTADAIIDERFSAAESIVAQGIRSAMAVPLKVNGKIQAVLFLDSRQQINAFS
EKDLTILSGIASQASIALENAALAEQIRAEAVTRAELSRFLSKAVADAVIAGETEDLAQSRLAEVSCLFADIRGFTTISE
NDSPQEVVDMLNAFFTAMAGVVFRHEGNLDKFIGDCVMAVWGPPLSHPDDAARALRAALEMQDAVHELNRRRVAAGKQPI
EVGIGVNTGQAVVGYMGSAERHEFTAIGDTVNTASRLCGMAKSGEVLASESTVRRAGAGFDVEGLPALQVKGKEKAVPTY
RVHGLEYTTAASSSRRA

Sequences:

>Translated_577_residues
MVISERSPVPMASGSVRAGEDFRVSQSPVPFAPKPGQIRGPRLTGRFADGTLGEFPLGPATSLGRHPSNTLRLVDREVSK
EHAVIERVGKDFILKDLGSSNGTFVNGRRVKELKLRDGDEISLGASRLIFHSGEPVAPANAPTAPGVTVVAQSISMPAFL
AQMDQVPQNFRPAEQVSDVEALRRDYEKLRIAHEFHRQVSLQGSQTGLFEQILKVAFQLLAADHGVILKVAADGEFIPSA
VHHRSDKAVNVMLSDTVLKRVVETGKAVLTADAIIDERFSAAESIVAQGIRSAMAVPLKVNGKIQAVLFLDSRQQINAFS
EKDLTILSGIASQASIALENAALAEQIRAEAVTRAELSRFLSKAVADAVIAGETEDLAQSRLAEVSCLFADIRGFTTISE
NDSPQEVVDMLNAFFTAMAGVVFRHEGNLDKFIGDCVMAVWGPPLSHPDDAARALRAALEMQDAVHELNRRRVAAGKQPI
EVGIGVNTGQAVVGYMGSAERHEFTAIGDTVNTASRLCGMAKSGEVLASESTVRRAGAGFDVEGLPALQVKGKEKAVPTY
RVHGLEYTTAASSSRRA
>Mature_577_residues
MVISERSPVPMASGSVRAGEDFRVSQSPVPFAPKPGQIRGPRLTGRFADGTLGEFPLGPATSLGRHPSNTLRLVDREVSK
EHAVIERVGKDFILKDLGSSNGTFVNGRRVKELKLRDGDEISLGASRLIFHSGEPVAPANAPTAPGVTVVAQSISMPAFL
AQMDQVPQNFRPAEQVSDVEALRRDYEKLRIAHEFHRQVSLQGSQTGLFEQILKVAFQLLAADHGVILKVAADGEFIPSA
VHHRSDKAVNVMLSDTVLKRVVETGKAVLTADAIIDERFSAAESIVAQGIRSAMAVPLKVNGKIQAVLFLDSRQQINAFS
EKDLTILSGIASQASIALENAALAEQIRAEAVTRAELSRFLSKAVADAVIAGETEDLAQSRLAEVSCLFADIRGFTTISE
NDSPQEVVDMLNAFFTAMAGVVFRHEGNLDKFIGDCVMAVWGPPLSHPDDAARALRAALEMQDAVHELNRRRVAAGKQPI
EVGIGVNTGQAVVGYMGSAERHEFTAIGDTVNTASRLCGMAKSGEVLASESTVRRAGAGFDVEGLPALQVKGKEKAVPTY
RVHGLEYTTAASSSRRA

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=234, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI24497587, Length=180, Percent_Identity=32.2222222222222, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4557257, Length=265, Percent_Identity=26.7924528301887, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4504217, Length=201, Percent_Identity=31.3432835820896, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI115387102, Length=214, Percent_Identity=27.5700934579439, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI134152694, Length=205, Percent_Identity=31.219512195122, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI4557255, Length=169, Percent_Identity=28.9940828402367, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI148536830, Length=194, Percent_Identity=29.3814432989691, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI222080083, Length=229, Percent_Identity=30.1310043668122, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4580422, Length=232, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI50959205, Length=190, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17534659, Length=254, Percent_Identity=31.496062992126, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71989805, Length=226, Percent_Identity=30.0884955752212, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71989822, Length=226, Percent_Identity=30.0884955752212, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71995305, Length=222, Percent_Identity=31.0810810810811, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551720, Length=184, Percent_Identity=30.9782608695652, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508769, Length=175, Percent_Identity=32, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17561802, Length=201, Percent_Identity=28.3582089552239, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561800, Length=212, Percent_Identity=27.3584905660377, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71995300, Length=162, Percent_Identity=32.0987654320988, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17561804, Length=201, Percent_Identity=27.363184079602, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=174, Percent_Identity=32.7586206896552, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193207841, Length=218, Percent_Identity=25.2293577981651, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212659371, Length=213, Percent_Identity=29.5774647887324, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212645052, Length=247, Percent_Identity=27.9352226720648, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17534655, Length=215, Percent_Identity=28.8372093023256, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534657, Length=177, Percent_Identity=29.9435028248588, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71990146, Length=176, Percent_Identity=28.4090909090909, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI62484477, Length=254, Percent_Identity=31.1023622047244, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI62484298, Length=254, Percent_Identity=31.1023622047244, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI116008008, Length=254, Percent_Identity=31.1023622047244, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI161078020, Length=213, Percent_Identity=31.4553990610329, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585694, Length=168, Percent_Identity=29.1666666666667, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221330470, Length=259, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221330468, Length=259, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24663839, Length=220, Percent_Identity=30.9090909090909, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24663843, Length=220, Percent_Identity=30.9090909090909, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281366459, Length=224, Percent_Identity=29.0178571428571, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281366457, Length=224, Percent_Identity=29.0178571428571, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281366455, Length=224, Percent_Identity=29.0178571428571, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI56292422, Length=224, Percent_Identity=29.0178571428571, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI56292424, Length=224, Percent_Identity=29.0178571428571, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666940, Length=224, Percent_Identity=29.0178571428571, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076872, Length=173, Percent_Identity=31.7919075144509, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574512, Length=173, Percent_Identity=31.7919075144509, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667100, Length=202, Percent_Identity=28.2178217821782, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161084260, Length=179, Percent_Identity=29.608938547486, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281366320, Length=179, Percent_Identity=29.608938547486, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24647268, Length=177, Percent_Identity=32.7683615819209, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24642014, Length=174, Percent_Identity=28.1609195402299, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85725044, Length=173, Percent_Identity=30.0578034682081, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 61766; Mature: 61766

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50006 FHA_DOMAIN ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVISERSPVPMASGSVRAGEDFRVSQSPVPFAPKPGQIRGPRLTGRFADGTLGEFPLGPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCC
TSLGRHPSNTLRLVDREVSKEHAVIERVGKDFILKDLGSSNGTFVNGRRVKELKLRDGDE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCEECCCEEEEEECCCCCC
ISLGASRLIFHSGEPVAPANAPTAPGVTVVAQSISMPAFLAQMDQVPQNFRPAEQVSDVE
EECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHH
ALRRDYEKLRIAHEFHRQVSLQGSQTGLFEQILKVAFQLLAADHGVILKVAADGEFIPSA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHH
VHHRSDKAVNVMLSDTVLKRVVETGKAVLTADAIIDERFSAAESIVAQGIRSAMAVPLKV
HHCCCCCEEEEEHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
NGKIQAVLFLDSRQQINAFSEKDLTILSGIASQASIALENAALAEQIRAEAVTRAELSRF
CCEEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKAVADAVIAGETEDLAQSRLAEVSCLFADIRGFTTISENDSPQEVVDMLNAFFTAMAG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHH
VVFRHEGNLDKFIGDCVMAVWGPPLSHPDDAARALRAALEMQDAVHELNRRRVAAGKQPI
HHEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
EVGIGVNTGQAVVGYMGSAERHEFTAIGDTVNTASRLCGMAKSGEVLASESTVRRAGAGF
EEEECCCCCCHHHHHCCCCCCCCEEECCCHHHHHHHHHCCCCCCCEEECCHHHHHCCCCC
DVEGLPALQVKGKEKAVPTYRVHGLEYTTAASSSRRA
CCCCCCEEEECCCCCCCCEEEECCCEEEECCCCCCCC
>Mature Secondary Structure
MVISERSPVPMASGSVRAGEDFRVSQSPVPFAPKPGQIRGPRLTGRFADGTLGEFPLGPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCC
TSLGRHPSNTLRLVDREVSKEHAVIERVGKDFILKDLGSSNGTFVNGRRVKELKLRDGDE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCEECCCEEEEEECCCCCC
ISLGASRLIFHSGEPVAPANAPTAPGVTVVAQSISMPAFLAQMDQVPQNFRPAEQVSDVE
EECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHH
ALRRDYEKLRIAHEFHRQVSLQGSQTGLFEQILKVAFQLLAADHGVILKVAADGEFIPSA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHH
VHHRSDKAVNVMLSDTVLKRVVETGKAVLTADAIIDERFSAAESIVAQGIRSAMAVPLKV
HHCCCCCEEEEEHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
NGKIQAVLFLDSRQQINAFSEKDLTILSGIASQASIALENAALAEQIRAEAVTRAELSRF
CCEEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKAVADAVIAGETEDLAQSRLAEVSCLFADIRGFTTISENDSPQEVVDMLNAFFTAMAG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHH
VVFRHEGNLDKFIGDCVMAVWGPPLSHPDDAARALRAALEMQDAVHELNRRRVAAGKQPI
HHEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
EVGIGVNTGQAVVGYMGSAERHEFTAIGDTVNTASRLCGMAKSGEVLASESTVRRAGAGF
EEEECCCCCCHHHHHCCCCCCCCEEECCCHHHHHHHHHCCCCCCCEEECCHHHHHCCCCC
DVEGLPALQVKGKEKAVPTYRVHGLEYTTAASSSRRA
CCCCCCEEEECCCCCCCCEEEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]