Click here to switch to the map view.

The map label for this gene is upp

Identifier: 108757185

GI number: 108757185

Start: 146048

End: 146683

Strand: Direct

Name: upp

Synonym: MXAN_0124

Alternate gene names: 108757185

Gene position: 146048-146683 (Clockwise)

Preceding gene: 108760567

Following gene: 108763640

Centisome position: 1.6

GC content: 67.77

Gene sequence:

>636_bases
ATGGAGTTTCCGAACTGCACGGTGGTGGACCACCCGCTGGTGAAGCACAAGCTCACGCAGATGCGCCGGGTGGAGACGAG
CACCGCCTCCTTTCGGGCGCTGCTCCAGGAAATCTCACTGCTGCTCGCCTATGAGGCGCTGAGAGACCTCAAGGTGCGCG
AGGAGGACATCCAGACGCCCATGGCACGCACGGTGGCGCCGGTGCTGGATGGCAAGAAGTTGGTGCTGGTGGCCATCATG
CGCGCGGGGCAGGGCATCCTCGACGGGATGTTGCAACTGGTGCCCTCCGCGCGCGTGGGGCACATCGGCCTGTACCGAGA
CCCGGAGACGCTGTCGCCGGTGGAGTACTACTACCGCGTGCCCGGCCAGCTCGCGGACCGGGACGTGGTGGTGTGCGACC
CGATGCTCGCCACGGGGAACTCGGCGGTGGCCGCGCTCCAGCGGCTGAAGAAGAGCAAGCCCGGCTCATTGCGCTTCGTC
TGTCTGCTGGCGTGCCCGGAGGGCCTGACGAACCTGCGCGAGCACCACCCGGACGTCCACGTCTACACCGCCGCCATCGA
CGAGCGATTGGACGAGCACGGCTACATCCTCCCGGGCCTGGGCGACGCGGGCGACCGGCTCTTCGGGACCAAGTAG

Upstream 100 bases:

>100_bases
GTGGACCGCGGGCCGGCGCGTGGCGGCGGAGCGGCGCCCTGGTGGCGGGCCGCCCATCCGCGTGGACAGTGACGGCACGG
TGTTCTGACGGGAGGACGCA

Downstream 100 bases:

>100_bases
CGCGGTGGAGGAGATACCCCTTACCCGGCAACGGTGACTTGGCGCGCGGACGTGTCCGGGACAGGATGCGCGCCGCGGAC
GGGGCCGGCGCAATCGGTTG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MEFPNCTVVDHPLVKHKLTQMRRVETSTASFRALLQEISLLLAYEALRDLKVREEDIQTPMARTVAPVLDGKKLVLVAIM
RAGQGILDGMLQLVPSARVGHIGLYRDPETLSPVEYYYRVPGQLADRDVVVCDPMLATGNSAVAALQRLKKSKPGSLRFV
CLLACPEGLTNLREHHPDVHVYTAAIDERLDEHGYILPGLGDAGDRLFGTK

Sequences:

>Translated_211_residues
MEFPNCTVVDHPLVKHKLTQMRRVETSTASFRALLQEISLLLAYEALRDLKVREEDIQTPMARTVAPVLDGKKLVLVAIM
RAGQGILDGMLQLVPSARVGHIGLYRDPETLSPVEYYYRVPGQLADRDVVVCDPMLATGNSAVAALQRLKKSKPGSLRFV
CLLACPEGLTNLREHHPDVHVYTAAIDERLDEHGYILPGLGDAGDRLFGTK
>Mature_211_residues
MEFPNCTVVDHPLVKHKLTQMRRVETSTASFRALLQEISLLLAYEALRDLKVREEDIQTPMARTVAPVLDGKKLVLVAIM
RAGQGILDGMLQLVPSARVGHIGLYRDPETLSPVEYYYRVPGQLADRDVVVCDPMLATGNSAVAALQRLKKSKPGSLRFV
CLLACPEGLTNLREHHPDVHVYTAAIDERLDEHGYILPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=29.2079207920792, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=29.2079207920792, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI21450816, Length=199, Percent_Identity=24.6231155778894, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=48.2758620689655, Blast_Score=204, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17539892, Length=217, Percent_Identity=24.8847926267281, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=217, Percent_Identity=24.8847926267281, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=35.4166666666667, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=26.6009852216749, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=26.6009852216749, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=26.6009852216749, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=26.6009852216749, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_MYXXD (Q1DG16)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_628407.1
- ProteinModelPortal:   Q1DG16
- SMR:   Q1DG16
- STRING:   Q1DG16
- GeneID:   4101606
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_0124
- TIGR:   MXAN_0124
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   LRAGNGF
- PhylomeDB:   Q1DG16
- BioCyc:   MXAN246197:MXAN_0124-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23337; Mature: 23337

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: BINDING 81-81 BINDING 106-106 BINDING 196-196 BINDING 202-202

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFPNCTVVDHPLVKHKLTQMRRVETSTASFRALLQEISLLLAYEALRDLKVREEDIQTP
CCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
MARTVAPVLDGKKLVLVAIMRAGQGILDGMLQLVPSARVGHIGLYRDPETLSPVEYYYRV
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHCC
PGQLADRDVVVCDPMLATGNSAVAALQRLKKSKPGSLRFVCLLACPEGLTNLREHHPDVH
CCCCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCEE
VYTAAIDERLDEHGYILPGLGDAGDRLFGTK
EEHHHHHHHHHHCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MEFPNCTVVDHPLVKHKLTQMRRVETSTASFRALLQEISLLLAYEALRDLKVREEDIQTP
CCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
MARTVAPVLDGKKLVLVAIMRAGQGILDGMLQLVPSARVGHIGLYRDPETLSPVEYYYRV
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHCC
PGQLADRDVVVCDPMLATGNSAVAALQRLKKSKPGSLRFVCLLACPEGLTNLREHHPDVH
CCCCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCEE
VYTAAIDERLDEHGYILPGLGDAGDRLFGTK
EEHHHHHHHHHHCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA