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The map label for this gene is mutS [H]

Identifier: 108757176

GI number: 108757176

Start: 6413076

End: 6415010

Strand: Direct

Name: mutS [H]

Synonym: MXAN_5134

Alternate gene names: 108757176

Gene position: 6413076-6415010 (Clockwise)

Preceding gene: 108758774

Following gene: 108757087

Centisome position: 70.17

GC content: 70.44

Gene sequence:

>1935_bases
GTGCTGGCCGGGCCTCCGTCGACCCGGCGTCACGCATTTGCACCTGCCGCTTGCCCTGAACGCCGCGTGACCGCAGCATG
CGTGCCCATCGTGTCCGCCACCGCCGAGCCCCCATCCCCGCATCGCACGTACACCGAGCGCCGAGCCGCCGCGCAGGCGG
AACTGACCGCGCTGGACCGCGTGAGCGCCCGCTACGCCAACTTGCGAACACTCGCCTTCCTGGCCGCGGCCGGCGTCGCG
GGCTTCGTGCTGGCGGGGCGTCTGCCCAAGGTGTGGTGGTGGGCCAGCGCCGCCGCGCTGGTGCTCTACGGCGTGCTCGC
CGTCCTCCACCACCAGGTCTTCCGCCGCGAGGCCCGGGCGAAGCTGTACGTGACGCTCAACGAACGCGGATTGGCGCGGC
TGGGGCCCGGCTGGCACGACTTCACCGAGCGCGGTGAACGCTTCCTCTCCCCCGGTCACCTGTACACCCCGGACCTGGAT
GTCTTCGGACAGGGAAGCCTCTTCCAACTCCTCAACGAGACGGCCACGCGCGCTGGAGAAGAACGGTTGGCGGCGTGGCT
CTCCGCCCCCGCGTCCGCCCAGGAGGTCGAAGCCAGACAGGGCGCCGCGCGCGAACTGGCGCCCAACCTGGACTTCCGCC
AGGACCTCTGCGTGGACGCGCGGGACGCCTCGCGCGAGAAGGCGGACCCGGCGCTGTTCATCCAGTGGGCGGAGTCGGGT
CCACAGCTGAATGCCATCCGCTGGGCCCGACCGGTGGCGGTGGTGCTGCCCCTGGTGACGCTGGCCGTCTACGTCCTGGG
CAAGTTCGAGGTACTGCCGGAGTCGGCTTTCTGGGTGGGCTTGGCCGCGCAACTGGGCGTGGCCGTCATCACCCGCCGCC
CGCTGAAGGTCATGGACGAAGGCGTGGAGGTGGGTGAGCGCGGCTTCGTGCGCTACGCCCCCATCTTCGAGCGCGTGGAG
GCCCAGCGCTTCGAGCACCCGCGACTGAAGACGCTCCAGTCCGGCCTCCAGCAGCCCGGCCAGCCGCCCGTGTCCGAGCA
CTTCAAGCGCTTCAGCCGGCTGTTCTCCTTCATCGAGTTCAAGCGCCACCAGTTCCACCCGCTGATTCACTGGCTCACGC
TCTGGGACATCCACGCGCACTTCGCGCTGGAGCGCTGGCGCGAGGCCCACGGTAAGCAGCTGCGCCAGTGGTTCGAGGCC
CTGGCCGAACTGGAAGCCCTGTCTTGCGTCGCGGGCCTCGCCCATGACCGGCCGGACTTCACCTGGCCCGTCTTGGCGGC
CAATGGCCCCTGTGTGGAGGCGACAGCGCTGGGCCACCCGCTGCTGGACGCTCCGGTGCCCAACGACGTGTCCCTGCCCG
GTCCCCGGCACGCGCTGCTCATCACCGGCTCCAACATGAGCGGCAAGACGACGCTGATGCGCGCGGTTGGAGCCAACGTG
GTGCTGGCGTTGGCGGGCGCGCCGGTGAGCGCGAAGCACTTCCGCCTGACACCGCTCCAGACGCTCACCAGCATGCGGGT
GAAGGACTCGCTGGAGCGCGGCGTCTCCTACTTCTACGCGGAGGTACAGCGCATCAAGGCGGTGCTGGACGCGGCGCAGG
CCGCGCGCGGGCAGGTGCTGTTCCTCCTGGACGAAATCCTCCTGGGGACGAACACCCGCGAGCGGCAGATTGCCTCGCGC
GAGGTGCTGCGCCTGCTGCTGGGCACCGGCGCCATTGGCGCGGTGACGACGCACGACTTGTCCCTGGCGGTGCTCGCGGA
CGAGCCGGGCGCCCATGTCGTCAACGTCCACTTCCGGGACCACCTGGAGGCCGGGAAGATGATGTTCGACTACAAGCTGC
GCCAGGGCGTGGTGGACACCACCAACGCCCTGCGCGTGCTGCGCCTGGCCGGCGTACCGGTGGACGACCCGGACGAAGCC
ACGGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
TTATCAATGACTGACGTGCTCATTCCGGTGCCCCCCTCGTGACCGCCGATGAGGACAAATCTACGCGCCGGGTCTGACAT
GAATCAGGCCAGGAAACGGG

Downstream 100 bases:

>100_bases
GCCCGAAACGCAGGCCCGAAACGACACGGGCCCCGGGGTTTCCCCCGAGGCCCGCGCTTGAATCAGTGACTTGCGTCGAA
GCGGTGACTACTTGGGCGCC

Product: MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MLAGPPSTRRHAFAPAACPERRVTAACVPIVSATAEPPSPHRTYTERRAAAQAELTALDRVSARYANLRTLAFLAAAGVA
GFVLAGRLPKVWWWASAAALVLYGVLAVLHHQVFRREARAKLYVTLNERGLARLGPGWHDFTERGERFLSPGHLYTPDLD
VFGQGSLFQLLNETATRAGEERLAAWLSAPASAQEVEARQGAARELAPNLDFRQDLCVDARDASREKADPALFIQWAESG
PQLNAIRWARPVAVVLPLVTLAVYVLGKFEVLPESAFWVGLAAQLGVAVITRRPLKVMDEGVEVGERGFVRYAPIFERVE
AQRFEHPRLKTLQSGLQQPGQPPVSEHFKRFSRLFSFIEFKRHQFHPLIHWLTLWDIHAHFALERWREAHGKQLRQWFEA
LAELEALSCVAGLAHDRPDFTWPVLAANGPCVEATALGHPLLDAPVPNDVSLPGPRHALLITGSNMSGKTTLMRAVGANV
VLALAGAPVSAKHFRLTPLQTLTSMRVKDSLERGVSYFYAEVQRIKAVLDAAQAARGQVLFLLDEILLGTNTRERQIASR
EVLRLLLGTGAIGAVTTHDLSLAVLADEPGAHVVNVHFRDHLEAGKMMFDYKLRQGVVDTTNALRVLRLAGVPVDDPDEA
TAAR

Sequences:

>Translated_644_residues
MLAGPPSTRRHAFAPAACPERRVTAACVPIVSATAEPPSPHRTYTERRAAAQAELTALDRVSARYANLRTLAFLAAAGVA
GFVLAGRLPKVWWWASAAALVLYGVLAVLHHQVFRREARAKLYVTLNERGLARLGPGWHDFTERGERFLSPGHLYTPDLD
VFGQGSLFQLLNETATRAGEERLAAWLSAPASAQEVEARQGAARELAPNLDFRQDLCVDARDASREKADPALFIQWAESG
PQLNAIRWARPVAVVLPLVTLAVYVLGKFEVLPESAFWVGLAAQLGVAVITRRPLKVMDEGVEVGERGFVRYAPIFERVE
AQRFEHPRLKTLQSGLQQPGQPPVSEHFKRFSRLFSFIEFKRHQFHPLIHWLTLWDIHAHFALERWREAHGKQLRQWFEA
LAELEALSCVAGLAHDRPDFTWPVLAANGPCVEATALGHPLLDAPVPNDVSLPGPRHALLITGSNMSGKTTLMRAVGANV
VLALAGAPVSAKHFRLTPLQTLTSMRVKDSLERGVSYFYAEVQRIKAVLDAAQAARGQVLFLLDEILLGTNTRERQIASR
EVLRLLLGTGAIGAVTTHDLSLAVLADEPGAHVVNVHFRDHLEAGKMMFDYKLRQGVVDTTNALRVLRLAGVPVDDPDEA
TAAR
>Mature_644_residues
MLAGPPSTRRHAFAPAACPERRVTAACVPIVSATAEPPSPHRTYTERRAAAQAELTALDRVSARYANLRTLAFLAAAGVA
GFVLAGRLPKVWWWASAAALVLYGVLAVLHHQVFRREARAKLYVTLNERGLARLGPGWHDFTERGERFLSPGHLYTPDLD
VFGQGSLFQLLNETATRAGEERLAAWLSAPASAQEVEARQGAARELAPNLDFRQDLCVDARDASREKADPALFIQWAESG
PQLNAIRWARPVAVVLPLVTLAVYVLGKFEVLPESAFWVGLAAQLGVAVITRRPLKVMDEGVEVGERGFVRYAPIFERVE
AQRFEHPRLKTLQSGLQQPGQPPVSEHFKRFSRLFSFIEFKRHQFHPLIHWLTLWDIHAHFALERWREAHGKQLRQWFEA
LAELEALSCVAGLAHDRPDFTWPVLAANGPCVEATALGHPLLDAPVPNDVSLPGPRHALLITGSNMSGKTTLMRAVGANV
VLALAGAPVSAKHFRLTPLQTLTSMRVKDSLERGVSYFYAEVQRIKAVLDAAQAARGQVLFLLDEILLGTNTRERQIASR
EVLRLLLGTGAIGAVTTHDLSLAVLADEPGAHVVNVHFRDHLEAGKMMFDYKLRQGVVDTTNALRVLRLAGVPVDDPDEA
TAAR

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=231, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI4504191, Length=293, Percent_Identity=26.962457337884, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1789089, Length=252, Percent_Identity=31.7460317460317, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508445, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664545, Length=258, Percent_Identity=27.5193798449612, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 70883; Mature: 70883

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAGPPSTRRHAFAPAACPERRVTAACVPIVSATAEPPSPHRTYTERRAAAQAELTALDR
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VSARYANLRTLAFLAAAGVAGFVLAGRLPKVWWWASAAALVLYGVLAVLHHQVFRREARA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
KLYVTLNERGLARLGPGWHDFTERGERFLSPGHLYTPDLDVFGQGSLFQLLNETATRAGE
EEEEEECCCCCHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ERLAAWLSAPASAQEVEARQGAARELAPNLDFRQDLCVDARDASREKADPALFIQWAESG
HHHHHHHCCCCCHHHHHHHHCCHHHHCCCCCCHHHHCCCCHHCCCCCCCCEEEEEECCCC
PQLNAIRWARPVAVVLPLVTLAVYVLGKFEVLPESAFWVGLAAQLGVAVITRRPLKVMDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
GVEVGERGFVRYAPIFERVEAQRFEHPRLKTLQSGLQQPGQPPVSEHFKRFSRLFSFIEF
HHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KRHQFHPLIHWLTLWDIHAHFALERWREAHGKQLRQWFEALAELEALSCVAGLAHDRPDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TWPVLAANGPCVEATALGHPLLDAPVPNDVSLPGPRHALLITGSNMSGKTTLMRAVGANV
CCEEEECCCCEEEHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCE
VLALAGAPVSAKHFRLTPLQTLTSMRVKDSLERGVSYFYAEVQRIKAVLDAAQAARGQVL
EEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FLLDEILLGTNTRERQIASREVLRLLLGTGAIGAVTTHDLSLAVLADEPGAHVVNVHFRD
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCEEEEEEECCCCCEEEEEEEHH
HLEAGKMMFDYKLRQGVVDTTNALRVLRLAGVPVDDPDEATAAR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLAGPPSTRRHAFAPAACPERRVTAACVPIVSATAEPPSPHRTYTERRAAAQAELTALDR
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VSARYANLRTLAFLAAAGVAGFVLAGRLPKVWWWASAAALVLYGVLAVLHHQVFRREARA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
KLYVTLNERGLARLGPGWHDFTERGERFLSPGHLYTPDLDVFGQGSLFQLLNETATRAGE
EEEEEECCCCCHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ERLAAWLSAPASAQEVEARQGAARELAPNLDFRQDLCVDARDASREKADPALFIQWAESG
HHHHHHHCCCCCHHHHHHHHCCHHHHCCCCCCHHHHCCCCHHCCCCCCCCEEEEEECCCC
PQLNAIRWARPVAVVLPLVTLAVYVLGKFEVLPESAFWVGLAAQLGVAVITRRPLKVMDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
GVEVGERGFVRYAPIFERVEAQRFEHPRLKTLQSGLQQPGQPPVSEHFKRFSRLFSFIEF
HHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KRHQFHPLIHWLTLWDIHAHFALERWREAHGKQLRQWFEALAELEALSCVAGLAHDRPDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TWPVLAANGPCVEATALGHPLLDAPVPNDVSLPGPRHALLITGSNMSGKTTLMRAVGANV
CCEEEECCCCEEEHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCE
VLALAGAPVSAKHFRLTPLQTLTSMRVKDSLERGVSYFYAEVQRIKAVLDAAQAARGQVL
EEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FLLDEILLGTNTRERQIASREVLRLLLGTGAIGAVTTHDLSLAVLADEPGAHVVNVHFRD
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCEEEEEEECCCCCEEEEEEEHH
HLEAGKMMFDYKLRQGVVDTTNALRVLRLAGVPVDDPDEATAAR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]