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The map label for this gene is lpxC

Identifier: 108757173

GI number: 108757173

Start: 6212286

End: 6213230

Strand: Reverse

Name: lpxC

Synonym: MXAN_4967

Alternate gene names: 108757173

Gene position: 6213230-6212286 (Counterclockwise)

Preceding gene: 108763192

Following gene: 108762810

Centisome position: 67.98

GC content: 69.31

Gene sequence:

>945_bases
ATGCGACCGTCCTCCTACAACCAGCGCACTCTCTCGAAGATCGCCTCCCTGCAGGGCGTCGGGCTCCACTCGGGTGCCCG
GGTGACGCTCACCCTGCGCCCGGCGCCCCCGGGGCATGGCATCGTCTTCGTGCGCACGGACCTCGCCCGCCCGGTGAGCA
TCCCCGCGCTGGCGGAGTACGTGGTGGACACGTCGCTGGCCACGACGCTGGGGCGTGACGGTGTCCGCGTGGGCACGGTG
GAGCACCTGATGGCGGCGCTGGCCGGCATGGGCATCGACAACCTCCGGGTGGAGCTGGACGGTCCGGAAGTCCCCATCAT
GGACGGCAGCGCGGCGCCCTTCGCGGCGCTCATCCAGAGCGCGGGCGTGCGGGAGCAGGAGGCGCCCAAGGAGCTGCTGG
TCATCCGCAAGGCGGTGTCGGTGGTGGACGGCGACAAGCAGGCCTCGCTCACGCCGGCCCGGCACTTCCGCATCAGCTGC
ACCATCGACTTCGAGCACCCCGTCATCCAGGGCCAGTCCTTCGACCTGGACTTCGGTGACCGGGACTTCGCGCGTGAGAT
TTCCCGCGCGCGCACCTTCGGCTTCCTGCGGGACGTGGAGAAGCTGAAGCAGATGGGCCTGGCCCGGGGCGGTTCGCTGG
AGAACGCCATCGTCGTGGACGAGGTCTCCATCCTCAACCCGGACGGGCTGCGCTTCCCGGACGAGTTCGTTCGCCACAAG
ATCCTGGACGCCATCGGCGACGTGTCGCTGTTCGGCCGGCCCGTCATCGGCCACATGACGGCGTACAAGACGGGCCACGC
GCTCAACCACAAGCTGGTGCGCAAGGTGATGTCCGACCCGAGCTGCTACGAAATCGTTCCCGCCCGCCGCCGCGAGCTGG
AGGGCATGGGATTGGGCTTCTCTGGACTGGCCGGCGCGCTGGACTTCGAGCCGCTTGTCGCCTGA

Upstream 100 bases:

>100_bases
CTCGCGCGTCACATCAGACCACTGATGAACGTTTCCAGCCCTCCGGCGGGTCTGGAGCGGAAGCTCCGCAGCACCGAGAA
GCCACGAGGCGACACCCACA

Downstream 100 bases:

>100_bases
CGTCATTAACTTGCAGGTCCGGTAAGGCTCGGCTAAGTGGGCGGGATATGCTCAACCGTCCCACCCGCGTCATCCTCGCC
GCGCTCCTGGCGGCCTCCTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRPSSYNQRTLSKIASLQGVGLHSGARVTLTLRPAPPGHGIVFVRTDLARPVSIPALAEYVVDTSLATTLGRDGVRVGTV
EHLMAALAGMGIDNLRVELDGPEVPIMDGSAAPFAALIQSAGVREQEAPKELLVIRKAVSVVDGDKQASLTPARHFRISC
TIDFEHPVIQGQSFDLDFGDRDFAREISRARTFGFLRDVEKLKQMGLARGGSLENAIVVDEVSILNPDGLRFPDEFVRHK
ILDAIGDVSLFGRPVIGHMTAYKTGHALNHKLVRKVMSDPSCYEIVPARRRELEGMGLGFSGLAGALDFEPLVA

Sequences:

>Translated_314_residues
MRPSSYNQRTLSKIASLQGVGLHSGARVTLTLRPAPPGHGIVFVRTDLARPVSIPALAEYVVDTSLATTLGRDGVRVGTV
EHLMAALAGMGIDNLRVELDGPEVPIMDGSAAPFAALIQSAGVREQEAPKELLVIRKAVSVVDGDKQASLTPARHFRISC
TIDFEHPVIQGQSFDLDFGDRDFAREISRARTFGFLRDVEKLKQMGLARGGSLENAIVVDEVSILNPDGLRFPDEFVRHK
ILDAIGDVSLFGRPVIGHMTAYKTGHALNHKLVRKVMSDPSCYEIVPARRRELEGMGLGFSGLAGALDFEPLVA
>Mature_314_residues
MRPSSYNQRTLSKIASLQGVGLHSGARVTLTLRPAPPGHGIVFVRTDLARPVSIPALAEYVVDTSLATTLGRDGVRVGTV
EHLMAALAGMGIDNLRVELDGPEVPIMDGSAAPFAALIQSAGVREQEAPKELLVIRKAVSVVDGDKQASLTPARHFRISC
TIDFEHPVIQGQSFDLDFGDRDFAREISRARTFGFLRDVEKLKQMGLARGGSLENAIVVDEVSILNPDGLRFPDEFVRHK
ILDAIGDVSLFGRPVIGHMTAYKTGHALNHKLVRKVMSDPSCYEIVPARRRELEGMGLGFSGLAGALDFEPLVA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=282, Percent_Identity=53.5460992907801, Blast_Score=302, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_MYXXD (Q1D2K0)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633123.1
- ProteinModelPortal:   Q1D2K0
- SMR:   Q1D2K0
- STRING:   Q1D2K0
- GeneID:   4101594
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4967
- TIGR:   MXAN_4967
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   Q1D2K0
- ProtClustDB:   PRK13186
- BioCyc:   MXAN246197:MXAN_4967-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33953; Mature: 33953

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPSSYNQRTLSKIASLQGVGLHSGARVTLTLRPAPPGHGIVFVRTDLARPVSIPALAEY
CCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHH
VVDTSLATTLGRDGVRVGTVEHLMAALAGMGIDNLRVELDGPEVPIMDGSAAPFAALIQS
HHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCCHHHHHHHH
AGVREQEAPKELLVIRKAVSVVDGDKQASLTPARHFRISCTIDFEHPVIQGQSFDLDFGD
CCCCCHHCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEECCCCCCCCCCC
RDFAREISRARTFGFLRDVEKLKQMGLARGGSLENAIVVDEVSILNPDGLRFPDEFVRHK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHH
ILDAIGDVSLFGRPVIGHMTAYKTGHALNHKLVRKVMSDPSCYEIVPARRRELEGMGLGF
HHHHHCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEECCCHHHHHHCCCCCCH
SGLAGALDFEPLVA
HHHCCCCCCCCCCC
>Mature Secondary Structure
MRPSSYNQRTLSKIASLQGVGLHSGARVTLTLRPAPPGHGIVFVRTDLARPVSIPALAEY
CCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHH
VVDTSLATTLGRDGVRVGTVEHLMAALAGMGIDNLRVELDGPEVPIMDGSAAPFAALIQS
HHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCCHHHHHHHH
AGVREQEAPKELLVIRKAVSVVDGDKQASLTPARHFRISCTIDFEHPVIQGQSFDLDFGD
CCCCCHHCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEECCCCCCCCCCC
RDFAREISRARTFGFLRDVEKLKQMGLARGGSLENAIVVDEVSILNPDGLRFPDEFVRHK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHH
ILDAIGDVSLFGRPVIGHMTAYKTGHALNHKLVRKVMSDPSCYEIVPARRRELEGMGLGF
HHHHHCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEECCCHHHHHHCCCCCCH
SGLAGALDFEPLVA
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA