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The map label for this gene is lpxP [H]

Identifier: 108757080

GI number: 108757080

Start: 1235492

End: 1236445

Strand: Direct

Name: lpxP [H]

Synonym: MXAN_1057

Alternate gene names: 108757080

Gene position: 1235492-1236445 (Clockwise)

Preceding gene: 108756932

Following gene: 108757694

Centisome position: 13.52

GC content: 72.85

Gene sequence:

>954_bases
GTGGAGCGTCCACCCTTAGCAAAGCGCCTCAAGCGTTTCCTCCGCTACGTGCTCATCCGTGGCGTCCTGTTGCTCCTTCA
ACCTCTTCCCCTGGGCGTCGCCCGGAGCCTGGGTGCGCGTCTGGGCGCCCTGGCCTACACCCTGGCCGGAGGGGAACGCC
GCAAGGCCCTCAAGTCCCTTTCCGTGGCCTTCCCGGAAAAGTCGGATGCGGACCGGCAGGCGCTGGCCCGCGACGCCTTC
CGCCACCTGGCCGCCGCCGCGCTGGAGGTGGCCTGCACGGGCGCCCTCGACGAGGCCCTGGAGCGCCTGGTCGCCTGGCC
GGACGCCGACCGGCAGGTGCTGGAGACGGCCCTGGCCCGGGGGCGCGGCGTCGTCTTCGTGTCCGGGCACGTGGGGAACT
GGGAGCTGCTCGCCCGCCGCGTGGCTCGCGCCGGCTACCCCAGCCAGAGCATCGCGAAGGAGACCACCGACCCCCGGCTG
ACGGAGCTGGTGGGTCAGTTCCGGGCCCGGGGCGGGGTGCGGAGCATCTGGCGCGGCCAGGAAGGCGCTGCCCGGGCCAT
GCTGCGCGCCCTGCGCAACGGCGAAATCCTCGGCATCCTCATCGACCAGGACACGAAGGTGCAGTCCCTCTTCGTGCCCT
TCTTCGGGCAACTGGCCGCCACACCACGCGCCGCCGCTGACCTGGCCATCCGCACGGGCGCGGCGGTGGTGACGGGCTTC
TGTCACCGCGAAGGGGCGGGGTACCGCCTGTCCATGGAAGAGGTCCCGGTGCCCCAGGACACGGACCGCGAGGCGGCCGC
CCTGGCCCTCACGGCCGCCCTGTCCAGCCGAATCGAAGCCGCCATCCGGCGGACGCCGGAACAGTGGGTGTGGATGCACC
AGCGCTGGAAGACGCGTCCGCCGGTGAGCGAGGACGTCCCACTTCCGGAGGCGGCGCCCGCATCCGCCGGGTGA

Upstream 100 bases:

>100_bases
CTCTGCGATGCCAGGTTGCCGGGCGAGAGGCCGCCGTAATTGTGGGTGGGCCCAACGAGCCCGTCGAAGTTGTATTCGCG
CATGGGATATTGAACGCCTC

Downstream 100 bases:

>100_bases
TAAGGAAGCCCTGTGTCTCGCCTGCTCGCTGCCAGCCTTCTCATCCTGGTGTTCGCCCCCGGTTGCAAGCCGGGCTCCGG
CGAGGGTGCGTCTGGCGGCC

Product: lipid A biosynthesis acyltransferase

Products: KDO2-(palmitoleoyl)-lipid IVA [C]

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MERPPLAKRLKRFLRYVLIRGVLLLLQPLPLGVARSLGARLGALAYTLAGGERRKALKSLSVAFPEKSDADRQALARDAF
RHLAAAALEVACTGALDEALERLVAWPDADRQVLETALARGRGVVFVSGHVGNWELLARRVARAGYPSQSIAKETTDPRL
TELVGQFRARGGVRSIWRGQEGAARAMLRALRNGEILGILIDQDTKVQSLFVPFFGQLAATPRAAADLAIRTGAAVVTGF
CHREGAGYRLSMEEVPVPQDTDREAAALALTAALSSRIEAAIRRTPEQWVWMHQRWKTRPPVSEDVPLPEAAPASAG

Sequences:

>Translated_317_residues
MERPPLAKRLKRFLRYVLIRGVLLLLQPLPLGVARSLGARLGALAYTLAGGERRKALKSLSVAFPEKSDADRQALARDAF
RHLAAAALEVACTGALDEALERLVAWPDADRQVLETALARGRGVVFVSGHVGNWELLARRVARAGYPSQSIAKETTDPRL
TELVGQFRARGGVRSIWRGQEGAARAMLRALRNGEILGILIDQDTKVQSLFVPFFGQLAATPRAAADLAIRTGAAVVTGF
CHREGAGYRLSMEEVPVPQDTDREAAALALTAALSSRIEAAIRRTPEQWVWMHQRWKTRPPVSEDVPLPEAAPASAG
>Mature_317_residues
MERPPLAKRLKRFLRYVLIRGVLLLLQPLPLGVARSLGARLGALAYTLAGGERRKALKSLSVAFPEKSDADRQALARDAF
RHLAAAALEVACTGALDEALERLVAWPDADRQVLETALARGRGVVFVSGHVGNWELLARRVARAGYPSQSIAKETTDPRL
TELVGQFRARGGVRSIWRGQEGAARAMLRALRNGEILGILIDQDTKVQSLFVPFFGQLAATPRAAADLAIRTGAAVVTGF
CHREGAGYRLSMEEVPVPQDTDREAAALALTAALSSRIEAAIRRTPEQWVWMHQRWKTRPPVSEDVPLPEAAPASAG

Specific function: Unknown

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI87082094, Length=314, Percent_Identity=32.8025477707006, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787292, Length=294, Percent_Identity=29.2517006802721, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788161, Length=267, Percent_Identity=28.0898876404494, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: NA

Molecular weight: Translated: 34442; Mature: 34442

Theoretical pI: Translated: 10.92; Mature: 10.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERPPLAKRLKRFLRYVLIRGVLLLLQPLPLGVARSLGARLGALAYTLAGGERRKALKSL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SVAFPEKSDADRQALARDAFRHLAAAALEVACTGALDEALERLVAWPDADRQVLETALAR
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GRGVVFVSGHVGNWELLARRVARAGYPSQSIAKETTDPRLTELVGQFRARGGVRSIWRGQ
CCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHHHCCC
EGAARAMLRALRNGEILGILIDQDTKVQSLFVPFFGQLAATPRAAADLAIRTGAAVVTGF
CHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHH
CHREGAGYRLSMEEVPVPQDTDREAAALALTAALSSRIEAAIRRTPEQWVWMHQRWKTRP
HHCCCCCCEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCC
PVSEDVPLPEAAPASAG
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MERPPLAKRLKRFLRYVLIRGVLLLLQPLPLGVARSLGARLGALAYTLAGGERRKALKSL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SVAFPEKSDADRQALARDAFRHLAAAALEVACTGALDEALERLVAWPDADRQVLETALAR
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GRGVVFVSGHVGNWELLARRVARAGYPSQSIAKETTDPRLTELVGQFRARGGVRSIWRGQ
CCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHHHCCC
EGAARAMLRALRNGEILGILIDQDTKVQSLFVPFFGQLAATPRAAADLAIRTGAAVVTGF
CHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHH
CHREGAGYRLSMEEVPVPQDTDREAAALALTAALSSRIEAAIRRTPEQWVWMHQRWKTRP
HHCCCCCCEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCC
PVSEDVPLPEAAPASAG
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: KDO2-lipid IVA; palmitoleoyl-ACP [C]

Specific reaction: KDO2-lipid IVA + palmitoleoyl-ACP = KDO2-(palmitoleoyl)-lipid IVA + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]