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The map label for this gene is pepP [H]

Identifier: 108757035

GI number: 108757035

Start: 525874

End: 527277

Strand: Direct

Name: pepP [H]

Synonym: MXAN_0463

Alternate gene names: 108757035

Gene position: 525874-527277 (Clockwise)

Preceding gene: 108761939

Following gene: 108760883

Centisome position: 5.75

GC content: 72.08

Gene sequence:

>1404_bases
ATGCTGCTCCCTTCCGTTTCCGAGCGCTCCGCTCTCACCCGACGGCGGGAGCAGCTGGCGAAAGCCCTGGGGAGCGCGGC
CGCGCTGCTGGCGTCGAGCCGCCCCCGTCCTCGCAACTACGCCGCCGACCAGTTCCCTTTTCGGGCGTCGAGCCACTTCC
TCTACCTCTTCGGGCTCGCGACGCCGGACGGCGTGGGTCTGTATGACGGCCAGGGCTGGACGCTGTACCTGCCCGAGCCC
GGTCCCGACGACGCGCTGTGGGACGGCGCGGTGCCCGGCTTCGCTGAAATCGCGGAGCGGACGGGCTGCACCGTGCGTTC
GCGCGCCGAGCTGCCCGCGGCGCTGAAGGGCCGCGACGTGGCGGCGCTGCCCACGCCGGACCTGGAGACGTGCCTGGACG
TGGCCGCGCTGCTGGGCCGCGAGGTGCGTCCCGGCCACCTGGCGGCGGTGGACGTGCCGCTGGCGGACGCGATGATTGCG
CTGCGGCTTCGCCATGACGACGCCGCGCAGGCGCAGCTTCGTCAGGCCGCGGAAGTCACGGTGCTGGCCCACATGGCGGG
CATGCGCGCCACGCGGCCGGGCATCCTGGAGGCCGCGGTGCGCGCCGCGATGGAGGCGGAGTTCGTCTCGCGCGACGTGC
GGCCGGCGTATCAGCCCATCGTCACCGTGCACGGCGAGGTGCTGCACAACCTGCGCTATGACCACACGCTGCGCGAGGGA
GACCTGCTGCTGGCGGACGTGGGTGGTGAAAGCCCGGCCGGCTTCGCCTGTGACGTGACGCGCACGTGGCCGGTGACGGG
CCGCTTCAGCACGACGCAGCGCGAGCTGTACGACGTCGTGCTGCGCATGCAGAAAGCCAGCATCGACGCGGTCCAGCCGG
GGACGCGCTACCGCGACGTGCACCTGGCCGCGCACCGGGAGATGGCGCGAGGCCTGGTGGCGTTGGGCATCCTCCGTGGG
GACCCGGAGGAGTTGGTGGTGGACGGCGTCACCGCGCTCTTCTTCCCGCACGGCGTGGGCCACCTGCTGGGGCTGGACGT
GCATGACATGGAGGACCTGGGGGACCGGGCGGGCTATGCGCCGGGCCGCACGCGCTCGCCGGAGTTCGGTCACCGCTCGC
TGCGGTTGGACCGCGATTTGGAGCCCGGCATGGCGGTGACGATTGAGCCGGGCATGTACCAGGTGCCCGCCATCCTGTCG
GACGCGCGGCTCATGGCGCGCGCGAAGGACAGGCTCCAGCGCGACGTGCTGGCGCGCTACGCGGACGTGCGCGGCATCCG
CATCGAGGACGACGTGCTCGTCACTTCGGATGGCAACGAGGTGCTTACCGCCGCCATCCCCAAGGAGGCCTCGGACATCG
AGGCCGTCATGACCAGCTCTGCCCGTCCAGCTCCGGGAAGGTGA

Upstream 100 bases:

>100_bases
CGCCGTCTTCCGCAAGGGCGGCCACTTCGACGACCTGCTGGCCTTCCTTTTCAAGCTGTTGCCCCAGCGCCCGCTGGGTG
CCTGAACGCGAGGTTCCAGA

Downstream 100 bases:

>100_bases
CCTGGCACTGGCCGGGATTCACGCCGTCCACGCGCGCGTAGCCATTCTTGTTGAGGGTGCCCTCGCGCGTACTCCCATCC
GGGAGCGTCACCAGGTAGCG

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MLLPSVSERSALTRRREQLAKALGSAAALLASSRPRPRNYAADQFPFRASSHFLYLFGLATPDGVGLYDGQGWTLYLPEP
GPDDALWDGAVPGFAEIAERTGCTVRSRAELPAALKGRDVAALPTPDLETCLDVAALLGREVRPGHLAAVDVPLADAMIA
LRLRHDDAAQAQLRQAAEVTVLAHMAGMRATRPGILEAAVRAAMEAEFVSRDVRPAYQPIVTVHGEVLHNLRYDHTLREG
DLLLADVGGESPAGFACDVTRTWPVTGRFSTTQRELYDVVLRMQKASIDAVQPGTRYRDVHLAAHREMARGLVALGILRG
DPEELVVDGVTALFFPHGVGHLLGLDVHDMEDLGDRAGYAPGRTRSPEFGHRSLRLDRDLEPGMAVTIEPGMYQVPAILS
DARLMARAKDRLQRDVLARYADVRGIRIEDDVLVTSDGNEVLTAAIPKEASDIEAVMTSSARPAPGR

Sequences:

>Translated_467_residues
MLLPSVSERSALTRRREQLAKALGSAAALLASSRPRPRNYAADQFPFRASSHFLYLFGLATPDGVGLYDGQGWTLYLPEP
GPDDALWDGAVPGFAEIAERTGCTVRSRAELPAALKGRDVAALPTPDLETCLDVAALLGREVRPGHLAAVDVPLADAMIA
LRLRHDDAAQAQLRQAAEVTVLAHMAGMRATRPGILEAAVRAAMEAEFVSRDVRPAYQPIVTVHGEVLHNLRYDHTLREG
DLLLADVGGESPAGFACDVTRTWPVTGRFSTTQRELYDVVLRMQKASIDAVQPGTRYRDVHLAAHREMARGLVALGILRG
DPEELVVDGVTALFFPHGVGHLLGLDVHDMEDLGDRAGYAPGRTRSPEFGHRSLRLDRDLEPGMAVTIEPGMYQVPAILS
DARLMARAKDRLQRDVLARYADVRGIRIEDDVLVTSDGNEVLTAAIPKEASDIEAVMTSSARPAPGR
>Mature_467_residues
MLLPSVSERSALTRRREQLAKALGSAAALLASSRPRPRNYAADQFPFRASSHFLYLFGLATPDGVGLYDGQGWTLYLPEP
GPDDALWDGAVPGFAEIAERTGCTVRSRAELPAALKGRDVAALPTPDLETCLDVAALLGREVRPGHLAAVDVPLADAMIA
LRLRHDDAAQAQLRQAAEVTVLAHMAGMRATRPGILEAAVRAAMEAEFVSRDVRPAYQPIVTVHGEVLHNLRYDHTLREG
DLLLADVGGESPAGFACDVTRTWPVTGRFSTTQRELYDVVLRMQKASIDAVQPGTRYRDVHLAAHREMARGLVALGILRG
DPEELVVDGVTALFFPHGVGHLLGLDVHDMEDLGDRAGYAPGRTRSPEFGHRSLRLDRDLEPGMAVTIEPGMYQVPAILS
DARLMARAKDRLQRDVLARYADVRGIRIEDDVLVTSDGNEVLTAAIPKEASDIEAVMTSSARPAPGR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=467, Percent_Identity=31.4775160599572, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI260593665, Length=308, Percent_Identity=35.7142857142857, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI260593663, Length=463, Percent_Identity=30.0215982721382, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI11559925, Length=465, Percent_Identity=28.8172043010753, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1789275, Length=472, Percent_Identity=31.9915254237288, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1790282, Length=281, Percent_Identity=33.0960854092527, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788728, Length=228, Percent_Identity=28.5087719298246, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=477, Percent_Identity=30.6079664570231, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=251, Percent_Identity=28.2868525896414, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321118, Length=471, Percent_Identity=28.0254777070064, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6320922, Length=473, Percent_Identity=24.9471458773784, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357079, Length=460, Percent_Identity=29.3478260869565, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI19920384, Length=450, Percent_Identity=28.4444444444444, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50608; Mature: 50608

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPSVSERSALTRRREQLAKALGSAAALLASSRPRPRNYAADQFPFRASSHFLYLFGLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
TPDGVGLYDGQGWTLYLPEPGPDDALWDGAVPGFAEIAERTGCTVRSRAELPAALKGRDV
CCCCCEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEECCCCCCHHHCCCCE
AALPTPDLETCLDVAALLGREVRPGHLAAVDVPLADAMIALRLRHDDAAQAQLRQAAEVT
EECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHEEEEEECCCCHHHHHHHHHHHHH
VLAHMAGMRATRPGILEAAVRAAMEAEFVSRDVRPAYQPIVTVHGEVLHNLRYDHTLREG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
DLLLADVGGESPAGFACDVTRTWPVTGRFSTTQRELYDVVLRMQKASIDAVQPGTRYRDV
CEEEEECCCCCCCCEEEECCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHH
HLAAHREMARGLVALGILRGDPEELVVDGVTALFFPHGVGHLLGLDVHDMEDLGDRAGYA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCC
PGRTRSPEFGHRSLRLDRDLEPGMAVTIEPGMYQVPAILSDARLMARAKDRLQRDVLARY
CCCCCCCCCCCCCEEECCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVRGIRIEDDVLVTSDGNEVLTAAIPKEASDIEAVMTSSARPAPGR
HHCCCEEEECCEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLLPSVSERSALTRRREQLAKALGSAAALLASSRPRPRNYAADQFPFRASSHFLYLFGLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
TPDGVGLYDGQGWTLYLPEPGPDDALWDGAVPGFAEIAERTGCTVRSRAELPAALKGRDV
CCCCCEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEECCCCCCHHHCCCCE
AALPTPDLETCLDVAALLGREVRPGHLAAVDVPLADAMIALRLRHDDAAQAQLRQAAEVT
EECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHEEEEEECCCCHHHHHHHHHHHHH
VLAHMAGMRATRPGILEAAVRAAMEAEFVSRDVRPAYQPIVTVHGEVLHNLRYDHTLREG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
DLLLADVGGESPAGFACDVTRTWPVTGRFSTTQRELYDVVLRMQKASIDAVQPGTRYRDV
CEEEEECCCCCCCCEEEECCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHH
HLAAHREMARGLVALGILRGDPEELVVDGVTALFFPHGVGHLLGLDVHDMEDLGDRAGYA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCC
PGRTRSPEFGHRSLRLDRDLEPGMAVTIEPGMYQVPAILSDARLMARAKDRLQRDVLARY
CCCCCCCCCCCCCEEECCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVRGIRIEDDVLVTSDGNEVLTAAIPKEASDIEAVMTSSARPAPGR
HHCCCEEEECCEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]