Click here to switch to the map view.

The map label for this gene is hsfA [H]

Identifier: 108756988

GI number: 108756988

Start: 6677567

End: 6679024

Strand: Reverse

Name: hsfA [H]

Synonym: MXAN_5364

Alternate gene names: 108756988

Gene position: 6679024-6677567 (Counterclockwise)

Preceding gene: 108763090

Following gene: 108758383

Centisome position: 73.08

GC content: 68.04

Gene sequence:

>1458_bases
GTGAACCAAGTCAAGCGCGCCAAAGTCCTCGTCGTGGATGACGACTCCGTCGTCCTCAAGGCCGTGACGCAGATTCTCCA
GCGCGAGGGCCACCCGGTGGTGGCCATTGACGACGCGGTGGAGGGCCTGGCGGCCGCGAAGGATCCGACCATCGACGTGG
TCGTCCTCGACATCAAGATGCCCAACCTGTCCGGCATGGACCTGCTGCGCGGCATCAAGGCCGACCGCCCGGACGTGGAG
GTCATCATGATGACGGCCTTCGCCACCGTGGAGACGGCGGTGGAGGCGGTGAAGGCGGGGGCGTACGACTACCTCACCAA
GCCCTTCGAGAACATCGACGAGGTCAGCCTCACGGTGGCCAAGGCGGCCGAGCGCAAGGCGCTCAAGGACCGCACCCGCG
CGCTGGAGGAGGCCCTCACGGTCCGCAGCCAGTTCGAGGACCTCATCGGCCAGTCCACGCAGATGCGCTCCGTCTTCAAG
CTGGTGGAGACGGTGAGCCACTCCACCGCCACGGTGCTCATCCAGGGGGAGAGCGGCACCGGCAAGGAGCTGGTGGCCCG
CGCCATCCACTACCGCAGCGCGCGCAAGGACAAGCCCTTCGTGGCGGTCAACTGTTCGGCGCTGACGGAGACGCTGCTGG
AGAGCGAGCTCTTCGGCCACGTGAAGGGCAGCTTCACCGGCGCCACCGGCAACAAGAAGGGCCTCTTCGAGGCGGCTGAC
GGCGGCACCATCTTCCTGGACGAAATTGGCGACGTGCCCCCGGCCACCCAGGTCCGCCTGCTGCGCGTGCTCCAGGAAGG
GGAAGTCAAACGCGTGGGCGCCAACGAGCCGGTGAAGGTGGACGTGCGCGTCATCGCCGCCACCCACGTGGACCTGTCCC
GCGCCAAGGAGCAGGGCAAGTTCCGCGAGGACCTCTTCTACCGCCTCAACGTCATCACCATCGACCTGCCGCCCCTGCGT
GACCGGCCCGAGGACGTGCCCCTGCTGGCGCACCACTTCCTCAAGCTCTACGCCTCCAAGGCGGACAAGAAGGTGACGGG
CATCTCCCCGCGCGCCATGGAAGCCCTCACCTGCAACCGGTGGACGGGCAACGTGCGTGAGCTGGAGAACGTCATCGAGC
GCGCGGTGGTGCTGACGGGCAACGAGGTCATCGACGTGGAGGACCTGCCGCCGGGCTTCCAGTCCGCGCCGCAGCCGGAC
TCCACGGTGGAGGTGTTCAGCCTGGCACACCTGCCGTACGCCCAGGCCAAGCGCCTGGCGATGCGTGCCTTCGAGCGCCG
CTACCTGTCCGCCCTGCTGGAGAAGAACAACCAGAACGTCTCCAGCGCCGCGCGCGCGGCGGGCGTGGACCGCTCCAACT
TCCGTCGTCTGCTCAAGCAGTACGAGGTGGCCGGCCGGTCCATGAAGCCCCGCGTGGTCTCCCAGGACGACGGCGAGGCG
CTGGAAGCCGCGTCCTGA

Upstream 100 bases:

>100_bases
TCCAGGACCACGGGGGCAGCTTCCACGTGGACACCGAGGTCGGAGAAGGCTCCTGCTTCACCGTTTTTCTGCCCATCCCC
CTGCAGCTCGAGAGGTTGCC

Downstream 100 bases:

>100_bases
CGTGTGTCGGCCGGCGGGCACCCGGGCATTTCCCATGCGCGCCCGGGGCCCTCCTGGACTACAAGGCGGGGTTGCGTGCA
GACCCTGGCAATCGTCGCGA

Product: DNA-binding reponse regulator HsfA

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MNQVKRAKVLVVDDDSVVLKAVTQILQREGHPVVAIDDAVEGLAAAKDPTIDVVVLDIKMPNLSGMDLLRGIKADRPDVE
VIMMTAFATVETAVEAVKAGAYDYLTKPFENIDEVSLTVAKAAERKALKDRTRALEEALTVRSQFEDLIGQSTQMRSVFK
LVETVSHSTATVLIQGESGTGKELVARAIHYRSARKDKPFVAVNCSALTETLLESELFGHVKGSFTGATGNKKGLFEAAD
GGTIFLDEIGDVPPATQVRLLRVLQEGEVKRVGANEPVKVDVRVIAATHVDLSRAKEQGKFREDLFYRLNVITIDLPPLR
DRPEDVPLLAHHFLKLYASKADKKVTGISPRAMEALTCNRWTGNVRELENVIERAVVLTGNEVIDVEDLPPGFQSAPQPD
STVEVFSLAHLPYAQAKRLAMRAFERRYLSALLEKNNQNVSSAARAAGVDRSNFRRLLKQYEVAGRSMKPRVVSQDDGEA
LEAAS

Sequences:

>Translated_485_residues
MNQVKRAKVLVVDDDSVVLKAVTQILQREGHPVVAIDDAVEGLAAAKDPTIDVVVLDIKMPNLSGMDLLRGIKADRPDVE
VIMMTAFATVETAVEAVKAGAYDYLTKPFENIDEVSLTVAKAAERKALKDRTRALEEALTVRSQFEDLIGQSTQMRSVFK
LVETVSHSTATVLIQGESGTGKELVARAIHYRSARKDKPFVAVNCSALTETLLESELFGHVKGSFTGATGNKKGLFEAAD
GGTIFLDEIGDVPPATQVRLLRVLQEGEVKRVGANEPVKVDVRVIAATHVDLSRAKEQGKFREDLFYRLNVITIDLPPLR
DRPEDVPLLAHHFLKLYASKADKKVTGISPRAMEALTCNRWTGNVRELENVIERAVVLTGNEVIDVEDLPPGFQSAPQPD
STVEVFSLAHLPYAQAKRLAMRAFERRYLSALLEKNNQNVSSAARAAGVDRSNFRRLLKQYEVAGRSMKPRVVSQDDGEA
LEAAS
>Mature_485_residues
MNQVKRAKVLVVDDDSVVLKAVTQILQREGHPVVAIDDAVEGLAAAKDPTIDVVVLDIKMPNLSGMDLLRGIKADRPDVE
VIMMTAFATVETAVEAVKAGAYDYLTKPFENIDEVSLTVAKAAERKALKDRTRALEEALTVRSQFEDLIGQSTQMRSVFK
LVETVSHSTATVLIQGESGTGKELVARAIHYRSARKDKPFVAVNCSALTETLLESELFGHVKGSFTGATGNKKGLFEAAD
GGTIFLDEIGDVPPATQVRLLRVLQEGEVKRVGANEPVKVDVRVIAATHVDLSRAKEQGKFREDLFYRLNVITIDLPPLR
DRPEDVPLLAHHFLKLYASKADKKVTGISPRAMEALTCNRWTGNVRELENVIERAVVLTGNEVIDVEDLPPGFQSAPQPD
STVEVFSLAHLPYAQAKRLAMRAFERRYLSALLEKNNQNVSSAARAAGVDRSNFRRLLKQYEVAGRSMKPRVVSQDDGEA
LEAAS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=43.421052631579, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=45.5357142857143, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1790299, Length=477, Percent_Identity=41.5094339622642, Blast_Score=344, Evalue=7e-96,
Organism=Escherichia coli, GI1788905, Length=471, Percent_Identity=42.0382165605096, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=45.5108359133127, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI87082117, Length=260, Percent_Identity=53.4615384615385, Blast_Score=278, Evalue=8e-76,
Organism=Escherichia coli, GI1789087, Length=282, Percent_Identity=49.645390070922, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1786524, Length=382, Percent_Identity=40.8376963350785, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI87082152, Length=319, Percent_Identity=45.4545454545455, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI87081872, Length=328, Percent_Identity=39.9390243902439, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1787583, Length=255, Percent_Identity=41.9607843137255, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1789828, Length=229, Percent_Identity=37.5545851528384, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081858, Length=309, Percent_Identity=30.0970873786408, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786784, Length=102, Percent_Identity=31.3725490196078, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53189; Mature: 53189

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVKRAKVLVVDDDSVVLKAVTQILQREGHPVVAIDDAVEGLAAAKDPTIDVVVLDIKM
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCEEEEEEEEEC
PNLSGMDLLRGIKADRPDVEVIMMTAFATVETAVEAVKAGAYDYLTKPFENIDEVSLTVA
CCCCCHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHH
KAAERKALKDRTRALEEALTVRSQFEDLIGQSTQMRSVFKLVETVSHSTATVLIQGESGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCC
GKELVARAIHYRSARKDKPFVAVNCSALTETLLESELFGHVKGSFTGATGNKKGLFEAAD
CHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEECC
GGTIFLDEIGDVPPATQVRLLRVLQEGEVKRVGANEPVKVDVRVIAATHVDLSRAKEQGK
CCEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEEEHHHHHHHHHHCC
FREDLFYRLNVITIDLPPLRDRPEDVPLLAHHFLKLYASKADKKVTGISPRAMEALTCNR
HHHHHEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCHHHHHHHCCCC
WTGNVRELENVIERAVVLTGNEVIDVEDLPPGFQSAPQPDSTVEVFSLAHLPYAQAKRLA
CCCCHHHHHHHHHHHEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
MRAFERRYLSALLEKNNQNVSSAARAAGVDRSNFRRLLKQYEVAGRSMKPRVVSQDDGEA
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
LEAAS
HCCCC
>Mature Secondary Structure
MNQVKRAKVLVVDDDSVVLKAVTQILQREGHPVVAIDDAVEGLAAAKDPTIDVVVLDIKM
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCEEEEEEEEEC
PNLSGMDLLRGIKADRPDVEVIMMTAFATVETAVEAVKAGAYDYLTKPFENIDEVSLTVA
CCCCCHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHH
KAAERKALKDRTRALEEALTVRSQFEDLIGQSTQMRSVFKLVETVSHSTATVLIQGESGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCC
GKELVARAIHYRSARKDKPFVAVNCSALTETLLESELFGHVKGSFTGATGNKKGLFEAAD
CHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEECC
GGTIFLDEIGDVPPATQVRLLRVLQEGEVKRVGANEPVKVDVRVIAATHVDLSRAKEQGK
CCEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEEEHHHHHHHHHHCC
FREDLFYRLNVITIDLPPLRDRPEDVPLLAHHFLKLYASKADKKVTGISPRAMEALTCNR
HHHHHEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCHHHHHHHCCCC
WTGNVRELENVIERAVVLTGNEVIDVEDLPPGFQSAPQPDSTVEVFSLAHLPYAQAKRLA
CCCCHHHHHHHHHHHEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
MRAFERRYLSALLEKNNQNVSSAARAAGVDRSNFRRLLKQYEVAGRSMKPRVVSQDDGEA
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
LEAAS
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]