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The map label for this gene is aspC [H]

Identifier: 108756883

GI number: 108756883

Start: 1654646

End: 1655767

Strand: Direct

Name: aspC [H]

Synonym: MXAN_1407

Alternate gene names: 108756883

Gene position: 1654646-1655767 (Clockwise)

Preceding gene: 108758146

Following gene: 108761683

Centisome position: 18.1

GC content: 70.41

Gene sequence:

>1122_bases
ATGCGCATCCCCGACTTCAAGCTGGAGCGGTACTTCGCGCGCTGGGAGTTCGCGGCGCCGTACCTGCTGTGTTCCTCGGA
CATCGAGGGCTGGCGGATGGCGGACTTGCTGGCGCTCGCCGGCCCGGACGAGCGGGCCCGCTGGGAGGGGCTGACGCTGG
GCTACACCGAATCCACCGGCCTGCCCGCGCTGCGCGAGGAGATTGCCGCCCTGTACCCCGGGCTCTCCCCGGAGCAGGTG
CTCACCTTCGCCGGCGCGGAGGAGGCGCTCTTCGTCCTGGTCAACGTCCTGCTGGGCCCCGGGGACCACGCCGTCGTCAC
CTGGCCGGGCTACCAGTCCCTGCACGAGGTGGCACGCGCCACGGGCGCGGACGTGACACTGCTGCGCCTGCGCGAGGAGG
ACGGATGGGCATTGGATTTGGATGCGCTGCGCCGCGCGCTGACGCCCCGGACGCGGCTGCTGCTGGTGAACTTCCCCCAC
AACCCCACGGGCGCGTTGTTGGACCGGGCCGCCTTCGACGCGCTGTGCGAACTGTCGCGCGAGCGTGGCATCCACCTGCT
GTCCGATGAGGTGTACCGGTTGCTGGAGTACGACACGCGCGACACGTTGCCGCCCGCGGCCAGCCACACGCCGCACGGCA
TCAGCCTGGGGGTGATGTCCAAGGCCTTCGGACTGGCGGGGCTGCGCGTGGGGTGGCTGGCCTGCCGTGACGTGGAGCTC
TTGCGGCGCTGCGCGGCCTACAAGGACTACACGACCATCTGCAACAGCGCGCCCAGCGAGGTGCTGTCACTCATCGCGCT
GCGCGCGAAGGCGCGGGTGCTGGCGCGCAGCCGGGAGTTGCTCGCGGCGAACCTCTCCCTGTTGGATGGCTTCTTCGCGC
GGCACCCGGACACTTTCCAGTGGGTGCGCCCGCGCGCGGGCAGCGTGGCTTTTCCCAGGCTGCTGCGTGAGACGCCCGTG
GCCCGCTTCACCGAGGAATTGCGCGAGCGCGAAGGCGTGCTGCTGCTGCCCGGAGACGTCTACGACTTCCCCGGCAACCA
CTTCCGCCTGGGGCTGGGCCGCACGAATCTGCCCGACGCGCTGGAACGATTGGAGCGCTACGTGGTCGACACATCGCGTT
GA

Upstream 100 bases:

>100_bases
AAGACCTGGGTTCGGAAAGGACGCGACTCAAGCTAGGCACGCGTGGCCGCTTCCGGGCGTCGCTGGACGGCAGGTCGCGA
AGCAGGCAGACACTCACGGC

Downstream 100 bases:

>100_bases
CGCGGCTGTCTCGAGTGTCACCTCCCCGCGGGAATCCACGGGGTGATGCGTTGCGTCAGTCCTCGCGCGCACTTCAAGGT
TTCCGTGACCTCGACCTTTT

Product: class I/II aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRIPDFKLERYFARWEFAAPYLLCSSDIEGWRMADLLALAGPDERARWEGLTLGYTESTGLPALREEIAALYPGLSPEQV
LTFAGAEEALFVLVNVLLGPGDHAVVTWPGYQSLHEVARATGADVTLLRLREEDGWALDLDALRRALTPRTRLLLVNFPH
NPTGALLDRAAFDALCELSRERGIHLLSDEVYRLLEYDTRDTLPPAASHTPHGISLGVMSKAFGLAGLRVGWLACRDVEL
LRRCAAYKDYTTICNSAPSEVLSLIALRAKARVLARSRELLAANLSLLDGFFARHPDTFQWVRPRAGSVAFPRLLRETPV
ARFTEELREREGVLLLPGDVYDFPGNHFRLGLGRTNLPDALERLERYVVDTSR

Sequences:

>Translated_373_residues
MRIPDFKLERYFARWEFAAPYLLCSSDIEGWRMADLLALAGPDERARWEGLTLGYTESTGLPALREEIAALYPGLSPEQV
LTFAGAEEALFVLVNVLLGPGDHAVVTWPGYQSLHEVARATGADVTLLRLREEDGWALDLDALRRALTPRTRLLLVNFPH
NPTGALLDRAAFDALCELSRERGIHLLSDEVYRLLEYDTRDTLPPAASHTPHGISLGVMSKAFGLAGLRVGWLACRDVEL
LRRCAAYKDYTTICNSAPSEVLSLIALRAKARVLARSRELLAANLSLLDGFFARHPDTFQWVRPRAGSVAFPRLLRETPV
ARFTEELREREGVLLLPGDVYDFPGNHFRLGLGRTNLPDALERLERYVVDTSR
>Mature_373_residues
MRIPDFKLERYFARWEFAAPYLLCSSDIEGWRMADLLALAGPDERARWEGLTLGYTESTGLPALREEIAALYPGLSPEQV
LTFAGAEEALFVLVNVLLGPGDHAVVTWPGYQSLHEVARATGADVTLLRLREEDGWALDLDALRRALTPRTRLLLVNFPH
NPTGALLDRAAFDALCELSRERGIHLLSDEVYRLLEYDTRDTLPPAASHTPHGISLGVMSKAFGLAGLRVGWLACRDVEL
LRRCAAYKDYTTICNSAPSEVLSLIALRAKARVLARSRELLAANLSLLDGFFARHPDTFQWVRPRAGSVAFPRLLRETPV
ARFTEELREREGVLLLPGDVYDFPGNHFRLGLGRTNLPDALERLERYVVDTSR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=323, Percent_Identity=26.3157894736842, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI56713254, Length=195, Percent_Identity=27.1794871794872, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI56713256, Length=195, Percent_Identity=27.1794871794872, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI95147551, Length=204, Percent_Identity=25, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI169881279, Length=204, Percent_Identity=25, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788332, Length=253, Percent_Identity=29.6442687747036, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788627, Length=323, Percent_Identity=23.5294117647059, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788722, Length=321, Percent_Identity=25.2336448598131, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786816, Length=191, Percent_Identity=29.3193717277487, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71994476, Length=231, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=231, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17567369, Length=195, Percent_Identity=25.6410256410256, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=336, Percent_Identity=22.6190476190476, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=224, Percent_Identity=27.2321428571429, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28573069, Length=217, Percent_Identity=26.2672811059908, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646114, Length=217, Percent_Identity=26.2672811059908, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573067, Length=217, Percent_Identity=26.2672811059908, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573065, Length=217, Percent_Identity=26.2672811059908, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859735, Length=311, Percent_Identity=22.508038585209, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 41702; Mature: 41702

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPDFKLERYFARWEFAAPYLLCSSDIEGWRMADLLALAGPDERARWEGLTLGYTESTG
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHCCEEEECCCCCC
LPALREEIAALYPGLSPEQVLTFAGAEEALFVLVNVLLGPGDHAVVTWPGYQSLHEVARA
CHHHHHHHHHHCCCCCHHHHEECCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
TGADVTLLRLREEDGWALDLDALRRALTPRTRLLLVNFPHNPTGALLDRAAFDALCELSR
CCCCEEEEEEECCCCCEECHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ERGIHLLSDEVYRLLEYDTRDTLPPAASHTPHGISLGVMSKAFGLAGLRVGWLACRDVEL
HCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
LRRCAAYKDYTTICNSAPSEVLSLIALRAKARVLARSRELLAANLSLLDGFFARHPDTFQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
WVRPRAGSVAFPRLLRETPVARFTEELREREGVLLLPGDVYDFPGNHFRLGLGRTNLPDA
HHCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCCCCHHH
LERLERYVVDTSR
HHHHHHHHHCCCC
>Mature Secondary Structure
MRIPDFKLERYFARWEFAAPYLLCSSDIEGWRMADLLALAGPDERARWEGLTLGYTESTG
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHCCEEEECCCCCC
LPALREEIAALYPGLSPEQVLTFAGAEEALFVLVNVLLGPGDHAVVTWPGYQSLHEVARA
CHHHHHHHHHHCCCCCHHHHEECCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
TGADVTLLRLREEDGWALDLDALRRALTPRTRLLLVNFPHNPTGALLDRAAFDALCELSR
CCCCEEEEEEECCCCCEECHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ERGIHLLSDEVYRLLEYDTRDTLPPAASHTPHGISLGVMSKAFGLAGLRVGWLACRDVEL
HCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
LRRCAAYKDYTTICNSAPSEVLSLIALRAKARVLARSRELLAANLSLLDGFFARHPDTFQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
WVRPRAGSVAFPRLLRETPVARFTEELREREGVLLLPGDVYDFPGNHFRLGLGRTNLPDA
HHCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCCCCHHH
LERLERYVVDTSR
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8907187; 10029535 [H]