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The map label for this gene is accB [H]

Identifier: 108756800

GI number: 108756800

Start: 91284

End: 92900

Strand: Direct

Name: accB [H]

Synonym: MXAN_0081

Alternate gene names: 108756800

Gene position: 91284-92900 (Clockwise)

Preceding gene: 108762575

Following gene: 108759202

Centisome position: 1.0

GC content: 67.47

Gene sequence:

>1617_bases
ATGCCACGCATCACCTCGCGAATCGACCCGGGCTCCGAATCCTTCAAGGTGAACCGCGCGGACATGCTGGCCCGCGTTTC
GGAGTTGCGCGCCATCGAGGCGAAGGTCCGCAACACGGAGAACCAGGCGAAGGAGAAGTTCCACAAGCGCGGGCAGCTCC
TGCCTCGGGAGCGGCTGATGCTGCTGCTCGACCGGGGCTCGCCCTTCCTGGAGCTGTCCACGCTGTGTGGCTATGGCTAC
CACGACGACAGTGACGGCTCGCTGGCGGGCGGCAACAGCATCATCGGCATTGGCTACGTGTCCGGCGTGCGGTGCATCGT
CTTCGTGAACAACTCCGCCATCAAGGGCGGCACCGCGTCGCCGTGGGGCGTGCAGAAGGCGCTGCGCGCGCAGGCATTGG
CGCTGGAGAACAAGCTGCCCATGGTGTCGCTGGTGGAGAGCGGCGGCGCCAACCTGATGTACCAGCAGGAAATCTTCATC
CCGGGTGGGGAGACCTTCTACAACCAGGCACGGCTGTCGGCGGCGGGCATCCCCCAGGTGACGGTGGTGCACGGCTCCAG
CACGGCGGGCGGCGCGTACCTGCCGGGCCTGTCCGACTACGTGGTGATGGTGAAGAAGAAGGCGAAGGTGTTCCTCGCGG
GCCCGCCGCTGCTCAAGGCGGCCACGGGGGAAGTCGCCACGGATGAGGAGCTGGGCGGCGCCCAGATGCACGCCACGGTG
GCGGGCACCGCGGACTACCTGGCGGAGGACGACGCGGACGCCATCCGCATGGCCCGCGAAATCGTGGCGAAGCTCGGGTG
GAACGCGCAGCTTCCGCCCACCGAGCGCCCCGCCTATGCCGAGCCCGTGTACTCGCCCGACGAACTCTGCGGCGCCGTGC
CCGTGGACTACCGCAAACCCTACGATTGCCGCGAGGTCATCGCGCGCATCGTGGATGGCTCGGAGTTCACCGGCTTCAAG
GACGAGTACGACGCGCACACCGTTTGCGGCTGGGCGAACCTGTACGGCCACCCGCTGGGCATCATCGGAAACAACGGGCC
GATTTCGCCCCAGGGCGCGACGAAGGCGGCGCAGTTCATCCAGTTGTGCTGCCAGAAGGACACGCCCATCCTCTACCTGC
AGAACACCACGGGCTACCTCGTGGGCACGCAGCCGGAGCAGGGGGGCATCGTGAAGCACGGCGCGAAGATGATTCAGGCC
GTGGCCAACGCGACGGTGCCACAGCTCACGGTGCTGATTGGCGGTGCGTTTGGCGCGGGCAACTACGGCATGTGCGGCCG
TCCGTTCCATCCGCGCTTCATCTTCGGGTGGCCCAACTCGCGCACCGCCGTCATGGGCGGCGAGCAGGCGGCGAAGGTGA
TGTCCATCGTCTTCGGGGAGAAGCTGGCCCGGCAGGGGCAGGTGGTGGACGAGGAGCAGCTCAAGGCGTTCTGCCAGCCC
ATCATCGACCAGTTCGACAAGGAGTCGCATCCGTTCAACTGCAGCGCGCGGATGTTCGACGACGGGCTCATCGACCCGCG
GGACACGCGGCGGGTGCTCGGGTTCGCGCTGTCGGTGTGCCGTGAAGCGAAGCGGCGGCAGGTCCATCCCAACACGTTCG
GCGTCGCGCGGCTGTGA

Upstream 100 bases:

>100_bases
ACCCGGTTCGACCCGCAGGGCAAGGCCCTGGGCGAGTGGCTGCGCTCGCGGCACATGGACATTCCCGAGGCGCTGCTGCG
CGAAGGACAGGAGTAGACCG

Downstream 100 bases:

>100_bases
GAGGAGCGGACACGATGGAGCGCTTCAAGAAGGTCCTCATCGCGAACCGCGGCGAGATTGCCGTCCGGGTGATTCGCACC
TGCCAGCGGCTGGGTTACAG

Product: acetyl-CoA carboxylase carboxyltransferase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MPRITSRIDPGSESFKVNRADMLARVSELRAIEAKVRNTENQAKEKFHKRGQLLPRERLMLLLDRGSPFLELSTLCGYGY
HDDSDGSLAGGNSIIGIGYVSGVRCIVFVNNSAIKGGTASPWGVQKALRAQALALENKLPMVSLVESGGANLMYQQEIFI
PGGETFYNQARLSAAGIPQVTVVHGSSTAGGAYLPGLSDYVVMVKKKAKVFLAGPPLLKAATGEVATDEELGGAQMHATV
AGTADYLAEDDADAIRMAREIVAKLGWNAQLPPTERPAYAEPVYSPDELCGAVPVDYRKPYDCREVIARIVDGSEFTGFK
DEYDAHTVCGWANLYGHPLGIIGNNGPISPQGATKAAQFIQLCCQKDTPILYLQNTTGYLVGTQPEQGGIVKHGAKMIQA
VANATVPQLTVLIGGAFGAGNYGMCGRPFHPRFIFGWPNSRTAVMGGEQAAKVMSIVFGEKLARQGQVVDEEQLKAFCQP
IIDQFDKESHPFNCSARMFDDGLIDPRDTRRVLGFALSVCREAKRRQVHPNTFGVARL

Sequences:

>Translated_538_residues
MPRITSRIDPGSESFKVNRADMLARVSELRAIEAKVRNTENQAKEKFHKRGQLLPRERLMLLLDRGSPFLELSTLCGYGY
HDDSDGSLAGGNSIIGIGYVSGVRCIVFVNNSAIKGGTASPWGVQKALRAQALALENKLPMVSLVESGGANLMYQQEIFI
PGGETFYNQARLSAAGIPQVTVVHGSSTAGGAYLPGLSDYVVMVKKKAKVFLAGPPLLKAATGEVATDEELGGAQMHATV
AGTADYLAEDDADAIRMAREIVAKLGWNAQLPPTERPAYAEPVYSPDELCGAVPVDYRKPYDCREVIARIVDGSEFTGFK
DEYDAHTVCGWANLYGHPLGIIGNNGPISPQGATKAAQFIQLCCQKDTPILYLQNTTGYLVGTQPEQGGIVKHGAKMIQA
VANATVPQLTVLIGGAFGAGNYGMCGRPFHPRFIFGWPNSRTAVMGGEQAAKVMSIVFGEKLARQGQVVDEEQLKAFCQP
IIDQFDKESHPFNCSARMFDDGLIDPRDTRRVLGFALSVCREAKRRQVHPNTFGVARL
>Mature_537_residues
PRITSRIDPGSESFKVNRADMLARVSELRAIEAKVRNTENQAKEKFHKRGQLLPRERLMLLLDRGSPFLELSTLCGYGYH
DDSDGSLAGGNSIIGIGYVSGVRCIVFVNNSAIKGGTASPWGVQKALRAQALALENKLPMVSLVESGGANLMYQQEIFIP
GGETFYNQARLSAAGIPQVTVVHGSSTAGGAYLPGLSDYVVMVKKKAKVFLAGPPLLKAATGEVATDEELGGAQMHATVA
GTADYLAEDDADAIRMAREIVAKLGWNAQLPPTERPAYAEPVYSPDELCGAVPVDYRKPYDCREVIARIVDGSEFTGFKD
EYDAHTVCGWANLYGHPLGIIGNNGPISPQGATKAAQFIQLCCQKDTPILYLQNTTGYLVGTQPEQGGIVKHGAKMIQAV
ANATVPQLTVLIGGAFGAGNYGMCGRPFHPRFIFGWPNSRTAVMGGEQAAKVMSIVFGEKLARQGQVVDEEQLKAFCQPI
IDQFDKESHPFNCSARMFDDGLIDPRDTRRVLGFALSVCREAKRRQVHPNTFGVARL

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=535, Percent_Identity=46.1682242990654, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI119943100, Length=486, Percent_Identity=31.2757201646091, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI295821216, Length=506, Percent_Identity=30.0395256916996, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI310133460, Length=140, Percent_Identity=41.4285714285714, Blast_Score=90, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17552936, Length=544, Percent_Identity=47.2426470588235, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI25147362, Length=491, Percent_Identity=29.7352342158859, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI25147359, Length=491, Percent_Identity=29.7352342158859, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24586065, Length=557, Percent_Identity=46.3195691202873, Blast_Score=497, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 58126; Mature: 57995

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRITSRIDPGSESFKVNRADMLARVSELRAIEAKVRNTENQAKEKFHKRGQLLPRERLM
CCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHEE
LLLDRGSPFLELSTLCGYGYHDDSDGSLAGGNSIIGIGYVSGVRCIVFVNNSAIKGGTAS
EEECCCCCCEEHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCC
PWGVQKALRAQALALENKLPMVSLVESGGANLMYQQEIFIPGGETFYNQARLSAAGIPQV
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCEE
TVVHGSSTAGGAYLPGLSDYVVMVKKKAKVFLAGPPLLKAATGEVATDEELGGAQMHATV
EEEECCCCCCCCCCCCCCCEEEEEEECCEEEEECCCCHHHCCCCCCCCCCCCCCEEEEEE
AGTADYLAEDDADAIRMAREIVAKLGWNAQLPPTERPAYAEPVYSPDELCGAVPVDYRKP
CCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
YDCREVIARIVDGSEFTGFKDEYDAHTVCGWANLYGHPLGIIGNNGPISPQGATKAAQFI
CCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHCCCCEEEECCCCCCCCCCHHHHHHHH
QLCCQKDTPILYLQNTTGYLVGTQPEQGGIVKHGAKMIQAVANATVPQLTVLIGGAFGAG
HHHHCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
NYGMCGRPFHPRFIFGWPNSRTAVMGGEQAAKVMSIVFGEKLARQGQVVDEEQLKAFCQP
CCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IIDQFDKESHPFNCSARMFDDGLIDPRDTRRVLGFALSVCREAKRRQVHPNTFGVARL
HHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PRITSRIDPGSESFKVNRADMLARVSELRAIEAKVRNTENQAKEKFHKRGQLLPRERLM
CCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHEE
LLLDRGSPFLELSTLCGYGYHDDSDGSLAGGNSIIGIGYVSGVRCIVFVNNSAIKGGTAS
EEECCCCCCEEHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCC
PWGVQKALRAQALALENKLPMVSLVESGGANLMYQQEIFIPGGETFYNQARLSAAGIPQV
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCEE
TVVHGSSTAGGAYLPGLSDYVVMVKKKAKVFLAGPPLLKAATGEVATDEELGGAQMHATV
EEEECCCCCCCCCCCCCCCEEEEEEECCEEEEECCCCHHHCCCCCCCCCCCCCCEEEEEE
AGTADYLAEDDADAIRMAREIVAKLGWNAQLPPTERPAYAEPVYSPDELCGAVPVDYRKP
CCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
YDCREVIARIVDGSEFTGFKDEYDAHTVCGWANLYGHPLGIIGNNGPISPQGATKAAQFI
CCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHCCCCEEEECCCCCCCCCCHHHHHHHH
QLCCQKDTPILYLQNTTGYLVGTQPEQGGIVKHGAKMIQAVANATVPQLTVLIGGAFGAG
HHHHCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
NYGMCGRPFHPRFIFGWPNSRTAVMGGEQAAKVMSIVFGEKLARQGQVVDEEQLKAFCQP
CCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IIDQFDKESHPFNCSARMFDDGLIDPRDTRRVLGFALSVCREAKRRQVHPNTFGVARL
HHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]