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The map label for this gene is mrdA [H]

Identifier: 108563939

GI number: 108563939

Start: 1578564

End: 1580330

Strand: Reverse

Name: mrdA [H]

Synonym: HPAG1_1514

Alternate gene names: 108563939

Gene position: 1580330-1578564 (Counterclockwise)

Preceding gene: 108563940

Following gene: 108563936

Centisome position: 99.0

GC content: 40.97

Gene sequence:

>1767_bases
ATGAAAAATCTTCGCTATAAGCTTTTGCTTTTTGTTTTTATAGGGTTTTGGGGGTTATTGGTTTTAAATTTATTTATTTT
AAGCGTTAAAAATCAAGAATACTATGAAAAACTGGCTGAACGAAACATGACTAAAAAGGAATTTCTAGTCCCTACAAGGG
GCAATATTACAGACAGAAACCATGAGTTTTTAGCCACTAATGAATTGGTATTTGGCGTGTTTTTGCCCAACGGACTGAAA
CAAAAAGATCTTTTGGAAAAAATTGAAATCATCCAAAAGTTTTTCCCTAACTTTTCCAAAGAAACGCTTTTAAACAATTA
CCAAAAAGAAAATTCGCTTTATAACCATAACCTCATTAAAGTGGTTGGCCTCATTCCTTATGCCACCATACAACCTCTTT
ATGCCAAACTCATCCAAACTCAAGGCATTTTTGTGCTTCCCTTAGACAAGCGTTACTACCCTAATAACGCTTTAGCTTCG
CATGTTTTAGGCTATGTGGGGGTGGCAAGTTTGCAAGATTTAAAAGACGATGAGGAGAATCAATATAGCCAGATTGTGGG
CAAAACCGGCATTGAAAAAGAATACAACAAGCTTTTACAAGGCAAGGTGGGCTATAAAATCATGCGTGTCAATGCGCTCA
ATCAAGAATTAGCCACTTTAGAAGTAGTGCCACCAAGCACCAACAACCACTTGCAATTGAGTTTAGACAAACGCTTGCAA
AAAGAAGCGGACAAGCTCTTTGAAAATAAAAGGGGGGCTATTTTGGTGATGGATGCAGAAAATGGGGAATTGCTCGTTGC
AGGAAGTTACCCTGAATACAATTTGAACGATTTTGTGGGCGGGATCAGTCAAGACAAATGGCAAAAACTTCAAAATGATA
TTTATAACCCCTTATTAAACCGCTTCGCTAACGCCTTGTACCCGCCGGGATCTGTGGTTAAAATGGGCGTGGGCTTGAGC
TTTTTAGAAAACCTTAATATCACAGAAAACACCACCATACCCACCCCGCCTTTCATTGAAGTGGGTAAGCGCAAATTCAG
AGACTGGAAAAAAACAGGGCATGGCAATTCTAATTTGTATAAAGCCATTAGGGAGTCCGTGGATGTGTATTTTTATAAGT
TTGGGCTTGAAATCTCTATAGAAAAACTCTCTAAAACCTTAAGGGAAGTGGGCTTTGGGGAAAAAACGGGCGTTGATTTG
CCGAATGAATTTGTGGGGATTGTGCCGGACAATTTATGGAAACTCAAACGCTTCAATCAAGATTGGCGCGTTGGGGACAC
GCTCATTACCGCTATTGGGCAAGGCTCTTTTTTAGCCACGCCCTTGCAGGTTCTAGCCTACACGGGACTCATTGCTACGG
GCAAACTGGCAACGCCTCATTTTGCTATCAACAACAAACAGCCGCTCAAAGATCCCCTAAACAGCTTTCAAAAAAAGAAG
CTCCAAGCCTTGAGAGTGGGCATGTATGAAGTGTGCAACCATAAAGACGGCACCGCTTATCATTCCACAAGGGGTTCTAA
GGTTACTTTAGCGTGTAAAACCGGCACCGCGCAAGTCGTGGAAATCGCTCAAAACATCGTCAATCGCATGAAAGAAAAGG
ATATGGAATATTTCCAACGATCCCATGCGTGGATTACCGCATTTTTGCCTTATGAAAAACCCAAATACGCTATCACTATT
TTAGTAGAACATGGGGAAGGGGGGTCAAAACTAGGGGGCCTGTTAGTGAAGATGAGTAATAAACTCTATGAGCTTGGCTA
TCTTTAA

Upstream 100 bases:

>100_bases
TACCTTTATTTATCGCGCTTTTTTTCGGTGTCCTTGAGTTTGAAAATACTCGGCTTTCTCGCTCTTTTTGCTTTAATAGA
GAGCGCTTTGTGGGGTTTGT

Downstream 100 bases:

>100_bases
TAAAATTCTAAATCTTTTCAAAAACGCATTACTCTCTAAACGCTAAAACCATTAGCCAACTTGTTTCAGCACTCTATAAC
TCAGTCTAATGGGTGGTTTA

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNHEFLATNELVFGVFLPNGLK
QKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGLIPYATIQPLYAKLIQTQGIFVLPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQNDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFQRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVKMSNKLYELGYL

Sequences:

>Translated_588_residues
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNHEFLATNELVFGVFLPNGLK
QKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGLIPYATIQPLYAKLIQTQGIFVLPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQNDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFQRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVKMSNKLYELGYL
>Mature_588_residues
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNHEFLATNELVFGVFLPNGLK
QKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGLIPYATIQPLYAKLIQTQGIFVLPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQNDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFQRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVKMSNKLYELGYL

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=604, Percent_Identity=30.794701986755, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1786272, Length=449, Percent_Identity=22.4944320712695, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66813; Mature: 66813

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHEECCCCCCCCCCC
HEFLATNELVFGVFLPNGLKQKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIK
CCEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
VVGLIPYATIQPLYAKLIQTQGIFVLPLDKRYYPNNALASHVLGYVGVASLQDLKDDEEN
HHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
QYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
HHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEHHCCCCEEEEEECCCCCCEEEEEHHHHHH
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQNDIYNPLLN
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RFANALYPPGSVVKMGVGLSFLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLY
HHHHHCCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
KAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDLPNEFVGIVPDNLWKLKRFNQ
HHHHHHHHEEEEEECCEEEHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCHHHHHHHCCC
DWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCHHHHHHHHHHH
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFQR
HHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SHAWITAFLPYEKPKYAITILVEHGEGGSKLGGLLVKMSNKLYELGYL
CCCEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHEECCCCCCCCCCC
HEFLATNELVFGVFLPNGLKQKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIK
CCEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
VVGLIPYATIQPLYAKLIQTQGIFVLPLDKRYYPNNALASHVLGYVGVASLQDLKDDEEN
HHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
QYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
HHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEHHCCCCEEEEEECCCCCCEEEEEHHHHHH
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQNDIYNPLLN
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RFANALYPPGSVVKMGVGLSFLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLY
HHHHHCCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
KAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDLPNEFVGIVPDNLWKLKRFNQ
HHHHHHHHEEEEEECCEEEHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCHHHHHHHCCC
DWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCHHHHHHHHHHH
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFQR
HHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SHAWITAFLPYEKPKYAITILVEHGEGGSKLGGLLVKMSNKLYELGYL
CCCEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]