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The map label for this gene is leuS [H]

Identifier: 108563921

GI number: 108563921

Start: 1556640

End: 1559060

Strand: Reverse

Name: leuS [H]

Synonym: HPAG1_1496

Alternate gene names: 108563921

Gene position: 1559060-1556640 (Counterclockwise)

Preceding gene: 108563922

Following gene: 108563920

Centisome position: 97.66

GC content: 40.48

Gene sequence:

>2421_bases
ATGGATTTTATTAATATAGAAAAAAAATGGCAAGAATTTTGGTGGAAAAATAAGAGTTTTGAGCCTAAAGACGATTTTAA
TCTCCCTAAAAAATACATTCTAAGCATGCTGCCTTATCCTAGTGGGGAAATCCACATGGGGCATGTGCGCAATTACACCA
TTGGCGATGCGTTGGCGCGTTATTATCGTTTGCACCATTACAATGTGTTACACCCTATGGGGTTTGATTCTTTTGGGATG
CCTGCAGAAAATGCGGCCATTAAGCATGGTATCCACCCTAAAACCTGGACTTATGAAAACATTGAAGCCATGCAAAAAGA
GTTTGAAGCTTTAGGGTTTTCTTTTTCTAAAAACAGGGAATTTGCCACTTCAGATCCGGATTACACGAAATTTGAACAGC
AATTTTTCATTGATTTGTGGGAAAAGGGGCTAATTTATCGCAAGAAAGCCATGCTCAATTGGTGCCCTAACGACAAGACC
GTTTTAGCTAATGAGCAAGTCATTGATGGGAGGTGTTGGCGTTGCGATACGGAAGTTGTTCAAAAAGAACTCTATCAATA
TTATTTGAAGATCACAAACTACGCTGAAGAATTACTAAAAGACTTAGAAACTTTAGAAGATCATTGGCCTTCTCAAGTTT
TAATTATGCAAAAAAACTGGATAGGGAAATCTAGCGGGTTGCAATTTGGCTTTAAAATCGCTGATGAGTGCTTAAAAGCT
TGCAACGGCATTCAAGAAATTGAAGTTTTTACCACAAGAGCGGATACTATTTATGGCGTTACTTACATCGCCATCGCCCC
AGAACACCCTTTAGTAGAGCATGCCATTAAGCGAGTGAGTCAAGAAGATTCAAAGATCATTAAAGCGATTTTAAACACGA
CTCAAAGAGAAAGAGCTTTAGAGAAAAAAGGGGCGTTTTTAGGCATTTACGCTATCCACCCTTTAACAAAGCAAAAAATC
CCTGTCTGGGTGGCTAATTTCGCCCTAGCCAATTATGGTTCTGGGGCGTTAATGGGCGTGCCAGCCTGCGATGAAAGGGA
TTTTGAATTCGCTAATCTTTATCATATCCCTATTAAAGTGATCACTCAAAGCCTTCAAAATTTGCCCCACACCAAAGAAG
AGGTTTTAAAAAATAGCGGGGAGTGGAGCGATCTTTCTAGCTCAGTGGCCAGAGAGCAAATCATCGCTTATTTTGAAAAA
GAAAACCTCGGTAAAAGGGTGATCAACTACCGCTTGCAAGATTGGGGGGTGAGCCGTCAAAGGTATTGGGGAGCACCCAT
TCCTATGATTCATTGCAAACATTGCGGGATTGTGCCTGAAACCCAACTGCCGGTAACTTTACCTGAAGACATTGTGATTG
ATGGGGAGGGCAATCCGTTAGAAAAGCATGCGAGTTGGAAATTCGCTCAATGCCCTAAATGCCACAAAGACGCTTTAAGA
GAAACAGACACTATGGATACTTTCATTCAGTCTAGTTGGTATTTCTTGCGCTACACCACGCCCAAAAATCAGCGTGAAAA
TCAAGCGTTTGATCAAAATTACTTGAAATATTTCATGCCGGTGGACACTTATATTGGCGGCATTGAACATGCGATTTTGC
ACTTGTTATACGCGCGCTTTTTCACTAAGGCTTTAAGGGATTTGGGCTATCTTCATTTAGATGAGCCTTTCAAACAGCTT
ATCACTCAAGGCATGGTCTTAAAAGATGGCGCTAAGATGAGCAAATCTAAAGGCAATGTCGTTAGCCCTAAAGAGATACT
TAAAAAATACGGGGCCGATGCCGCAAGGCTCTTTATCCTTTTTGCTGCCCCACCGGCTAAAGAGTTAGAATGGAATGACA
GCGCTTTAGAGGGCGCGCACCGGTTTATCAAGCGCTTATACGATAAAGCGAACGCCATTACCCCTACCACTTCTAAGCCT
GAATTTAAAGGAGTGATCCTGAATGAAGCGCAAAAACTAGCTCGTAAAAAAGTCTATGAAGCGTTAAAAAAATCGCATGA
AATTTTCAACAAGACTGAAAGCACTTACGCGTTTAACACTTTGATCGCAAGTTGCATGGAAGCTTTAAACGCTTTGAGTG
CGCAAAATAATGAGCGGATTTTATGCGAGGGTTATTTTGTGTTGTTGCAGATTTTAGAGCCTATTATCCCGCACACGGCA
TGGGAATTGAGTGAAAGGCTTTTTAAAAGGGAGAATTTTAAGCCTATAGCGATCGATGAAAGCGCTTTGATGGAAGACTT
TATGACTTTAGGGCTTACCATTAATGGCAAAAGGCGCGCGGAATTGAAAGTTAATATTAACGCTAGTAAAGAAGAAATTA
TTGTTTTGGCCAAAAAAGAATTAGAGAAATATTTAGAAAAGGCGAGCGTTAAAAAAGAAATTTATGTGCCTAATAAGCTT
GTTAATTTTGTTATCGCATGA

Upstream 100 bases:

>100_bases
TACATGCTCATGATCGGGGCGTTGATTAGCAACGCTTTCAGTCTCATCTTTTTGTTGATTGAAAGCGTTGTAACGAGCGA
AACAGATTAAGGGGTAGTTG

Downstream 100 bases:

>100_bases
GAGCTTTACTTTTTTTTATTTTATTGTTTTGGTTCAAGGGCTGTGGGTATAAGCCCATCGCCGCTTACGCTCAAAACGCG
CTTGGCGATAGCGTGTATGT

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 806; Mature: 806

Protein sequence:

>806_residues
MDFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGM
PAENAAIKHGIHPKTWTYENIEAMQKEFEALGFSFSKNREFATSDPDYTKFEQQFFIDLWEKGLIYRKKAMLNWCPNDKT
VLANEQVIDGRCWRCDTEVVQKELYQYYLKITNYAEELLKDLETLEDHWPSQVLIMQKNWIGKSSGLQFGFKIADECLKA
CNGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKRVSQEDSKIIKAILNTTQRERALEKKGAFLGIYAIHPLTKQKI
PVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQSLQNLPHTKEEVLKNSGEWSDLSSSVAREQIIAYFEK
ENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCKHCGIVPETQLPVTLPEDIVIDGEGNPLEKHASWKFAQCPKCHKDALR
ETDTMDTFIQSSWYFLRYTTPKNQRENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRDLGYLHLDEPFKQL
ITQGMVLKDGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEGAHRFIKRLYDKANAITPTTSKP
EFKGVILNEAQKLARKKVYEALKKSHEIFNKTESTYAFNTLIASCMEALNALSAQNNERILCEGYFVLLQILEPIIPHTA
WELSERLFKRENFKPIAIDESALMEDFMTLGLTINGKRRAELKVNINASKEEIIVLAKKELEKYLEKASVKKEIYVPNKL
VNFVIA

Sequences:

>Translated_806_residues
MDFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGM
PAENAAIKHGIHPKTWTYENIEAMQKEFEALGFSFSKNREFATSDPDYTKFEQQFFIDLWEKGLIYRKKAMLNWCPNDKT
VLANEQVIDGRCWRCDTEVVQKELYQYYLKITNYAEELLKDLETLEDHWPSQVLIMQKNWIGKSSGLQFGFKIADECLKA
CNGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKRVSQEDSKIIKAILNTTQRERALEKKGAFLGIYAIHPLTKQKI
PVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQSLQNLPHTKEEVLKNSGEWSDLSSSVAREQIIAYFEK
ENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCKHCGIVPETQLPVTLPEDIVIDGEGNPLEKHASWKFAQCPKCHKDALR
ETDTMDTFIQSSWYFLRYTTPKNQRENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRDLGYLHLDEPFKQL
ITQGMVLKDGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEGAHRFIKRLYDKANAITPTTSKP
EFKGVILNEAQKLARKKVYEALKKSHEIFNKTESTYAFNTLIASCMEALNALSAQNNERILCEGYFVLLQILEPIIPHTA
WELSERLFKRENFKPIAIDESALMEDFMTLGLTINGKRRAELKVNINASKEEIIVLAKKELEKYLEKASVKKEIYVPNKL
VNFVIA
>Mature_806_residues
MDFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGM
PAENAAIKHGIHPKTWTYENIEAMQKEFEALGFSFSKNREFATSDPDYTKFEQQFFIDLWEKGLIYRKKAMLNWCPNDKT
VLANEQVIDGRCWRCDTEVVQKELYQYYLKITNYAEELLKDLETLEDHWPSQVLIMQKNWIGKSSGLQFGFKIADECLKA
CNGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKRVSQEDSKIIKAILNTTQRERALEKKGAFLGIYAIHPLTKQKI
PVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQSLQNLPHTKEEVLKNSGEWSDLSSSVAREQIIAYFEK
ENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCKHCGIVPETQLPVTLPEDIVIDGEGNPLEKHASWKFAQCPKCHKDALR
ETDTMDTFIQSSWYFLRYTTPKNQRENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRDLGYLHLDEPFKQL
ITQGMVLKDGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEGAHRFIKRLYDKANAITPTTSKP
EFKGVILNEAQKLARKKVYEALKKSHEIFNKTESTYAFNTLIASCMEALNALSAQNNERILCEGYFVLLQILEPIIPHTA
WELSERLFKRENFKPIAIDESALMEDFMTLGLTINGKRRAELKVNINASKEEIIVLAKKELEKYLEKASVKKEIYVPNKL
VNFVIA

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=871, Percent_Identity=33.2950631458094, Blast_Score=454, Evalue=1e-127,
Organism=Escherichia coli, GI1786861, Length=868, Percent_Identity=42.5115207373272, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=413, Percent_Identity=23.728813559322, Blast_Score=93, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71997510, Length=728, Percent_Identity=29.9450549450549, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71997517, Length=728, Percent_Identity=29.9450549450549, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI212645227, Length=271, Percent_Identity=30.2583025830258, Blast_Score=113, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323414, Length=804, Percent_Identity=38.0597014925373, Blast_Score=509, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6321531, Length=874, Percent_Identity=21.1670480549199, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21355409, Length=668, Percent_Identity=36.377245508982, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281366294, Length=141, Percent_Identity=29.0780141843972, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR009008 [H]

Pfam domain/function: PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 93123; Mature: 93123

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALAR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCHHHHHHH
YYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIEAMQKEFEALGFSFSKNRE
HHHHHHCCEECCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
FATSDPDYTKFEQQFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQVIDGRCWRCDTEVV
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCCEECCCCCCCCHHHH
QKELYQYYLKITNYAEELLKDLETLEDHWPSQVLIMQKNWIGKSSGLQFGFKIADECLKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
CNGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKRVSQEDSKIIKAILNTTQRERAL
HCCCEEEEEEEECCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKKGAFLGIYAIHPLTKQKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKV
HHCCCEEEEEEECCCCCCCCCEEEEHHHHHCCCCCCEECCCCCCCCCCCCHHEEEHHHHH
ITQSLQNLPHTKEEVLKNSGEWSDLSSSVAREQIIAYFEKENLGKRVINYRLQDWGVSRQ
HHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RYWGAPIPMIHCKHCGIVPETQLPVTLPEDIVIDGEGNPLEKHASWKFAQCPKCHKDALR
HCCCCCCCEEEECCCCCCCCCCCCEECCCCEEECCCCCCCHHHCCCCCCCCCHHHHHHHH
ETDTMDTFIQSSWYFLRYTTPKNQRENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARF
HHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTKALRDLGYLHLDEPFKQLITQGMVLKDGAKMSKSKGNVVSPKEILKKYGADAARLFIL
HHHHHHHCCCEECCHHHHHHHHCCCEEECCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEE
FAAPPAKELEWNDSALEGAHRFIKRLYDKANAITPTTSKPEFKGVILNEAQKLARKKVYE
EECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ALKKSHEIFNKTESTYAFNTLIASCMEALNALSAQNNERILCEGYFVLLQILEPIIPHTA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCHH
WELSERLFKRENFKPIAIDESALMEDFMTLGLTINGKRRAELKVNINASKEEIIVLAKKE
HHHHHHHHHHCCCCCEEECHHHHHHHHHHHCEEECCCEEEEEEEEECCCCCCEEEEEHHH
LEKYLEKASVKKEIYVPNKLVNFVIA
HHHHHHHHCCCHHEECCHHHHHHHCC
>Mature Secondary Structure
MDFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALAR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCHHHHHHH
YYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIEAMQKEFEALGFSFSKNRE
HHHHHHCCEECCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
FATSDPDYTKFEQQFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQVIDGRCWRCDTEVV
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCCEECCCCCCCCHHHH
QKELYQYYLKITNYAEELLKDLETLEDHWPSQVLIMQKNWIGKSSGLQFGFKIADECLKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
CNGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKRVSQEDSKIIKAILNTTQRERAL
HCCCEEEEEEEECCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKKGAFLGIYAIHPLTKQKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKV
HHCCCEEEEEEECCCCCCCCCEEEEHHHHHCCCCCCEECCCCCCCCCCCCHHEEEHHHHH
ITQSLQNLPHTKEEVLKNSGEWSDLSSSVAREQIIAYFEKENLGKRVINYRLQDWGVSRQ
HHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RYWGAPIPMIHCKHCGIVPETQLPVTLPEDIVIDGEGNPLEKHASWKFAQCPKCHKDALR
HCCCCCCCEEEECCCCCCCCCCCCEECCCCEEECCCCCCCHHHCCCCCCCCCHHHHHHHH
ETDTMDTFIQSSWYFLRYTTPKNQRENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARF
HHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTKALRDLGYLHLDEPFKQLITQGMVLKDGAKMSKSKGNVVSPKEILKKYGADAARLFIL
HHHHHHHCCCEECCHHHHHHHHCCCEEECCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEE
FAAPPAKELEWNDSALEGAHRFIKRLYDKANAITPTTSKPEFKGVILNEAQKLARKKVYE
EECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ALKKSHEIFNKTESTYAFNTLIASCMEALNALSAQNNERILCEGYFVLLQILEPIIPHTA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCHH
WELSERLFKRENFKPIAIDESALMEDFMTLGLTINGKRRAELKVNINASKEEIIVLAKKE
HHHHHHHHHHCCCCCEEECHHHHHHHHHHHCEEECCCEEEEEEEEECCCCCCEEEEEHHH
LEKYLEKASVKKEIYVPNKLVNFVIA
HHHHHHHHCCCHHEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA