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The map label for this gene is folC [H]

Identifier: 108563919

GI number: 108563919

Start: 1554972

End: 1556141

Strand: Reverse

Name: folC [H]

Synonym: HPAG1_1494

Alternate gene names: 108563919

Gene position: 1556141-1554972 (Counterclockwise)

Preceding gene: 108563920

Following gene: 108563918

Centisome position: 97.48

GC content: 37.86

Gene sequence:

>1170_bases
ATGAAAAATAGTCATGGGTTGAAGGCGTTTTTAGAAACAAAGCCTAAGGAATACCATAAATTTGAACCTAGCCGTTTCAT
TCAAATTTATAAAGATTTTAAAAACGCTTTTTTTGAGGTTCAAGCGAAAGTCATTCATGTGGTAGGGACTAATGGTAAGG
GCAGCACAGGGCGGTTTTTAACCCTTTTATTGGCCGATCAAAATTTTAAGGTGTTGCATTTCACCTCCCCTCATGTTTTT
GAATTTAGGGAGCGCTTTTTTTTGAATGGCTCTGTTGTTGAAGAAAGCGTTTTAGAAAACGCCCACCAGCAATTGCAATC
GCACGCTTTCAGCAACGCTTGCTCGTATTTTGAATACGCTACCCTACTGGCTGTTATGCTCGCTAAGGATTGCGATTATT
TGGTTTTAGAAGCGGGGCTTGGGGGGGAGTTTGACAGCACGAACGCTTTAGAAAAAACCCTAAGCGTTTTCACCCCCATT
GATTACGATCATAAGGAATTTTTAGGGGATAGTTTAGAGAGCATTGCGCAAACCAAATTAAAAGCGATGGGCTCTCTTAG
CATCATCGCTCCCCAACAAGAACTGGTTTTGAATGCGGCTCAAAAAATCGCTAAAGAAAAACACGCAAAATTGATTGTGG
TTCAAAATGAAATTTCAAAAGGAGTGAGAGATTATATTGAACGCCACCATTTAGCCCGTTTTTTAGCGATGAATTTGGAA
GTGGCTCTAAAAGCGTTTGAAACGCTTATGCCATGCAATAAACAAGAAGTTTTAAAAAACCTAAAGCCCCTAAATTTAAT
CGGCCGTTGCGAGCTTTTAAGCCCTAATATCTTAATAGATGTGGGGCATAACCCCCATAGCGCCAAAGCCTTAAAAGAAG
AAATCAAACGCCTTTTTAACGCTAAAATCATTTTAATTTATAATTGCTATCAAGATAAAGACGCTTTTTTGGTGCTAGAA
ATTTTAAAGCCTGTGGTTAAAAAGGTTTTGATTTTAGAATTGCATAATGAAAGAATTATCCAATTAGAAAAGCTTAAAGG
GATTTTAGAAACTTTAGGGTTAGAATACGCTTTGTTTGAAGATTTGGAAGAAAATGAAAATTATTTGGTGTATGGCTCAT
TTCTAGTGGCCAACGCTTTTTACGGACGCTATCAAAAGAAGAGGGATTGA

Upstream 100 bases:

>100_bases
CTTAACACCTACCAGAACCGCTATTACGCTATCAATCAGGCTGTGGAACAAACTTTGACTAAATTTGTGGCTCAAATCGC
TTATGAAGGGAAATTCAATA

Downstream 100 bases:

>100_bases
TGCCGCAAAACCAGCTCATGATCACCATCATTGATGAATCAGGCTCTAAACAGCTCAAATTTTCTAAAAATTTAAAACGC
AACCTCATCATTTCTGTTAT

Product: folylpolyglutamate synthase

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKNSHGLKAFLETKPKEYHKFEPSRFIQIYKDFKNAFFEVQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFTSPHVF
EFRERFFLNGSVVEESVLENAHQQLQSHAFSNACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPI
DYDHKEFLGDSLESIAQTKLKAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERHHLARFLAMNLE
VALKAFETLMPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEIKRLFNAKIILIYNCYQDKDAFLVLE
ILKPVVKKVLILELHNERIIQLEKLKGILETLGLEYALFEDLEENENYLVYGSFLVANAFYGRYQKKRD

Sequences:

>Translated_389_residues
MKNSHGLKAFLETKPKEYHKFEPSRFIQIYKDFKNAFFEVQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFTSPHVF
EFRERFFLNGSVVEESVLENAHQQLQSHAFSNACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPI
DYDHKEFLGDSLESIAQTKLKAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERHHLARFLAMNLE
VALKAFETLMPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEIKRLFNAKIILIYNCYQDKDAFLVLE
ILKPVVKKVLILELHNERIIQLEKLKGILETLGLEYALFEDLEENENYLVYGSFLVANAFYGRYQKKRD
>Mature_389_residues
MKNSHGLKAFLETKPKEYHKFEPSRFIQIYKDFKNAFFEVQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFTSPHVF
EFRERFFLNGSVVEESVLENAHQQLQSHAFSNACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPI
DYDHKEFLGDSLESIAQTKLKAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERHHLARFLAMNLE
VALKAFETLMPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEIKRLFNAKIILIYNCYQDKDAFLVLE
ILKPVVKKVLILELHNERIIQLEKLKGILETLGLEYALFEDLEENENYLVYGSFLVANAFYGRYQKKRD

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=177, Percent_Identity=30.5084745762712, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI66932990, Length=177, Percent_Identity=30.5084745762712, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1788654, Length=358, Percent_Identity=30.1675977653631, Blast_Score=128, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17553150, Length=320, Percent_Identity=27.8125, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71984923, Length=320, Percent_Identity=27.8125, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17553148, Length=320, Percent_Identity=27.8125, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6323760, Length=329, Percent_Identity=24.6200607902736, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324815, Length=313, Percent_Identity=27.4760383386581, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641571, Length=183, Percent_Identity=32.7868852459016, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 44428; Mature: 44428

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSHGLKAFLETKPKEYHKFEPSRFIQIYKDFKNAFFEVQAKVIHVVGTNGKGSTGRFL
CCCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCEE
TLLLADQNFKVLHFTSPHVFEFRERFFLNGSVVEESVLENAHQQLQSHAFSNACSYFEYA
EEEEECCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPIDYDHKEFLGDSLESIAQTKL
HHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERHHLARFLAMNLE
HHHCCEEEECCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VALKAFETLMPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEIKRLFN
HHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHC
AKIILIYNCYQDKDAFLVLEILKPVVKKVLILELHNERIIQLEKLKGILETLGLEYALFE
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHH
DLEENENYLVYGSFLVANAFYGRYQKKRD
HHCCCCCEEEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNSHGLKAFLETKPKEYHKFEPSRFIQIYKDFKNAFFEVQAKVIHVVGTNGKGSTGRFL
CCCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCEE
TLLLADQNFKVLHFTSPHVFEFRERFFLNGSVVEESVLENAHQQLQSHAFSNACSYFEYA
EEEEECCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPIDYDHKEFLGDSLESIAQTKL
HHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERHHLARFLAMNLE
HHHCCEEEECCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VALKAFETLMPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEIKRLFN
HHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHC
AKIILIYNCYQDKDAFLVLEILKPVVKKVLILELHNERIIQLEKLKGILETLGLEYALFE
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHH
DLEENENYLVYGSFLVANAFYGRYQKKRD
HHCCCCCEEEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]