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The map label for this gene is ald [H]

Identifier: 108563897

GI number: 108563897

Start: 1533938

End: 1535080

Strand: Direct

Name: ald [H]

Synonym: HPAG1_1472

Alternate gene names: 108563897

Gene position: 1533938-1535080 (Clockwise)

Preceding gene: 108563893

Following gene: 108563898

Centisome position: 96.09

GC content: 44.01

Gene sequence:

>1143_bases
ATGACTATTGGGCTAGTCAAAGAAAGCATGGATTTGGAATCACGAGTGGCTTTGGTGCCTGATGATGTGGCGCTAATCAT
TCAAAAGGGCGTGGAGGTTTTAGTGGAAAATAATGCCGGCGCTAATAGCGGTTATAGTAACGAAGCGTATGAAAGCGTGG
GGGCTAAAATCGTGGATTCTAAAACGGCGTGGGGGCAGGATTTGGTGGTCAAATGCAAAGAGCCTTTAGAACATGAGTAT
CATTTGCTAAAAGAAAAAGCGGCTCTGTTTAGTTATTTGGATCTAGCGTATCAAAAAAGCTTGTGCGAAATGTTTATAGA
TAAAAAAATCACTTCTATTTGCACTGAAACCATTGCCGGGCCTAAAAACGACTACCCTATTTTAGCACCTATGAGCGTGG
TGGCTGGGAGGTTGGCTGCGCATTTAGTCCAGCATTATTTGCTGGCTTTAGAGCATGTTAAGGGGTTTATGGGTAAGGGG
GTCATGCTTGGGGGGTTATCCGGAGCTCAAAGGGCTAAAATCGTCGTAATTGGGGGCGGTGTGGTTGGCATGGAGAGCGC
GAAAGTCTTAAGCCAAATGGGGGCTAAAGTAACGATTTTAGAATTAGACTACGCTAAATTGCAAAACCACCCCTATTATC
ATTTGTATGATTTAGAAGTTTTAAGCGTGAATGAAGCCAATATCATTCAGGCTTTAAATGGAGCGGTGGGGCTAGTGGGA
GCGGTGTTAGTTACAGCGAGCCAAACCCCTAAAGTGATCTTAAGAAGGCATTTAAAATACATGCAAAAACAAGGGGTAGT
GATAGATGTGGCTTGCGATTTAGGGGGGTGCATAGAGACCATACACCAGACAAGCCATTCTAATCCGGTGTATGTGGAAG
AGGATCTGTTGCATTATGGCGTGCCGAACATGCCAGGGATTGCCGCTAAAACAAGCTCTGTGGCTTATAGCCATGCGAGC
GCGCCGTATTTATTGTATTATTTAGAACATGGCTTGAAGGGTTTTTTAAAAGCCAACACTAAAATCGTAGCAAACACCCT
TGGAGGCTTGAGCGCTTATAACGGCTATATCACCCAAGAAGGCATCGCTAAAACTTTTAATCTAGCATTCAAATCGCCTT
TAGAGGTTTTAAAGGAGCTTTGA

Upstream 100 bases:

>100_bases
TGTAAAAAAGTAAGACTATTTAGCTTTTTAAAAGAAAGATACCCAATCGTTTAATGGAGTGAGTATAATCATAACTGACA
CTACTATTTAAAGGATTAAC

Downstream 100 bases:

>100_bases
AGCGAGCTTTAAAAAGAGCATGGCGATAAACCATGCGTCTTCATGTGTGGAAATATTTCAAAAAAAAAAAAAAACACTTT
TTAATGTTATAATCTACCCT

Product: alanine dehydrogenase

Products: NA

Alternate protein names: Stage V sporulation protein N [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTIGLVKESMDLESRVALVPDDVALIIQKGVEVLVENNAGANSGYSNEAYESVGAKIVDSKTAWGQDLVVKCKEPLEHEY
HLLKEKAALFSYLDLAYQKSLCEMFIDKKITSICTETIAGPKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKG
VMLGGLSGAQRAKIVVIGGGVVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALNGAVGLVG
AVLVTASQTPKVILRRHLKYMQKQGVVIDVACDLGGCIETIHQTSHSNPVYVEEDLLHYGVPNMPGIAAKTSSVAYSHAS
APYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGYITQEGIAKTFNLAFKSPLEVLKEL

Sequences:

>Translated_380_residues
MTIGLVKESMDLESRVALVPDDVALIIQKGVEVLVENNAGANSGYSNEAYESVGAKIVDSKTAWGQDLVVKCKEPLEHEY
HLLKEKAALFSYLDLAYQKSLCEMFIDKKITSICTETIAGPKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKG
VMLGGLSGAQRAKIVVIGGGVVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALNGAVGLVG
AVLVTASQTPKVILRRHLKYMQKQGVVIDVACDLGGCIETIHQTSHSNPVYVEEDLLHYGVPNMPGIAAKTSSVAYSHAS
APYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGYITQEGIAKTFNLAFKSPLEVLKEL
>Mature_379_residues
TIGLVKESMDLESRVALVPDDVALIIQKGVEVLVENNAGANSGYSNEAYESVGAKIVDSKTAWGQDLVVKCKEPLEHEYH
LLKEKAALFSYLDLAYQKSLCEMFIDKKITSICTETIAGPKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKGV
MLGGLSGAQRAKIVVIGGGVVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALNGAVGLVGA
VLVTASQTPKVILRRHLKYMQKQGVVIDVACDLGGCIETIHQTSHSNPVYVEEDLLHYGVPNMPGIAAKTSSVAYSHASA
PYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGYITQEGIAKTFNLAFKSPLEVLKEL

Specific function: This enzyme is a key factor in the assimilation of L- alanine as an energy source through the tricarboxylic acid cycle during sporulation [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=349, Percent_Identity=26.9340974212034, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI122939153, Length=349, Percent_Identity=26.9340974212034, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1787887, Length=312, Percent_Identity=25.3205128205128, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17550456, Length=355, Percent_Identity=26.4788732394366, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 41076; Mature: 40945

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGLVKESMDLESRVALVPDDVALIIQKGVEVLVENNAGANSGYSNEAYESVGAKIVDS
CCCCCCHHHCCCCCCEEECCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHCCEEECC
KTAWGQDLVVKCKEPLEHEYHLLKEKAALFSYLDLAYQKSLCEMFIDKKITSICTETIAG
CCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKGVMLGGLSGAQRAKIVVIGGG
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECC
VVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALNGAVGLVG
EECCHHHHHHHHCCCEEEEEEEEHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHH
AVLVTASQTPKVILRRHLKYMQKQGVVIDVACDLGGCIETIHQTSHSNPVYVEEDLLHYG
HHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHCCCCCCEEEEHHHHHCC
VPNMPGIAAKTSSVAYSHASAPYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGYITQE
CCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHCCCCCHH
GIAKTFNLAFKSPLEVLKEL
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIGLVKESMDLESRVALVPDDVALIIQKGVEVLVENNAGANSGYSNEAYESVGAKIVDS
CCCCCHHHCCCCCCEEECCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHCCEEECC
KTAWGQDLVVKCKEPLEHEYHLLKEKAALFSYLDLAYQKSLCEMFIDKKITSICTETIAG
CCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKGVMLGGLSGAQRAKIVVIGGG
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECC
VVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALNGAVGLVG
EECCHHHHHHHHCCCEEEEEEEEHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHH
AVLVTASQTPKVILRRHLKYMQKQGVVIDVACDLGGCIETIHQTSHSNPVYVEEDLLHYG
HHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHCCCCCCEEEEHHHHHCC
VPNMPGIAAKTSSVAYSHASAPYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGYITQE
CCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHCCCCCHH
GIAKTFNLAFKSPLEVLKEL
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226620; 9384377 [H]