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The map label for this gene is nuoD [H]

Identifier: 108563632

GI number: 108563632

Start: 1268075

End: 1269304

Strand: Direct

Name: nuoD [H]

Synonym: HPAG1_1207

Alternate gene names: 108563632

Gene position: 1268075-1269304 (Clockwise)

Preceding gene: 108563631

Following gene: 108563633

Centisome position: 79.44

GC content: 43.25

Gene sequence:

>1230_bases
ATGGCTCAAAATTTCACGAAACTCAACCCCCAGTTTGAAAACATCATTTTTGAACATGACGACAACCAAATGATTTTAAA
CTTTGGTCCCCAACACCCCAGCAGTCATGGGCAATTGCGCTTGATTTTGGAATTAGAGGGCGAAAAAATCATTAAAGCTA
CCCCTGAAATTGGCTACTTGCATAGAGGCTGTGAAAAGTTAGGCGAAAACATGACCTATAACGAATACATGCCCACTACC
GACAGATTGGATTACACTTCTTCTACTAGCAATAATTACGCTTACGCTTATGCGGTAGAGACCTTGCTCAATTTAGAAAT
CCCTCGCCGAGCGCAGGTGATTCGCACAATTTTACTAGAGCTTAACCGCATGATCTCACACATCTTTTTTATCAGCGTGC
ATGCTTTAGATGTGGGGGCGATGAGCGTGTTTTTGTATGCGTTTAAAACGAGGGAATACGGCTTGGATTTGATGGAGGAT
TATTGCGGGGCTAGGCTCACGCATAACGCTATAAGGATTGGGGGCGTGCCTTTAGATTTACCCCCTAATTGGTTAGAAGG
CTTAAAAAAGTTTTTAGGCGAAATGAGGGAATGCAAAAAACTCATTCAAGGCTTATTGGATAAGAATCGCATTTGGCGGA
TGCGTTTGGAAAATGTGGGCGTTGTAACGCAAAAAATGGCGCAAAGTTGGGGCATGAGCGGTATCATGTTAAGAGGGACT
GGGATCGCTTATGATATTAGAAAAGAAGAACCTTATGAGCTTTATAAAGAGCTTGATTTTGATGTGCCGGTGGGCAATTA
TGGCGATAGTTATGATCGGTATTGTTTGTATATGTTAGAAATTGATGAAAGCATTCGCATCATTGAACAACTCATTCCCA
TGTATGCTAAAACCGATACGCCTATCATGGCTCAAAACCCGCATTATATTTCTGCCCCTAAAGAAGATATAATGACGCAA
AACTACGCCTTGATGCAGCATTTTGTTTTAGTGGCTCAAGGCATGCGCCCGCCCATTGGGGAAGTGTATGCCCCCACAGA
AAGCCCTAAAGGGGAATTAGGGTTTTTTATCCATTCAGAGGGCGAGCCTTACCCTCACAGACTAAAAATCAGAGCCCCTA
GCTTTTATCACATTGGGGCTTTAAGCGATATTTTAGTGGGGCAATATTTAGCGGATGCGGTAACCGTGATTGGCTCAACC
AATGCGGTGTTTGGCGAGGTGGATAGATGA

Upstream 100 bases:

>100_bases
GAATTGAAAGAAACAGAAGAAAAGCATGCGTTTAAGAAAATCCCTTTTGTCAAAGATTTGCACAAAATCGCCCCCACTAT
CTTAAAAAAGAGGCTATAAA

Downstream 100 bases:

>100_bases
AACGCTTTGATTTACGCCCCTTAAAAGCGGGTATTTTTGAACGCTTAGAAGAATTGATTGAAAAAGAAATGCAACCTAAT
GAAGTCGCTATTTTCATGTT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYLHRGCEKLGENMTYNEYMPTT
DRLDYTSSTSNNYAYAYAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMED
YCGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTQKMAQSWGMSGIMLRGT
GIAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQ
NYALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSEGEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGST
NAVFGEVDR

Sequences:

>Translated_409_residues
MAQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYLHRGCEKLGENMTYNEYMPTT
DRLDYTSSTSNNYAYAYAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMED
YCGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTQKMAQSWGMSGIMLRGT
GIAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQ
NYALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSEGEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGST
NAVFGEVDR
>Mature_408_residues
AQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYLHRGCEKLGENMTYNEYMPTTD
RLDYTSSTSNNYAYAYAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMEDY
CGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTQKMAQSWGMSGIMLRGTG
IAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQN
YALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSEGEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGSTN
AVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=406, Percent_Identity=42.3645320197044, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI260898743, Length=400, Percent_Identity=41.5, Blast_Score=314, Evalue=9e-86,
Organism=Escherichia coli, GI145693162, Length=391, Percent_Identity=37.0843989769821, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789076, Length=394, Percent_Identity=27.1573604060914, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788832, Length=399, Percent_Identity=27.5689223057644, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17568379, Length=393, Percent_Identity=43.765903307888, Blast_Score=344, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI17555284, Length=403, Percent_Identity=42.6799007444169, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=43.1122448979592, Blast_Score=346, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221459469, Length=386, Percent_Identity=42.7461139896373, Blast_Score=322, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46786; Mature: 46654

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYL
CCCCCCCCCCCHHCEEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCEEEECCCCHHHH
HRGCEKLGENMTYNEYMPTTDRLDYTSSTSNNYAYAYAVETLLNLEIPRRAQVIRTILLE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHEEHHHHHCCCCCHHHHHHHHHHHH
LNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMEDYCGARLTHNAIRIGGVPLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCEEEECCEECCC
PPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTQKMAQSWGMSGIMLRGT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHHHHHHHCCCCEEEEECC
GIAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDT
CEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCC
PIMAQNPHYISAPKEDIMTQNYALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEEECC
GEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGSTNAVFGEVDR
CCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYL
CCCCCCCCCCHHCEEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCEEEECCCCHHHH
HRGCEKLGENMTYNEYMPTTDRLDYTSSTSNNYAYAYAVETLLNLEIPRRAQVIRTILLE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHEEHHHHHCCCCCHHHHHHHHHHHH
LNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMEDYCGARLTHNAIRIGGVPLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCEEEECCEECCC
PPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTQKMAQSWGMSGIMLRGT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHHHHHHHCCCCEEEEECC
GIAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDT
CEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCC
PIMAQNPHYISAPKEDIMTQNYALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEEECC
GEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGSTNAVFGEVDR
CCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA