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The map label for this gene is uvrB [H]

Identifier: 108563478

GI number: 108563478

Start: 1108727

End: 1110703

Strand: Reverse

Name: uvrB [H]

Synonym: HPAG1_1053

Alternate gene names: 108563478

Gene position: 1110703-1108727 (Counterclockwise)

Preceding gene: 108563479

Following gene: 108563471

Centisome position: 69.58

GC content: 40.47

Gene sequence:

>1977_bases
ATGCCTTTATTTGATTTAAAAAGCCCTTACCCACCAGCAGGCGATCAGCCCCAAGCCATAGAAGCTTTAGCAAAAAGCTT
GAAAAATAACAACCATTATCAAACTCTAGTGGGGGTTACAGGAAGCGGTAAGACTTATACGATGGCCAATATCATCGCTC
AAACCAATAAACCCGCTTTGATCATGAGCCATAATAAAACCTTATGCGCGCAGCTTTATAGCGAGTTTAAGGCGTTTTTC
CCGCATAATAGGGTGGAGTATTTTATCTCCCACTTTGATTACTACCAGCCTGAAAGCTATATCCCTAGGAGGGATTTGTT
CATTGAAAAAGACAGCTCTATTAATGATGATTTAGAGCGTTTGAGATTGAGCGCGACCACCTCACTTTTAGGTTATGATG
ATGTGATCGTGATAGCGAGCGTTTCGGCTAATTATGGCTTGGGTAACCCTGAAGAATATTTAAAAGTCATGGAAAAAATC
AAAGTGGGCGAGAAGCGCGCTTATAAGAACTTTTTATTAAAGCTAGTGGAAATGGGTTATAGCCGTAATGAAGTGGTGTT
TGATAGGGGGAGCTTTAGAGCGACGGGGGAATGCGTGGATATTTTCCCCGCTTATAATGACGCTGAATTTATTAGGATTG
AATTTTTTGGCGATGAGATAGAAAGGATTGCGGTCTTTGACGCTTTAGAAAAAAATGAAATCAAGCGCTTGGATTCTGTC
ATGCTTTATGCGGCCAGTCAGTTTGCCGTAGGGAGTGAGAGGTTGAATTTAGCCATTAAAAGCATTGAAGATGAACTCGC
TCTAAGGTTGAAATTTTTTAAAGAGCAGGATAAAATGCTTGAATACAACCGCCTCAAACAACGCACCGAGCATGATTTAG
AAATGATTAGCGCGACCGGTGTGTGTAAGGGCATTGAAAATTACGCGCGCCATTTTACAGGCAAAGCCCCCAATGAAACG
CCTTTTTGTTTGTTTGATTATTTAGGGATTTTTGAGCGGGAGTTTTTAGTCATTGTAGATGAAAGCCATGTGAGTTTGCC
GCAGTTTGGAGGGATGTATGCAGGGGATATGAGCAGGAAAAGCGTTTTAGTGGAATATGGTTTTAGATTGCCTAGCGCTT
TAGACAACCGCCCTTTAAAATTTGATGAATTTATCCATAAAAATTGCCAGTTCCTTTTTGTGTCCGCTACGCCCAATAAG
CTAGAATTAGAGCTTTCCAAAAAGAATGTCGCTGAGCAAATCATTCGCCCTACAGGGCTTTTAGACCCTAAATTTGAAGT
GCGAGACAGCGATAAGCAAGTCCAGGATTTATTTGATGAAATCAAGTTAGTGGTGGCCAGAGATGAAAGGGTGCTCATCA
CCACGCTTACTAAAAAAATGGCAGAAGAATTGTGCAAATATTATGCTGAATGGGGCTTGAAAGTGCGTTACATGCATAGT
GAAATTGATGCGATTGAAAGGAATCACATTATCCGCTCTTTAAGGCTTAAGGAATTTGACATTTTAATAGGGATCAATCT
TTTAAGAGAAGGGCTGGATTTGCCTGAAGTCTCTTTAGTAGCGATCATGGATGCAGATAAAGAAGGGTTTTTAAGGAGCG
AAACAAGCCTCATTCAAACCATGGGGCGAGCCGCTAGAAACGCTAATGGCAAGGTTTTACTATACGCTAAAAAGATCACT
CAAAGCATGCAAAAAGCCTTTGAGATCACGAGTTATAGGCGTGCCAAACAAGAAGAGTTCAATAAAATCCATAACATCAC
CCCCAAAACCGTTACTCGCGCTTTAGAAGAGGAGTTGAAATTAAGAGACGATGAGATTAGAATCGCTAAAGCCTTAAAAA
AGGACAAAATGCCTAAAAGCGAAAGGGAAAAAATCATTAAAGAACTGGATAAAAAAATGCGAGAATGCGCGAAAAATTTG
GATTTTGAAGAAGCGATGCGTTTGAGAGATGAAATCGCTAAATTAAGAACGCTTTAA

Upstream 100 bases:

>100_bases
AGCGAAAAAACGATCATTATCAAAACATTGATTTTTTTGAGTTTGAATAAGGCTTGTTAAAAATCCACTATAATACCCCT
AAAAAATGCGAGTTTTAAAG

Downstream 100 bases:

>100_bases
AAACTATAAGTGTAGTTGAAATAAACCGAGTAATTGCGCCTGAAATCAACTTGGTATAACAAGCTGTTGATCCCGTATTC
TAAAAATCGTAAAACCTTTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MPLFDLKSPYPPAGDQPQAIEALAKSLKNNNHYQTLVGVTGSGKTYTMANIIAQTNKPALIMSHNKTLCAQLYSEFKAFF
PHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKI
KVGEKRAYKNFLLKLVEMGYSRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKRLDSV
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNET
PFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNK
LELELSKKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHS
EIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKIT
QSMQKAFEITSYRRAKQEEFNKIHNITPKTVTRALEEELKLRDDEIRIAKALKKDKMPKSEREKIIKELDKKMRECAKNL
DFEEAMRLRDEIAKLRTL

Sequences:

>Translated_658_residues
MPLFDLKSPYPPAGDQPQAIEALAKSLKNNNHYQTLVGVTGSGKTYTMANIIAQTNKPALIMSHNKTLCAQLYSEFKAFF
PHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKI
KVGEKRAYKNFLLKLVEMGYSRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKRLDSV
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNET
PFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNK
LELELSKKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHS
EIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKIT
QSMQKAFEITSYRRAKQEEFNKIHNITPKTVTRALEEELKLRDDEIRIAKALKKDKMPKSEREKIIKELDKKMRECAKNL
DFEEAMRLRDEIAKLRTL
>Mature_657_residues
PLFDLKSPYPPAGDQPQAIEALAKSLKNNNHYQTLVGVTGSGKTYTMANIIAQTNKPALIMSHNKTLCAQLYSEFKAFFP
HNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIK
VGEKRAYKNFLLKLVEMGYSRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKRLDSVM
LYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNETP
FCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKL
ELELSKKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHSE
IDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKITQ
SMQKAFEITSYRRAKQEEFNKIHNITPKTVTRALEEELKLRDDEIRIAKALKKDKMPKSEREKIIKELDKKMRECAKNLD
FEEAMRLRDEIAKLRTL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=52.0119225037258, Blast_Score=674, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75970; Mature: 75839

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFDLKSPYPPAGDQPQAIEALAKSLKNNNHYQTLVGVTGSGKTYTMANIIAQTNKPAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCEEEHHHHHHHCCCCEE
IMSHNKTLCAQLYSEFKAFFPHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLER
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHH
LRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIKVGEKRAYKNFLLKLVEMGY
HHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
SRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKRLDSV
CCCCEEEECCCCCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCKGIENYARHFTGKAPNETPFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHH
SVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKLELELSKKNVAEQIIRPTGL
HHHHHHCCCCCHHHCCCCCCHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHCCCCC
LDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHS
CCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEEHH
EIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQT
HHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
MGRAARNANGKVLLYAKKITQSMQKAFEITSYRRAKQEEFNKIHNITPKTVTRALEEELK
HHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRDDEIRIAKALKKDKMPKSEREKIIKELDKKMRECAKNLDFEEAMRLRDEIAKLRTL
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLFDLKSPYPPAGDQPQAIEALAKSLKNNNHYQTLVGVTGSGKTYTMANIIAQTNKPAL
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCEEEHHHHHHHCCCCEE
IMSHNKTLCAQLYSEFKAFFPHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLER
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHH
LRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIKVGEKRAYKNFLLKLVEMGY
HHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
SRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKRLDSV
CCCCEEEECCCCCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCKGIENYARHFTGKAPNETPFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHH
SVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKLELELSKKNVAEQIIRPTGL
HHHHHHCCCCCHHHCCCCCCHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHCCCCC
LDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHS
CCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEEHH
EIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQT
HHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
MGRAARNANGKVLLYAKKITQSMQKAFEITSYRRAKQEEFNKIHNITPKTVTRALEEELK
HHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRDDEIRIAKALKKDKMPKSEREKIIKELDKKMRECAKNLDFEEAMRLRDEIAKLRTL
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA