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The map label for this gene is edd [H]

Identifier: 108563463

GI number: 108563463

Start: 1092223

End: 1094049

Strand: Reverse

Name: edd [H]

Synonym: HPAG1_1038

Alternate gene names: 108563463

Gene position: 1094049-1092223 (Counterclockwise)

Preceding gene: 108563468

Following gene: 108563462

Centisome position: 68.53

GC content: 42.69

Gene sequence:

>1827_bases
ATGCCTAAGCATTCTTTAGAACAAATCAAAGAAAAAATTACAGAGCGTAGCAAAAAAACCAGAGAGCTTTATTTAGAAAA
TATCTTTAACCCTAAAAACCAGCCCAAGATTGAGAGCTTGGGTTGCGCGAATATTGCCCATGTTACTGCGAGCATGCCAG
AGCATTTAAAAATGCCTTTAGGTTCGCATAAAAGAAAGCATTTTGCGATTATCACCGCTTATAATGATATGCTTTCAGCC
CACCAACCTTTTAAAAATTACCCTGACTGGATTAAAAAAGAATTGCAAGAGCATAACGCTTATGCGAGCGTCGCTAGTGG
GGTGCCAGCGATGTGTGATGGTATCACGCAGGGTTATGATGGCATGGAATTGAGCTTATTCAGTAGAGATGTGATCGCCT
TAAGCACCGCCGTAGGGTTAAGCCATAATGTTTTTGACGGGGCGTTTTTTTTGGGCGTGTGCGATAAGATTGTGCCAGGC
TTGCTCATAGGAGCGTTAAGCTTTGGGAATTTAGCGAGCGTGTTTGTGCCAAGCGGGCCTATGGTGAGCGGGATAGAAAA
TTATAAAAAAGCCAAAGCGCGCCAAGATTTTGCAATGGGAAAGATCAACAGAGAAGAGCTTTTAAAAGTGGAAATGCAAA
GCTATCATGATGTGGGCACTTGCACTTTTTATGGCACGGCTAATTCTAACCAAATGATGATGGAGTTTATGGGGTTGCAT
GTGGCTAATTCTAGCTTTATCAACCCTAACAACCCCTTACGGAAGGTTTTAGTAGAAGAGAGCGCGAAGAGATTAGCGAG
CGGGAAGGTTCTGCCTTTAGCCAAACTCATTGATGAAAAAAGCATTCTTAACGCTCTTATAGGCTTAATGGCAACCGGAG
GTTCTACCAACCACACTTTGCATTTGATCGCTATCGCTAGATCGTGTGGGGTGATTCTCAATTGGGATGATTTTGACGCT
GTTTCTAACCTCATACCCCTTTTAGCTAAAGTCTATCCTAACGGATCAGCGGATGTGAACGCTTTTGAAGCGTGTGGGGG
CTTAGCGTTTGTGATCAAGGAATTGCTAAAAGAGGGGCTTTTATTTGAGGACACTCATACCATTATGGATACCAAAACGC
AAAAAGGCATGCAAAATTACACCAAAACCCCCTTTTTAGAAAACGACCAATTGGTGTATAAAGACGCTGTTAATCATAGC
CTGAATACGGATATTTTACGCCCTGTGAGTGAGCCTTTTGCCGCTAATGGGGGGCTTAAAATTTTAAAGGGTAATTTAGG
GCGGGCCGTGATTAAAATTTCAGCCATTAAAGATGAGCACAGGAAAGTTAAAGCCAGAGCGATTGTTTTTAAAACCCAAA
GCGAATTTTTAGAACGCTTTAAAAATAAAGAATTAGAAAGGGACTTTGTGGCGGTCTTGCCTTTCCAAGGACCTAAGTCT
AACGGCATGCCAGAATTGCACAAACTCACCACGAATTTAGGGGCTTTGCAGGATATGGGCTATAAGGTCGCGCTGGTTAC
GGATGGGCGCATGAGTGGGGCGAGCGGGAAAGTGCCTAGCGCGATCCATTTAAGCCCTGAGGGAGCGTTAAATGGGGCGA
TCATTAAGATTAAAGATGGCGATTGGATAGAATTAGACGCTCCTAATAACGCCCTGAATGTGCTTGAAAAGGATTTTGAA
AATAGAGGGATCAACCCTTTGTTTTTAGAAACCTTAGAAAATTTAGAAAAGCCTACTTTTGGGCTGGGTAGGGAATTGTT
TACGAGTTTGAGATTGAATGTTAATACGGCTGAAGAGGGTGGCATGAGTTTTGGTATAAAGGTATAA

Upstream 100 bases:

>100_bases
GTCGCACCAAAAAGAACCAAATCAAAATCCAACATCAATAACCCTTTTAGAGTGTTTTTAAGTTATTATTATATATTAAA
TCTTAATTGAAGGGGTGTTC

Downstream 100 bases:

>100_bases
AAATATAAAGGAGATAAAATGCAAGATAAAATAATAGAGGTTTTACAAATTAGCCCCATTGTCCCTGTGGTGGTGATTGA
GGATATAAAAGATGCTGTGC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MPKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIESLGCANIAHVTASMPEHLKMPLGSHKRKHFAIITAYNDMLSA
HQPFKNYPDWIKKELQEHNAYASVASGVPAMCDGITQGYDGMELSLFSRDVIALSTAVGLSHNVFDGAFFLGVCDKIVPG
LLIGALSFGNLASVFVPSGPMVSGIENYKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLH
VANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTLHLIAIARSCGVILNWDDFDA
VSNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGLLFEDTHTIMDTKTQKGMQNYTKTPFLENDQLVYKDAVNHS
LNTDILRPVSEPFAANGGLKILKGNLGRAVIKISAIKDEHRKVKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKS
NGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIKIKDGDWIELDAPNNALNVLEKDFE
NRGINPLFLETLENLEKPTFGLGRELFTSLRLNVNTAEEGGMSFGIKV

Sequences:

>Translated_608_residues
MPKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIESLGCANIAHVTASMPEHLKMPLGSHKRKHFAIITAYNDMLSA
HQPFKNYPDWIKKELQEHNAYASVASGVPAMCDGITQGYDGMELSLFSRDVIALSTAVGLSHNVFDGAFFLGVCDKIVPG
LLIGALSFGNLASVFVPSGPMVSGIENYKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLH
VANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTLHLIAIARSCGVILNWDDFDA
VSNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGLLFEDTHTIMDTKTQKGMQNYTKTPFLENDQLVYKDAVNHS
LNTDILRPVSEPFAANGGLKILKGNLGRAVIKISAIKDEHRKVKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKS
NGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIKIKDGDWIELDAPNNALNVLEKDFE
NRGINPLFLETLENLEKPTFGLGRELFTSLRLNVNTAEEGGMSFGIKV
>Mature_607_residues
PKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIESLGCANIAHVTASMPEHLKMPLGSHKRKHFAIITAYNDMLSAH
QPFKNYPDWIKKELQEHNAYASVASGVPAMCDGITQGYDGMELSLFSRDVIALSTAVGLSHNVFDGAFFLGVCDKIVPGL
LIGALSFGNLASVFVPSGPMVSGIENYKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLHV
ANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTLHLIAIARSCGVILNWDDFDAV
SNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGLLFEDTHTIMDTKTQKGMQNYTKTPFLENDQLVYKDAVNHSL
NTDILRPVSEPFAANGGLKILKGNLGRAVIKISAIKDEHRKVKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKSN
GMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIKIKDGDWIELDAPNNALNVLEKDFEN
RGINPLFLETLENLEKPTFGLGRELFTSLRLNVNTAEEGGMSFGIKV

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=601, Percent_Identity=49.9168053244592, Blast_Score=614, Evalue=1e-177,
Organism=Escherichia coli, GI48994964, Length=533, Percent_Identity=26.4540337711069, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI2367371, Length=455, Percent_Identity=29.010989010989, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786464, Length=456, Percent_Identity=26.9736842105263, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=473, Percent_Identity=31.9238900634249, Blast_Score=181, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 66774; Mature: 66643

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIESLGCANIAHVTASMPEHLKMPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHCCHHHHCCCC
GSHKRKHFAIITAYNDMLSAHQPFKNYPDWIKKELQEHNAYASVASGVPAMCDGITQGYD
CCCCCCEEEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
GMELSLFSRDVIALSTAVGLSHNVFDGAFFLGVCDKIVPGLLIGALSFGNLASVFVPSGP
CCEEEHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
MVSGIENYKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLH
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
VANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
HLIAIARSCGVILNWDDFDAVSNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGL
EEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHHHHCCC
LFEDTHTIMDTKTQKGMQNYTKTPFLENDQLVYKDAVNHSLNTDILRPVSEPFAANGGLK
EECCCHHHHHCHHHHHHHHHCCCCCCCCCCEEEHHHHCCCCCHHHHHHCCCCCCCCCCEE
ILKGNLGRAVIKISAIKDEHRKVKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKS
EEECCCCEEEEEEEEHHHHHHHHHHHHEEEECHHHHHHHHHCCCCCCCEEEEECCCCCCC
NGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIKIKDG
CCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEEECC
DWIELDAPNNALNVLEKDFENRGINPLFLETLENLEKPTFGLGRELFTSLRLNVNTAEEG
CEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
GMSFGIKV
CCCCCCCC
>Mature Secondary Structure 
PKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIESLGCANIAHVTASMPEHLKMPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHCCHHHHCCCC
GSHKRKHFAIITAYNDMLSAHQPFKNYPDWIKKELQEHNAYASVASGVPAMCDGITQGYD
CCCCCCEEEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
GMELSLFSRDVIALSTAVGLSHNVFDGAFFLGVCDKIVPGLLIGALSFGNLASVFVPSGP
CCEEEHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
MVSGIENYKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLH
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
VANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
HLIAIARSCGVILNWDDFDAVSNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGL
EEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHHHHCCC
LFEDTHTIMDTKTQKGMQNYTKTPFLENDQLVYKDAVNHSLNTDILRPVSEPFAANGGLK
EECCCHHHHHCHHHHHHHHHCCCCCCCCCCEEEHHHHCCCCCHHHHHHCCCCCCCCCCEE
ILKGNLGRAVIKISAIKDEHRKVKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKS
EEECCCCEEEEEEEEHHHHHHHHHHHHEEEECHHHHHHHHHCCCCCCCEEEEECCCCCCC
NGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIKIKDG
CCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEEECC
DWIELDAPNNALNVLEKDFENRGINPLFLETLENLEKPTFGLGRELFTSLRLNVNTAEEG
CEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
GMSFGIKV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]