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The map label for this gene is guaA [H]

Identifier: 108563408

GI number: 108563408

Start: 1033970

End: 1035496

Strand: Reverse

Name: guaA [H]

Synonym: HPAG1_0983

Alternate gene names: 108563408

Gene position: 1035496-1033970 (Counterclockwise)

Preceding gene: 108563409

Following gene: 108563407

Centisome position: 64.87

GC content: 41.58

Gene sequence:

>1527_bases
ATGATTTTAGTATTAGATTTTGGGAGCCAATACACACAGCTGATTGCTAGAAGATTGAGAGAGAGTGGGATTTATGCAGA
AATAGTCCCTTTTTTTGAAAGCATAGAAAACATTCAAAAAAAAGCCCCTAAAGGTTTGATTTTGAGTGGGGGGCCAGCGA
GCGTGTACGCTAAAGACGCTTACAAGCCTAGCGAGAAAATCTTTGATTTGAATGTGCCGATTTTAGGGATTTGCTACGGC
ATGCAATATTTGGTGGATTTTTTTGGGGGGGTAGTGGCTGGTGCGAACGAGCAAGAATTTGGTAAGGCTGTTTTAGAAAT
CACTCAAGATTCTGTGATTTTTGAAGGCGTGAAAACCAAAAGCCTTGTGTGGATGAGCCATATGGATAAAGTCATAGAAT
TGCCTAAAGGCTTCATTACCCTTGCAAAAAGCCCTAATTCCCCCCATTGCGCGATTGAAAACGGCAAGATTTTTGGCTTG
CAATTCCACCCAGAAGTCATTCAAAGCGAAGAGGGGGGTAAGATTTTAGAAAATTTTGCCCTTTTAGTTTGCGACTGTGA
AAAAACTTGGGGGATGCAGCATTTCGCTCAAAGAGAAATCGCGCGATTGAAAGAAAAAATTGCTAACGATAAGGTTTTGT
GTGCGGTGAGTGGGGGCGTGGATTCTACGGTGGTCGCTACGCTATTATACAGAGCCATTAAGGATAATTTGATCGCTGTT
TTTGTGGATCATGGCTTGTTGCGTAAAAATGAAAAAGAAAGGGTGCAAGCGATGTTTAAAGACTTGCAAATCCCCTTAAA
CACGATAGACGCTAAAGGAATCTTTTTGTCTAAATTAAAGGGCGTGAGCGAGCCTGAATTGAAGCGAAAAATCATCGGCG
AAACCTTTATTGAAGTGTTTGAAAAAGAAGCTAAGAAGCACCATTTAAAAGGCAAAATTGAGTTTTTAGCCCAAGGCACT
TTATATCCTGATGTGATTGAATCCGTGAGCGTTAAAGGGCCTTCAAAAGTGATCAAAACCCACCATAATGTGGGCGGACT
GCCTGAATGGATGGACTTTAAACTCATAGAGCCTTTAAGGGAGTTGTTTAAAGATGAGGCGCGTTTGTTGGGTAAGGAAT
TGGGCATTAGCCAGGATTTTTTAATGCGCCACCCTTTTCCAGGGCCTGGGCTTGCTGTAAGGATTTTAGGCGAAGTCAGC
GAGAGTAAGATCAAACGCTTGCAAGAAGCGGATTTTATTTTTATAGAGGAGCTTAAAAAAGCCAATTTGTATGACAAGGT
TTGGCAAGCTTTTTGCGTGCTGTTGAATGTCAATTCTGTGGGGGTTATGGGGGATAACCGCACTTATGAAAACGCTATTT
GTTTGAGAGCGGTAAATGCGAGCGACGGCATGACAGCGAGTTTTTCATTTTTAGAGCATTCTTTTTTAGAAAAGGTTTCT
AATCGTATCACTAATGAAGTGAGCGGTATCAATAGGGTGGTGTATGATATTACTTCTAAGCCACCAGGAACGATTGAATG
GGAATGA

Upstream 100 bases:

>100_bases
TGGTTTGTGCAAAAAGTGCCCGCATTGGCTGAAAGCTATAGGGTGAATTACAAGAATCAATACAATAAAACACAGATCCC
ACAAAAATAAAGAATGAGCG

Downstream 100 bases:

>100_bases
TTATCTTAAAAAATAGCGCTAAAAGTGGGATTTTTTGGGTAAGATTAGGAATTGATTTTAAAGAAAAAGAAAGAAAGGAA
GTTAATGAAAAAAGGTAGTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDAYKPSEKIFDLNVPILGICYG
MQYLVDFFGGVVAGANEQEFGKAVLEITQDSVIFEGVKTKSLVWMSHMDKVIELPKGFITLAKSPNSPHCAIENGKIFGL
QFHPEVIQSEEGGKILENFALLVCDCEKTWGMQHFAQREIARLKEKIANDKVLCAVSGGVDSTVVATLLYRAIKDNLIAV
FVDHGLLRKNEKERVQAMFKDLQIPLNTIDAKGIFLSKLKGVSEPELKRKIIGETFIEVFEKEAKKHHLKGKIEFLAQGT
LYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEARLLGKELGISQDFLMRHPFPGPGLAVRILGEVS
ESKIKRLQEADFIFIEELKKANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
NRITNEVSGINRVVYDITSKPPGTIEWE

Sequences:

>Translated_508_residues
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDAYKPSEKIFDLNVPILGICYG
MQYLVDFFGGVVAGANEQEFGKAVLEITQDSVIFEGVKTKSLVWMSHMDKVIELPKGFITLAKSPNSPHCAIENGKIFGL
QFHPEVIQSEEGGKILENFALLVCDCEKTWGMQHFAQREIARLKEKIANDKVLCAVSGGVDSTVVATLLYRAIKDNLIAV
FVDHGLLRKNEKERVQAMFKDLQIPLNTIDAKGIFLSKLKGVSEPELKRKIIGETFIEVFEKEAKKHHLKGKIEFLAQGT
LYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEARLLGKELGISQDFLMRHPFPGPGLAVRILGEVS
ESKIKRLQEADFIFIEELKKANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
NRITNEVSGINRVVYDITSKPPGTIEWE
>Mature_508_residues
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDAYKPSEKIFDLNVPILGICYG
MQYLVDFFGGVVAGANEQEFGKAVLEITQDSVIFEGVKTKSLVWMSHMDKVIELPKGFITLAKSPNSPHCAIENGKIFGL
QFHPEVIQSEEGGKILENFALLVCDCEKTWGMQHFAQREIARLKEKIANDKVLCAVSGGVDSTVVATLLYRAIKDNLIAV
FVDHGLLRKNEKERVQAMFKDLQIPLNTIDAKGIFLSKLKGVSEPELKRKIIGETFIEVFEKEAKKHHLKGKIEFLAQGT
LYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEARLLGKELGISQDFLMRHPFPGPGLAVRILGEVS
ESKIKRLQEADFIFIEELKKANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
NRITNEVSGINRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=545, Percent_Identity=35.045871559633, Blast_Score=290, Evalue=3e-78,
Organism=Escherichia coli, GI1788854, Length=519, Percent_Identity=51.252408477842, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1787517, Length=184, Percent_Identity=31.5217391304348, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992710, Length=566, Percent_Identity=33.0388692579505, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71992717, Length=566, Percent_Identity=33.0388692579505, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI133901714, Length=566, Percent_Identity=33.5689045936396, Blast_Score=268, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6323873, Length=514, Percent_Identity=56.420233463035, Blast_Score=552, Evalue=1e-158,
Organism=Drosophila melanogaster, GI281365319, Length=543, Percent_Identity=34.8066298342541, Blast_Score=270, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56827; Mature: 56827

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDA
CEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCC
YKPSEKIFDLNVPILGICYGMQYLVDFFGGVVAGANEQEFGKAVLEITQDSVIFEGVKTK
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCCCCCHH
SLVWMSHMDKVIELPKGFITLAKSPNSPHCAIENGKIFGLQFHPEVIQSEEGGKILENFA
HHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCEEEEEEECHHHHCCCCCCHHHHCCE
LLVCDCEKTWGMQHFAQREIARLKEKIANDKVLCAVSGGVDSTVVATLLYRAIKDNLIAV
EEEEECHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEE
FVDHGLLRKNEKERVQAMFKDLQIPLNTIDAKGIFLSKLKGVSEPELKRKIIGETFIEVF
EECCHHHCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
EKEAKKHHLKGKIEFLAQGTLYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLR
HHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHH
ELFKDEARLLGKELGISQDFLMRHPFPGPGLAVRILGEVSESKIKRLQEADFIFIEELKK
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHH
ANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
NRITNEVSGINRVVYDITSKPPGTIEWE
HHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDA
CEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCC
YKPSEKIFDLNVPILGICYGMQYLVDFFGGVVAGANEQEFGKAVLEITQDSVIFEGVKTK
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCCCCCHH
SLVWMSHMDKVIELPKGFITLAKSPNSPHCAIENGKIFGLQFHPEVIQSEEGGKILENFA
HHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCEEEEEEECHHHHCCCCCCHHHHCCE
LLVCDCEKTWGMQHFAQREIARLKEKIANDKVLCAVSGGVDSTVVATLLYRAIKDNLIAV
EEEEECHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEE
FVDHGLLRKNEKERVQAMFKDLQIPLNTIDAKGIFLSKLKGVSEPELKRKIIGETFIEVF
EECCHHHCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
EKEAKKHHLKGKIEFLAQGTLYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLR
HHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHH
ELFKDEARLLGKELGISQDFLMRHPFPGPGLAVRILGEVSESKIKRLQEADFIFIEELKK
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHH
ANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
NRITNEVSGINRVVYDITSKPPGTIEWE
HHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA