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The map label for this gene is ribB [H]

Identifier: 108563214

GI number: 108563214

Start: 826230

End: 827264

Strand: Reverse

Name: ribB [H]

Synonym: HPAG1_0789

Alternate gene names: 108563214

Gene position: 827264-826230 (Counterclockwise)

Preceding gene: 108563215

Following gene: 108563213

Centisome position: 51.82

GC content: 41.16

Gene sequence:

>1035_bases
ATGATCTTAAAACGAGTTACTGAAGCTTTAGAAGCGTATAAAAATGGCGAAATGCTTATTGTTATGGACGATGAAGACAG
AGAAAATGAGGGGGATTTGGTTTTAGCCGGGATTTTTTCCACCCCTGAGAAAATCAACTTCATGGCCACGCATGCTAGGG
GGTTGATTTGCGTGTCTTTGACCAAAGATTTAGCGAAAAAATTTGAATTACCCCCTATGGTTAGCGTGAATGATTCTAAC
CATGAGACCGCTTTCACGGTGTCCATTGACGCTAAAGAAGCCAAAACCGGGATTTCTGCTTTTGAAAGGCATTTAACGAT
TGAATTATTGTGTAAAGACACCACCAAACCGAGCGATTTTGTGCGCCCAGGGCATATTTTCCCTTTGATCGCAAAAGATG
GAGGCGTGCTAGCGCGCACGGGCCATACTGAAGCGAGCGTGGATTTGTGCAAATTAGCTGGATTAAAGCCCGTGAGCGTG
ATTTGTGAAATCATGAAAGAAGACGGCTCTATGGCGAGAAGGGGGGATAAATTTTTGAGCGACTTTGCCCTTAAGCACAA
CCTTAAAACCCTCTATGTCTCTGATTTGATTAGCTATCGTTTGGAAAATGAAAGTTTGCTGAAAATGTTTTGTCAAGAAG
AGAGAGAATTTTTAAAACACCAAACGCAATGCTACACTTTTTTAGACCACCAGCAAAAAAACCATTACGCTTTTAAATTT
AAAGGCGCAAAAACCCATGATTTGGCCCCTTTAGTGCGTTTCCACCCTATCAAAGAGGATTTTGATTTTTTAACGACTGG
CGCGTTTGAAGCGTTTTTTAAGGCTTTAGAATACTTAAAGCGCGAGGGGGGTTATTTGATCTTTATGAACACGCATTCCA
AAGAAAACAATATCGTTAAAGATTTTGGGATCGGAGCGTTAGTGTTAAAAAATTTGGGGATAAAGGATTTCAGGCTTTTA
AGCTCTTCTGAAGACAGGCAGTATAAGGCTTTGAGCGGGTTTGGGCTTAAGCTTGTAGAAACGATTAGCCTTTGA

Upstream 100 bases:

>100_bases
TGTATCTAAATAAAGCAATAAAGTAATCATCGTTATTAAACATGCTATATTTCTTTTTTCTATAAAACTCAATATTATTG
AATAAAACTAGGGAGTTAGA

Downstream 100 bases:

>100_bases
AGCTTGTTCAGTTTTATTGAATGTGTTGTAATGTTTTTAAGGTATAATAAACTCTTTTTAAGTCAAGCAATAAAGTTTGC
AATCTGATGAGAGTAATAAT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLAKKFELPPMVSVNDSN
HETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTHDLAPLVRFHPIKEDFDFLTTGAFEAFFKALEYLKREGGYLIFMNTHSKENNIVKDFGIGALVLKNLGIKDFRLL
SSSEDRQYKALSGFGLKLVETISL

Sequences:

>Translated_344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLAKKFELPPMVSVNDSN
HETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTHDLAPLVRFHPIKEDFDFLTTGAFEAFFKALEYLKREGGYLIFMNTHSKENNIVKDFGIGALVLKNLGIKDFRLL
SSSEDRQYKALSGFGLKLVETISL
>Mature_344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLAKKFELPPMVSVNDSN
HETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTHDLAPLVRFHPIKEDFDFLTTGAFEAFFKALEYLKREGGYLIFMNTHSKENNIVKDFGIGALVLKNLGIKDFRLL
SSSEDRQYKALSGFGLKLVETISL

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=45.5445544554455, Blast_Score=187, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6320695, Length=203, Percent_Identity=41.871921182266, Blast_Score=163, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 38875; Mature: 38875

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSL
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEH
TKDLAKKFELPPMVSVNDSNHETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDF
HHHHHHHCCCCCEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHEEEEEEECCCCCCHHC
VRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSVICEIMKEDGSMARRGDKFLS
CCCCCEEEEEECCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
DFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KGAKTHDLAPLVRFHPIKEDFDFLTTGAFEAFFKALEYLKREGGYLIFMNTHSKENNIVK
CCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHH
DFGIGALVLKNLGIKDFRLLSSSEDRQYKALSGFGLKLVETISL
HHCHHHHHHHHCCCCCEEECCCCCCCHHHHHHCCCHHHHHEECC
>Mature Secondary Structure
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSL
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEH
TKDLAKKFELPPMVSVNDSNHETAFTVSIDAKEAKTGISAFERHLTIELLCKDTTKPSDF
HHHHHHHCCCCCEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHEEEEEEECCCCCCHHC
VRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSVICEIMKEDGSMARRGDKFLS
CCCCCEEEEEECCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
DFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KGAKTHDLAPLVRFHPIKEDFDFLTTGAFEAFFKALEYLKREGGYLIFMNTHSKENNIVK
CCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHH
DFGIGALVLKNLGIKDFRLLSSSEDRQYKALSGFGLKLVETISL
HHCHHHHHHHHCCCCCEEECCCCCCCHHHHHHCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]