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The map label for this gene is 108563150

Identifier: 108563150

GI number: 108563150

Start: 763487

End: 763972

Strand: Direct

Name: 108563150

Synonym: HPAG1_0725

Alternate gene names: NA

Gene position: 763487-763972 (Clockwise)

Preceding gene: 108563149

Following gene: 108563151

Centisome position: 47.83

GC content: 39.51

Gene sequence:

>486_bases
ATGCAACATTTATACGCTCCTTGGCGCGAAAGTTATTTGAAAGAGAAAAATAAGAGTTGTGTCTTTTGCGAGATTTCTCA
AAACCCTACAAAAGATTCAGAAAACAGAGTGCTTTATAGAAATAGCGATCTCTTTGTGGTGATGAACGCCTACCCTTATA
ACCCAGGGCATTTGTTGATCATTCCTCATGCGCATCAAGCGAGCGTGGAACTTTTAGATCTCAATACTTGGCTGAACATG
AATAAATTAGTGCCTAAAATTTTAAAAGCGTTGTATGCTTATGGCGCTCAAGGGATTAATTTAGGTTTGAACTTGCACAG
AAACGCCGGAGCAGGGATTCCTGAGCATTTGCACATGCATTTAGTGCCTAGGTTTTTAGGCGATAGCAATTTTATGAGCG
TTATCGCTCAAACCAGGGTGTGCGGGATGGATTTAAATGAAACCTATCTTACCTTAAAAAACTTATTAGAAAAGGAGCTT
GGTTGA

Upstream 100 bases:

>100_bases
GGATAAGGCGCAATTGGAAAATATCTTACAAGCCACCACGATTCAAGGCGATTTGATTTTATTCGCTAATGACACCCCTA
ATTACATTTAGGAAATGAAC

Downstream 100 bases:

>100_bases
AAACAAACGCTTTTAGTTTGGGTGCGCTACAATTGATTTTAATTCATTTTAGGGAGTGTAAGCGATGAAGGCGCGTGGGT
TTAAGGCAAAGATGCGTGGG

Product: histidine triad (HIT) family protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MQHLYAPWRESYLKEKNKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHAHQASVELLDLNTWLNM
NKLVPKILKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKEL
G

Sequences:

>Translated_161_residues
MQHLYAPWRESYLKEKNKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHAHQASVELLDLNTWLNM
NKLVPKILKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKEL
G
>Mature_161_residues
MQHLYAPWRESYLKEKNKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHAHQASVELLDLNTWLNM
NKLVPKILKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKEL
G

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 18376; Mature: 18376

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHLYAPWRESYLKEKNKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLI
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCEEEE
IPHAHQASVELLDLNTWLNMNKLVPKILKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH
EECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEECEEEECCCCCCCHHHHHHH
LVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKELG
HHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHLYAPWRESYLKEKNKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLI
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCEEEE
IPHAHQASVELLDLNTWLNMNKLVPKILKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH
EECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEECEEEECCCCCCCHHHHHHH
LVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKELG
HHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]