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The map label for this gene is mraW [H]

Identifier: 108563117

GI number: 108563117

Start: 728737

End: 729663

Strand: Direct

Name: mraW [H]

Synonym: HPAG1_0692

Alternate gene names: 108563117

Gene position: 728737-729663 (Clockwise)

Preceding gene: 108563116

Following gene: 108563118

Centisome position: 45.65

GC content: 39.48

Gene sequence:

>927_bases
TTGCAAGAAATAGAGAGTTTGCACCAAAGCGTTTTGTTGCAAGAAGTTTTGCAAGCGTTCACGCCTTTAGAAGAAGGGGT
TTTGATTGATTGCACTTTAGGGTTAGGGGGGCATTCTAAAGCCCTTTTATCCCAAAAACCGCACCTGAAACTCATTGGCA
TTGATAAGGATAAATTCGCTCAAGAAATCGCTAAAGAACGATTGAAAGCCTTTGAAGGGCGTTATAATCTCTTAAGTGGA
GGGTTTGCCAAACGCTTTAAAGAAGCCCTAGAAACGCATAACAAGGAGATTAAAGGGGTTTTAGTGGATTTAGGGGTGAG
CTCTTTGCAGCTTGATGATGATAACAGAGGGTTTAATTTCCACTCGCACACTCTGGATATGCGCATGGATTTAAAGAGCG
ATTTGAACGCTCAAAAAGTCATCAACTCTTATCCTGTAGTGGCGTTAGAAAAAATCTTTAGAGACTATGGCGAGATCAAA
GAATACAAAAAAATCGCCCACAAAATTGCAGAAAGGCGCGCTAAAAAACCCTTTAAAGACGCTAAGGATTTGAGCGATTT
TTTAAGCTCCCTTTCTAAAAATAAAAAAATCCATCCAGCGACTTTGGTGTTTCAAGCCGTTCGCATAGAAGTTAATAGCG
AATTAGAAGAGTTAAAAGAGTTTTTACAATGCGCTAGAAACCTTAAGGGAGCGATTTTGTGCGTGATTTCTTTTCATTCT
TTAGAAGACGCATTAGTGAAAAACGCTTTCAAAGATTACGCTAAAAATTGCATTTGTGATCCTTCAAGTTTCCAATGCAC
TTGCTCTAACAACCACGCTTTAGGCGCAATTTTAACCAAAAAGCCCATCACTCCAAGCCCAGAAGAAATTAAAAACAACA
GGCGTTCACGAAGCGCTAAAATGAGGGTTTTTCAATTCAAGCCATGA

Upstream 100 bases:

>100_bases
GCTAAAATTGGTTATAAAGAAACTTTTGAGTGTAACCAACAAAACCAATACCATTGAGTGGATATTTGGAAAATTCATCT
AGGGGTTTTAAGGGGGTTGT

Downstream 100 bases:

>100_bases
GTAAGTTATATGAGTAAGCCATGAATATCAAAACCCATTCTTCAAATGAAAAAGAACGCTTTGTGCGCATAGAAGAGGAC
GAAAAGAAAGAATTATTCGC

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MQEIESLHQSVLLQEVLQAFTPLEEGVLIDCTLGLGGHSKALLSQKPHLKLIGIDKDKFAQEIAKERLKAFEGRYNLLSG
GFAKRFKEALETHNKEIKGVLVDLGVSSLQLDDDNRGFNFHSHTLDMRMDLKSDLNAQKVINSYPVVALEKIFRDYGEIK
EYKKIAHKIAERRAKKPFKDAKDLSDFLSSLSKNKKIHPATLVFQAVRIEVNSELEELKEFLQCARNLKGAILCVISFHS
LEDALVKNAFKDYAKNCICDPSSFQCTCSNNHALGAILTKKPITPSPEEIKNNRRSRSAKMRVFQFKP

Sequences:

>Translated_308_residues
MQEIESLHQSVLLQEVLQAFTPLEEGVLIDCTLGLGGHSKALLSQKPHLKLIGIDKDKFAQEIAKERLKAFEGRYNLLSG
GFAKRFKEALETHNKEIKGVLVDLGVSSLQLDDDNRGFNFHSHTLDMRMDLKSDLNAQKVINSYPVVALEKIFRDYGEIK
EYKKIAHKIAERRAKKPFKDAKDLSDFLSSLSKNKKIHPATLVFQAVRIEVNSELEELKEFLQCARNLKGAILCVISFHS
LEDALVKNAFKDYAKNCICDPSSFQCTCSNNHALGAILTKKPITPSPEEIKNNRRSRSAKMRVFQFKP
>Mature_308_residues
MQEIESLHQSVLLQEVLQAFTPLEEGVLIDCTLGLGGHSKALLSQKPHLKLIGIDKDKFAQEIAKERLKAFEGRYNLLSG
GFAKRFKEALETHNKEIKGVLVDLGVSSLQLDDDNRGFNFHSHTLDMRMDLKSDLNAQKVINSYPVVALEKIFRDYGEIK
EYKKIAHKIAERRAKKPFKDAKDLSDFLSSLSKNKKIHPATLVFQAVRIEVNSELEELKEFLQCARNLKGAILCVISFHS
LEDALVKNAFKDYAKNCICDPSSFQCTCSNNHALGAILTKKPITPSPEEIKNNRRSRSAKMRVFQFKP

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA [H]

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family [H]

Homologues:

Organism=Homo sapiens, GI165377209, Length=340, Percent_Identity=31.4705882352941, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI165377202, Length=196, Percent_Identity=33.6734693877551, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786270, Length=305, Percent_Identity=35.7377049180328, Blast_Score=168, Evalue=5e-43,
Organism=Drosophila melanogaster, GI62472493, Length=328, Percent_Identity=32.9268292682927, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571637, Length=328, Percent_Identity=32.9268292682927, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002903 [H]

Pfam domain/function: PF01795 Methyltransf_5 [H]

EC number: NA

Molecular weight: Translated: 34843; Mature: 34843

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEIESLHQSVLLQEVLQAFTPLEEGVLIDCTLGLGGHSKALLSQKPHLKLIGIDKDKFA
CHHHHHHHHHHHHHHHHHHHCCHHCCEEEEEEECCCCCCHHHHCCCCCEEEEECCHHHHH
QEIAKERLKAFEGRYNLLSGGFAKRFKEALETHNKEIKGVLVDLGVSSLQLDDDNRGFNF
HHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHEECCCCEEEECCCCCCCCE
HSHTLDMRMDLKSDLNAQKVINSYPVVALEKIFRDYGEIKEYKKIAHKIAERRAKKPFKD
ECCCHHEEECHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AKDLSDFLSSLSKNKKIHPATLVFQAVRIEVNSELEELKEFLQCARNLKGAILCVISFHS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHH
LEDALVKNAFKDYAKNCICDPSSFQCTCSNNHALGAILTKKPITPSPEEIKNNRRSRSAK
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
MRVFQFKP
EEEEEECC
>Mature Secondary Structure
MQEIESLHQSVLLQEVLQAFTPLEEGVLIDCTLGLGGHSKALLSQKPHLKLIGIDKDKFA
CHHHHHHHHHHHHHHHHHHHCCHHCCEEEEEEECCCCCCHHHHCCCCCEEEEECCHHHHH
QEIAKERLKAFEGRYNLLSGGFAKRFKEALETHNKEIKGVLVDLGVSSLQLDDDNRGFNF
HHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHEECCCCEEEECCCCCCCCE
HSHTLDMRMDLKSDLNAQKVINSYPVVALEKIFRDYGEIKEYKKIAHKIAERRAKKPFKD
ECCCHHEEECHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AKDLSDFLSSLSKNKKIHPATLVFQAVRIEVNSELEELKEFLQCARNLKGAILCVISFHS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHH
LEDALVKNAFKDYAKNCICDPSSFQCTCSNNHALGAILTKKPITPSPEEIKNNRRSRSAK
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
MRVFQFKP
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA