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The map label for this gene is gyrA [H]

Identifier: 108563111

GI number: 108563111

Start: 719749

End: 722232

Strand: Direct

Name: gyrA [H]

Synonym: HPAG1_0686

Alternate gene names: 108563111

Gene position: 719749-722232 (Clockwise)

Preceding gene: 108563110

Following gene: 108563112

Centisome position: 45.09

GC content: 41.1

Gene sequence:

>2484_bases
ATGCAAGATCATTTAGTCAATGAAACAAAAAATATTGTAGAAGTGGGGATTGATTCTTCTATTGAAGAGAGCTATCTAGC
CTATTCCATGAGCGTGATCATAGGGCGTGCTTTACCGGACGCTAGAGATGGCTTAAAGCCTGTGCATAGGCGTATTTTGT
ATGCGATGCATGAATTAGGCCTTACTTCCAAAGTCGCTTATAAAAAAAGCGCTAGGATCGTGGGTGATGTGATTGGTAAA
TACCACCCCCATGGCGATAACGCGGTTTATGATGCGCTAGTGAGAATGGCGCAAGATTTTTCCATGCGTTTGGAATTAGT
GGATGGGCAGGGCAACTTTGGCTCTATTGATGGCGATAACGCTGCAGCGATGCGTTACACTGAAGCCAGAATGACTAAGG
CGAGTGAAGAAATTTTAAGGGATATTGATAAAGACACCATTGATTTTGTGCCTAATTACGATGACACCTTAAAAGAGCCA
GATATTTTACCAAGCCGTCTGCCTAACCTTTTAGTCAATGGGGCTAATGGGATCGCCGTAGGGATGGCGACTTCTATCCC
CCCTCATAGGATTGATGAAATCATAGACGCTTTAGCGCATGTCTTAGAAAACCCTAACGCTGAATTAGATGAAATTTTAG
AATTTGTCAAAGGGCCTGATTTTCCCACCGGTGGGATCATTTATGGTAAAGCAGGGATTATTGAATCCTATAAAACGGGG
CGAGGGCGCGTGAAAGTGCGGGCCAAAGTGCATGTGGAAAAGACGAAAAATAAAGAAATCATCGTTTTAGATGAAATGCC
TTTCCAAACCAATAAAGCCAAATTAGTGGAACAAATCAGCGATTTAGCACGAGAAAAGCAAATTGAAGGCATTAGCGAAG
TTCGTGATGAGAGCGATAGAGAGGGCATTAGAGTGGTGATTGAATTAAAAAGAGACGCAATGAGTGAAATTGTCTTAAAC
CACCTTTACAAACTCACCACTATGGAGACCACTTTTAGCATCATTCTACTCGCTATTTATAATAAAGAGCCTAAGATTTT
CACGCTTTTAGAGTTGTTGCGCCTTTTCTTAAACCACAGAAAAACCATTATTATAAGACGCACGATTTTTGAATTGGAAA
AGGCTAAAGCTAGAGCGCATATTTTAGAGGGCTATTTGATCGCACTAGACAATATTGATGAAATCGTGCAGCTCATTAAA
ACAAGCCCAAGCCCAGAAGCGGCTAAAAACGCCTTAATGGAGCGTTTTAGTTTGAGCGAAATCCAAAGCAAAGCCATTTT
AGAAATGCGTTTGCAACGCTTAACAGGCCTTGAAAGGGATAAGATCAAAGAAGAATACCAAAACTTATTAGAGCTTATTG
ATGATCTCAATGGCATTTTAAAGAGCGAAGAACGCTTGAATGAGGTCGTCAAAACAGAGCTTTTAGAAGTCAAAGAGCAA
TTTTCTTCTCCAAGACGCACTGAAATTCAAGAATCTTATGAAAATATTGACATAGAAGATTTGATCGCTAATGAGCCTAT
GGTGGTGAGCATTAGCTATAAAGGCTATGTGAAAAGAGTGGATTTAAAAGCTTATGAAAAGCAAAATCGTGGCGGTAAGG
GCAAGCTTTCAGGCAGCACTTATGAAGACGATTTCATTGAAAACTTTTTTGTGGCTAACACGCATGATATTTTGCTCTTT
ATCACCAATAAGGGGCAATTGTATCATTTGAAAGTCTATAAAATCCCAGAAGCGAGCCGGATCGCTATGGGTAAAGCTAT
TGTGAATTTAATCTCGCTCGCTCCGGATGAAAAGATCATGGCGACTCTAAGCACCAAAGACTTTAGCGATGAACGCTCTT
TAGCTTTCTTCACCAAAAAAGGCGTGGTGAAGCGCACCAATTTGAGCGAATTTGGGAGCAATAGGAGTTATAGCGGTATC
AGAGCGATTGTTTTAGATGAAGGCGATGAATTGGTGAGCGCAAAAGTTGTGGATAAAAACGCTAAGCATTTGCTCATCGC
ATCGCATTTGGGTATTTTCATTAAATTCCCTTTAGAAGATGTGCGCGAGATCGGAAGAACTACTCGTGGGGTTAAGGGTA
TTAGATTGGCTGAAAATGATTTTGTTGTCGGCGCGGTCGTTATTAGCGATGATGGCAACAAGCTTTTGAGCGTGAGTGAA
AACGGGCTTGGCAAGCAAACTTTAGCCGAAGCGTATAGAGAGCAAAATCGTGGAGGTAAGGGGATCATTGGCATGAGGCT
CACTCAAAAAACCGGCAATCTAGTGAGCGTTATCAGCGTGGATGATGAAAATTTGGATTTGATGATCCTTACTGCAAGCG
CGAAAATGATCAGAGTTTCTATTAAAGATATTAGAGAAACCGGAAGAAACGCTAGTGGGGTAAAGCTCATAAACACCGCC
GATAAAGTCATGTATGTCAATTCTTGCCCTAAAGAAGAAGAGCCAGAAAATTTAGAAAACACTCCTGCACAATTATTTGA
GTGA

Upstream 100 bases:

>100_bases
CATGGCCAGTGCAGCCCAACTGATAGGGCTTATTTTTTGGGCTTTTGTTTGGGGGCATTATCTTATAACGCTTTATTTTA
ATTAAATTTTAGGGAGACAC

Downstream 100 bases:

>100_bases
TGCGTTTCTTTTCATTCTTTTATTTTTTATTGTATTTTTTAGGGGTTTCTTTGCATGCCCTAAGCCCCCTAGAAGATCAA
GAATTTTTAATTTCGTATCG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 827; Mature: 827

Protein sequence:

>827_residues
MQDHLVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGK
YHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEP
DILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALAHVLENPNAELDEILEFVKGPDFPTGGIIYGKAGIIESYKTG
RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLN
HLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVQLIK
TSPSPEAAKNALMERFSLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEERLNEVVKTELLEVKEQ
FSSPRRTEIQESYENIDIEDLIANEPMVVSISYKGYVKRVDLKAYEKQNRGGKGKLSGSTYEDDFIENFFVANTHDILLF
ITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKKGVVKRTNLSEFGSNRSYSGI
RAIVLDEGDELVSAKVVDKNAKHLLIASHLGIFIKFPLEDVREIGRTTRGVKGIRLAENDFVVGAVVISDDGNKLLSVSE
NGLGKQTLAEAYREQNRGGKGIIGMRLTQKTGNLVSVISVDDENLDLMILTASAKMIRVSIKDIRETGRNASGVKLINTA
DKVMYVNSCPKEEEPENLENTPAQLFE

Sequences:

>Translated_827_residues
MQDHLVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGK
YHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEP
DILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALAHVLENPNAELDEILEFVKGPDFPTGGIIYGKAGIIESYKTG
RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLN
HLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVQLIK
TSPSPEAAKNALMERFSLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEERLNEVVKTELLEVKEQ
FSSPRRTEIQESYENIDIEDLIANEPMVVSISYKGYVKRVDLKAYEKQNRGGKGKLSGSTYEDDFIENFFVANTHDILLF
ITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKKGVVKRTNLSEFGSNRSYSGI
RAIVLDEGDELVSAKVVDKNAKHLLIASHLGIFIKFPLEDVREIGRTTRGVKGIRLAENDFVVGAVVISDDGNKLLSVSE
NGLGKQTLAEAYREQNRGGKGIIGMRLTQKTGNLVSVISVDDENLDLMILTASAKMIRVSIKDIRETGRNASGVKLINTA
DKVMYVNSCPKEEEPENLENTPAQLFE
>Mature_827_residues
MQDHLVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGK
YHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEP
DILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALAHVLENPNAELDEILEFVKGPDFPTGGIIYGKAGIIESYKTG
RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLN
HLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVQLIK
TSPSPEAAKNALMERFSLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEERLNEVVKTELLEVKEQ
FSSPRRTEIQESYENIDIEDLIANEPMVVSISYKGYVKRVDLKAYEKQNRGGKGKLSGSTYEDDFIENFFVANTHDILLF
ITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKKGVVKRTNLSEFGSNRSYSGI
RAIVLDEGDELVSAKVVDKNAKHLLIASHLGIFIKFPLEDVREIGRTTRGVKGIRLAENDFVVGAVVISDDGNKLLSVSE
NGLGKQTLAEAYREQNRGGKGIIGMRLTQKTGNLVSVISVDDENLDLMILTASAKMIRVSIKDIRETGRNASGVKLINTA
DKVMYVNSCPKEEEPENLENTPAQLFE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=343, Percent_Identity=25.6559766763848, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI19913408, Length=430, Percent_Identity=23.953488372093, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1788562, Length=829, Percent_Identity=47.0446320868516, Blast_Score=768, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=673, Percent_Identity=38.3358098068351, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI212645845, Length=474, Percent_Identity=23.4177215189873, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535065, Length=211, Percent_Identity=26.5402843601896, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=210, Percent_Identity=26.1904761904762, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=376, Percent_Identity=25, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92776; Mature: 92776

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDHLVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELG
CCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHCC
LTSKVAYKKSARIVGDVIGKYHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDN
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCC
AAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAV
CHHEEHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCHHHCCHHEEECCCCEEE
GMATSIPPHRIDEIIDALAHVLENPNAELDEILEFVKGPDFPTGGIIYGKAGIIESYKTG
EEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCHHCCCCC
RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDR
CCEEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCC
EGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHR
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCC
KTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVQLIKTSPSPEAAKNALMERFSLSE
CEEEEHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEERLNEVVKTELLEVKEQ
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FSSPRRTEIQESYENIDIEDLIANEPMVVSISYKGYVKRVDLKAYEKQNRGGKGKLSGST
HCCCCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCEEEEECHHHHHHHCCCCCCCCCCCC
YEDDFIENFFVANTHDILLFITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPDEKIM
CCHHHHHHEEEECCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHE
ATLSTKDFSDERSLAFFTKKGVVKRTNLSEFGSNRSYSGIRAIVLDEGDELVSAKVVDKN
EEECCCCCCCCCCEEEEECCCCEEECCHHHHCCCCCCCCEEEEEEECCCCEEEEEEECCC
AKHLLIASHLGIFIKFPLEDVREIGRTTRGVKGIRLAENDFVVGAVVISDDGNKLLSVSE
CCEEEEEECCCEEEECCHHHHHHHHHHHCCCCCEEEECCCEEEEEEEEECCCCEEEEECC
NGLGKQTLAEAYREQNRGGKGIIGMRLTQKTGNLVSVISVDDENLDLMILTASAKMIRVS
CCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCEEEEHH
IKDIRETGRNASGVKLINTADKVMYVNSCPKEEEPENLENTPAQLFE
HHHHHHCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MQDHLVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELG
CCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHCC
LTSKVAYKKSARIVGDVIGKYHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDN
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCC
AAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAV
CHHEEHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCHHHCCHHEEECCCCEEE
GMATSIPPHRIDEIIDALAHVLENPNAELDEILEFVKGPDFPTGGIIYGKAGIIESYKTG
EEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCHHCCCCC
RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDR
CCEEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCC
EGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHR
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCC
KTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVQLIKTSPSPEAAKNALMERFSLSE
CEEEEHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEERLNEVVKTELLEVKEQ
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FSSPRRTEIQESYENIDIEDLIANEPMVVSISYKGYVKRVDLKAYEKQNRGGKGKLSGST
HCCCCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCEEEEECHHHHHHHCCCCCCCCCCCC
YEDDFIENFFVANTHDILLFITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPDEKIM
CCHHHHHHEEEECCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHE
ATLSTKDFSDERSLAFFTKKGVVKRTNLSEFGSNRSYSGIRAIVLDEGDELVSAKVVDKN
EEECCCCCCCCCCEEEEECCCCEEECCHHHHCCCCCCCCEEEEEEECCCCEEEEEEECCC
AKHLLIASHLGIFIKFPLEDVREIGRTTRGVKGIRLAENDFVVGAVVISDDGNKLLSVSE
CCEEEEEECCCEEEECCHHHHHHHHHHHCCCCCEEEECCCEEEEEEEEECCCCEEEEECC
NGLGKQTLAEAYREQNRGGKGIIGMRLTQKTGNLVSVISVDDENLDLMILTASAKMIRVS
CCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCEEEEHH
IKDIRETGRNASGVKLINTADKVMYVNSCPKEEEPENLENTPAQLFE
HHHHHHCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]