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The map label for this gene is bioF [C]

Identifier: 108563003

GI number: 108563003

Start: 595498

End: 596619

Strand: Reverse

Name: bioF [C]

Synonym: HPAG1_0578

Alternate gene names: 108563003

Gene position: 596619-595498 (Counterclockwise)

Preceding gene: 108563004

Following gene: 108563002

Centisome position: 37.37

GC content: 39.04

Gene sequence:

>1122_bases
ATGTTTTCTAAATCTTTAGAAGCCCTACGCCATGCCAAACGCTACCGCAAAAGAGAGTTGTTTGACCCTTCATTAAAGGA
TTACGCTTCTAACGATTATTTGGGTTTGAGCGTTAAAAAAGACTTGCTTCAAAACGCTTTTGATAAGCTCCAATCCTTTG
ATGCTCATTCCCCCAAGGCTTCCATGCTAGTGAATGGCTACCACCCTTTGCATGCAGAATTAGAAGATCAATTAGCGGAT
TTGTTGGGGTTTGAAAGCGCTCTTTTAGTGGGGAGTGGTTTTTTGGGCAATCTGGCTTTGATAGACACCCTATTAGTCAA
AAACGCCCTCTTATTCATGGACGCACACTACCATGCAAGCGGTATTTTTAGCACCAAAGCTAAGCCCAATCAAGTGGTTT
TTTTCTCGCACAATGACGCTAAGGATTTAAAACAAAAACTCTTTAACGCTCCTAAAAATAAGCTCAAATTCATAGCCATT
GAGGGGGTTTATTCTATGGATGCGAGCGTCGCTCCTTATGATTTTTATGCAATCACTCAAGAAATTCCTAACGCTTTTTT
AATCGTTGATGAAGCCCATAGTTTTGGGACTATCGGCGAGAATTTATTGGGTTTTTTAGAATATTATCGCATCAAAGAAA
AAGATAAAATCATTAAACTCAGCACTTTCTCTAAAGCGCTTGCGAGCTATGGGGCGTGTATTTTAGCCCCCTTACAAATC
ATAGAGTTTTTAACCAATCGCGCTAAAAGCGTGATTTACACCACCGCTTTAAGCCTGTTAGACACCGCTTTGACTTTGGC
CCATTTAGAATACTTTATCGCGCAAAAACAAGAATTAAAAGATGAGCTTAGCAAACACCAACAGATTATTTTTGAAACTT
TAGGTATTAGAACGCTCGCAGGATTTTTTACTTTAGAATTTGAAAGCAATCCCGCTCTTTTAAACGCTCATCATTTTTTG
AAAGAAAAGGGGTTTTTAGTGGGAGCTATCCGCCCCCCCACGATTTCTAAACCCCTTTTACGAGTTTCTTTATCCCTCAA
AAACAGCTTAGAAGACACTAAAGAGCTTGCGAACGCCCTTTTAGATTATTCTAAAATACAATCTTCTTTTAAGAGTGATT
AA

Upstream 100 bases:

>100_bases
GAAAATATTGATAAGATGTTTTATGAAAAACAAGATGAACTCAATAAAATCATTGAAAAAATCCAAAAAGGCGAATGATT
TTATTCAATGAAGTGTTTTG

Downstream 100 bases:

>100_bases
TGTTAAAAAAGATTTTTTATGGTTTTATCGTTTTATTTTTGATTATCATAGGGTTATTGGCCATTCTTATCGCTCAAGTT
TGGGTAACTACGGATAAGGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MFSKSLEALRHAKRYRKRELFDPSLKDYASNDYLGLSVKKDLLQNAFDKLQSFDAHSPKASMLVNGYHPLHAELEDQLAD
LLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHASGIFSTKAKPNQVVFFSHNDAKDLKQKLFNAPKNKLKFIAI
EGVYSMDASVAPYDFYAITQEIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQI
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIAQKQELKDELSKHQQIIFETLGIRTLAGFFTLEFESNPALLNAHHFL
KEKGFLVGAIRPPTISKPLLRVSLSLKNSLEDTKELANALLDYSKIQSSFKSD

Sequences:

>Translated_373_residues
MFSKSLEALRHAKRYRKRELFDPSLKDYASNDYLGLSVKKDLLQNAFDKLQSFDAHSPKASMLVNGYHPLHAELEDQLAD
LLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHASGIFSTKAKPNQVVFFSHNDAKDLKQKLFNAPKNKLKFIAI
EGVYSMDASVAPYDFYAITQEIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQI
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIAQKQELKDELSKHQQIIFETLGIRTLAGFFTLEFESNPALLNAHHFL
KEKGFLVGAIRPPTISKPLLRVSLSLKNSLEDTKELANALLDYSKIQSSFKSD
>Mature_373_residues
MFSKSLEALRHAKRYRKRELFDPSLKDYASNDYLGLSVKKDLLQNAFDKLQSFDAHSPKASMLVNGYHPLHAELEDQLAD
LLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHASGIFSTKAKPNQVVFFSHNDAKDLKQKLFNAPKNKLKFIAI
EGVYSMDASVAPYDFYAITQEIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQI
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIAQKQELKDELSKHQQIIFETLGIRTLAGFFTLEFESNPALLNAHHFL
KEKGFLVGAIRPPTISKPLLRVSLSLKNSLEDTKELANALLDYSKIQSSFKSD

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4758668, Length=242, Percent_Identity=28.5123966942149, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI284448556, Length=363, Percent_Identity=24.7933884297521, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI7657118, Length=396, Percent_Identity=23.7373737373737, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI83977444, Length=346, Percent_Identity=27.7456647398844, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI83977442, Length=346, Percent_Identity=27.7456647398844, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI83977440, Length=346, Percent_Identity=27.7456647398844, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI119220554, Length=244, Percent_Identity=27.0491803278689, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4502025, Length=232, Percent_Identity=29.7413793103448, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI40316939, Length=232, Percent_Identity=29.7413793103448, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1786993, Length=345, Percent_Identity=28.4057971014493, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790046, Length=358, Percent_Identity=27.9329608938547, Blast_Score=105, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI32566772, Length=202, Percent_Identity=30.1980198019802, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994529, Length=238, Percent_Identity=27.3109243697479, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560912, Length=197, Percent_Identity=29.4416243654822, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560914, Length=197, Percent_Identity=29.4416243654822, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982617, Length=176, Percent_Identity=26.7045454545455, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71982625, Length=176, Percent_Identity=26.7045454545455, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320438, Length=367, Percent_Identity=25.8855585831063, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320267, Length=256, Percent_Identity=27.34375, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24662918, Length=360, Percent_Identity=26.9444444444444, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17137420, Length=249, Percent_Identity=29.3172690763052, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136286, Length=196, Percent_Identity=29.0816326530612, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24653280, Length=262, Percent_Identity=24.4274809160305, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653276, Length=262, Percent_Identity=24.4274809160305, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653278, Length=262, Percent_Identity=24.4274809160305, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41810; Mature: 41810

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKSLEALRHAKRYRKRELFDPSLKDYASNDYLGLSVKKDLLQNAFDKLQSFDAHSPKA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCH
SMLVNGYHPLHAELEDQLADLLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHAS
HEEECCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCCCC
GIFSTKAKPNQVVFFSHNDAKDLKQKLFNAPKNKLKFIAIEGVYSMDASVAPYDFYAITQ
CEEECCCCCCEEEEEECCCHHHHHHHHHHCCCHHEEEEEEECEEECCCCCCCHHHHHHHH
EIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQI
HCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHHHHHHHHH
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIAQKQELKDELSKHQQIIFETLGIRTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFFTLEFESNPALLNAHHFLKEKGFLVGAIRPPTISKPLLRVSLSLKNSLEDTKELANAL
HEEEEEECCCCCEEHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LDYSKIQSSFKSD
HHHHHHHHHHCCC
>Mature Secondary Structure
MFSKSLEALRHAKRYRKRELFDPSLKDYASNDYLGLSVKKDLLQNAFDKLQSFDAHSPKA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCH
SMLVNGYHPLHAELEDQLADLLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHAS
HEEECCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCCCC
GIFSTKAKPNQVVFFSHNDAKDLKQKLFNAPKNKLKFIAIEGVYSMDASVAPYDFYAITQ
CEEECCCCCCEEEEEECCCHHHHHHHHHHCCCHHEEEEEEECEEECCCCCCCHHHHHHHH
EIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQI
HCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHHHHHHHHH
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIAQKQELKDELSKHQQIIFETLGIRTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFFTLEFESNPALLNAHHFLKEKGFLVGAIRPPTISKPLLRVSLSLKNSLEDTKELANAL
HEEEEEECCCCCEEHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LDYSKIQSSFKSD
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]