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The map label for this gene is pyrC [H]

Identifier: 108562985

GI number: 108562985

Start: 577729

End: 578748

Strand: Reverse

Name: pyrC [H]

Synonym: HPAG1_0560

Alternate gene names: 108562985

Gene position: 578748-577729 (Counterclockwise)

Preceding gene: 108562986

Following gene: 108562984

Centisome position: 36.25

GC content: 40.0

Gene sequence:

>1020_bases
ATGGAAATCACGCTTTTTGACCCCATAGACGCCCACTTGCATGTGCGAGAAAACGCGCTTTTAAAAGCGGTATTAAGATA
TTCTAGCGAGCCTTTTAGCGCTGCGGTGATCATGCCTAATCTCAGTAAGCCCTTGATTGACACTCCAACCACCCTTGAAT
ATGAAGAAGAAATTTTAAAAAATTCTTCAAACTTCAAGCCTTTAATGAGTTTGTATTTTAACGATGATTTGACTTTAGAA
GAACTGCAACGCGCTCACGAAAAAGGCGTCAGGTTTTTAAAACTCTACCCCAAAGGCATGACCACAAACGCGCAGAACGG
CACTTCGGATTTGTTGGATGAAAAAACCTTAGAGATTTTAGAAAACGCCCAAAAATTAGGCTTTATTTTATGCATCCATG
CAGAACAAGCCGGGTTTTGTTTGGATAAAGAATTTTTATGCCATAGCGTTTTAGAAACTTTCGCCCTTTCATTCCCTAAA
CTCAAAATCATTATAGAGCATTTGAGCGATTGGCGCAGTATCGCTTTAATTGAAAAGCATGACAACCTCTATGCGACTTT
AACTTTACACCATATCAGCATGACTTTAGATGATTTATTGGGGGGGAGTTTGAACCCGCATTGTTTTTGCAAACCTTTAA
TCAAAACCAAAAAAGACCAAGAAAGGCTTTTATCCCTTGCTTTAAAAGCCCACCCTAAAATCTCTTTTGGCTCTGATAGC
GCCCCGCATTTTGTCTCTAAAAAACATAGCGCTAACATCCCAGCAGGCATCTTTTCTGCCCCTATTTTGCTGCCTGCGTT
ATGCGAACTTTTTGAAAAACACAACGCTTTAGAAAACTTGCAAGCCTTCATCAGCAATAACGCTAAAACAATCTATGGGC
TAGACAATTTGCCCAGTAAAAAAGCGCGTTTGTCTAAAAAACCCTTTATAGTCCCTACACACGCACTTTGTTTGAATGAA
AAAATCGCTATCTTAAGAGGGGGCGAAACGCTATCTTGGAACCTTCAAGAAATCGCCTAA

Upstream 100 bases:

>100_bases
CTTAAAGACCATTCAAATCGCTTATAAGGATTACCCACGCCCCAAAACTAAAACCCTCATTCGCATCAGAGTGCGCTATT
ACTTAGGAGGCAATTAAAAA

Downstream 100 bases:

>100_bases
AGCATGCCGCCTTTTTTGTGGGGCTTTTTATCGTTTTATTTTTAATTGTAATGAAGCACCAAACCCCCCCCTATGCTTTT
ATGCACAATCAAACCCTTTC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILKNSSNFKPLMSLYFNDDLTLE
ELQRAHEKGVRFLKLYPKGMTTNAQNGTSDLLDEKTLEILENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFVSKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISNNAKTIYGLDNLPSKKARLSKKPFIVPTHALCLNE
KIAILRGGETLSWNLQEIA

Sequences:

>Translated_339_residues
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILKNSSNFKPLMSLYFNDDLTLE
ELQRAHEKGVRFLKLYPKGMTTNAQNGTSDLLDEKTLEILENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFVSKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISNNAKTIYGLDNLPSKKARLSKKPFIVPTHALCLNE
KIAILRGGETLSWNLQEIA
>Mature_339_residues
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILKNSSNFKPLMSLYFNDDLTLE
ELQRAHEKGVRFLKLYPKGMTTNAQNGTSDLLDEKTLEILENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFVSKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISNNAKTIYGLDNLPSKKARLSKKPFIVPTHALCLNE
KIAILRGGETLSWNLQEIA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=339, Percent_Identity=30.6784660766962, Blast_Score=173, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323452, Length=361, Percent_Identity=32.409972299169, Blast_Score=165, Evalue=1e-41,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006992
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF04909 Amidohydro_2 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38045; Mature: 38045

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILK
CEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHC
NSSNFKPLMSLYFNDDLTLEELQRAHEKGVRFLKLYPKGMTTNAQNGTSDLLDEKTLEIL
CCCCCCHHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
ENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPKLKIIIEHLSDWRSIALIEKH
HHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHEEEEEEC
DNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
CCEEEEEEEEHHHHHHHHHHCCCCCCCCEECHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
APHFVSKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISNNAKTIYGLDNLPSK
CCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCH
KARLSKKPFIVPTHALCLNEKIAILRGGETLSWNLQEIA
HHHCCCCCEEEECHHHHHCCCEEEEECCCEEECCHHHCC
>Mature Secondary Structure
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILK
CEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHC
NSSNFKPLMSLYFNDDLTLEELQRAHEKGVRFLKLYPKGMTTNAQNGTSDLLDEKTLEIL
CCCCCCHHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
ENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPKLKIIIEHLSDWRSIALIEKH
HHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHEEEEEEC
DNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
CCEEEEEEEEHHHHHHHHHHCCCCCCCCEECHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
APHFVSKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISNNAKTIYGLDNLPSK
CCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCH
KARLSKKPFIVPTHALCLNEKIAILRGGETLSWNLQEIA
HHHCCCCCEEEECHHHHHCCCEEEEECCCEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA