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The map label for this gene is fabF [H]

Identifier: 108562961

GI number: 108562961

Start: 558008

End: 559246

Strand: Reverse

Name: fabF [H]

Synonym: HPAG1_0536

Alternate gene names: 108562961

Gene position: 559246-558008 (Counterclockwise)

Preceding gene: 108562962

Following gene: 108562960

Centisome position: 35.03

GC content: 44.63

Gene sequence:

>1239_bases
GTGCGTCGGATTGTAGTAACTGGAATGGGAATGATCAATTCGCTAGGTTTAAATAAAGAAGATTCTTTTTTAGCGATCGC
TAAAGGGGAATGCGGTATCAAACACATAGAAAGTTTTGATGCGAGCGCGTTTCCTGTGCGTATTGCTGGAGAAATCACTG
ACTTTGACCCTACAGAGGTGATGAATCCCAAAGATGTTAAAAAGGCGGGTCGTTTCATTCAATTAGCCTTGAAAGCCACA
AAAGAGGCGATGAAAGATAGTGGGATTTTAGACGCTCACAATAAATGCCCTGAAGAATTGGCAAATCGCATGGGCGTAAG
CTCTGGCTCTGGGATTGGCGGGTTAGGCAATATTGAAGCGAATTCCATTTTTTGTTTTGAAAAAGGCCCTAGAAAAGTCA
ACCCCTTTTTCATCACTTCTGCGTTAGTGAATATGATTGGTGGTTTCACTTCCATTGAGTTTGGCATTAAAGGGCCTAAT
CTCTCTAGCGTAACGGCTTGTGCAGCAGGCACTCATGCCATTATTGAAGCCGTTAAAACCATTCTGCTTAATGGGGCTGA
TAAAATGCTAGTCGTGGGAGCGGAATCCACCATTTGTCCTGTAGGGATTGGGGGGTTTGCGAGCATTAAAGCCCTTTCTA
CAAGGAATGATGATCCCAAAAAAGCTTCAAGACCTTTTGATAAGGATCGCAATGGTTTTGTGATGGGCGAAGGCGCTGGG
GCTTTGGTGCTTGAAGAATACGAGAGTGCGAAAAAAAGAGGAGCAAAAATTTATGCAGAATTTGCTGGGTATGGCGAGAG
CGGCGATGCTAACCACATCACAGCCCCAGCCCCTGAGGGTGAAGGGGCTTTTAGAGCCATGAAAATGGCTTTAGAAATGG
CGAAAGTGGAAGTAGGCTATGTGAACGCTCATGGGACTAGCACGCATTATAACGATTGGTATGAAAGCATCGCTTTAAAA
AATGTGTTTGGCTCTAAAGAAAAAGTTCCTCCTGTTAGCTCCACTAAAGGGCAGATTGGGCATTGTTTGGGCGCTGCGGG
TGCGTTAGAAGCCGTTATTTCTATCATGGCCATGAATCAAGGGATCTTACCTCCTACCATCAATCAAGAAACGCCTGACC
CCGAATGCGATCTGGATTATATCCCTAATGCGGCCAGAGAAAAACAAGTGGATGCGGTGATGAGTAACTCATTTGGTTTT
GGTGGCACTAATGGTGTTGTGATTTTCAAAAAAGCCTAA

Upstream 100 bases:

>100_bases
CTTTCGTGTTAGCATTCAATGGAATGCTTTAGTTAGGAAGCCCCTTTCTTTAGAAAGGGGCGGTTTCACTGAATTAAAGT
TTTGAAATGAGGAGCTATTG

Downstream 100 bases:

>100_bases
TTTTAAAAGTTGGGAATTTGAATGGCCATTTATTTAGATTTCGAAAATCATATTAAAGAGATTCAAAATGAAATTGAATT
AGCCCTTATTAGAGGCGATG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKHIESFDASAFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAT
KEAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPN
LSSVTACAAGTHAIIEAVKTILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEVGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGF
GGTNGVVIFKKA

Sequences:

>Translated_412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKHIESFDASAFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAT
KEAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPN
LSSVTACAAGTHAIIEAVKTILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEVGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGF
GGTNGVVIFKKA
>Mature_412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKHIESFDASAFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAT
KEAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPN
LSSVTACAAGTHAIIEAVKTILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEVGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGF
GGTNGVVIFKKA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=42.1428571428571, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=49.3150684931507, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI41872631, Length=393, Percent_Identity=24.1730279898219, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=49.2753623188406, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=36.0381861575179, Blast_Score=237, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=35.8669833729216, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=41.6666666666667, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=430, Percent_Identity=26.9767441860465, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=367, Percent_Identity=26.7029972752044, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=35.6502242152466, Blast_Score=239, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=41.5865384615385, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI221330659, Length=391, Percent_Identity=27.8772378516624, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19920632, Length=391, Percent_Identity=27.8772378516624, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24581345, Length=398, Percent_Identity=26.8844221105528, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43481; Mature: 43481

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKHIESFDASAFPVRIAGEITDFDPTEV
CCEEEEECCCHHHHCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEEEECCCCCCCCHHC
MNPKDVKKAGRFIQLALKATKEAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
NSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPNLSSVTACAAGTHAIIEAVKT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHHH
ILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
HHHCCCCCEEEEECCCCCCEECCCCHHHEEEECCCCCCCHHHCCCCCCCCCCEEEECCCC
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEVGY
EEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHEEEEE
VNAHGTSTHYNDWYESIALKNVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQ
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGFGGTNGVVIFKKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKHIESFDASAFPVRIAGEITDFDPTEV
CCEEEEECCCHHHHCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEEEECCCCCCCCHHC
MNPKDVKKAGRFIQLALKATKEAMKDSGILDAHNKCPEELANRMGVSSGSGIGGLGNIEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
NSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPNLSSVTACAAGTHAIIEAVKT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHHH
ILLNGADKMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAG
HHHCCCCCEEEEECCCCCCEECCCCHHHEEEECCCCCCCHHHCCCCCCCCCCEEEECCCC
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEVGY
EEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHEEEEE
VNAHGTSTHYNDWYESIALKNVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQ
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GILPPTINQETPDPECDLDYIPNAAREKQVDAVMSNSFGFGGTNGVVIFKKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]