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The map label for this gene is pyrD [H]

Identifier: 108562860

GI number: 108562860

Start: 443733

End: 444788

Strand: Reverse

Name: pyrD [H]

Synonym: HPAG1_0435

Alternate gene names: 108562860

Gene position: 444788-443733 (Counterclockwise)

Preceding gene: 108562861

Following gene: 108562859

Centisome position: 27.86

GC content: 39.58

Gene sequence:

>1056_bases
ATGCTTTATTCATTAGTAAAAAAATATCTTTTTAGCCTGGACGCTGAAGACGCGCATGAAAAAGTGTGTAAGATTTTAAG
AATGCTTTCTTCATCGCCCTTTTTGTGCAATTTGATTGATTCTCAATGGGGTTATAAAAACCCAAAGCTTGAAAATGAAA
TTTTAGGCTTGCATTTCCCTAACCCCTTAGGTTTAGCCGCCGGTTTTGATAAAAACGCTTCCATGCTCAGGGCGTTAACC
GCTTTTGGGTTTGGCTATTTAGAAGCAGGCACTCTCACCAATGAAGCGCAAATGGGGAATGAAAGACCAAGGCTTTTCAG
GCACATTGAAGAAGAGTCCTTGCAAAATGCGATGGGGTTTAATAATTACGGGGCGGTTTTAGGAGCGAGATCGTTTAAGC
GCTTCGCCCCTTATAAAACCCCCATTGGCATCAATTTAGGCAAAAACAAACACATAGAACAAGCGCATGCCCTAGAAGAT
TACAAGGCGGTTTTAAATCAATGTTTAAACATTGGCGATTATTACACTTTCAACCTTTCTTCGCCCAACACCCCTAATTT
AAGGGATTTACAAAATAAAGCGTTTGTGCATGAGCTTTTTTGCATGGCGAAAGAAATGACCCATAAGCCTTTATTTTTAA
AAATCGCTCCGGATTTAGAAACAGATGACATGCTAGAGATTGTCAATAGCGCTATTGAAGCCGGAGCGCATGGGATTATT
GCGACTAACACCACGATTGATAAAAGCCTGGTATTCGCTCCTAAAGAAATGGGGGGCTTGAGCGGGAAATGCTTGACCAA
AAAAAGCCGTGAAATCTTTAAAGAATTGGCTAAAGCTTTTTTTAACAAGACTATTCTTGTTTCTGTGGGGGGGATTAGCG
GTGCCAAAGAAGCTTATGAAAGGATTAAAATGGGAGCGAGTCTGTTACAAATTTATAGCGCTTTTATTTACAACGGGCCA
AATTTATGCCAAAATATTCTTAAAGATTTGGTAAAATTACTCCAAAAAGATGGATTTTTGAGCGTTAAAGAGGCTATAGG
AGCGGATTTAAGATGA

Upstream 100 bases:

>100_bases
AACCCTAACGATCCTTTAAATTCGCAGGATTATTTTGAAAAACAAGCCCTTAAAACCTTTTGAAGGTTATCGTTCAAATC
ATAAAAGATTAAGGATTTAA

Downstream 100 bases:

>100_bases
GATATTTTTCTGTTAAAAGACTTTTAGGGCTTAGTTCTGTCTTGTTAGTCACTTTAGGAGCGAGCATGCACGCACAATCT
TACTTACCCAAACATGAGAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MLYSLVKKYLFSLDAEDAHEKVCKILRMLSSSPFLCNLIDSQWGYKNPKLENEILGLHFPNPLGLAAGFDKNASMLRALT
AFGFGYLEAGTLTNEAQMGNERPRLFRHIEEESLQNAMGFNNYGAVLGARSFKRFAPYKTPIGINLGKNKHIEQAHALED
YKAVLNQCLNIGDYYTFNLSSPNTPNLRDLQNKAFVHELFCMAKEMTHKPLFLKIAPDLETDDMLEIVNSAIEAGAHGII
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKTILVSVGGISGAKEAYERIKMGASLLQIYSAFIYNGP
NLCQNILKDLVKLLQKDGFLSVKEAIGADLR

Sequences:

>Translated_351_residues
MLYSLVKKYLFSLDAEDAHEKVCKILRMLSSSPFLCNLIDSQWGYKNPKLENEILGLHFPNPLGLAAGFDKNASMLRALT
AFGFGYLEAGTLTNEAQMGNERPRLFRHIEEESLQNAMGFNNYGAVLGARSFKRFAPYKTPIGINLGKNKHIEQAHALED
YKAVLNQCLNIGDYYTFNLSSPNTPNLRDLQNKAFVHELFCMAKEMTHKPLFLKIAPDLETDDMLEIVNSAIEAGAHGII
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKTILVSVGGISGAKEAYERIKMGASLLQIYSAFIYNGP
NLCQNILKDLVKLLQKDGFLSVKEAIGADLR
>Mature_351_residues
MLYSLVKKYLFSLDAEDAHEKVCKILRMLSSSPFLCNLIDSQWGYKNPKLENEILGLHFPNPLGLAAGFDKNASMLRALT
AFGFGYLEAGTLTNEAQMGNERPRLFRHIEEESLQNAMGFNNYGAVLGARSFKRFAPYKTPIGINLGKNKHIEQAHALED
YKAVLNQCLNIGDYYTFNLSSPNTPNLRDLQNKAFVHELFCMAKEMTHKPLFLKIAPDLETDDMLEIVNSAIEAGAHGII
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKTILVSVGGISGAKEAYERIKMGASLLQIYSAFIYNGP
NLCQNILKDLVKLLQKDGFLSVKEAIGADLR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=358, Percent_Identity=36.8715083798883, Blast_Score=208, Evalue=7e-54,
Organism=Escherichia coli, GI1787177, Length=339, Percent_Identity=41.0029498525074, Blast_Score=238, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17509475, Length=360, Percent_Identity=38.8888888888889, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281361352, Length=352, Percent_Identity=34.9431818181818, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17137316, Length=352, Percent_Identity=34.9431818181818, Blast_Score=198, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39032; Mature: 39032

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSLVKKYLFSLDAEDAHEKVCKILRMLSSSPFLCNLIDSQWGYKNPKLENEILGLHFP
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCCCEEEEECC
NPLGLAAGFDKNASMLRALTAFGFGYLEAGTLTNEAQMGNERPRLFRHIEEESLQNAMGF
CCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCC
NNYGAVLGARSFKRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNQCLNIGDYYTFNLS
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SPNTPNLRDLQNKAFVHELFCMAKEMTHKPLFLKIAPDLETDDMLEIVNSAIEAGAHGII
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKTILVSVGGISGAKEAYE
EECCCCCCHHEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHH
RIKMGASLLQIYSAFIYNGPNLCQNILKDLVKLLQKDGFLSVKEAIGADLR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCC
>Mature Secondary Structure
MLYSLVKKYLFSLDAEDAHEKVCKILRMLSSSPFLCNLIDSQWGYKNPKLENEILGLHFP
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCCCEEEEECC
NPLGLAAGFDKNASMLRALTAFGFGYLEAGTLTNEAQMGNERPRLFRHIEEESLQNAMGF
CCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCC
NNYGAVLGARSFKRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNQCLNIGDYYTFNLS
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SPNTPNLRDLQNKAFVHELFCMAKEMTHKPLFLKIAPDLETDDMLEIVNSAIEAGAHGII
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKTILVSVGGISGAKEAYE
EECCCCCCHHEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHH
RIKMGASLLQIYSAFIYNGPNLCQNILKDLVKLLQKDGFLSVKEAIGADLR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA