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The map label for this gene is acsA [H]

Identifier: 108562827

GI number: 108562827

Start: 410346

End: 412334

Strand: Reverse

Name: acsA [H]

Synonym: HPAG1_0402

Alternate gene names: 108562827

Gene position: 412334-410346 (Counterclockwise)

Preceding gene: 108562830

Following gene: 108562814

Centisome position: 25.83

GC content: 41.63

Gene sequence:

>1989_bases
ATGCAATTAGACGATGATTTGGAATTCGCTAAAAAAATCTTTAACCCTAACAGAGCGTTTGCCAAGCAAGCCAGGATTAA
AAACATGTGCGAATATAAAGATTTAGTGCATGAAGCCAATGAAGATTATGAACATTTTTGGGGCGAGTTAGCCAAGCAAA
AACTCACATGGTTTAAACCTTTTGATAAGGTTTTAAACAGCGATAACGCCCCTTTTTTCAAATGGTTTGAAAACGGCAAG
ATCAATGTTTCTTACAATTGCATAGACAGGCATTTAAAAGACAAAAAAAATAAAGTGGCGATCATTTTTGAAGGGGAAAT
GGGGGATTATAATGTCATCACTTACAGAAAACTCCACTCTGAAGTCAATAAAACAGCCAACCTTTTAAAAAACGAATTCA
ATGTCAAAAAAGGCGATAGAGTCATTATCTATATGCCTATGATTGTAGAAAGCGTTTATATGATGCTCGCATGCGCTAGG
ATTGGAGCGATCCATAGCATCGTTTTTGCTGGGTTTAGCCCTGAAGCCTTAAGGGATAGGATCAACGACGCTCAAGCTAA
ATTAGTTATCACAGCGGACGGGACTTTTAGAAAAGGCAAACCTTATATGCTCAAGCCAGCCCTTGACAAGGCTCTAGAAA
ATAACGCCTGCCCTAGCGTGGAAAAAGCGCTCATTGTGATACGAAACGCCAAAGAGATTGACTATGTGAGAGGGCGCGAT
TTTGTCTATAATGAAATGGTCAATTACCAATCCGATAAATGCGAGCCTGAAATGATGGACTCTGAAGATCCTTTATTCTT
GCTCTATACAAGCGGATCAACCGGAAAGCCTAAAGGCGTTCAACACAGCAATGCAGGGTATTTGCTATGGGCGCAAATGA
CGATGGAGTGGGTTTTTGATATTAGAGATAACGATAATTTTTGGTGCACCGCTGATATTGGCTGGATCACAGGGCACACT
TATGTGGTTTATGGGCCCTTAGCTTGTGGGGCGACAACTTTGATACTAGAAGGCACGATGTCTTATCCGGATTATGGAAG
ATGGTGGAGAATGATAGAAGAATACCGCGTGGATAAATTCTACACTTCCCCCACTGCTATAAGAATGCTGCATGCCAAAG
GCGAAAACGAACCCTTAAAGTATAATTTAGAGTCACTCAAAGTTTTAGGAACGGTAGGAGAGCCCATTAACCCTACGGCA
TGGAAATGGTTTTATGAAAAAATCGGCAACTCAAAATGCAGTATCGTGGATACTTGGTGGCAGACAGAAACAGGTGGGCA
TATCATCAGCCCTTTACCGGGAGCTACGCCTATAAGGGCCAGCTGTGCAACTTTGCCTTTGCCTGGAATCCATGCAGAAG
TTTTAAACGAAGACGGCACCAAAACAAAGCCCGGAGAGCAAGGGTTTTTATGCATCACTAAGCCATGGCCTTCTATGGTA
AGAAACATTTGGGGCGATGAAAAACGATACATTGATAGCTATTTTTCTCAGATCAAGTTGAATGGGGAATATGTCTACCT
CTCTGGAGATGGCGCTATCGTGGATGAAAACGGATACATCACTATTATTGGGCGCACAGATGATATTGTGAATGTGAGTG
GGCATAGGATTGGCACGGCTGAAGTGGAGAGCGCTATTTCTAAACATGAAATGGTGGTTGAATGCGCGGTAGTGGGTATC
CCTGATACGATTAAAGGAGAGGGCTTGTTTGCGTTTGTGGTGCTGTGTGATGGGGCTAAATGCAATCTTGGCGAGAGTTT
AGAATTATTAAAAGAAATGAATCATATCTTATCCGTTGAAATTGGAAAGATCGCTAAATTAGACAATGTCATGTATGTGC
CGGGTTTACCTAAAACCAGAAGCGGGAAAATCATGAGAAGGCTTTTAAAATCCATCGCCAAAAAAGAGCCCATCACTCAA
GATTTAAGCACGCTAGAAGATGTGAATGTGGTTAAAGAAATAATGAGTATCGTTCAAATGGAAGAGTGA

Upstream 100 bases:

>100_bases
CAATCCCCACAGAAAGAGAAAAGTATCCCTCCCTTTAAAAGAGTGTGAGTTTGGATACAATAATAAAAAATGCGCTTAAA
ACCATGAAAAAGGAGATGCG

Downstream 100 bases:

>100_bases
AATCTCAAAAATGCTTTTTGGCGTTTTTTAGCCAAATAACAAGAGCCAATTTCAATCAAGCGGTAATTTCTCATAAAGTG
TAGGAAACGCTACCGCTTCG

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MQLDDDLEFAKKIFNPNRAFAKQARIKNMCEYKDLVHEANEDYEHFWGELAKQKLTWFKPFDKVLNSDNAPFFKWFENGK
INVSYNCIDRHLKDKKNKVAIIFEGEMGDYNVITYRKLHSEVNKTANLLKNEFNVKKGDRVIIYMPMIVESVYMMLACAR
IGAIHSIVFAGFSPEALRDRINDAQAKLVITADGTFRKGKPYMLKPALDKALENNACPSVEKALIVIRNAKEIDYVRGRD
FVYNEMVNYQSDKCEPEMMDSEDPLFLLYTSGSTGKPKGVQHSNAGYLLWAQMTMEWVFDIRDNDNFWCTADIGWITGHT
YVVYGPLACGATTLILEGTMSYPDYGRWWRMIEEYRVDKFYTSPTAIRMLHAKGENEPLKYNLESLKVLGTVGEPINPTA
WKWFYEKIGNSKCSIVDTWWQTETGGHIISPLPGATPIRASCATLPLPGIHAEVLNEDGTKTKPGEQGFLCITKPWPSMV
RNIWGDEKRYIDSYFSQIKLNGEYVYLSGDGAIVDENGYITIIGRTDDIVNVSGHRIGTAEVESAISKHEMVVECAVVGI
PDTIKGEGLFAFVVLCDGAKCNLGESLELLKEMNHILSVEIGKIAKLDNVMYVPGLPKTRSGKIMRRLLKSIAKKEPITQ
DLSTLEDVNVVKEIMSIVQMEE

Sequences:

>Translated_662_residues
MQLDDDLEFAKKIFNPNRAFAKQARIKNMCEYKDLVHEANEDYEHFWGELAKQKLTWFKPFDKVLNSDNAPFFKWFENGK
INVSYNCIDRHLKDKKNKVAIIFEGEMGDYNVITYRKLHSEVNKTANLLKNEFNVKKGDRVIIYMPMIVESVYMMLACAR
IGAIHSIVFAGFSPEALRDRINDAQAKLVITADGTFRKGKPYMLKPALDKALENNACPSVEKALIVIRNAKEIDYVRGRD
FVYNEMVNYQSDKCEPEMMDSEDPLFLLYTSGSTGKPKGVQHSNAGYLLWAQMTMEWVFDIRDNDNFWCTADIGWITGHT
YVVYGPLACGATTLILEGTMSYPDYGRWWRMIEEYRVDKFYTSPTAIRMLHAKGENEPLKYNLESLKVLGTVGEPINPTA
WKWFYEKIGNSKCSIVDTWWQTETGGHIISPLPGATPIRASCATLPLPGIHAEVLNEDGTKTKPGEQGFLCITKPWPSMV
RNIWGDEKRYIDSYFSQIKLNGEYVYLSGDGAIVDENGYITIIGRTDDIVNVSGHRIGTAEVESAISKHEMVVECAVVGI
PDTIKGEGLFAFVVLCDGAKCNLGESLELLKEMNHILSVEIGKIAKLDNVMYVPGLPKTRSGKIMRRLLKSIAKKEPITQ
DLSTLEDVNVVKEIMSIVQMEE
>Mature_662_residues
MQLDDDLEFAKKIFNPNRAFAKQARIKNMCEYKDLVHEANEDYEHFWGELAKQKLTWFKPFDKVLNSDNAPFFKWFENGK
INVSYNCIDRHLKDKKNKVAIIFEGEMGDYNVITYRKLHSEVNKTANLLKNEFNVKKGDRVIIYMPMIVESVYMMLACAR
IGAIHSIVFAGFSPEALRDRINDAQAKLVITADGTFRKGKPYMLKPALDKALENNACPSVEKALIVIRNAKEIDYVRGRD
FVYNEMVNYQSDKCEPEMMDSEDPLFLLYTSGSTGKPKGVQHSNAGYLLWAQMTMEWVFDIRDNDNFWCTADIGWITGHT
YVVYGPLACGATTLILEGTMSYPDYGRWWRMIEEYRVDKFYTSPTAIRMLHAKGENEPLKYNLESLKVLGTVGEPINPTA
WKWFYEKIGNSKCSIVDTWWQTETGGHIISPLPGATPIRASCATLPLPGIHAEVLNEDGTKTKPGEQGFLCITKPWPSMV
RNIWGDEKRYIDSYFSQIKLNGEYVYLSGDGAIVDENGYITIIGRTDDIVNVSGHRIGTAEVESAISKHEMVVECAVVGI
PDTIKGEGLFAFVVLCDGAKCNLGESLELLKEMNHILSVEIGKIAKLDNVMYVPGLPKTRSGKIMRRLLKSIAKKEPITQ
DLSTLEDVNVVKEIMSIVQMEE

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI253970489, Length=691, Percent_Identity=43.5600578871201, Blast_Score=560, Evalue=1e-159,
Organism=Homo sapiens, GI8923896, Length=678, Percent_Identity=44.1002949852507, Blast_Score=559, Evalue=1e-159,
Organism=Homo sapiens, GI28416953, Length=635, Percent_Identity=44.8818897637795, Blast_Score=544, Evalue=1e-154,
Organism=Homo sapiens, GI13375727, Length=650, Percent_Identity=34.6153846153846, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI38505220, Length=523, Percent_Identity=27.151051625239, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI122937307, Length=527, Percent_Identity=27.134724857685, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI42544132, Length=520, Percent_Identity=27.6923076923077, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI31982927, Length=643, Percent_Identity=25.194401244168, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI58082049, Length=523, Percent_Identity=27.5334608030593, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI115511026, Length=535, Percent_Identity=25.7943925233645, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI157311624, Length=523, Percent_Identity=26.7686424474187, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI157311622, Length=523, Percent_Identity=26.7686424474187, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI195947378, Length=459, Percent_Identity=23.7472766884532, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI42544134, Length=313, Percent_Identity=25.8785942492013, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI156151445, Length=547, Percent_Identity=24.6800731261426, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI187761345, Length=424, Percent_Identity=23.8207547169811, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI187761343, Length=424, Percent_Identity=23.8207547169811, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790505, Length=633, Percent_Identity=46.9194312796209, Blast_Score=599, Evalue=1e-172,
Organism=Escherichia coli, GI1786529, Length=641, Percent_Identity=36.6614664586583, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1788107, Length=544, Percent_Identity=24.0808823529412, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI221142682, Length=539, Percent_Identity=24.1187384044527, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI145693145, Length=551, Percent_Identity=23.049001814882, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786810, Length=532, Percent_Identity=21.4285714285714, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71983001, Length=667, Percent_Identity=43.328335832084, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI71982997, Length=676, Percent_Identity=43.1952662721894, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17569507, Length=658, Percent_Identity=23.4042553191489, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531443, Length=490, Percent_Identity=25.9183673469388, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17557194, Length=562, Percent_Identity=24.7330960854093, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=567, Percent_Identity=23.2804232804233, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=531, Percent_Identity=21.4689265536723, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=414, Percent_Identity=22.2222222222222, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560140, Length=520, Percent_Identity=21.1538461538462, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=134, Percent_Identity=30.5970149253731, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323182, Length=648, Percent_Identity=44.7530864197531, Blast_Score=545, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6319264, Length=664, Percent_Identity=44.7289156626506, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6319699, Length=537, Percent_Identity=21.7877094972067, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24667955, Length=669, Percent_Identity=46.6367713004484, Blast_Score=586, Evalue=1e-167,
Organism=Drosophila melanogaster, GI62472339, Length=557, Percent_Identity=50.2692998204668, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24667959, Length=525, Percent_Identity=49.9047619047619, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI21355225, Length=643, Percent_Identity=32.1928460342146, Blast_Score=328, Evalue=9e-90,
Organism=Drosophila melanogaster, GI18859661, Length=532, Percent_Identity=25.187969924812, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24648260, Length=376, Percent_Identity=23.1382978723404, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656500, Length=373, Percent_Identity=22.7882037533512, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358303, Length=486, Percent_Identity=20.9876543209877, Blast_Score=70, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 75030; Mature: 75030

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLDDDLEFAKKIFNPNRAFAKQARIKNMCEYKDLVHEANEDYEHFWGELAKQKLTWFKP
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCH
FDKVLNSDNAPFFKWFENGKINVSYNCIDRHLKDKKNKVAIIFEGEMGDYNVITYRKLHS
HHHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEEECCCCCCEEEEHHHHHH
EVNKTANLLKNEFNVKKGDRVIIYMPMIVESVYMMLACARIGAIHSIVFAGFSPEALRDR
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
INDAQAKLVITADGTFRKGKPYMLKPALDKALENNACPSVEKALIVIRNAKEIDYVRGRD
CCCCCEEEEEEECCCCCCCCCEEECHHHHHHHCCCCCCCHHEEEEEEECCCCCCCCCCCC
FVYNEMVNYQSDKCEPEMMDSEDPLFLLYTSGSTGKPKGVQHSNAGYLLWAQMTMEWVFD
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEEEE
IRDNDNFWCTADIGWITGHTYVVYGPLACGATTLILEGTMSYPDYGRWWRMIEEYRVDKF
EECCCCEEEEEECCEEECCEEEEEECHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHHE
YTSPTAIRMLHAKGENEPLKYNLESLKVLGTVGEPINPTAWKWFYEKIGNSKCSIVDTWW
ECCCHHEEEEECCCCCCCEEECHHHEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECC
QTETGGHIISPLPGATPIRASCATLPLPGIHAEVLNEDGTKTKPGEQGFLCITKPWPSMV
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCHHHH
RNIWGDEKRYIDSYFSQIKLNGEYVYLSGDGAIVDENGYITIIGRTDDIVNVSGHRIGTA
HHHCCCHHHHHHHHHHHEEECCEEEEEECCCEEEECCCEEEEEECCCCEEECCCCCCCHH
EVESAISKHEMVVECAVVGIPDTIKGEGLFAFVVLCDGAKCNLGESLELLKEMNHILSVE
HHHHHHHHHHEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHEEE
IGKIAKLDNVMYVPGLPKTRSGKIMRRLLKSIAKKEPITQDLSTLEDVNVVKEIMSIVQM
HHHHEECCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
EE
CC
>Mature Secondary Structure
MQLDDDLEFAKKIFNPNRAFAKQARIKNMCEYKDLVHEANEDYEHFWGELAKQKLTWFKP
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCH
FDKVLNSDNAPFFKWFENGKINVSYNCIDRHLKDKKNKVAIIFEGEMGDYNVITYRKLHS
HHHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEEECCCCCCEEEEHHHHHH
EVNKTANLLKNEFNVKKGDRVIIYMPMIVESVYMMLACARIGAIHSIVFAGFSPEALRDR
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
INDAQAKLVITADGTFRKGKPYMLKPALDKALENNACPSVEKALIVIRNAKEIDYVRGRD
CCCCCEEEEEEECCCCCCCCCEEECHHHHHHHCCCCCCCHHEEEEEEECCCCCCCCCCCC
FVYNEMVNYQSDKCEPEMMDSEDPLFLLYTSGSTGKPKGVQHSNAGYLLWAQMTMEWVFD
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEEEE
IRDNDNFWCTADIGWITGHTYVVYGPLACGATTLILEGTMSYPDYGRWWRMIEEYRVDKF
EECCCCEEEEEECCEEECCEEEEEECHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHHE
YTSPTAIRMLHAKGENEPLKYNLESLKVLGTVGEPINPTAWKWFYEKIGNSKCSIVDTWW
ECCCHHEEEEECCCCCCCEEECHHHEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECC
QTETGGHIISPLPGATPIRASCATLPLPGIHAEVLNEDGTKTKPGEQGFLCITKPWPSMV
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCHHHH
RNIWGDEKRYIDSYFSQIKLNGEYVYLSGDGAIVDENGYITIIGRTDDIVNVSGHRIGTA
HHHCCCHHHHHHHHHHHEEECCEEEEEECCCEEEECCCEEEEEECCCCEEECCCCCCCHH
EVESAISKHEMVVECAVVGIPDTIKGEGLFAFVVLCDGAKCNLGESLELLKEMNHILSVE
HHHHHHHHHHEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHEEE
IGKIAKLDNVMYVPGLPKTRSGKIMRRLLKSIAKKEPITQDLSTLEDVNVVKEIMSIVQM
HHHHEECCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
EE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA