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The map label for this gene is hemA [H]

Identifier: 108562667

GI number: 108562667

Start: 246783

End: 248132

Strand: Reverse

Name: hemA [H]

Synonym: HPAG1_0242

Alternate gene names: 108562667

Gene position: 248132-246783 (Counterclockwise)

Preceding gene: 108562668

Following gene: 108562666

Centisome position: 15.54

GC content: 38.15

Gene sequence:

>1350_bases
ATGGAGTTAGAAACTCATTTGTCAAAATATTTCACCCTAGCCTTTACGCATAAAAGCATGAGCTTAGAAATGCGAGAAAA
ACTCGCTATCAATTCAAGCGCAACGCTTAAAGAATTTTTACAAACCATTAAAAACCATTGCCCTAACATCAAAGAGTGCA
TGGTGTTATCCACATGCAACCGCTTTGAAATCTATGCGAGCCTAAGGCATGGCGCTCACGCTAATGAACAAAAAAGCGCG
TTATTAAAAATTTTGGCTCAAAATAAAAAAATGAGCGTGTCTGATTTAGAAAAATGCGTTTTAATGAACACTGATGAAAG
CGCCGTCCATCATGTCTTTAGCGTGTGCAGCAGTTTGGATAGCCTAGTAGTGGGGGAAACTCAAATCACAGGGCAGATGA
AAAACGCCTATAAATTCGCTTTTGAAGAGAAATTTTGCTCCAAAGATTTAACCCGATTGCTCCATTTTGCTTTCAAATGC
GCCGCTAAAGTGCGCAATTTAACCGGCATTTCCAAGCAAGGGGTCTCCATCTCTTCAGTGGCAGTCAAAGAAGCGCTTAA
TATTTTTGAAAAAGAAAGGATTAAGGATAAAAAAGCCCTTGTGATAGGGCTTGGCGAGATGGCTCAATTAGTCATCAAAC
ACCTTTTAAACAAGCAATTTGAAGCGCTTATCTTAGGGCGTAATGCGGCTAAATTTGAAGATTTCATCAAAGAATTAGAA
GAGCCTAAAAAAGTAAGCTTTCAAAATATAGAAAATTTAAACGCTTATATCAATGAATACGAATTGCTTTTTTGCGCCAC
TTCTTCGCCGCATTTTATCGTGCAAAATTCCATGTTAAAAGAAACGATTTTCAGGCGTTTTTGGTTTGATTTAGCCGTGC
CAAGGAATATTGAAAAGCCGGTATTGGATAATATTTTCTTATACAGCGTGGATGATTTAGAGCCTATGGTGAAAGAAAAT
GTGGGAAACAGACAAGAGAGTAGGACGAAAGCTTATGAGATTGTAGGGCTTGCCACGATGGAGTTTTACCAATGGATCCA
AAGTTTAGAAGTAGAGCCTTTGATTAAGGATTTAAGGGAATTGGCTAGGATTTCAGCCCAAAAAGAATTGCAAAAAGCGC
TTAAAAAACGCTATGTGCCTAAAGAATACGAAAGCAACATTGAAAAGATCTTGCACAACGCTTTCAACACTTTTTTGCAC
CACCCCACCATCGCTTTAAAAAAGAACGCTCAAAAAGAAGAATCCGATGTGCTTGTGGGCGCGATTAAAAACTTGTTTAA
TTTAGACAAATCTAACGCTAACCATGCCCAGAATTTGAATCTCTATAAATGCGAATATTACGAGGAATAA

Upstream 100 bases:

>100_bases
TCGCTCAAGTTTATTCTAAAAAGGCCCTTGAAGCCATTAAAGGGGAAAACAATTTGATTTTAGAAAAACTAGCGCAAGAT
GTCATTTATAGGACTTTTTA

Downstream 100 bases:

>100_bases
TGCATGCTATTTTCAAAACTCTTTGCCCCCACTCTCAAAGAACCCCCTAAAGATGCCGTGTTAAAAAGCCATAAACACTT
AGCTCAAGCAGGATACATTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MELETHLSKYFTLAFTHKSMSLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLRHGAHANEQKSA
LLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNSMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVKEN
VGNRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRELARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLH
HPTIALKKNAQKEESDVLVGAIKNLFNLDKSNANHAQNLNLYKCEYYEE

Sequences:

>Translated_449_residues
MELETHLSKYFTLAFTHKSMSLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLRHGAHANEQKSA
LLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNSMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVKEN
VGNRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRELARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLH
HPTIALKKNAQKEESDVLVGAIKNLFNLDKSNANHAQNLNLYKCEYYEE
>Mature_449_residues
MELETHLSKYFTLAFTHKSMSLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLRHGAHANEQKSA
LLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNSMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVKEN
VGNRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRELARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLH
HPTIALKKNAQKEESDVLVGAIKNLFNLDKSNANHAQNLNLYKCEYYEE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=415, Percent_Identity=27.710843373494, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 51652; Mature: 51652

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELETHLSKYFTLAFTHKSMSLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCN
CCHHHHHHHHHHHEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
RFEIYASLRHGAHANEQKSALLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLD
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKCAAKVRNLTGISKQGVSISSV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
HHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHC
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNSMLKETIFRRFWFDLAVPRNIEKP
CCHHCCHHHHHHHHHHHCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCH
VLDNIFLYSVDDLEPMVKENVGNRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRE
HHCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLHHPTIALKKNAQKEESDVLVG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHH
AIKNLFNLDKSNANHAQNLNLYKCEYYEE
HHHHHHHCCCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
MELETHLSKYFTLAFTHKSMSLEMREKLAINSSATLKEFLQTIKNHCPNIKECMVLSTCN
CCHHHHHHHHHHHEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
RFEIYASLRHGAHANEQKSALLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLD
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKCAAKVRNLTGISKQGVSISSV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
HHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHC
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNSMLKETIFRRFWFDLAVPRNIEKP
CCHHCCHHHHHHHHHHHCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCH
VLDNIFLYSVDDLEPMVKENVGNRQESRTKAYEIVGLATMEFYQWIQSLEVEPLIKDLRE
HHCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LARISAQKELQKALKKRYVPKEYESNIEKILHNAFNTFLHHPTIALKKNAQKEESDVLVG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHH
AIKNLFNLDKSNANHAQNLNLYKCEYYEE
HHHHHHHCCCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA