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The map label for this gene is ndk [H]

Identifier: 108562617

GI number: 108562617

Start: 199054

End: 199467

Strand: Direct

Name: ndk [H]

Synonym: HPAG1_0192

Alternate gene names: 108562617

Gene position: 199054-199467 (Clockwise)

Preceding gene: 108562616

Following gene: 108562618

Centisome position: 12.47

GC content: 42.51

Gene sequence:

>414_bases
TTGAAACAAAGAACGCTGTCTATTATTAAACCGGATGCACTTAAGAAAAAAGTGGTAGGCAAGATCATTGATCGCTTTGA
AAGTAACGGCTTGGAAGTCATTGCTATGAAACGCTTGCATTTAAGCGTTAAAGACGCTGAAAACTTTTATGCGATCCACA
GAGAGAGACCCTTTTTTAAAGATTTGATAGAATTTATGGTCAGTGGTCCGGTGGTGGTTATGGTTTTAGAGGGCAAAGAT
GCGGTGGCTAAAAACAGAGATCTTATGGGAGCGACTGATCCCAAACTCGCTCAAAAAGGCACTATCAGAGCGGATTTTGC
TGAGAGCATTGACGCTAATGCGGTGCATGGGAGCGATAGCTTGGAAAACGCGCACAATGAAATCGCTTTCTTTTTTGCCG
CTAGGGATCTTTAA

Upstream 100 bases:

>100_bases
AAGATGAGGAGATTAAAGCGTTCTTTAAGCGTTAAAAAATATTTTAAGGGTAATATTTTAAAAAATTTTTGTATAATCAA
CAATTCACAAGGAGTTTAAA

Downstream 100 bases:

>100_bases
GATTTAAGGGCGTTTTAAGTAAGCATGCAATTTGAAATGCGTAAAATCGCTTTTAATGCACCTAAAGCGTTTTCTTTAGA
GCATGAGGGAGTGGTTTTAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFKDLIEFMVSGPVVVMVLEGKD
AVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDSLENAHNEIAFFFAARDL

Sequences:

>Translated_137_residues
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFKDLIEFMVSGPVVVMVLEGKD
AVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDSLENAHNEIAFFFAARDL
>Mature_137_residues
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFKDLIEFMVSGPVVVMVLEGKD
AVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDSLENAHNEIAFFFAARDL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=45.1851851851852, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392203, Length=135, Percent_Identity=42.2222222222222, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI66392227, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392205, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4505409, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392192, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.1764705882353, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=40.7407407407407, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=40.7407407407407, Blast_Score=118, Evalue=1e-27,
Organism=Homo sapiens, GI37574614, Length=141, Percent_Identity=36.8794326241135, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI7019465, Length=141, Percent_Identity=36.8794326241135, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI5031951, Length=134, Percent_Identity=36.5671641791045, Blast_Score=86, Evalue=9e-18,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=32.8467153284672, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=32.089552238806, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI148839372, Length=133, Percent_Identity=34.5864661654135, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=54.9618320610687, Blast_Score=159, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.962962962963, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=40, Blast_Score=117, Evalue=6e-28,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.1176470588235, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18860097, Length=140, Percent_Identity=32.1428571428571, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24645457, Length=143, Percent_Identity=31.4685314685315, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15300; Mature: 15300

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFK
CCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEHEEEEECCCCEEEECCCCCHHH
DLIEFMVSGPVVVMVLEGKDAVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDS
HHHHHHHCCCEEEEEECCCCCHHCCCCCCCCCCCCHHCCCCCCCHHHHCCCCCCCCCCCH
LENAHNEIAFFFAARDL
HHHHCCCEEEEEEECCC
>Mature Secondary Structure
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFK
CCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEHEEEEECCCCEEEECCCCCHHH
DLIEFMVSGPVVVMVLEGKDAVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDS
HHHHHHHCCCEEEEEECCCCCHHCCCCCCCCCCCCHHCCCCCCCHHHHCCCCCCCCCCCH
LENAHNEIAFFFAARDL
HHHHCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA