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The map label for this gene is sdaC [H]

Identifier: 108562556

GI number: 108562556

Start: 139050

End: 140291

Strand: Reverse

Name: sdaC [H]

Synonym: HPAG1_0131

Alternate gene names: 108562556

Gene position: 140291-139050 (Counterclockwise)

Preceding gene: 108562559

Following gene: 108562555

Centisome position: 8.79

GC content: 39.05

Gene sequence:

>1242_bases
ATGGCACAAGAAAAAGCAGTTCCAAGAGATCCTAAAAAACTCAACGCGTTTGATTTGCGTTGGATGGTGTCCTTATTTGG
CACGGCGGTGGGGGCTGGGATTTTATTTTTGCCTATTAGAGCCGGTGGGCATGGGGTATGGGCTATTGTGGTGATGAGCG
CGATCATCTTCCCTTTAACTTATCTGGGGCATAGAGCTTTAGCTTATTTCATAGGATCTAAAGATAAAGAAGACATTACC
ATGGTCGTTCGCTCTCATTTTGGCGCTCAATGGGGTTTTCTTATCACTTTGCTTTATTTCTTGGCGATTTATCCTATTTG
CTTGGTTTATGGGGTGGGTATCACTAATGTGTTTGATCATTTTTTCACTAACCAGTTGCATTTAGCGCCTTTTCATCGGG
GCTTACTGGCTGTAGTGTTAGTTTCTTTAATGATGTTGGTGATGGTTTTTAACGCTACGATTGTTACGCGCATTTGTAAC
GCTTTAGTGTATCCTTTGTGCTTGATTTTATTGCTTTTTTCTTTGTATCTTATCCCTTATTGGCAAGGCGCTAATCTTTT
TGTGGTGCCGAGTTTTAAAGAATTTGTGTTAGCGATTTGGCTAACCTTACCGGTGCTTGTGTTTTCATTCGACCATAGCC
CCATCATTTCAACCTTCACTCAAAATGTGGAAAAAGAATACGGCGCTTTCAAAGAGTATAAACTCAATCAAATTGAATTA
GGGACATCGCTGATGCTTTTAGGGTTTGTGATGTTTTTTGTGTTTTCGTGCGTCATGTGCTTGAATGCTGATGATTTTGT
GAAAGCAAGGGAACAAAATATCCCCATTTTAAGCTATTTGGCTAACACCTTAAACAACCCTTTAATCAATTATGCGGGGC
CTGTGGTGGCTTTTTTAGCGATTTTTTCATCTTTTTTTGGGCATTATTATGGGGCTAAGGAGGGTTTAGAAGGCATTATT
GTTCAAAGTTTAAAATTGAAAAAAGCTTCTAAAACCTTGAGTGTTAGCGTAACGATTTTTTTATGGCTGACTATCACGCT
TGTGGCTTATATTAACCCTAATATCTTGGATTTTATTGAAAATTTAGGCGGCCCCATTATCGCGCTCATTCTGTTTGTGA
TGCCCATGATAGCTTTTTATAGCGTTTCTAGTTTGAAGCGTTTTAGAAACTTCAAAGTGGATATTTTTGTGTTTGTCTTT
GGGAGCTTGACGGCTTTGAGCGTGTTTTTAGGACTATTTTAA

Upstream 100 bases:

>100_bases
GCGCTAAAAACCACCCCCCTAATCTCAAAAAACCCCAATCATAAAAAGCTTTATGCTACAATGAAAGCTCTTTAACACGA
TAAAAGGGCGGTTTAATAGC

Downstream 100 bases:

>100_bases
TGGCTAGTTTTTCTATTTTATCCATTTTTAAAATCGGCGTGGGGCCTAGCTCTTCACACACCATAGGGCCTATGGAAGCG
GGAGCGAGATTTTGCAAGTC

Product: L-serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MAQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLTYLGHRALAYFIGSKDKEDIT
MVVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDHFFTNQLHLAPFHRGLLAVVLVSLMMLVMVFNATIVTRICN
ALVYPLCLILLLFSLYLIPYWQGANLFVVPSFKEFVLAIWLTLPVLVFSFDHSPIISTFTQNVEKEYGAFKEYKLNQIEL
GTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLAIFSSFFGHYYGAKEGLEGII
VQSLKLKKASKTLSVSVTIFLWLTITLVAYINPNILDFIENLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVF
GSLTALSVFLGLF

Sequences:

>Translated_413_residues
MAQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLTYLGHRALAYFIGSKDKEDIT
MVVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDHFFTNQLHLAPFHRGLLAVVLVSLMMLVMVFNATIVTRICN
ALVYPLCLILLLFSLYLIPYWQGANLFVVPSFKEFVLAIWLTLPVLVFSFDHSPIISTFTQNVEKEYGAFKEYKLNQIEL
GTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLAIFSSFFGHYYGAKEGLEGII
VQSLKLKKASKTLSVSVTIFLWLTITLVAYINPNILDFIENLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVF
GSLTALSVFLGLF
>Mature_412_residues
AQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLTYLGHRALAYFIGSKDKEDITM
VVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDHFFTNQLHLAPFHRGLLAVVLVSLMMLVMVFNATIVTRICNA
LVYPLCLILLLFSLYLIPYWQGANLFVVPSFKEFVLAIWLTLPVLVFSFDHSPIISTFTQNVEKEYGAFKEYKLNQIELG
TSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLAIFSSFFGHYYGAKEGLEGIIV
QSLKLKKASKTLSVSVTIFLWLTITLVAYINPNILDFIENLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVFG
SLTALSVFLGLF

Specific function: Involved in the import of serine into the cell [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=407, Percent_Identity=43.980343980344, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=39.2776523702032, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1789211, Length=380, Percent_Identity=36.8421052631579, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1789961, Length=412, Percent_Identity=25, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI145693183, Length=421, Percent_Identity=24.9406175771971, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46322; Mature: 46191

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
YLGHRALAYFIGSKDKEDITMVVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDH
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FFTNQLHLAPFHRGLLAVVLVSLMMLVMVFNATIVTRICNALVYPLCLILLLFSLYLIPY
HHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WQGANLFVVPSFKEFVLAIWLTLPVLVFSFDHSPIISTFTQNVEKEYGAFKEYKLNQIEL
CCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCCCHHHH
GTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
IFSSFFGHYYGAKEGLEGIIVQSLKLKKASKTLSVSVTIFLWLTITLVAYINPNILDFIE
HHHHHHHHHCCHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
NLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVFGSLTALSVFLGLF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
YLGHRALAYFIGSKDKEDITMVVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDH
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FFTNQLHLAPFHRGLLAVVLVSLMMLVMVFNATIVTRICNALVYPLCLILLLFSLYLIPY
HHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WQGANLFVVPSFKEFVLAIWLTLPVLVFSFDHSPIISTFTQNVEKEYGAFKEYKLNQIEL
CCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCCCHHHH
GTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
IFSSFFGHYYGAKEGLEGIIVQSLKLKKASKTLSVSVTIFLWLTITLVAYINPNILDFIE
HHHHHHHHHCCHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
NLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVFGSLTALSVFLGLF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]