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The map label for this gene is cysM [H]

Identifier: 108562532

GI number: 108562532

Start: 112042

End: 112962

Strand: Reverse

Name: cysM [H]

Synonym: HPAG1_0107

Alternate gene names: 108562532

Gene position: 112962-112042 (Counterclockwise)

Preceding gene: 108562534

Following gene: 108562531

Centisome position: 7.08

GC content: 46.8

Gene sequence:

>921_bases
ATGATGATTATCACCACAATGCAAGACGCCATAGGCCGCACTCCCATTTTTAAATTCACTAACAAGGATTACCCCATTCC
GTTAAATTCCGCCATTTACGCCAAGCTGGAGCATCTAAACCCAGGGGGGAGCATCAAAGATCGCTTAGGCCAATACCTTA
TAGAAGAAGGGTTTAAAACGGGCAAAATCACTTCTAAAACAACCATCATTGAGCCTACCGCAGGCAATACCGGCATCGCT
CTAGCCTTAGTGGCGCTCAAGCACCATCTCAAAACCATCTTTGTTGTCCCAGAAAAATTCAGCACAGAAAAACAGCAAAT
CATGAGGGCTTTGGGGGCTTTAGTAATCAACACGCCTACTAGCGAGGGGATTTCTGGCGCCATTAAAAAAAGTAAAGAGT
TAGCCGAAAGTATCCCTGATAGCTATTTGCCCTTACAATTTGAAAACCCTAATAATCCCGCCGCTTACTACCACACCCTA
GCCCCTGAGATTGTCCAAGAATTAGGCACAAACCTTACGAGCTTTGTAGCCGGGATAGGGAGTGGTGGCACTTTTGCGGG
CACGGCTAGGTATTTGAAAGAACGCATTCCTGCGATTCGTTTGATTGGGGTGGAGCCGGAGGGTTCTATTTTGAATGGGG
GCGAGCCTGGGCCTCATGAGATTGAGGGCATTGGCGTGGAGTTCATCCCCCCTTTTTTTGCAAACTTGGATATTGATGGC
TTTGAAACGATTTCAGATGAAGAGGGTTTTAGCTACACTAGGAAGTTAGCCAAGAAAAACGGCTTATTAGTGGGGAGCTC
TAGCGGGGCAGCTTTTGTGGCAGCGCTGAAAGAAGTGCAACGCCTCCCCGAAGGCAGCCAGGTTTTAACCATTTTCCCGG
ATGTTGCCGATCGTTATCTTTCAAAAGGTATTTACTTATAA

Upstream 100 bases:

>100_bases
TAATCCATCTCAATAAACCAACATTTTACCCTAAACTTATTCCATTTAATGAGTTTAGGCATAATCGCAAAATTGAATTT
TATTGTTTGTTATAGGAGGA

Downstream 100 bases:

>100_bases
ATTCATCAAAAGGAAAAATCATGCGCATGCAAACAAAACTAATCCATGGGGGCATTAGTGAGGATACGACAACGGGGGCG
GTGAGCGTGCCTATTTATCA

Product: cysteine synthetase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MMIITTMQDAIGRTPIFKFTNKDYPIPLNSAIYAKLEHLNPGGSIKDRLGQYLIEEGFKTGKITSKTTIIEPTAGNTGIA
LALVALKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELAESIPDSYLPLQFENPNNPAAYYHTL
APEIVQELGTNLTSFVAGIGSGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDG
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEVQRLPEGSQVLTIFPDVADRYLSKGIYL

Sequences:

>Translated_306_residues
MMIITTMQDAIGRTPIFKFTNKDYPIPLNSAIYAKLEHLNPGGSIKDRLGQYLIEEGFKTGKITSKTTIIEPTAGNTGIA
LALVALKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELAESIPDSYLPLQFENPNNPAAYYHTL
APEIVQELGTNLTSFVAGIGSGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDG
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEVQRLPEGSQVLTIFPDVADRYLSKGIYL
>Mature_306_residues
MMIITTMQDAIGRTPIFKFTNKDYPIPLNSAIYAKLEHLNPGGSIKDRLGQYLIEEGFKTGKITSKTTIIEPTAGNTGIA
LALVALKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELAESIPDSYLPLQFENPNNPAAYYHTL
APEIVQELGTNLTSFVAGIGSGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDG
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEVQRLPEGSQVLTIFPDVADRYLSKGIYL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=301, Percent_Identity=40.531561461794, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI295821200, Length=301, Percent_Identity=40.531561461794, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI4557415, Length=301, Percent_Identity=40.531561461794, Blast_Score=231, Evalue=9e-61,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=35.1973684210526, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=39.4822006472492, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=313, Percent_Identity=37.0607028753994, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17562970, Length=311, Percent_Identity=37.620578778135, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI32566674, Length=306, Percent_Identity=38.2352941176471, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=39.1304347826087, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=37.1428571428571, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=36.4217252396166, Blast_Score=180, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=38.8157894736842, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32566672, Length=216, Percent_Identity=37.962962962963, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6321594, Length=312, Percent_Identity=39.1025641025641, Blast_Score=208, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=31.7073170731707, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=37.5404530744337, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=37.5404530744337, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33011; Mature: 33011

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIITTMQDAIGRTPIFKFTNKDYPIPLNSAIYAKLEHLNPGGSIKDRLGQYLIEEGFKT
CEEEEECHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
GKITSKTTIIEPTAGNTGIALALVALKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPT
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHEEEECCC
SEGISGAIKKSKELAESIPDSYLPLQFENPNNPAAYYHTLAPEIVQELGTNLTSFVAGIG
CCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHCC
SGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDG
CCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCC
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEVQRLPEGSQVLTIFPDVADRYL
CCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHH
SKGIYL
HCCCCC
>Mature Secondary Structure
MMIITTMQDAIGRTPIFKFTNKDYPIPLNSAIYAKLEHLNPGGSIKDRLGQYLIEEGFKT
CEEEEECHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
GKITSKTTIIEPTAGNTGIALALVALKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPT
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHEEEECCC
SEGISGAIKKSKELAESIPDSYLPLQFENPNNPAAYYHTLAPEIVQELGTNLTSFVAGIG
CCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHCC
SGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDG
CCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCC
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEVQRLPEGSQVLTIFPDVADRYL
CCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHH
SKGIYL
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]