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The map label for this gene is envZ [H]

Identifier: 107023337

GI number: 107023337

Start: 1976544

End: 1977809

Strand: Reverse

Name: envZ [H]

Synonym: Bcen_1788

Alternate gene names: 107023337

Gene position: 1977809-1976544 (Counterclockwise)

Preceding gene: 107023338

Following gene: 107023335

Centisome position: 60.03

GC content: 72.2

Gene sequence:

>1266_bases
ATGCGCAAACCCATTGATTCACTGTTCGGGCGGCTGGCGCTGCTCGTCGTCGGTGTCCTGCTCCTGTCGCACTTCGCGTG
GTTCTTCGCGATGCGGCTCGAGCGCAACCAGATGCAGACGCGTTATGCGGTCGAGGAAGCCGCATTCCTCGTCGACGCGG
TGCGCCAGCACATCGAGCGTACGCCCGACCAGCCGTTGCCGTCGCGCGTGCGGCTCGTGTCGCCCGATAGTGCCGATGTG
CCGAAGAGCGGCGATTCGGGGCTGCCGCCGCCGCTGAAGCGGTTCCGCGACGACGTGAGCGAGCGCATGCCGCCCGGCAC
GCAGGTCGAGATCGGCACGCCCGGCCATCCGCCGGTGCTGTGGGTGAAGGAGCCGACCGACCGCAACTGGATCGTGGTGC
CCGTGCAGCCGCTGCGGCCGCCGCGCTCGCTCGACCGGATGCTGCTGTGGCTCGGCACGATCTTCTCGGCCGGCGTGATC
GCCGCGCTGTTCGCGGCCTGGCAGTTGCAGCAGCCGCTGCGCTCGCTCGCGCGCGCGGTCGCGCGTTTCGGTCGCGGGCA
GCCGGTGCCGCCGCTGCGCGAGCGCGGCCCGCGCGAGCTGCGCCAGCTCACGCACGGCTTCAACCAGATGGTGGAGCAGG
TGTCGCAGGCCGAGAGCGATCGCGCGGTGATGCTGGCCGGCGTCGCGCACGACCTGCGCACGCCGCTCGCGCGGATGCGC
CTGCGGGCCGAAATGATGGACGACGCACGGCTGCGCGACGGCGTCGTGCGCGACGTCGACTCGATGTCGCACATCGTCGA
CCAGTTCCTGGTGTTTGCGCACGGCGGGGCCGACCGCAGCGAGCCGGTGCCGGTCGACCAGGCGTGCGAGCGGATCGCGC
GTAGCTATCGTGCGGTTGCGCCGAATGCGCCGACGGTCCAGACGCGGCTGGAGGCCGATCCCGGCTTCCGGCTGCCGACG
GCGACGCTCGACCGGATCTTGTCGAACCTGCTGGACAACGCGCATGCGTACGGTGCACCGCCCGTATTCGTCGAGACGGC
GCGCACGCCGGCCGGCTACGTGCTGTCGGTCAGCGACAGCGGCGGCGGCATCGCGCCGCGCGACCTCGCGGCCGCCACGC
GGCCGTTCGTGCGGCTCGATCCCGCGCGCGGCGGGAACGGCCACAGCGGGCTCGGGCTCGCGATCGTCGAGCGGCTCGTG
CTCAGGCTGGGGGGGGCGCGTGCGACATCGGCAATCGCCCCGAGGGCGGCCTGCGGGTATCGATGA

Upstream 100 bases:

>100_bases
TGGCGCCTGCGCCGCATCCTCGAAACGGATCCGTCGACGCCGCGCTTCATCCAGACGGTCCGCGGGCGCGGCTACGTGTT
CGTGCCCGACGGCGAGGCCC

Downstream 100 bases:

>100_bases
CGTTCCCGTTCGACGCCGTGCCGAAGGACGAACCCCACGCACAGGCCGCATGAGCGGCCGCGGCGCCTGCCCGGGCGGGC
AAGCGCCGCGCGGCATCATT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERNQMQTRYAVEEAAFLVDAVRQHIERTPDQPLPSRVRLVSPDSADV
PKSGDSGLPPPLKRFRDDVSERMPPGTQVEIGTPGHPPVLWVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
LRAEMMDDARLRDGVVRDVDSMSHIVDQFLVFAHGGADRSEPVPVDQACERIARSYRAVAPNAPTVQTRLEADPGFRLPT
ATLDRILSNLLDNAHAYGAPPVFVETARTPAGYVLSVSDSGGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGARATSAIAPRAACGYR

Sequences:

>Translated_421_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERNQMQTRYAVEEAAFLVDAVRQHIERTPDQPLPSRVRLVSPDSADV
PKSGDSGLPPPLKRFRDDVSERMPPGTQVEIGTPGHPPVLWVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
LRAEMMDDARLRDGVVRDVDSMSHIVDQFLVFAHGGADRSEPVPVDQACERIARSYRAVAPNAPTVQTRLEADPGFRLPT
ATLDRILSNLLDNAHAYGAPPVFVETARTPAGYVLSVSDSGGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGARATSAIAPRAACGYR
>Mature_421_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERNQMQTRYAVEEAAFLVDAVRQHIERTPDQPLPSRVRLVSPDSADV
PKSGDSGLPPPLKRFRDDVSERMPPGTQVEIGTPGHPPVLWVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
LRAEMMDDARLRDGVVRDVDSMSHIVDQFLVFAHGGADRSEPVPVDQACERIARSYRAVAPNAPTVQTRLEADPGFRLPT
ATLDRILSNLLDNAHAYGAPPVFVETARTPAGYVLSVSDSGGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGARATSAIAPRAACGYR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=307, Percent_Identity=32.8990228013029, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787894, Length=246, Percent_Identity=32.1138211382114, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790346, Length=250, Percent_Identity=28.4, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=211, Percent_Identity=32.7014218009479, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=306, Percent_Identity=26.797385620915, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082128, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081816, Length=271, Percent_Identity=25.0922509225092, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46179; Mature: 46179

Theoretical pI: Translated: 10.78; Mature: 10.78

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERNQMQTRYAVEEAAFLVDAVRQHIER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDQPLPSRVRLVSPDSADVPKSGDSGLPPPLKRFRDDVSERMPPGTQVEIGTPGHPPVL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCEE
WVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVIAALFAAWQLQQPLRSLARAV
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
HHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
LRAEMMDDARLRDGVVRDVDSMSHIVDQFLVFAHGGADRSEPVPVDQACERIARSYRAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
PNAPTVQTRLEADPGFRLPTATLDRILSNLLDNAHAYGAPPVFVETARTPAGYVLSVSDS
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECC
GGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLVLRLGGARATSAIAPRAACGY
CCCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHCCC
R
C
>Mature Secondary Structure
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERNQMQTRYAVEEAAFLVDAVRQHIER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDQPLPSRVRLVSPDSADVPKSGDSGLPPPLKRFRDDVSERMPPGTQVEIGTPGHPPVL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCEE
WVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVIAALFAAWQLQQPLRSLARAV
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
HHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
LRAEMMDDARLRDGVVRDVDSMSHIVDQFLVFAHGGADRSEPVPVDQACERIARSYRAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
PNAPTVQTRLEADPGFRLPTATLDRILSNLLDNAHAYGAPPVFVETARTPAGYVLSVSDS
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECC
GGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLVLRLGGARATSAIAPRAACGY
CCCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]