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The map label for this gene is dht [H]

Identifier: 107023144

GI number: 107023144

Start: 1767384

End: 1768841

Strand: Reverse

Name: dht [H]

Synonym: Bcen_1593

Alternate gene names: 107023144

Gene position: 1768841-1767384 (Counterclockwise)

Preceding gene: 107023145

Following gene: 107023143

Centisome position: 53.69

GC content: 68.24

Gene sequence:

>1458_bases
ATGGCAATCCTGATTCGTGGCGGCACCGTGGTCGATGCGGACCGCTCCTATCGCGCGGACGTGCTCTGCGCGGACCCGCA
GGACGGCGGCACGATCCTGCAGATTGCGGAGCAGATCGACGCGCCGGCCGGCGCAACCGTGGTCGACGCGCACGACCAGT
ACGTGATGCCGGGCGGTATCGACCCGCACACGCACATGGAACTGCCGTTCATGGGTACCACCGCGAGCGACGATTTCTAC
TCGGGCACCGCGGCCGGGCTGTCGGGCGGCACGACGAGCATCATCGACTTCGTGATTCCGAGCCCGAAGCAGCCGCTGAT
GGATGCGTTCCGCGAATGGCGCGGCTGGGCCGAGAAGGCGGCTTCCGATTACGGTTTCCACGTGGCCGTGACGTGGTGGG
ACGACAGCGTGCACCGCGACATGGGCACGCTCGTGCGCGAGCATGGCGTGTCGAGCTTCAAGCACTTCATGGCGTACAAG
AACGCGATCATGGCCGACGACGAGGTGCTCGTGAACAGCTTCACGCGTTCGCTCGAACTCGGCGCGCTGCCGACCGTGCA
CGCGGAAAACGGTGAGCTCGTGTTCCAGCTGCAAAAGGCGCTGCTCGCGCGCGGGATCACGGGGCCGGAGGCGCATCCGC
TGTCGCGGCCGCCGGAGGTGGAAGGCGAGGCCGCGAACCGCGCGATCCGGATCGCGCAGGTACTCGGCGTGCCCGTGTAT
ATCGTGCACGTGTCGGCGAAGGACGCGGTGGACGTGATCACCCGTGCGCGCAGCGAAGGGCTGCGTGTGTTCGGCGAAGT
GCTGCCGGGCCACCTCGTGATCGACGAGGCCGTCTATCGCGATCCGGACTGGACGCGCGCGGCGGCCCACGTGATGAGCC
CGCCGTTCCGCTCGGCCGAGCATCGCGAGGCGCTGTGGCGCGGGCTGCAGTCGGGCCAGCTGCATACGACCGCGACCGAT
CACTGCGTATTCTGCGCGTCGCAGAAGGCGATGGGCCGCGAGGATTTCACGAAGATCCCGAACGGCTGCGGCGGTGTCGA
GGATCGCATGTCGGTGCTGTGGCACCACGGCGTGAATCACGGCCGCATCACGCCGAACGAGTTCGTGCGGATCACGTCGA
CCAATGCCGCACAGATCTTCAACCTGTATCCGCGCAAGGGCGCCGTGCAGGTTGGCGCCGATGCCGACCTCGTCGTGTGG
GACCCGGCCGCGACGAAGACGATCTCGGTGAAGACCCATCACCAGCAGGTCGACTTCAACGTGTTCGAGGGGATGACGGT
GCAGGGCGTCGCGACGCACACGCTCACGCGCGGCGCACTCGCATGGGCCGACGGCGAATTGCGCGCGGTGCGCGGCGCGG
GCCGCTACCTCAAGCGCCCGCCGGGCGCGGGCTACTACGAGGCCGCGCGGATCGCGAACCGGCTGCGCGAGCCGCATCCG
GTCGAACGCGCCGGTTGA

Upstream 100 bases:

>100_bases
CCGGACAGCGCGCGCAGATCGCGAGCGCATGACGCACGCGCGGGCCGGATGCGGCTCGCGCGCGGCATGCGGCACCGACA
GTCAACGAGGAGGCAACGAA

Downstream 100 bases:

>100_bases
ACGACGCAGGTCATGCGGGGCGTGTCCGTTCGAACGGCGCGCCCCGCGCGCGTTTTCGCAGGGTAGATAGAACAACTGAT
CAAGTCGTCGAGGCACGAAA

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MAILIRGGTVVDADRSYRADVLCADPQDGGTILQIAEQIDAPAGATVVDAHDQYVMPGGIDPHTHMELPFMGTTASDDFY
SGTAAGLSGGTTSIIDFVIPSPKQPLMDAFREWRGWAEKAASDYGFHVAVTWWDDSVHRDMGTLVREHGVSSFKHFMAYK
NAIMADDEVLVNSFTRSLELGALPTVHAENGELVFQLQKALLARGITGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
IVHVSAKDAVDVITRARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAEHREALWRGLQSGQLHTTATD
HCVFCASQKAMGREDFTKIPNGCGGVEDRMSVLWHHGVNHGRITPNEFVRITSTNAAQIFNLYPRKGAVQVGADADLVVW
DPAATKTISVKTHHQQVDFNVFEGMTVQGVATHTLTRGALAWADGELRAVRGAGRYLKRPPGAGYYEAARIANRLREPHP
VERAG

Sequences:

>Translated_485_residues
MAILIRGGTVVDADRSYRADVLCADPQDGGTILQIAEQIDAPAGATVVDAHDQYVMPGGIDPHTHMELPFMGTTASDDFY
SGTAAGLSGGTTSIIDFVIPSPKQPLMDAFREWRGWAEKAASDYGFHVAVTWWDDSVHRDMGTLVREHGVSSFKHFMAYK
NAIMADDEVLVNSFTRSLELGALPTVHAENGELVFQLQKALLARGITGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
IVHVSAKDAVDVITRARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAEHREALWRGLQSGQLHTTATD
HCVFCASQKAMGREDFTKIPNGCGGVEDRMSVLWHHGVNHGRITPNEFVRITSTNAAQIFNLYPRKGAVQVGADADLVVW
DPAATKTISVKTHHQQVDFNVFEGMTVQGVATHTLTRGALAWADGELRAVRGAGRYLKRPPGAGYYEAARIANRLREPHP
VERAG
>Mature_484_residues
AILIRGGTVVDADRSYRADVLCADPQDGGTILQIAEQIDAPAGATVVDAHDQYVMPGGIDPHTHMELPFMGTTASDDFYS
GTAAGLSGGTTSIIDFVIPSPKQPLMDAFREWRGWAEKAASDYGFHVAVTWWDDSVHRDMGTLVREHGVSSFKHFMAYKN
AIMADDEVLVNSFTRSLELGALPTVHAENGELVFQLQKALLARGITGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVYI
VHVSAKDAVDVITRARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAEHREALWRGLQSGQLHTTATDH
CVFCASQKAMGREDFTKIPNGCGGVEDRMSVLWHHGVNHGRITPNEFVRITSTNAAQIFNLYPRKGAVQVGADADLVVWD
PAATKTISVKTHHQQVDFNVFEGMTVQGVATHTLTRGALAWADGELRAVRGAGRYLKRPPGAGYYEAARIANRLREPHPV
ERAG

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=489, Percent_Identity=50.5112474437628, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI4503379, Length=487, Percent_Identity=43.5318275154004, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI4503377, Length=484, Percent_Identity=43.3884297520661, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI190194363, Length=487, Percent_Identity=44.9691991786448, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI4503051, Length=476, Percent_Identity=43.4873949579832, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI62422571, Length=476, Percent_Identity=43.4873949579832, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI19923821, Length=478, Percent_Identity=44.7698744769874, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI18105007, Length=410, Percent_Identity=26.3414634146341, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI87082175, Length=465, Percent_Identity=37.8494623655914, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1786722, Length=453, Percent_Identity=26.7108167770419, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539558, Length=485, Percent_Identity=47.2164948453608, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71989490, Length=460, Percent_Identity=46.304347826087, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI86575075, Length=472, Percent_Identity=30.9322033898305, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI193204318, Length=451, Percent_Identity=25.7206208425721, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=442, Percent_Identity=26.6968325791855, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221377917, Length=492, Percent_Identity=44.7154471544715, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI17137462, Length=490, Percent_Identity=44.2857142857143, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24644287, Length=300, Percent_Identity=44.3333333333333, Blast_Score=258, Evalue=8e-69,
Organism=Drosophila melanogaster, GI24644289, Length=241, Percent_Identity=46.4730290456432, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI18859883, Length=454, Percent_Identity=25.1101321585903, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24642586, Length=250, Percent_Identity=28.4, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52825; Mature: 52694

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILIRGGTVVDADRSYRADVLCADPQDGGTILQIAEQIDAPAGATVVDAHDQYVMPGGI
CEEEEECCEEEECCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCEECCCCC
DPHTHMELPFMGTTASDDFYSGTAAGLSGGTTSIIDFVIPSPKQPLMDAFREWRGWAEKA
CCCCEEECCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ASDYGFHVAVTWWDDSVHRDMGTLVREHGVSSFKHFMAYKNAIMADDEVLVNSFTRSLEL
CCCCCEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEC
GALPTVHAENGELVFQLQKALLARGITGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEE
IVHVSAKDAVDVITRARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAE
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCCHHHHHHHHCCCCCCCHH
HREALWRGLQSGQLHTTATDHCVFCASQKAMGREDFTKIPNGCGGVEDRMSVLWHHGVNH
HHHHHHCCCCCCCEEECCCCCEEEECCCHHCCCHHHHHCCCCCCCHHHHHHHHHHCCCCC
GRITPNEFVRITSTNAAQIFNLYPRKGAVQVGADADLVVWDPAATKTISVKTHHQQVDFN
CCCCHHHEEEEECCCCEEEEEECCCCCCEEECCCCCEEEECCCCCEEEEEEECCCEECEE
VFEGMTVQGVATHTLTRGALAWADGELRAVRGAGRYLKRPPGAGYYEAARIANRLREPHP
HHCCCEEECHHHHHHHCCEEEECCCCEEEEHHCCHHHCCCCCCCHHHHHHHHHHCCCCCC
VERAG
CCCCC
>Mature Secondary Structure 
AILIRGGTVVDADRSYRADVLCADPQDGGTILQIAEQIDAPAGATVVDAHDQYVMPGGI
EEEEECCEEEECCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCEECCCCC
DPHTHMELPFMGTTASDDFYSGTAAGLSGGTTSIIDFVIPSPKQPLMDAFREWRGWAEKA
CCCCEEECCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ASDYGFHVAVTWWDDSVHRDMGTLVREHGVSSFKHFMAYKNAIMADDEVLVNSFTRSLEL
CCCCCEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEC
GALPTVHAENGELVFQLQKALLARGITGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEE
IVHVSAKDAVDVITRARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAE
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCCHHHHHHHHCCCCCCCHH
HREALWRGLQSGQLHTTATDHCVFCASQKAMGREDFTKIPNGCGGVEDRMSVLWHHGVNH
HHHHHHCCCCCCCEEECCCCCEEEECCCHHCCCHHHHHCCCCCCCHHHHHHHHHHCCCCC
GRITPNEFVRITSTNAAQIFNLYPRKGAVQVGADADLVVWDPAATKTISVKTHHQQVDFN
CCCCHHHEEEEECCCCEEEEEECCCCCCEEECCCCCEEEECCCCCEEEEEEECCCEECEE
VFEGMTVQGVATHTLTRGALAWADGELRAVRGAGRYLKRPPGAGYYEAARIANRLREPHP
HHCCCEEECHHHHHHHCCEEEECCCCEEEEHHCCHHHCCCCCCCHHHHHHHHHHCCCCCC
VERAG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]